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Protein Alignment Tollo and TLR5

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_003259.2	Gene:	TLR5 / 7100	HGNCID:	11851	Length:	858	Species:	Homo sapiens

Alignment Length:	1071	Identity:	240/1071 - (22%)
Similarity:	388/1071 - (36%)	Gaps:	323/1071 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 SASLSSRKA--RVCG--------STLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLAD 251
            |.|...|.|  |.|.        :|.:.|.||.|.:.::..:....|.:|..|.:.........|
Human    23 SCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTID 87

  Fly   252 R-AFEGLLSLRVVDLSANRLTSLPPELFAETKQLQE--IYLRNNSINVLAPGIFGELAELLVLDL 313
            : ||..|.:||::||.::::..|.|:.|.....|.|  :|....|..||..|.|..|..|..|||
Human    88 KEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDL 152

  Fly   314 ASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPL--ASLQILKLEDNYIDQLPGGIF 376
            :.|::.|.::: .:|..|..|..:|.|:|:|..:..|...||  .:|....|..|.:
Human   153 SKNQIRSLYLH-PSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSL-------- 208

  Fly   377 ADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDF--------------NRISRMDQRSLVNC 427
                        .:|:||...:.:...:|:::..||.              |.||:....||:..
Human   209 ------------YSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILA 261

  Fly   428 SQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRR 492
            ..:.......:.::               |..:|..:.:..:|:..|:..:|...:.||
Human   262 HHIMGAGFGFHNIK---------------DPDQNTFAGLARSSVRHLDLSHGFVFSLNS------ 305

  Fly   493 GVFDRMSSLQILNLSQNKLKSI--EAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISG 555
            .||:.:..|::|||:.||:..|  ||                         |..|.||..||:
Human   306 RVFETLKDLKVLNLAYNKINKIADEA-------------------------FYGLDNLQVLNL-- 343

  Fly   556 NRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVL 620
                                                         |||||.|:.:|:.....:|.
Human   344 ---------------------------------------------SYNLLGELYSSNFYGLPKVA 363

  Fly   621 Y--LNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLE--PNALRLSPIAEDREIPEFYIGHNAYE 681
            |  |..|.|:.||..||.....|..:||..|.|||:.  |:            ||:.::..|
Human   364 YIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPS------------IPDIFLSGN--- 413

  Fly   682 CDCNLDWLQKVNRESR----TQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFAL 742
               .|..|.|:|..:.    ::.:|.:||.::..|..    .|:.::....:.|
Human   414 ---KLVTLPKINLTANLIHLSENRLENLDILYFLLRV----PHLQILILNQNRF----------- 460

  Fly   743 CHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFR--- 804
                              .||..||:                 ||..| ...||:|..|..:
Human   461 ------------------SSCSGDQT-----------------PSENP-SLEQLFLGENMLQLAW 489

  Fly   805 --ELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQE 867
              ||....|.|...|:||:|||:.:..|....|..|..|..|.|.||:|..|:.|:...  ||:.
Human   490 ETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPA--NLEI 552

  Fly   868 LYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLPSYLNELRLASNPWTCSCEFIDKL 932
            |.:..|.:...:...|.   .|.:|.:.|                       |.:.|.||    |
Human   553 LDISRNQLLAPNPDVFV---SLSVLDITH-----------------------NKFICECE----L 587

  Fly   933 RDYIN--RHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYAEQ 995
            ..:||  .|..|         .|:|.......:||.|....||                |:.:.:
Human   588 STFINWLNHTNV---------TIAGPPADIYCVYPDSFSGVSL----------------FSLSTE 627

  Fly   996 AGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFRQEMRVWCHSRFGVRLF 1060
             |.:......|.|..|          .:|..:|..:|:|..:::.     :.|.:|..     .:
Human   628 -GCDEEEVLKSLKFSL----------FIVCTVTLTLFLMTILTVT-----KFRGFCFI-----CY 671

  Fly  1061 YNAQKDVDKNEREKL------FDAFVSYSSKDELFVNEELAPMLE---MGEHRYKLCLHQRDFPV 1116
            ..||:.|.|:..:..      :||::.:||||..:|...|...|:   ..::|:.||..:|||..
Human   672 KTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVP 736

  Fly  1117 GGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKEL- 1180
            |......|..||.:||:.:.:||.:|::..||...|..|....|.|....||::|:|.:.|.:|
Human   737 GENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLM 801

  Fly  1181 -DPDLRLYLKTNTYLQWGDKL-----FWQKL 1205
             ...:|.:::...||:|.:.|     |..||
Human   802 KHQSIRGFVQKQQYLRWPEDLQDVGWFLHKL 832

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.