DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tollo and Tlr8

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_001094479.1 Gene:Tlr8 / 684440 RGDID:1590327 Length:1029 Species:Rattus norvegicus


Alignment Length:1259 Identity:279/1259 - (22%)
Similarity:469/1259 - (37%) Gaps:364/1259 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 NFSVIQP----QNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQE 123
            |||...|    ::...:..|||.....:...:...:.:.|:|.|.||.:     :|:.||   |:
  Rat    26 NFSRSYPCDEKRHNALVTAECNHRQLHEVPQTIGKYVTDVDLSDNTIMH-----ITNESF---QK 82

  Fly   124 LRNLT--IRTHNG-----DWSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHL 181
            .||||  ...||.     :.:...:.:...:|:..|.|..|.|..|.::.||.|:.   :||:.|
  Rat    83 FRNLTKINLNHNAKQQHPNENKNGMNITEGAFLSLRNLTELLLEDNQLYTIPAGLP---ESLKEL 144

  Fly   182 NASYNKIQDISNFYFSASLSSRKARVCG-STLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNS 245
            :...|.|..::           |....| ..|:.|.|..|.....                  |.
  Rat   145 SLIQNNIFQVT-----------KNNTFGLRNLERLYLGWNCYFKC------------------NQ 180

  Fly   246 MSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLV 310
            :..:.|.||..|::|:::.||.|.|.|:||:|   ...|.:::|.|..|:.:....|..|..|::
  Rat   181 IFKVEDGAFNNLINLKLLSLSFNNLFSVPPKL---PSSLSKLFLSNAKISTITQEDFKGLEHLIL 242

  Fly   311 LDLASN--------------ELN-SQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQI 360
            |||:.|              .|: |..|:...|..|.:|..|:||:..:..:.:..|..|.:|:.
  Rat   243 LDLSGNCPRCFNAPFPCESCNLSASIRIHPLAFQNLTQLRFLNLSSTSLRTIPSTWFDNLTNLKE 307

  Fly   361 LKLEDNYIDQ--LPGGIFADLTNLHTLILSRNRI--------------SVIEQ------------ 397
            |.||.||:.|  ..|.....|.:|.||.||.|.|              |::..            
  Rat   308 LHLEFNYLVQEIASGAFLTKLPSLQTLDLSFNFIHKEYLQYITISPNFSMLRSLRKLHLKGYVFR 372

  Fly   398 -------RTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHV----Q 451
                   :.||.|.||..::|..|.|.::|.::..:...|:.::|:.|::.:|.:...|.    :
  Rat   373 ELKKEHFKPLQNLPNLTTINLGINFIEKIDFKAFQDFPNLKVIYLSGNRIASVIDGTDHSSWRNR 437

  Fly   452 LLKTL-------DVGENMISQIENTSITQLESLYG--LRMTENSLTHIRRGVFDRMSSLQILNLS 507
            |.|.|       |...|.....|.....|. :.||  |.::.|::..|.:..|:....:..||||
  Rat   438 LRKPLSTDYDEFDPHMNFYHSTEPLIKPQC-TTYGKALDLSLNNIFVIGKSQFEGFQDIACLNLS 501

  Fly   508 QNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFD----YSHIPI 568
            .|           .|.|:    |:|.:       |:.:|::.:|:::.|||: ||    :|.:. 
  Rat   502 FN-----------ANGQV----LNGTE-------FSSMPHIKYLDLTNNRLD-FDDNQTFSDLH- 542

  Fly   569 GLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPY 633
            .|:.||:..|     .:||.|........|  ..||:          .::||.|:.|.|     |
  Rat   543 DLEVLDLSHN-----AHYFSIAGVTHRLGF--IQNLI----------KLKVLNLSHNGI-----Y 585

  Fly   634 TFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRT 698
            |...:..|                        :.:.:.|.....|      .||.|...|..   
  Rat   586 TLTDEYKL------------------------QSKSLKELVFSGN------RLDRLWNANDG--- 617

  Fly   699 QPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSC 763
                                               ||.|...:|                     
  Rat   618 -----------------------------------KYWSIFTSL--------------------- 626

  Fly   764 YHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIG-RKRLKVLHLNHSRI 827
                               :||        |:|.|..||.:::.:.||:. .:.|:.||:|.:|:
  Rat   627 -------------------ETL--------TRLDLSYNNLQQIPNEAFLNLPQSLQELHINDNRL 664

  Fly   828 EVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKIL 892
            ...:.........|.||.|..|:|..|.....:...:|:.|.|.||..:.:.....:...:|..|
  Rat   665 RFFNWTLLQYFPHLHVLDLGRNELYFLTNCLSKFTHSLKTLLLNHNHFSHLPAGFLSEARNLVYL 729

  Fly   893 RLDHNA---ITSFAVWNFLPSYLNELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVIS 954
            .|..|.   |...::.....:.|:.|.|..|.:.|:|:..| .|.::..:.:|  ::....|||.
  Rat   730 DLSFNTIKMINKSSLQTETKTNLSVLDLQGNHFDCTCDISD-FRSWLEENPHV--RIPRLVDVIC 791

  Fly   955 GNSTQQMVIYPGS---GEPASLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPK 1016
            .|        ||.   ....||.:..|.......:...|.:.          .|||         
  Rat   792 SN--------PGDQRWKSVMSLDLTTCVSDTTAAILFFFTFL----------TTST--------- 829

  Fly  1017 LDYIPILVAILTAFIFVMICISLVFIFRQEMRVWCHSRF-GVRLFYNAQKDVDKNEREKLFDAFV 1080
                 :|:|.|...:|..   .:.||:..     |.::. |.|         ..:..:..:||::
  Rat   830 -----VLLAALVHHLFYW---DVWFIYHM-----CSAKLRGYR---------SSSTSQTFYDAYI 872

  Fly  1081 SYSSKDEL---FVNEELAPMLEMGEHR-YKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSEN 1141
            ||.:||..   :|..||...||..|.: ..|||.:||:..|..:.:.::|:|:.|::||.|:::.
  Rat   873 SYDTKDASVTDWVINELRYHLEESEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKK 937

  Fly  1142 FIKSEWCRFEFKSAHQSVLR---DRRRRLIVIVLGEVPQKELDPDLRLYLK--TNTYLQW----- 1196
            :.|| |   .||:|....|:   |....:|:.:|.| |..:....|||..:  .::.|||     
  Rat   938 YAKS-W---NFKTAFYLALQRLMDENMDVIIFILLE-PVLQYSQYLRLRQRICKSSILQWPNNPK 997

  Fly  1197 GDKLFWQKLRFALPDVSSSQRSNV 1220
            .:.||||.|:..:...:.|:..|:
  Rat   998 AENLFWQSLKNVVLTENDSRYDNL 1021

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 49/203 (24%)
leucine-rich repeat 100..123 CDD:275380 7/22 (32%)
leucine-rich repeat 124..144 CDD:275380 6/26 (23%)
LRR_8 152..222 CDD:290566 19/70 (27%)
leucine-rich repeat 154..177 CDD:275380 7/22 (32%)
leucine-rich repeat 178..201 CDD:275380 4/22 (18%)
LRR 210..656 CDD:227223 120/512 (23%)
leucine-rich repeat 212..235 CDD:275380 4/22 (18%)
leucine-rich repeat 236..259 CDD:275380 5/22 (23%)
leucine-rich repeat 260..283 CDD:275380 9/22 (41%)
LRR_RI 276..558 CDD:238064 80/344 (23%)
leucine-rich repeat 284..307 CDD:275380 6/22 (27%)
leucine-rich repeat 308..333 CDD:275380 10/39 (26%)
leucine-rich repeat 334..357 CDD:275380 6/22 (27%)
leucine-rich repeat 358..381 CDD:275380 9/24 (38%)
leucine-rich repeat 382..405 CDD:275380 11/55 (20%)
leucine-rich repeat 406..429 CDD:275380 5/22 (23%)
leucine-rich repeat 430..452 CDD:275380 5/25 (20%)
leucine-rich repeat 453..500 CDD:275380 12/55 (22%)
leucine-rich repeat 501..521 CDD:275380 5/19 (26%)
leucine-rich repeat 525..547 CDD:275380 3/21 (14%)
leucine-rich repeat 548..573 CDD:275380 8/28 (29%)
leucine-rich repeat 604..640 CDD:275380 8/35 (23%)
leucine-rich repeat 641..688 CDD:275380 4/46 (9%)
leucine-rich repeat 689..816 CDD:275380 15/127 (12%)
LRR_8 815..875 CDD:290566 17/59 (29%)
leucine-rich repeat 817..864 CDD:275380 12/46 (26%)
LRR_8 864..921 CDD:290566 13/59 (22%)
leucine-rich repeat 865..888 CDD:275380 5/22 (23%)
leucine-rich repeat 889..910 CDD:275380 5/23 (22%)
TIR 1076..1211 CDD:214587 47/148 (32%)
Tlr8NP_001094479.1 PRK15370 <21..>218 CDD:185268 57/234 (24%)
leucine-rich repeat 62..85 CDD:275380 9/30 (30%)
leucine-rich repeat 86..119 CDD:275380 5/32 (16%)
leucine-rich repeat 120..140 CDD:275380 7/22 (32%)
PLN00113 141..>664 CDD:215061 149/717 (21%)
leucine-rich repeat 141..164 CDD:275380 6/33 (18%)
leucine-rich repeat 165..194 CDD:275380 9/46 (20%)
leucine-rich repeat 195..215 CDD:275380 9/22 (41%)
leucine-rich repeat 216..239 CDD:275380 6/22 (27%)
leucine-rich repeat 240..280 CDD:275380 10/39 (26%)
leucine-rich repeat 281..304 CDD:275380 6/22 (27%)
leucine-rich repeat 305..324 CDD:275380 8/18 (44%)
leucine-rich repeat 331..387 CDD:275380 11/55 (20%)
leucine-rich repeat 388..411 CDD:275380 5/22 (23%)
leucine-rich repeat 467..494 CDD:275380 6/27 (22%)
leucine-rich repeat 495..510 CDD:275380 7/29 (24%)
leucine-rich repeat 520..543 CDD:275380 7/24 (29%)
leucine-rich repeat 544..573 CDD:275380 10/45 (22%)
leucine-rich repeat 574..597 CDD:275380 8/51 (16%)
leucine-rich repeat 598..628 CDD:275380 10/113 (9%)
PRK15370 <629..>739 CDD:185268 29/117 (25%)
leucine-rich repeat 629..653 CDD:275380 8/31 (26%)
leucine-rich repeat 654..677 CDD:275380 5/22 (23%)
leucine-rich repeat 678..701 CDD:275380 7/22 (32%)
leucine-rich repeat 702..725 CDD:275380 5/22 (23%)
leucine-rich repeat 726..745 CDD:275380 5/18 (28%)
PCC 730..>813 CDD:188093 21/93 (23%)
TIR 868..1004 CDD:214587 44/140 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.