DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tollo and TLR4

DIOPT Version :10

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_612564.1 Gene:TLR4 / 7099 HGNCID:11850 Length:839 Species:Homo sapiens


Alignment Length:945 Identity:228/945 - (24%)
Similarity:380/945 - (40%) Gaps:226/945 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   337 LDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQ 401
            ||||.|.:..|.::.|.....||:|.|....|..:..|.:..|::|.||||:.|.|..:......
Human    59 LDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFS 123

  Fly   402 GLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQA--VPEALAHVQLLKTLDVGENMIS 464
            ||.:|..|......::.::...:.:...|::|::..|.:|:  :||..:::..|:.||:..|.|.
Human   124 GLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQ 188

  Fly   465 QIENTSITQLESL----YGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQL 525
            .|..|.:..|..:    ..|.::.|.:..|:.|.|                |.|....|...:..
Human   189 SIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAF----------------KEIRLHKLTLRNNF 237

  Fly   526 QAIRLDGNQLKSIAGLFTELPNLVW--LNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFE 588
            .::.:....::.:|||  |:..||.  ....|| |||||.|.:. ||..|.:...|:..|..|.:
Human   238 DSLNVMKTCIQGLAGL--EVHRLVLGEFRNEGN-LEKFDKSALE-GLCNLTIEEFRLAYLDYYLD 298

  Fly   589 IESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTF-FKKPNLTRVDLVRNRLT 652
            ...:|        :|.||.:::.|:   |.|      .|.:::.::: |...:|..|:....:..
Human   299 DIIDL--------FNCLTNVSSFSL---VSV------TIERVKDFSYNFGWQHLELVNCKFGQFP 346

  Fly   653 TLEPNALRLSPIAEDREIPEFYIGHNAY-ECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYAR 716
            ||:..:|:......::       |.||: |.|.               |.|..||.....|:: :
Human   347 TLKLKSLKRLTFTSNK-------GGNAFSEVDL---------------PSLEFLDLSRNGLSF-K 388

  Fly   717 GSSHVSLIEAKSDDFLCKYASHCFALCHCC---DFQACDCKMECPDRCSCYHDQSWTSNVVDCSR 778
            |                           ||   ||.....|         |.|.|:...:     
Human   389 G---------------------------CCSQSDFGTTSLK---------YLDLSFNGVI----- 412

  Fly   779 ASYEQTLPSHIPMDSTQL-YLD--GNNFRELQSHA-FIGRKRLKVLHLNHSRIEVLHNRTFYGLL 839
                 |:.|:. :...|| :||  .:|.:::...: |:..:.|..|.::|:...|..|..|.||.
Human   413 -----TMSSNF-LGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLS 471

  Fly   840 ELEVLQLQSN-------------------------QLKALNGNEFQGLDNLQELYLQHNAIATID 879
            .||||::..|                         ||:.|:...|..|.:||.|.:.||...::|
Human   472 SLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLD 536

  Fly   880 TLTFTHLYHLKIL--RLDHNAITSFAVWNFLPSYLNELRLASNPWTCSCE---FIDKLRDYINRH 939
            |..:..|..|::|  .|:|...:........||.|..|.|..|.:.|:||   |:..::|   :.
Human   537 TFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKD---QR 598

  Fly   940 EYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYAEQAGGENASNA 1004
            :.:|:..:|:|...|              :...:||:..:.|..:                    
Human   599 QLLVEVERMECATPS--------------DKQGMPVLSLNITCQM-------------------- 629

  Fly  1005 TSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFRQEMRVWCHSRFGVRLFYNAQKDVDK 1069
              .|.|:.       :.:|..::.:.:.|::   ..|.|...:...|               :..
Human   630 --NKTIIG-------VSVLSVLVVSVVAVLV---YKFYFHLMLLAGC---------------IKY 667

  Fly  1070 NEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPETIV-QAIDSSRR 1133
            ...|.::||||.|||:||.:|..||...||.|...::||||.|||..|..:...|: :....||:
Human   668 GRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHEGFHKSRK 732

  Fly  1134 TIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDPDLRLY--LKTNTYLQW 1196
            .|:|||::||:|.||.||::.|........|..:|.|||.:|.:..|...:.||  |..||||:|
Human   733 VIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNTYLEW 797

  Fly  1197 GDK-----LFWQKLRFALPDVSSSQRSNVAGQSCH 1226
            .|.     :||::||.||.|..|.......|..|:
Human   798 EDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCN 832

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR 54..400 CDD:443914 21/62 (34%)
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380
leucine-rich repeat 154..177 CDD:275380
leucine-rich repeat 178..201 CDD:275380
leucine-rich repeat 212..235 CDD:275380
leucine-rich repeat 236..259 CDD:275380
LRR 239..634 CDD:443914 75/304 (25%)
leucine-rich repeat 260..283 CDD:275380
leucine-rich repeat 284..307 CDD:275380
leucine-rich repeat 308..333 CDD:275380
leucine-rich repeat 334..357 CDD:275380 7/19 (37%)
leucine-rich repeat 358..381 CDD:275380 7/22 (32%)
leucine-rich repeat 382..405 CDD:275380 9/22 (41%)
leucine-rich repeat 406..429 CDD:275380 2/22 (9%)
leucine-rich repeat 430..452 CDD:275380 6/23 (26%)
leucine-rich repeat 453..500 CDD:275380 13/50 (26%)
leucine-rich repeat 501..521 CDD:275380 3/19 (16%)
leucine-rich repeat 525..547 CDD:275380 4/21 (19%)
leucine-rich repeat 548..573 CDD:275380 12/26 (46%)
leucine-rich repeat 604..640 CDD:275380 7/36 (19%)
LRR_8 616..>660 CDD:404697 8/44 (18%)
leucine-rich repeat 641..688 CDD:275380 10/47 (21%)
leucine-rich repeat 689..816 CDD:275380 22/133 (17%)
LRR <794..>920 CDD:443914 41/156 (26%)
leucine-rich repeat 817..864 CDD:275380 18/71 (25%)
leucine-rich repeat 865..888 CDD:275380 8/22 (36%)
leucine-rich repeat 889..910 CDD:275380 4/22 (18%)
TIR 1076..1211 CDD:214587 60/142 (42%)
TLR4NP_612564.1 LRR 1 55..76 7/16 (44%)
leucine-rich repeat 56..79 CDD:275378 7/19 (37%)
LRR_8 57..114 CDD:404697 20/54 (37%)
PPP1R42 76..>190 CDD:455733 29/113 (26%)
LRR 2 79..100 6/20 (30%)
leucine-rich repeat 80..103 CDD:275378 7/22 (32%)
LRR 3 103..124 7/20 (35%)
leucine-rich repeat 104..127 CDD:275378 9/22 (41%)
LRR 4 127..148 2/20 (10%)
leucine-rich repeat 128..176 CDD:275378 8/47 (17%)
leucine-rich repeat 130..151 CDD:275380 1/20 (5%)
LRR 5 151..172 6/20 (30%)
LRR 6 176..199 7/22 (32%)
leucine-rich repeat 177..190 CDD:275378 5/12 (42%)
leucine-rich repeat 195..224 CDD:275380 6/44 (14%)
LRR 7 205..225 5/35 (14%)
LRR 8 227..247 1/19 (5%)
LRR 290..>581 CDD:443914 79/377 (21%)
LRR 9 331..351 4/19 (21%)
LRR 10 352..373 6/42 (14%)
leucine-rich repeat 353..374 CDD:275380 6/42 (14%)
LRR 11 374..394 7/47 (15%)
LRR 12 400..422 6/41 (15%)
leucine-rich repeat 401..423 CDD:275380 6/41 (15%)
LRR 13 423..444 5/20 (25%)
leucine-rich repeat 424..448 CDD:275380 5/23 (22%)
LRR 14 448..456 2/7 (29%)
leucine-rich repeat 449..472 CDD:275380 8/22 (36%)
LRR 15 472..495 5/22 (23%)
leucine-rich repeat 473..497 CDD:275380 5/23 (22%)
LRR 16 497..518 4/20 (20%)
leucine-rich repeat 498..521 CDD:275380 5/22 (23%)
LRR 17 521..542 7/20 (35%)
LRR 18 545..565 4/19 (21%)
leucine-rich repeat 546..570 CDD:275380 5/23 (22%)
LRRCT 579..625 CDD:214507 12/62 (19%)
TIR 674..815 CDD:214587 58/140 (41%)
Blue background indicates that the domain is not in the aligned region.

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