DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tollo and TLR1

DIOPT Version :10

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_003254.2 Gene:TLR1 / 7096 HGNCID:11847 Length:786 Species:Homo sapiens


Alignment Length:1021 Identity:226/1021 - (22%)
Similarity:381/1021 - (37%) Gaps:326/1021 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   257 LLSLRV---------VDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLD 312
            :|.:|:         ||.|.|.|..:|.:|..:|..|.   :..|.|:.|.......|::|.:|.
Human    14 ILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILN---ISQNYISELWTSDILSLSKLRILI 75

  Fly   313 LASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFA 377
            ::.|.:  |:::.:.|...:.|..||||.||:.::..|   |..:|:.|.|..|..|.||     
Human    76 ISHNRI--QYLDISVFKFNQELEYLDLSHNKLVKISCH---PTVNLKHLDLSFNAFDALP----- 130

  Fly   378 DLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQ- 441
                                           :..:|.           |.|||:.|.|:...|: 
Human   131 -------------------------------ICKEFG-----------NMSQLKFLGLSTTHLEK 153

  Fly   442 --AVPEALAHVQLLKTLDVGENMISQIENTSITQ---LESLYGLRMTENSLTHIRRGVFDRMSSL 501
              .:|  :||:.:.|.|.|......:.|:....|   .|||:.:..|......|.......:::|
Human   154 SSVLP--IAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANL 216

  Fly   502 QILN----LSQNKLK---SIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVW------LNI 553
            ::.|    |..||..   ||.| .||.|.:|..:.|  |.:::....|..:..|||      .:|
Human   217 ELSNIKCVLEDNKCSYFLSILA-KLQTNPKLSNLTL--NNIETTWNSFIRILQLVWHTTVWYFSI 278

  Fly   554 SGNRLE------KFDYSHIPIGLQWLDVRANRITQL---------GNYFEIESELSLSTFDASYN 603
            |..:|:      .||||       ...::|..|.|:         ...:||.|.:::..|..|..
Human   279 SNVKLQGQLDFRDFDYS-------GTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGT 336

  Fly   604 LLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLV---RNRLTTLEPNALRLSPIA 665
            .:..:...                |||.|:......|....|.|   ...||.||...|:::.:.
Human   337 RMVHMLCP----------------SKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLK 385

  Fly   666 EDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQP---QLMDLDQIHCRLAYARGSSHVSLIEAK 727
            |                      |.|: .|..||.   |.:|:.|           :.||..|.|
Human   386 E----------------------LSKI-AEMTTQMKSLQQLDISQ-----------NSVSYDEKK 416

  Fly   728 SDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMD 792
            .|                                 |    |||.:::..:       :.|:|..|
Human   417 GD---------------------------------C----SWTKSLLSLN-------MSSNILTD 437

  Fly   793 STQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGN 857
            :.        ||.|..                               .::||.|.||::|:: ..
Human   438 TI--------FRCLPP-------------------------------RIKVLDLHSNKIKSI-PK 462

  Fly   858 EFQGLDNLQELYLQHNAIATIDTL-TFTHLYHLKILRLDHNAITSFAVWNFLPS--YLNELRLAS 919
            :...|:.||||.:..|::..:... :|:   .|.:|.:|||:: |....:|..|  .:..::...
Human   463 QVVKLEALQELNVAFNSLTDLPGCGSFS---SLSVLIIDHNSV-SHPSADFFQSCQKMRSIKAGD 523

  Fly   920 NPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPL 984
            ||:.|:||.          .|:|.:..::..:|:.|        :|.|        .:|      
Human   524 NPFQCTCEL----------GEFVKNIDQVSSEVLEG--------WPDS--------YKC------ 556

  Fly   985 GLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVM------IC--ISLVF 1041
                  :|.|...|....:...:::..|       |.:|:..:.|.:.|:      :|  :.|.:
Human   557 ------DYPESYRGTLLKDFHMSELSCN-------ITLLIVTIVATMLVLAVTVTSLCSYLDLPW 608

  Fly  1042 IFRQEMRVWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYK 1106
            ..|...: |..:|...|     ...:::.:|...|.||:|||..|..:|..||.|.||  :...:
Human   609 YLRMVCQ-WTQTRRRAR-----NIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLE--KEGMQ 665

  Fly  1107 LCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIV 1171
            :|||:|:|..|..:.|.|:..|:.|.::|.|:|.||::||||.:|...||.::..:....||:|:
Human   666 ICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILIL 730

  Fly  1172 LGEVPQKELDPD---LRLYLKTNTYLQWGDK-----LFWQKLRFAL 1209
            |..:||..:...   |:..:...|||:|..:     |||..||.|:
Human   731 LEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAI 776

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR 54..400 CDD:443914 36/151 (24%)
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380
leucine-rich repeat 154..177 CDD:275380
leucine-rich repeat 178..201 CDD:275380
leucine-rich repeat 212..235 CDD:275380
leucine-rich repeat 236..259 CDD:275380 0/1 (0%)
LRR 239..634 CDD:443914 94/419 (22%)
leucine-rich repeat 260..283 CDD:275380 9/31 (29%)
leucine-rich repeat 284..307 CDD:275380 5/22 (23%)
leucine-rich repeat 308..333 CDD:275380 5/24 (21%)
leucine-rich repeat 334..357 CDD:275380 9/22 (41%)
leucine-rich repeat 358..381 CDD:275380 7/22 (32%)
leucine-rich repeat 382..405 CDD:275380 0/22 (0%)
leucine-rich repeat 406..429 CDD:275380 2/22 (9%)
leucine-rich repeat 430..452 CDD:275380 7/24 (29%)
leucine-rich repeat 453..500 CDD:275380 10/49 (20%)
leucine-rich repeat 501..521 CDD:275380 9/26 (35%)
leucine-rich repeat 525..547 CDD:275380 4/21 (19%)
leucine-rich repeat 548..573 CDD:275380 10/36 (28%)
leucine-rich repeat 604..640 CDD:275380 4/35 (11%)
LRR_8 616..>660 CDD:404697 11/46 (24%)
leucine-rich repeat 641..688 CDD:275380 8/49 (16%)
leucine-rich repeat 689..816 CDD:275380 23/129 (18%)
LRR <794..>920 CDD:443914 24/128 (19%)
leucine-rich repeat 817..864 CDD:275380 7/46 (15%)
leucine-rich repeat 865..888 CDD:275380 6/23 (26%)
leucine-rich repeat 889..910 CDD:275380 7/20 (35%)
TIR 1076..1211 CDD:214587 52/142 (37%)
TLR1NP_003254.2 LRR <29..>152 CDD:443914 41/177 (23%)
leucine-rich repeat 47..70 CDD:275378 6/25 (24%)
LRR 1 54..77 6/22 (27%)
leucine-rich repeat 71..94 CDD:275378 5/24 (21%)
LRR 2 78..101 6/24 (25%)
leucine-rich repeat 95..115 CDD:275378 9/22 (41%)
LRR 3 102..125 7/25 (28%)
leucine-rich repeat 116..140 CDD:275378 9/70 (13%)
LRR 4 126..150 10/70 (14%)
leucine-rich repeat 141..152 CDD:275378 3/10 (30%)
LRR 5 151..175 7/25 (28%)
LRR 6 176..199 5/22 (23%)
LRR 7 200..223 3/22 (14%)
LRR 215..>526 CDD:443914 91/458 (20%)
LRR 8 224..250 10/26 (38%)
LRR 9 251..278 6/28 (21%)
LRR 10 279..308 9/35 (26%)
LRR 11 309..337 5/27 (19%)
Interaction with bacterial lipopeptide 313..316 0/2 (0%)
LRR 12 338..361 5/38 (13%)
leucine-rich repeat 352..373 CDD:275380 4/20 (20%)
LRR 13 362..388 8/47 (17%)
leucine-rich repeat 374..399 CDD:275380 9/47 (19%)
LRR 14 389..414 9/36 (25%)
leucine-rich repeat 400..424 CDD:275380 12/71 (17%)
LRR 15 415..437 8/65 (12%)
leucine-rich repeat 425..446 CDD:275380 6/66 (9%)
LRR 16 438..457 8/57 (14%)
leucine-rich repeat 447..469 CDD:275380 7/22 (32%)
LRR 17 458..478 6/20 (30%)
leucine-rich repeat 470..492 CDD:275380 6/24 (25%)
LRR 18 479..500 4/23 (17%)
leucine-rich repeat 494..515 CDD:275380 7/21 (33%)
LRR 19 501..524 3/23 (13%)
LRRCT 524..577 CDD:214507 15/90 (17%)
TIR 636..779 CDD:214587 52/143 (36%)
Blue background indicates that the domain is not in the aligned region.

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