DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tollo and TLR9

DIOPT Version :10

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_059138.1 Gene:TLR9 / 54106 HGNCID:15633 Length:1032 Species:Homo sapiens


Alignment Length:1363 Identity:297/1363 - (21%)
Similarity:447/1363 - (32%) Gaps:516/1363 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLATTHMLYVLIATCVIPIFGAALSKTVLYQAPDE--------CRWSGGGEHDITLVCHLRTINS 57
            :|....||.:.:|...:|.|           .|.|        |.|           ..|:::  
Human    13 LLVQAIMLAMTLALGTLPAF-----------LPCELQPHGLVNCNW-----------LFLKSV-- 53

  Fly    58 ELENTNFSVIQPQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQ 122
                .:||:..|:..|             :|||..|.|              :.:|.|..|..|.
Human    54 ----PHFSMAAPRGNV-------------TSLSLSSNR--------------IHHLHDSDFAHLP 87

  Fly   123 ELRNLTIRTHNGDWST-------------MSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCP 174
            .||:|.::     |:.             |::|  .::|:....||.|:||.|||..:|   ..|
Human    88 SLRHLNLK-----WNCPPVGLSPMHFPCHMTIE--PSTFLAVPTLEELNLSYNNIMTVP---ALP 142

  Fly   175 LKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSAN--------KMVSLPTAMLS 231
             |||..|:.|:..|..:.    ||||:...|      |:.|.:..|        :.:.:....|.
Human   143 -KSLISLSLSHTNILMLD----SASLAGLHA------LRFLFMDGNCYYKNPCRQALEVAPGALL 196

  Fly   232 ALGRLTHLNMAKNSMSF---------------------LADRAFEGLLSLRVVDLSAN------- 268
            .||.||||::..|:::.                     ||......|.:|||:|:..|       
Human   197 GLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHA 261

  Fly   269 ---------RLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWIN 324
                     ....|.|:.|:...:|:.:.|:::|::.|....|..|..|.||||:.|.|......
Human   262 PNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITK 326

  Fly   325 AATFVGLKRLMMLDLSANKISRLE-AHI-----------------------------FRPLA--- 356
            ...|.||.:|..|:||.|...|:. ||:                             .||||   
Human   327 TKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLP 391

  Fly   357 SLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQ------GLKNLL----VLSL 411
            .||.|:|:.|:|:|...|||.....|..:.||.||||...:.|..      |.|..|    :...
Human   392 MLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPA 456

  Fly   412 DFNRISRMDQRSLVNCSQLQ-DLHLNDNKLQAV-PEALAHVQLLKTLDVGENMISQIENTSITQL 474
            ..:..|..|.|.  |||.|. .|.|:.|.|..| ||..|.:..|:.|.:..|.|||..|.|    
Human   457 PVDTPSSEDFRP--NCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGS---- 515

  Fly   475 ESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIA 539
                               .|..::.||:|:||.|||......|                     
Human   516 -------------------QFLPLTGLQVLDLSHNKLDLYHEHS--------------------- 540

  Fly   540 GLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWL--------DVRANRITQLGN---YFEIESEL 593
              |||||.|..|::|        |:..|.|:|.:        .:|..|...|.:   :.::..:|
Human   541 --FTELPRLEALDLS--------YNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQL 595

  Fly   594 ---SLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFK-KPNLTRVDLVRNRLTTL 654
               ||...|.|.|.|..:.|..      .|||:           ||: ...|..:||.:|||.||
Human   596 CSTSLRALDFSGNALGHMWAEG------DLYLH-----------FFQGLSGLIWLDLSQNRLHTL 643

  Fly   655 EPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSS 719
            .|..||..|                                                        
Human   644 LPQTLRNLP-------------------------------------------------------- 652

  Fly   720 HVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQT 784
                                                                             
Human   653 ----------------------------------------------------------------- 652

  Fly   785 LPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSN 849
                                          |.|:||.|..:.:......:.:.|.:||||.|..|
Human   653 ------------------------------KSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGN 687

  Fly   850 QLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAI--TSFAVWNFLPSYL 912
            |||||..........|:.|.:..|:|:.:....|:....|:.|.|..||:  ...:.:..|.|.|
Human   688 QLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASAL 752

  Fly   913 NELRLASNPWTCSC--EFIDKLRDYINRHEYVVDKL--KMKCDVISGNSTQQMVIYPGSGEPASL 973
            ..|.:::||..|:|  .|:|.|.:.    :..|..|  ::||                 |.|..|
Human   753 QILDVSANPLHCACGAAFMDFLLEV----QAAVPGLPSRVKC-----------------GSPGQL 796

  Fly   974 PVVQC-SQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPI-LVAILTAFIFVMIC 1036
            ..:.. :|.|.|.||...::                         |...: |:|:.......|: 
Human   797 QGLSIFAQDLRLCLDEALSW-------------------------DCFALSLLAVALGLGVPML- 835

  Fly  1037 ISLVFIFRQEMRVWCHSRFGVRLFYNAQ----------KDVDKNEREKLFDAFVSYSSKDEL--- 1088
                           |...|..|:|...          :...::|....:||||.:......   
Human   836 ---------------HHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVAD 885

  Fly  1089 FVNEELAPMLE--MGEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFE 1151
            :|..||...||  .|....:|||.:||:..|..|.|.:..::..||:|:.|::.....|...|..
Human   886 WVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRAS 950

  Fly  1152 FKSAHQSVLRDRRRRLIVIVLGEVPQKELDPDLRLYLKTNTYLQW-----GDKLFWQKLRFAL 1209
            |..|.|.:|.||:..:::::|....::.....||..|...:.|.|     |.:.||.:|..||
Human   951 FLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMAL 1013

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR 54..400 CDD:443914 108/436 (25%)
leucine-rich repeat 100..123 CDD:275380 4/22 (18%)
leucine-rich repeat 124..144 CDD:275380 6/32 (19%)
leucine-rich repeat 154..177 CDD:275380 10/22 (45%)
leucine-rich repeat 178..201 CDD:275380 7/22 (32%)
leucine-rich repeat 212..235 CDD:275380 5/30 (17%)
leucine-rich repeat 236..259 CDD:275380 8/43 (19%)
LRR 239..634 CDD:443914 121/490 (25%)
leucine-rich repeat 260..283 CDD:275380 8/38 (21%)
leucine-rich repeat 284..307 CDD:275380 6/22 (27%)
leucine-rich repeat 308..333 CDD:275380 10/24 (42%)
leucine-rich repeat 334..357 CDD:275380 12/55 (22%)
leucine-rich repeat 358..381 CDD:275380 10/22 (45%)
leucine-rich repeat 382..405 CDD:275380 9/28 (32%)
leucine-rich repeat 406..429 CDD:275380 6/26 (23%)
leucine-rich repeat 430..452 CDD:275380 9/23 (39%)
leucine-rich repeat 453..500 CDD:275380 9/46 (20%)
leucine-rich repeat 501..521 CDD:275380 9/19 (47%)
leucine-rich repeat 525..547 CDD:275380 4/21 (19%)
leucine-rich repeat 548..573 CDD:275380 7/24 (29%)
leucine-rich repeat 604..640 CDD:275380 7/36 (19%)
LRR_8 616..>660 CDD:404697 14/44 (32%)
leucine-rich repeat 641..688 CDD:275380 12/46 (26%)
leucine-rich repeat 689..816 CDD:275380 0/126 (0%)
LRR <794..>920 CDD:443914 31/127 (24%)
leucine-rich repeat 817..864 CDD:275380 16/46 (35%)
leucine-rich repeat 865..888 CDD:275380 5/22 (23%)
leucine-rich repeat 889..910 CDD:275380 6/22 (27%)
TIR 1076..1211 CDD:214587 42/144 (29%)
TLR9NP_059138.1 leucine-rich repeat 43..64 CDD:275380 6/37 (16%)
LRR 1 62..85 9/49 (18%)
LRR_8 64..135 CDD:404697 23/104 (22%)
leucine-rich repeat 65..88 CDD:275380 10/49 (20%)
LRR 2 87..110 4/27 (15%)
leucine-rich repeat 89..124 CDD:275380 7/41 (17%)
LRR 113..504 CDD:443914 111/408 (27%)
LRR 3 122..147 13/28 (46%)
leucine-rich repeat 125..144 CDD:275380 10/22 (45%)
leucine-rich repeat 145..168 CDD:275380 8/26 (31%)
LRR 4 150..166 6/19 (32%)
LRR 5 167..190 4/28 (14%)
leucine-rich repeat 169..200 CDD:275380 5/30 (17%)
LRR 6 198..221 7/22 (32%)
leucine-rich repeat 201..221 CDD:275380 5/19 (26%)
leucine-rich repeat 222..245 CDD:275380 3/22 (14%)
LRR 7 223..242 2/18 (11%)
LRR 8 243..268 6/24 (25%)
leucine-rich repeat 246..285 CDD:275380 8/38 (21%)
LRR 9 283..306 5/22 (23%)
leucine-rich repeat 286..307 CDD:275380 5/20 (25%)
LRR 10 308..332 8/23 (35%)
leucine-rich repeat 310..335 CDD:275380 10/24 (42%)
LRR 11 333..356 9/22 (41%)
leucine-rich repeat 336..365 CDD:275380 8/28 (29%)
LRR 12 363..386 0/22 (0%)
leucine-rich repeat 366..392 CDD:275380 4/25 (16%)
LRR 13 390..413 10/22 (45%)
leucine-rich repeat 393..416 CDD:275380 10/22 (45%)
LRR 14 415..440 8/24 (33%)
leucine-rich repeat 417..472 CDD:275380 16/56 (29%)
LRR 15 470..494 10/23 (43%)
leucine-rich repeat 476..497 CDD:275380 8/20 (40%)
LRR 495..>739 CDD:443914 85/465 (18%)
LRR 16 496..519 9/45 (20%)
leucine-rich repeat 498..522 CDD:275380 9/46 (20%)
LRR 17 520..543 10/45 (22%)
leucine-rich repeat 523..546 CDD:275380 13/45 (29%)
LRR 18 545..572 8/34 (24%)
leucine-rich repeat 547..599 CDD:275380 11/59 (19%)
LRR 19 574..598 4/23 (17%)
leucine-rich repeat 600..629 CDD:275380 11/45 (24%)
LRR 20 600..622 8/27 (30%)
LRR 21 627..650 10/22 (45%)
leucine-rich repeat 630..654 CDD:275380 12/174 (7%)
LRR 22 652..675 6/173 (3%)
leucine-rich repeat 655..678 CDD:275380 5/22 (23%)
LRR 23 676..699 12/22 (55%)
leucine-rich repeat 679..702 CDD:275380 11/22 (50%)
LRR 24 701..723 5/21 (24%)
leucine-rich repeat 703..726 CDD:275380 5/22 (23%)
LRR 25 724..747 5/22 (23%)
leucine-rich repeat 727..748 CDD:275380 5/20 (25%)
LRR 26 749..772 8/22 (36%)
leucine-rich repeat 752..770 CDD:275380 6/17 (35%)
SEFIR 870..1009 CDD:474043 39/138 (28%)

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