DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tollo and LRRTM1

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001382551.1	Gene:	LRRTM1 / 679668	RGDID:	1585921	Length:	523	Species:	Rattus norvegicus

Alignment Length:	632	Identity:	136/632 - (21%)
Similarity:	214/632 - (33%)	Gaps:	221/632 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 LKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVI 395
            |..|:.|.|..|.:|.|.|..|..|..|..|.|:.|:|..:.|..|..|..:..|.||.|:|:.:
  Rat    64 LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITEL 128

  Fly   396 EQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGE 460
            ...|.:.:.||..:.|.:                        |||||:...|.|
  Rat   129 ANTTFRPMPNLRSVDLSY------------------------NKLQALAPDLFH----------- 158

  Fly   461 NMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQL 525
                        .|..|..|.|..|::..:...:|....||:.|::..|:||     ||.||
  Rat   159 ------------GLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLK-----SLARN--- 203

  Fly   526 QAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIP--IGLQWLDVRANRITQLGNYFE 588
                       |.||||    .|..|::..|.|.|.:::|.|  |.|..|.:|.|::.
  Rat   204 -----------SFAGLF----KLTELHLEHNDLIKVNFAHFPRLISLNSLCLRRNKVA------- 246

  Fly   589 IESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTT 653
                :.:|:.|..:||             |.:.|:.|:|..::|:.|...|.|..:.|..||||.
  Rat   247 ----IVVSSLDWVWNL-------------EKMDLSGNEIEYMEPHVFETVPYLQSLQLDSNRLTY 294

  Fly   654 LEPNALRLSPIAEDREIPEFYIGHNAYECDCNL----DWLQKVNRESRTQPQLMDLDQIHCRL-A 713
            :||..|.     ..:.:....:..|.::|..|:    .||.  |.:.|....|      .|.. .
  Rat   295 IEPRILN-----SWKSLTSITLAGNLWDCGRNVCALASWLS--NFQGRYDANL------QCASPE 346

  Fly   714 YARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSR 778
            ||:|...:..:          ||.|.                 |.|..     :..:.:::..:.
  Rat   347 YAQGEDVLDAV----------YAFHL-----------------CEDGA-----EPTSGHLLSAAV 379

  Fly   779 ASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEV 843
            .:.....|   |..|....:||.                          |.||:.|      ||.
  Rat   380 TNRSDLAP---PESSATTLVDGG--------------------------EGLHDST------LEP 409

  Fly   844 LQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFL 908
            :.:      |:.|.|.  .:|..::   |..:.....|.|:.|..:.:|         :..|...
  Rat   410 ITV------AIPGGEH--AENAVQI---HKVVTGTMALIFSFLIVVLVL---------YVSWKCF 454

  Fly   909 PSYLNELRLASNPWTCSCEFIDKLRDY-----------INRHEYVVD 944
            |:.|.:||        .| |:.:.|..           ::..||.||
  Rat   455 PASLRQLR--------QC-FVTQRRKQKQKQTMHQMAAMSAQEYYVD 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	84/326 (26%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380
		LRR_RI	276..558	CDD:238064	58/226 (26%)
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..333	CDD:275380	1/1 (100%)
		leucine-rich repeat	334..357	CDD:275380	9/22 (41%)
		leucine-rich repeat	358..381	CDD:275380	8/22 (36%)
		leucine-rich repeat	382..405	CDD:275380	6/22 (27%)
		leucine-rich repeat	406..429	CDD:275380	2/22 (9%)
		leucine-rich repeat	430..452	CDD:275380	7/21 (33%)
		leucine-rich repeat	453..500	CDD:275380	6/46 (13%)
		leucine-rich repeat	501..521	CDD:275380	7/19 (37%)
		leucine-rich repeat	525..547	CDD:275380	5/21 (24%)
		leucine-rich repeat	548..573	CDD:275380	9/26 (35%)
		leucine-rich repeat	604..640	CDD:275380	7/35 (20%)
		leucine-rich repeat	641..688	CDD:275380	12/50 (24%)
		leucine-rich repeat	689..816	CDD:275380	18/127 (14%)
		LRR_8	815..875	CDD:290566	11/59 (19%)
		leucine-rich repeat	817..864	CDD:275380	9/46 (20%)
		LRR_8	864..921	CDD:290566	11/56 (20%)
		leucine-rich repeat	865..888	CDD:275380	4/22 (18%)
		leucine-rich repeat	889..910	CDD:275380	2/20 (10%)
		TIR	1076..1211	CDD:214587
LRRTM1	NP_001382551.1	LRR 1	64..87		9/22 (41%)
		LRR 2	89..111		7/21 (33%)
		LRR 3	112..135		7/22 (32%)
		LRR 4	136..159		10/69 (14%)
		LRR 5	161..183		5/21 (24%)
		LRR 6	184..207		11/41 (27%)
		LRR 7	209..231		7/25 (28%)
		LRR 8	233..255		7/32 (22%)
		LRR 9	256..278		8/34 (24%)
		LRR 10	280..302		10/26 (38%)
		May be involved in DLG4-binding. /evidence=ECO:0000250	520..523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910