back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and TLR3

DIOPT Version :10

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_003256.1	Gene:	TLR3 / 7098	HGNCID:	11849	Length:	904	Species:	Homo sapiens

Alignment Length:	1054	Identity:	253/1054 - (24%)
Similarity:	391/1054 - (37%)	Gaps:	278/1054 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 LSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQW 322
            :|..|.|.|..:||.:|.:|                     |      ..:.||:|..|:|..
Human    30 VSHEVADCSHLKLTQVPDDL---------------------P------TNITVLNLTHNQLRR-- 65

  Fly   323 INAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLIL 387
            :.||.|....:|..||:..|.||:||..:.:.|..|::|.|:.|.:.||....||..|||..|.|
Human    66 LPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHL 130

  Fly   388 SRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHV-- 450
            ..|.|..|:.......|||:.|.|..|.:|.....:.|....||:|.|::||:||:......:
Human   131 MSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFA 195

  Fly   451 -QLLKTLDVGENMISQIENTSITQLESLYGLRMTENSL--------------THIRR-------- 492
             ..||.|::..|.|.:........:..|:||.:....|              |.||.
Human   196 NSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQL 260

  Fly   493 ---------GVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLK-----SIAGLFT 543
                     |:  :.::|.:|:||.|.|..:...|.....||:...|:.|.::     |:.|||
Human   261 STTSNTTFLGL--KWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLF- 322

  Fly   544 ELPNLVWLN---------ISGNRLEKFDYSHIPIGLQWL--------------DVRANRITQLGN 585
               |:.:||         ||...|.|.|    ....|||              .:::|..|.|.|
Human   323 ---NVRYLNLKRSFTKQSISLASLPKID----DFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLIN 380

  Fly   586 YFEIESELSLSTFDASYNLLTEITASSIPNS-VEVLYLNDNQISKIQPYTFFKKPNLTRVDL--- 646
            .    ..||||....|...||..|..|:.:| :.:|.|..|:||||:...|....:|..:||
Human   381 L----KYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLN 441

  Fly   647 -VRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHC 710
             :...||..|...|        ..|.|.|:.:|.|        ||.........|.|.
Human   442 EIGQELTGQEWRGL--------ENIFEIYLSYNKY--------LQLTRNSFALVPSLQ------- 483

  Fly   711 RLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVD 775
            ||...|       :..|:                                             ||
Human   484 RLMLRR-------VALKN---------------------------------------------VD 496

  Fly   776 CSRASYEQTLPSHIPM-DSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRT----- 834
            .|.:.::       |: :.|.|.|..||...:......|.::|::|.|.|:.:..|....
Human   497 SSPSPFQ-------PLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGP 554

  Fly   835 ---FYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDH 896
               ..||..|.:|.|:||....:....|:.|..|:.:.|..|.:.|:....|.:...||.|.|..
Human   555 IYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQK 619

  Fly   897 NAITSFAVWNFLPSY--LNELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISGNSTQ 959
            |.|||.....|.|::  |.||.:..||:.|:||.|....::||.....:.:|          |:.
Human   620 NLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPEL----------SSH 674

  Fly   960 QMVIYPG--SGEPASL-PVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIP 1021
            .:...|.  .|.|..| ....|..:.|..|                                :..
Human   675 YLCNTPPHYHGFPVRLFDTSSCKDSAPFEL--------------------------------FFM 707

  Fly  1022 ILVAILTAFIFVMICISLVFIFRQEMRVWCHSRFGVRLFYNAQ-------KDVDKNEREKLFDAF 1079
            |..:||..|||:::.|        ....|     .:..::|..       |::|:...:..:.|:
Human   708 INTSILLIFIFIVLLI--------HFEGW-----RISFYWNVSVHRVLGFKEIDRQTEQFEYAAY 759

  Fly  1080 VSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIK 1144
            :.::.||:.:|.|..:.| |..:...|.||.:|||..|.:..|.||.:|..||:.|.|::.:.:|
Human   760 IIHAYKDKDWVWEHFSSM-EKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLK 823

  Fly  1145 SEWC-RFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDPDL---RLYLKTNTYLQWGDK-----L 1200
            ...| ||:...|.|..:......:|::.|.|:|..:|:..|   |...|::..|.|..:     .
Human   824 DPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGA 888

  Fly  1201 FWQKLRFALPDVSS 1214
            |..||:.||...:|
Human   889 FRHKLQVALGSKNS 902

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.