DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tollo and TLR2

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_001305716.1 Gene:TLR2 / 7097 HGNCID:11848 Length:784 Species:Homo sapiens


Alignment Length:884 Identity:211/884 - (23%)
Similarity:370/884 - (41%) Gaps:195/884 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   407 LVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSI 471
            :::||.....|  :|.|| :|.:......:...|.::|..|  .:.:|:||:..|.|:.|.|:.:
Human    13 VIISLSKEESS--NQASL-SCDRNGICKGSSGSLNSIPSGL--TEAVKSLDLSNNRITYISNSDL 72

  Fly   472 TQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLK 536
            .:..:|..|.:|.|.:..|....|..:.||:.|:||.|.|.::.:...:..|.|..:.|.||..|
Human    73 QRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYK 137

  Fly   537 SI--AGLFTELPNLVWLNISGN-----RLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELS 594
            ::  ..||:.|..|..|.: ||     ::::.|::.:.. |:.|::.|:.:..    :|.:|..|
Human   138 TLGETSLFSHLTKLQILRV-GNMDTFTKIQRKDFAGLTF-LEELEIDASDLQS----YEPKSLKS 196

  Fly   595 LSTFD------ASYNLLTEITASSIPNSVEVLYLNDNQI--------------SKIQPYTF---- 635
            :....      ..:.||.||.. .:.:|||.|.|.|..:              |.|:.:||    
Human   197 IQNVSHLILHMKQHILLLEIFV-DVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVK 260

  Fly   636 FKKPNLTRVDLVRNR---LTTLEPNALRLSPI----AEDRE-----------------IPEFYIG 676
            ....:|.:|..:.|:   |..||.:...|:.:    |.|.:                 ||.||: 
Human   261 ITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYL- 324

  Fly   677 HNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIE--AKSDDFLC-KYASH 738
              .|:........::|.|.:....::.   .:.|.|     |.|:..:|  ..|::.:. :|..:
Human   325 --FYDLSTLYSLTERVKRITVENSKVF---LVPCLL-----SQHLKSLEYLDLSENLMVEEYLKN 379

  Fly   739 CFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSR----ASYEQTLPSHIPMDS-TQLYL 798
                      .||              :.:|.|......|    ||.|:|..:.:.:.: |.:.:
Human   380 ----------SAC--------------EDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDI 420

  Fly   799 DGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLD 863
            ..|:|..:........| :|.|:|:.:||   |:.|......||:|.:.:|.|...:.|    |.
Human   421 SKNSFHSMPETCQWPEK-MKYLNLSSTRI---HSVTGCIPKTLEILDVSNNNLNLFSLN----LP 477

  Fly   864 NLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLPSY--LNELRLASNPWTCSC 926
            .|:|||:..|.:.|:...:.  |..|.:|::..||||:|:. ..|.|:  |..|....|.:.|||
Human   478 QLKELYISRNKLMTLPDASL--LPMLLVLKISRNAITTFSK-EQLDSFHTLKTLEAGGNNFICSC 539

  Fly   927 EFIDKLRDYINRHEYVVD-KLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNF 990
            ||:...::.....:.::| .....||..|....||:       :...|.|.:|.:|         
Human   540 EFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQV-------QDVRLSVSECHRT--------- 588

  Fly   991 NYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFR-------QEMR 1048
                                           .||:.:...:|::|.::.|...|       :.|.
Human   589 -------------------------------ALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMW 622

  Fly  1049 VWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRD 1113
            .|..::         :|......|...:|||||||.:|..:|...:...||.....:|||||:||
Human   623 AWLQAK---------RKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRD 678

  Fly  1114 FPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQK 1178
            |..|.::.:.|:.:|:.|.:|:.|:||||:|||||::|...:|..:..:.....|:|:|..:.:|
Human   679 FIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKK 743

  Fly  1179 ELDP---DLRLYLKTNTYLQWG-DKL----FWQKLRFAL 1209
            .:..   .||..:.|.|||:|. |:.    ||..||.|:
Human   744 AIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAI 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380
LRR_8 152..222 CDD:290566
leucine-rich repeat 154..177 CDD:275380
leucine-rich repeat 178..201 CDD:275380
LRR 210..656 CDD:227223 69/282 (24%)
leucine-rich repeat 212..235 CDD:275380
leucine-rich repeat 236..259 CDD:275380
leucine-rich repeat 260..283 CDD:275380
LRR_RI 276..558 CDD:238064 43/157 (27%)
leucine-rich repeat 284..307 CDD:275380
leucine-rich repeat 308..333 CDD:275380
leucine-rich repeat 334..357 CDD:275380
leucine-rich repeat 358..381 CDD:275380
leucine-rich repeat 382..405 CDD:275380
leucine-rich repeat 406..429 CDD:275380 7/21 (33%)
leucine-rich repeat 430..452 CDD:275380 3/21 (14%)
leucine-rich repeat 453..500 CDD:275380 13/46 (28%)
leucine-rich repeat 501..521 CDD:275380 6/19 (32%)
leucine-rich repeat 525..547 CDD:275380 8/23 (35%)
leucine-rich repeat 548..573 CDD:275380 6/29 (21%)
leucine-rich repeat 604..640 CDD:275380 14/53 (26%)
leucine-rich repeat 641..688 CDD:275380 14/70 (20%)
leucine-rich repeat 689..816 CDD:275380 21/134 (16%)
LRR_8 815..875 CDD:290566 20/59 (34%)
leucine-rich repeat 817..864 CDD:275380 14/46 (30%)
LRR_8 864..921 CDD:290566 18/58 (31%)
leucine-rich repeat 865..888 CDD:275380 7/22 (32%)
leucine-rich repeat 889..910 CDD:275380 8/20 (40%)
TIR 1076..1211 CDD:214587 53/142 (37%)
TLR2NP_001305716.1 PLN00113 <40..>206 CDD:331614 43/173 (25%)
leucine-rich repeat 54..77 CDD:275380 7/22 (32%)
LRR 1 54..77 7/22 (32%)
LRR_8 77..135 CDD:316378 17/57 (30%)
leucine-rich repeat 78..101 CDD:275380 6/22 (27%)
LRR 2 78..101 6/22 (27%)
leucine-rich repeat 102..125 CDD:275380 6/22 (27%)
LRR 3 102..125 6/22 (27%)
leucine-rich repeat 126..150 CDD:275380 8/23 (35%)
LRR 4 126..150 8/23 (35%)
leucine-rich repeat 151..175 CDD:275380 5/24 (21%)
LRR 5 151..175 5/24 (21%)
LRR 6 176..199 6/26 (23%)
leucine-rich repeat 176..196 CDD:275380 5/23 (22%)
LRR 7 200..223 4/23 (17%)
LRR 8 224..250 5/25 (20%)
LRR 9 251..278 6/26 (23%)
LRR 10 279..308 6/28 (21%)
LRR 11 309..337 5/30 (17%)
NEL <324..>558 CDD:330839 61/279 (22%)
LRR 12 338..361 6/30 (20%)
leucine-rich repeat 362..388 CDD:275380 6/49 (12%)
LRR 13 362..388 6/49 (12%)
leucine-rich repeat 389..414 CDD:275380 5/24 (21%)
LRR 14 389..414 5/24 (21%)
leucine-rich repeat 415..437 CDD:275380 3/21 (14%)
LRR 15 415..437 3/21 (14%)
leucine-rich repeat 438..478 CDD:275380 14/46 (30%)
LRR 16 438..457 7/21 (33%)
LRR 17 458..478 7/23 (30%)
leucine-rich repeat 479..500 CDD:275380 7/22 (32%)
LRR 18 479..500 7/22 (32%)
leucine-rich repeat 501..524 CDD:275380 9/23 (39%)
LRR 19 501..524 9/23 (39%)
LRRCT 533..586 CDD:214507 14/59 (24%)
TIR 640..784 CDD:214587 53/143 (37%)
ATG16L1-binding motif 761..778 6/16 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.