DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and TLR1

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_003254.2	Gene:	TLR1 / 7096	HGNCID:	11847	Length:	786	Species:	Homo sapiens

Alignment Length:	1021	Identity:	226/1021 - (22%)
Similarity:	381/1021 - (37%)	Gaps:	326/1021 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 LLSLRV---------VDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLD 312
            :|.:|:         ||.|.|.|..:|.:|..:|..|.   :..|.|:.|.......|::|.:|.
Human    14 ILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILN---ISQNYISELWTSDILSLSKLRILI 75

  Fly   313 LASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFA 377
            ::.|.:  |:::.:.|...:.|..||||.||:.::..|   |..:|:.|.|..|..|.||
Human    76 ISHNRI--QYLDISVFKFNQELEYLDLSHNKLVKISCH---PTVNLKHLDLSFNAFDALP----- 130

  Fly   378 DLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQ- 441
                                           :..:|.           |.|||:.|.|:...|:
Human   131 -------------------------------ICKEFG-----------NMSQLKFLGLSTTHLEK 153

  Fly   442 --AVPEALAHVQLLKTLDVGENMISQIENTSITQ---LESLYGLRMTENSLTHIRRGVFDRMSSL 501
              .:|  :||:.:.|.|.|......:.|:....|   .|||:.:..|......|.......:::|
Human   154 SSVLP--IAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANL 216

  Fly   502 QILN----LSQNKLK---SIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVW------LNI 553
            ::.|    |..||..   ||.| .||.|.:|..:.|  |.:::....|..:..|||      .:|
Human   217 ELSNIKCVLEDNKCSYFLSILA-KLQTNPKLSNLTL--NNIETTWNSFIRILQLVWHTTVWYFSI 278

  Fly   554 SGNRLE------KFDYSHIPIGLQWLDVRANRITQL---------GNYFEIESELSLSTFDASYN 603
            |..:|:      .||||       ...::|..|.|:         ...:||.|.:::..|..|..
Human   279 SNVKLQGQLDFRDFDYS-------GTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGT 336

  Fly   604 LLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLV---RNRLTTLEPNALRLSPIA 665
            .:..:...                |||.|:......|....|.|   ...||.||...|:::.:.
Human   337 RMVHMLCP----------------SKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLK 385

  Fly   666 EDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQP---QLMDLDQIHCRLAYARGSSHVSLIEAK 727
            |                      |.|: .|..||.   |.:|:.|           :.||..|.|
Human   386 E----------------------LSKI-AEMTTQMKSLQQLDISQ-----------NSVSYDEKK 416

  Fly   728 SDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMD 792
            .|                                 |    |||.:::..:       :.|:|..|
Human   417 GD---------------------------------C----SWTKSLLSLN-------MSSNILTD 437

  Fly   793 STQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGN 857
            :.        ||.|..                               .::||.|.||::|:: ..
Human   438 TI--------FRCLPP-------------------------------RIKVLDLHSNKIKSI-PK 462

  Fly   858 EFQGLDNLQELYLQHNAIATIDTL-TFTHLYHLKILRLDHNAITSFAVWNFLPS--YLNELRLAS 919
            :...|:.||||.:..|::..:... :|:   .|.:|.:|||:: |....:|..|  .:..::...
Human   463 QVVKLEALQELNVAFNSLTDLPGCGSFS---SLSVLIIDHNSV-SHPSADFFQSCQKMRSIKAGD 523

  Fly   920 NPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPL 984
            ||:.|:||.          .|:|.:..::..:|:.|        :|.|        .:|
Human   524 NPFQCTCEL----------GEFVKNIDQVSSEVLEG--------WPDS--------YKC------ 556

  Fly   985 GLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVM------IC--ISLVF 1041
                  :|.|...|....:...:::..|       |.:|:..:.|.:.|:      :|  :.|.:
Human   557 ------DYPESYRGTLLKDFHMSELSCN-------ITLLIVTIVATMLVLAVTVTSLCSYLDLPW 608

  Fly  1042 IFRQEMRVWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYK 1106
            ..|...: |..:|...|     ...:::.:|...|.||:|||..|..:|..||.|.||  :...:
Human   609 YLRMVCQ-WTQTRRRAR-----NIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLE--KEGMQ 665

  Fly  1107 LCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIV 1171
            :|||:|:|..|..:.|.|:..|:.|.::|.|:|.||::||||.:|...||.::..:....||:|:
Human   666 ICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILIL 730

  Fly  1172 LGEVPQKELDPD---LRLYLKTNTYLQWGDK-----LFWQKLRFAL 1209
            |..:||..:...   |:..:...|||:|..:     |||..||.|:
Human   731 LEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAI 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	9/32 (28%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	100/444 (23%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380	0/1 (0%)
		leucine-rich repeat	260..283	CDD:275380	9/31 (29%)
		LRR_RI	276..558	CDD:238064	69/300 (23%)
		leucine-rich repeat	284..307	CDD:275380	5/22 (23%)
		leucine-rich repeat	308..333	CDD:275380	5/24 (21%)
		leucine-rich repeat	334..357	CDD:275380	9/22 (41%)
		leucine-rich repeat	358..381	CDD:275380	7/22 (32%)
		leucine-rich repeat	382..405	CDD:275380	0/22 (0%)
		leucine-rich repeat	406..429	CDD:275380	2/22 (9%)
		leucine-rich repeat	430..452	CDD:275380	7/24 (29%)
		leucine-rich repeat	453..500	CDD:275380	10/49 (20%)
		leucine-rich repeat	501..521	CDD:275380	9/26 (35%)
		leucine-rich repeat	525..547	CDD:275380	4/21 (19%)
		leucine-rich repeat	548..573	CDD:275380	10/36 (28%)
		leucine-rich repeat	604..640	CDD:275380	4/35 (11%)
		leucine-rich repeat	641..688	CDD:275380	8/49 (16%)
		leucine-rich repeat	689..816	CDD:275380	23/129 (18%)
		LRR_8	815..875	CDD:290566	12/59 (20%)
		leucine-rich repeat	817..864	CDD:275380	7/46 (15%)
		LRR_8	864..921	CDD:290566	14/59 (24%)
		leucine-rich repeat	865..888	CDD:275380	6/23 (26%)
		leucine-rich repeat	889..910	CDD:275380	7/20 (35%)
		TIR	1076..1211	CDD:214587	52/142 (37%)
TLR1	NP_003254.2	leucine-rich repeat	47..70	CDD:275378	6/25 (24%)
		LRR 1	54..77		6/22 (27%)
		LRR_8	69..124	CDD:316378	17/59 (29%)
		leucine-rich repeat	71..94	CDD:275378	5/24 (21%)
		LRR 2	78..101		6/24 (25%)
		leucine-rich repeat	95..115	CDD:275378	9/22 (41%)
		LRR 3	102..125		7/25 (28%)
		leucine-rich repeat	116..140	CDD:275378	9/70 (13%)
		LRR 4	126..150		10/70 (14%)
		leucine-rich repeat	141..152	CDD:275378	3/10 (30%)
		LRR 5	151..175		7/25 (28%)
		LRR 6	176..199		5/22 (23%)
		LRR 7	200..223		3/22 (14%)
		LRR 8	224..250		10/26 (38%)
		LRR 9	251..278		6/28 (21%)
		LRR 10	279..308		9/35 (26%)
		LRR 11	309..337		5/27 (19%)
		Interaction with bacterial lipopeptide	313..316		0/2 (0%)
		LRR 12	338..361		5/38 (13%)
		PLN00113	<352..>560	CDD:331614	66/367 (18%)
		leucine-rich repeat	352..373	CDD:275380	4/20 (20%)
		LRR 13	362..388		8/47 (17%)
		leucine-rich repeat	374..399	CDD:275380	9/47 (19%)
		LRR 14	389..414		9/36 (25%)
		leucine-rich repeat	400..424	CDD:275380	12/71 (17%)
		LRR 15	415..437		8/65 (12%)
		leucine-rich repeat	425..446	CDD:275380	6/66 (9%)
		LRR 16	438..457		8/57 (14%)
		leucine-rich repeat	447..469	CDD:275380	7/22 (32%)
		LRR 17	458..478		6/20 (30%)
		leucine-rich repeat	470..492	CDD:275380	6/24 (25%)
		LRR 18	479..500		4/23 (17%)
		leucine-rich repeat	494..515	CDD:275380	7/21 (33%)
		LRR 19	501..524		3/23 (13%)
		LRRCT	553..577	CDD:279765	5/43 (12%)
		TIR	636..779	CDD:214587	52/143 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820