Protein Alignment Tollo and nyx

DIOPT Version :10

• Sequence 1: NP_524757.1
• Gene: Tollo / 44497
• FlyBaseID: FBgn0029114
• Length: 1346
• Species: Drosophila melanogaster
• Sequence 2: NP_001071085.1
• Gene: nyx / 568821
• ZFINID: ZDB-GENE-061026-3
• Length: 469
• Species: Danio rerio
• Alignment Length: 431
• Identity: 111/431 - (25%)
• Similarity: 188/431 - (43%)
• Gaps: 92/431 - (21%)

  Fly   239 LNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFG 303
            :|:.|||:.||::|||..|.||:.:.                        |:.|:|:.:.||.|.
Zfish    63 INLDKNSLKFLSERAFGTLPSLKTLS------------------------LKYNNISFITPGAFK 103

  Fly   304 ELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYI 368
            .|..|:.|.:|.||. .::::..||..||||:.||||...:..:...||....:|:.|....|..
Zfish   104 GLPNLVELKMAHNEY-IRYLHTRTFTALKRLVRLDLSDCNLFNMPDRIFLEQITLKELLCFQNNF 167

  Fly   369 DQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDL 433
            .::||.: ..:.||..:.|.||:|..:...:|.||.:|..|:|..|||:.:...:..:..:|::.
Zfish   168 RRVPGAL-RGMENLTHVYLERNKIEAVAYNSLLGLTSLKYLNLQENRINVIHDEAFKDLIRLENF 231

  Fly   434 HLNDNKLQAVP-EALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDR 497
            :||||.|..:| :|...:..||.|::|.|:::.:..|..:.|..|..|.:..|.|::|..|.|:.
Zfish   232 YLNDNLLVDLPQQAFKGLSNLKMLNLGGNLLTNVSKTWFSDLVELEVLYLDRNRLSYIEDGSFEN 296

  Fly   498 MSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFD 562
            ::||..|:|:.|.|.|:.....|....:..:.|..|..:...       :|.||.
Zfish   297 LTSLITLHLNSNNLTSLPFSVFQPIYFIGRLYLFRNPWECTC-------DLEWLR---------- 344

  Fly   563 YSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQI 627
                    :|::                          ||.|:.:|..:| |:||..|.|::
Zfish   345 --------EWME--------------------------SYKLVRDIPCAS-PSSVAGLDLSE--- 371

  Fly   628 SKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDR 668
                  ..|...|.|.:|.....:||..|:    .|..|::
Zfish   372 ------VVFAHLNSTCLDPPELNMTTSLPD----YPTVENK 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR	54..400	CDD:443914	47/160 (29%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380	10/19 (53%)
		LRR	239..634	CDD:443914	102/395 (26%)
		leucine-rich repeat	260..283	CDD:275380	1/22 (5%)
		leucine-rich repeat	284..307	CDD:275380	7/22 (32%)
		leucine-rich repeat	308..333	CDD:275380	8/24 (33%)
		leucine-rich repeat	334..357	CDD:275380	7/22 (32%)
		leucine-rich repeat	358..381	CDD:275380	5/22 (23%)
		leucine-rich repeat	382..405	CDD:275380	8/22 (36%)
		leucine-rich repeat	406..429	CDD:275380	6/22 (27%)
		leucine-rich repeat	430..452	CDD:275380	8/22 (36%)
		leucine-rich repeat	453..500	CDD:275380	14/46 (30%)
		leucine-rich repeat	501..521	CDD:275380	6/19 (32%)
		leucine-rich repeat	525..547	CDD:275380	2/21 (10%)
		leucine-rich repeat	548..573	CDD:275380	3/24 (13%)
		leucine-rich repeat	604..640	CDD:275380	9/35 (26%)
		LRR_8	616..>660	CDD:404697	11/43 (26%)
		leucine-rich repeat	641..688	CDD:275380	7/28 (25%)
		leucine-rich repeat	689..816	CDD:275380
		LRR	<794..>920	CDD:443914
		leucine-rich repeat	817..864	CDD:275380
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
nyx	NP_001071085.1	LRR	64..>330	CDD:443914	86/291 (30%)
		leucine-rich repeat	64..83	CDD:275380	10/18 (56%)
		leucine-rich repeat	84..107	CDD:275380	8/46 (17%)
		leucine-rich repeat	108..132	CDD:275380	8/24 (33%)
		leucine-rich repeat	133..179	CDD:275380	12/46 (26%)
		leucine-rich repeat	180..203	CDD:275380	8/22 (36%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		leucine-rich repeat	228..251	CDD:275380	8/22 (36%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		leucine-rich repeat	276..299	CDD:275380	7/22 (32%)
		leucine-rich repeat	300..319	CDD:275380	6/18 (33%)
		LRRCT	332..>366	CDD:214507	13/85 (15%)