DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and LOC572462

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	XP_005167813.2	Gene:	LOC572462 / 572462	-ID:	-	Length:	951	Species:	Danio rerio

Alignment Length:	1269	Identity:	277/1269 - (21%)
Similarity:	448/1269 - (35%)	Gaps:	428/1269 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 CRWSGGGEHDITLVCHLRTINSELENTNF--------SVIQ--------------PQNTVRLRLE 78
            |.|       :...||   ..|::|..|.        |:.:              |.|.:.|.::
Zfish    26 CSW-------LAEKCH---FFSDVEGLNIASFYHGKTSIAECLSVTDIKEDLRGLPTNLLNLLVQ 80

  Fly    79 CNDALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQELRNLTIRTHNG--------D 135
            .:  |.|...|:|:||.....|.:|.|..| ...:...:|.||..:.:|||...:.        |
Zfish    81 MD--LHFHGVLAPNSFSRFGSLENLKIAGC-FSEIPPEAFNGLTNVTSLTITALDSKNCCEVALD 142

  Fly   136 WSTMSLEMASNSFVEFRQLERLDLSL-----NNIWLIPDG--------MVCPLKS---------- 177
            :|  .|...::.|:....|..|.|::     :..||..|.        ::|.|.:
Zfish   143 FS--HLPSLTSLFISHHDLSLLALNVFEKIPHLQWLYLDSVCLKDLSDVLCRLANVKLLKLFSLD 205

  Fly   178 -----LQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLT 237
                 ||:.|.|.....|||..:               :::::||...|:..:........|:|:
Zfish   206 DWNIRLQYQNCSVFNTTDISTEF---------------SIETVDLLLGKLEHIDEGAFKPFGKLS 255

  Fly   238 HLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIF 302
            .|:.:.::..||.|.:..|:                        .|:.:|....:.:||....:.
Zfish   256 LLHFSVSNTDFLEDLSLIGV------------------------HQISKISAIVDVLNVDDLCVA 296

  Fly   303 GELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLED-N 366
            .:|..:..:|:....:|.. :.:...||.|.:..:.|. |.|||            :|:.|.| |
Zfish   297 AKLYSVKSVDVYYKTINLS-LTSKGSVGCKEIGYITLE-NDISR------------EIVNLLDVN 347

  Fly   367 YIDQLPGGIFADLTN--LHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRS---LVN 426
            .:.|    ||::||:  ::..:|..|....:.....|.:|.|:.:.|...||.::....   .||
Zfish   348 SVFQ----IFSNLTSAAIYRHVLRSNDFQSLCASYPQNVKQLINMVLQTIRIDKIVSHQFMCFVN 408

  Fly   427 CSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIR 491
                                      ||||.:..:.||..|:.:...|..|..|.:..|.::.|.
Zfish   409 --------------------------LKTLKLVMSKISVFEDFAFIGLNKLKELNLHRNKISSIH 447

  Fly   492 RGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGN 556
            |..|..:..|::|:|.:|.:..||..|.                    |.||
Zfish   448 RHTFSGLHELRVLDLQENPIIYIEPKSF--------------------GHFT------------- 479

  Fly   557 RLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLY 621
                                                 :||:|     ||.::   :.|.::.::.
Zfish   480 -------------------------------------NLSSF-----LLGDL---NFPPNMSLIK 499

  Fly   622 LNDNQISKIQPYTF---FKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECD 683
            |:.:.|..:.||..   |....|..:.||....|||. |.|.|. |.....|.|          |
Zfish   500 LHLSDIFGVIPYNLSNVFISSGLRPMHLVIGSNTTLN-NGLNLH-IKGQYVIVE----------D 552

  Fly   684 CNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDF 748
            ||             ...|..:..:..:.||       .:.|   ::|:.||.....:|    :|
Zfish   553 CN-------------SLLLTSVFTLQIQAAY-------MICE---NEFIGKYVPSVVSL----EF 590

  Fly   749 QACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIG 813
            |:                 .::.|:.|.|..:              ||.
Zfish   591 QS-----------------MFSDNIGDLSVIN--------------QLV---------------- 608

  Fly   814 RKRLKVLHLNHSRIEVLHNR--TFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIA 876
              .||.|.|....:..|.|.  .|:.|.:||.|.|.:.:|..|:|:..:.|..|.:|     .:.
Zfish   609 --HLKTLKLEKLDLTNLPNMDIMFHNLTKLETLILANCKLFFLDGSLTKDLKALTKL-----GLI 666

  Fly   877 TIDTLTF--THLYHLKILRLDHNAITSFAVWNFLPSYLNELRLASNPWTCSCE---FIDKLRDYI 936
            ..||:..  |.:.||..||.               .||.:|.|     .|||:   .:..:||
Zfish   667 PKDTVNILQTFVDHLTQLRF---------------VYLEDLDL-----YCSCDNAWLVSWIRD-- 709

  Fly   937 NRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYAEQAG--GE 999
            ||          |.:|:..|.:.                    |.|....||..::.....  .|
Zfish   710 NR----------KVEVVMSNPSM--------------------QDLKCLTDNEVDHISFVSYVTE 744

  Fly  1000 NASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIF-RQEMRVWCHSRFGVRLFYNA 1063
            |.|.            .||:  :..|..:.|:.:.|.:.|::.| .|..:.:.|...|  .|..|
Zfish   745 NCSF------------DLDF--VFFACSSVFLCIFIVVVLMYKFVGQYFKPFYHIASG--WFREA 793

  Fly  1064 QKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEM-GEHRYKLCLHQRDFPVGGYLPETIVQA 1127
            .:  .|.:::..:|||||||||||.:|.|||.|.||. |....:||||.|||.:|..:.|.|..:
Zfish   794 FR--MKEKQQYRYDAFVSYSSKDEHWVIEELLPNLEQRGPPFLRLCLHSRDFQLGHDIVENITDS 856

  Fly  1128 IDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDPDLRL--YLKT 1190
            |.:||||:.:||.|::.|.||..|.:.|...:..:.|..||::.|..:|.:.|....||  .:||
Zfish   857 IYASRRTLCLVSRNYLNSNWCSVEMQLATYRLQVEHRDILILVFLETIPSRLLSSHHRLARLVKT 921

  Fly  1191 NTYLQWGD-----KLFWQKLRFALPDVSSSQRSN 1219
            .|||.|..     :.||.:|...|    ||.::|
Zfish   922 RTYLDWPQESKMHEAFWDRLWCKL----SSNKAN 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	44/231 (19%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		leucine-rich repeat	124..144	CDD:275380	6/27 (22%)
		LRR_8	152..222	CDD:290566	17/97 (18%)
		leucine-rich repeat	154..177	CDD:275380	8/35 (23%)
		leucine-rich repeat	178..201	CDD:275380	7/22 (32%)
		LRR	210..656	CDD:227223	85/454 (19%)
		leucine-rich repeat	212..235	CDD:275380	3/22 (14%)
		leucine-rich repeat	236..259	CDD:275380	6/22 (27%)
		leucine-rich repeat	260..283	CDD:275380	0/22 (0%)
		LRR_RI	276..558	CDD:238064	58/287 (20%)
		leucine-rich repeat	284..307	CDD:275380	4/22 (18%)
		leucine-rich repeat	308..333	CDD:275380	4/24 (17%)
		leucine-rich repeat	334..357	CDD:275380	5/22 (23%)
		leucine-rich repeat	358..381	CDD:275380	8/23 (35%)
		leucine-rich repeat	382..405	CDD:275380	3/22 (14%)
		leucine-rich repeat	406..429	CDD:275380	6/25 (24%)
		leucine-rich repeat	430..452	CDD:275380	0/21 (0%)
		leucine-rich repeat	453..500	CDD:275380	14/46 (30%)
		leucine-rich repeat	501..521	CDD:275380	7/19 (37%)
		leucine-rich repeat	525..547	CDD:275380	3/21 (14%)
		leucine-rich repeat	548..573	CDD:275380	0/24 (0%)
		leucine-rich repeat	604..640	CDD:275380	8/38 (21%)
		leucine-rich repeat	641..688	CDD:275380	15/46 (33%)
		leucine-rich repeat	689..816	CDD:275380	15/126 (12%)
		LRR_8	815..875	CDD:290566	18/61 (30%)
		leucine-rich repeat	817..864	CDD:275380	16/48 (33%)
		LRR_8	864..921	CDD:290566	13/58 (22%)
		leucine-rich repeat	865..888	CDD:275380	5/24 (21%)
		leucine-rich repeat	889..910	CDD:275380	3/20 (15%)
		TIR	1076..1211	CDD:214587	60/142 (42%)
LOC572462	XP_005167813.2	leucine-rich repeat	149..172	CDD:275380	4/22 (18%)
		leucine-rich repeat	173..195	CDD:275380	5/21 (24%)
		leucine-rich repeat	196..253	CDD:275380	10/71 (14%)
		leucine-rich repeat	254..350	CDD:275380	25/133 (19%)
		LRR_8	408..467	CDD:316378	19/84 (23%)
		leucine-rich repeat	409..432	CDD:275378	8/22 (36%)
		PLN00113	<427..>516	CDD:331614	27/166 (16%)
		leucine-rich repeat	433..456	CDD:275378	6/22 (27%)
		leucine-rich repeat	457..480	CDD:275378	10/92 (11%)
		leucine-rich repeat	541..584	CDD:275380	14/76 (18%)
		leucine-rich repeat	585..609	CDD:275380	8/76 (11%)
		leucine-rich repeat	610..635	CDD:275380	8/24 (33%)
		leucine-rich repeat	636..659	CDD:275380	8/22 (36%)
		TIR	803..941	CDD:214587	58/137 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920