DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tollo and TLR9

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_059138.1 Gene:TLR9 / 54106 HGNCID:15633 Length:1032 Species:Homo sapiens


Alignment Length:1363 Identity:297/1363 - (21%)
Similarity:447/1363 - (32%) Gaps:516/1363 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLATTHMLYVLIATCVIPIFGAALSKTVLYQAPDE--------CRWSGGGEHDITLVCHLRTINS 57
            :|....||.:.:|...:|.|           .|.|        |.|           ..|:::  
Human    13 LLVQAIMLAMTLALGTLPAF-----------LPCELQPHGLVNCNW-----------LFLKSV-- 53

  Fly    58 ELENTNFSVIQPQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQ 122
                .:||:..|:..|             :|||..|.|              :.:|.|..|..|.
Human    54 ----PHFSMAAPRGNV-------------TSLSLSSNR--------------IHHLHDSDFAHLP 87

  Fly   123 ELRNLTIRTHNGDWST-------------MSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCP 174
            .||:|.::     |:.             |::|  .::|:....||.|:||.|||..:|   ..|
Human    88 SLRHLNLK-----WNCPPVGLSPMHFPCHMTIE--PSTFLAVPTLEELNLSYNNIMTVP---ALP 142

  Fly   175 LKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSAN--------KMVSLPTAMLS 231
             |||..|:.|:..|..:.    ||||:...|      |:.|.:..|        :.:.:....|.
Human   143 -KSLISLSLSHTNILMLD----SASLAGLHA------LRFLFMDGNCYYKNPCRQALEVAPGALL 196

  Fly   232 ALGRLTHLNMAKNSMSF---------------------LADRAFEGLLSLRVVDLSAN------- 268
            .||.||||::..|:::.                     ||......|.:|||:|:..|       
Human   197 GLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHA 261

  Fly   269 ---------RLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWIN 324
                     ....|.|:.|:...:|:.:.|:::|::.|....|..|..|.||||:.|.|......
Human   262 PNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITK 326

  Fly   325 AATFVGLKRLMMLDLSANKISRLE-AHI-----------------------------FRPLA--- 356
            ...|.||.:|..|:||.|...|:. ||:                             .||||   
Human   327 TKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLP 391

  Fly   357 SLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQ------GLKNLL----VLSL 411
            .||.|:|:.|:|:|...|||.....|..:.||.||||...:.|..      |.|..|    :...
Human   392 MLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPA 456

  Fly   412 DFNRISRMDQRSLVNCSQLQ-DLHLNDNKLQAV-PEALAHVQLLKTLDVGENMISQIENTSITQL 474
            ..:..|..|.|.  |||.|. .|.|:.|.|..| ||..|.:..|:.|.:..|.|||..|.|    
Human   457 PVDTPSSEDFRP--NCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGS---- 515

  Fly   475 ESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIA 539
                               .|..::.||:|:||.|||......|                     
Human   516 -------------------QFLPLTGLQVLDLSHNKLDLYHEHS--------------------- 540

  Fly   540 GLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWL--------DVRANRITQLGN---YFEIESEL 593
              |||||.|..|::|        |:..|.|:|.:        .:|..|...|.:   :.::..:|
Human   541 --FTELPRLEALDLS--------YNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQL 595

  Fly   594 ---SLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFK-KPNLTRVDLVRNRLTTL 654
               ||...|.|.|.|..:.|..      .|||:           ||: ...|..:||.:|||.||
Human   596 CSTSLRALDFSGNALGHMWAEG------DLYLH-----------FFQGLSGLIWLDLSQNRLHTL 643

  Fly   655 EPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSS 719
            .|..||..|                                                        
Human   644 LPQTLRNLP-------------------------------------------------------- 652

  Fly   720 HVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQT 784
                                                                             
Human   653 ----------------------------------------------------------------- 652

  Fly   785 LPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSN 849
                                          |.|:||.|..:.:......:.:.|.:||||.|..|
Human   653 ------------------------------KSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGN 687

  Fly   850 QLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAI--TSFAVWNFLPSYL 912
            |||||..........|:.|.:..|:|:.:....|:....|:.|.|..||:  ...:.:..|.|.|
Human   688 QLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASAL 752

  Fly   913 NELRLASNPWTCSC--EFIDKLRDYINRHEYVVDKL--KMKCDVISGNSTQQMVIYPGSGEPASL 973
            ..|.:::||..|:|  .|:|.|.:.    :..|..|  ::||                 |.|..|
Human   753 QILDVSANPLHCACGAAFMDFLLEV----QAAVPGLPSRVKC-----------------GSPGQL 796

  Fly   974 PVVQC-SQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPI-LVAILTAFIFVMIC 1036
            ..:.. :|.|.|.||...::                         |...: |:|:.......|: 
Human   797 QGLSIFAQDLRLCLDEALSW-------------------------DCFALSLLAVALGLGVPML- 835

  Fly  1037 ISLVFIFRQEMRVWCHSRFGVRLFYNAQ----------KDVDKNEREKLFDAFVSYSSKDEL--- 1088
                           |...|..|:|...          :...::|....:||||.:......   
Human   836 ---------------HHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVAD 885

  Fly  1089 FVNEELAPMLE--MGEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFE 1151
            :|..||...||  .|....:|||.:||:..|..|.|.:..::..||:|:.|::.....|...|..
Human   886 WVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRAS 950

  Fly  1152 FKSAHQSVLRDRRRRLIVIVLGEVPQKELDPDLRLYLKTNTYLQW-----GDKLFWQKLRFAL 1209
            |..|.|.:|.||:..:::::|....::.....||..|...:.|.|     |.:.||.:|..||
Human   951 FLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMAL 1013

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 59/253 (23%)
leucine-rich repeat 100..123 CDD:275380 4/22 (18%)
leucine-rich repeat 124..144 CDD:275380 6/32 (19%)
LRR_8 152..222 CDD:290566 24/77 (31%)
leucine-rich repeat 154..177 CDD:275380 10/22 (45%)
leucine-rich repeat 178..201 CDD:275380 7/22 (32%)
LRR 210..656 CDD:227223 140/550 (25%)
leucine-rich repeat 212..235 CDD:275380 5/30 (17%)
leucine-rich repeat 236..259 CDD:275380 8/43 (19%)
leucine-rich repeat 260..283 CDD:275380 8/38 (21%)
LRR_RI 276..558 CDD:238064 91/326 (28%)
leucine-rich repeat 284..307 CDD:275380 6/22 (27%)
leucine-rich repeat 308..333 CDD:275380 10/24 (42%)
leucine-rich repeat 334..357 CDD:275380 12/55 (22%)
leucine-rich repeat 358..381 CDD:275380 10/22 (45%)
leucine-rich repeat 382..405 CDD:275380 9/28 (32%)
leucine-rich repeat 406..429 CDD:275380 6/26 (23%)
leucine-rich repeat 430..452 CDD:275380 9/23 (39%)
leucine-rich repeat 453..500 CDD:275380 9/46 (20%)
leucine-rich repeat 501..521 CDD:275380 9/19 (47%)
leucine-rich repeat 525..547 CDD:275380 4/21 (19%)
leucine-rich repeat 548..573 CDD:275380 7/24 (29%)
leucine-rich repeat 604..640 CDD:275380 7/36 (19%)
leucine-rich repeat 641..688 CDD:275380 12/46 (26%)
leucine-rich repeat 689..816 CDD:275380 0/126 (0%)
LRR_8 815..875 CDD:290566 20/59 (34%)
leucine-rich repeat 817..864 CDD:275380 16/46 (35%)
LRR_8 864..921 CDD:290566 14/58 (24%)
leucine-rich repeat 865..888 CDD:275380 5/22 (23%)
leucine-rich repeat 889..910 CDD:275380 6/22 (27%)
TIR 1076..1211 CDD:214587 42/144 (29%)
TLR9NP_059138.1 leucine-rich repeat 43..64 CDD:275380 6/37 (16%)
Interaction with CpG-DNA. /evidence=ECO:0000250|UniProtKB:Q2EEY0 47..51 1/14 (7%)
LRR 1 62..85 9/49 (18%)
LRR_8 64..135 CDD:290566 23/104 (22%)
leucine-rich repeat 65..88 CDD:275380 10/49 (20%)
Interaction with CpG-DNA. /evidence=ECO:0000250|UniProtKB:Q2EEY0 72..77 2/18 (11%)
LRR 2 87..110 4/27 (15%)
leucine-rich repeat 89..124 CDD:275380 7/41 (17%)
Interaction with CpG-DNA. /evidence=ECO:0000250|UniProtKB:Q2EEY0 95..109 1/18 (6%)
LRR 3 122..147 13/28 (46%)
LRR_8 123..177 CDD:290566 23/67 (34%)
leucine-rich repeat 125..144 CDD:275380 10/22 (45%)
leucine-rich repeat 145..168 CDD:275380 8/26 (31%)
LRR 4 150..166 6/19 (32%)
LRR 5 167..190 4/28 (14%)
leucine-rich repeat 169..200 CDD:275380 5/30 (17%)
Interaction with CpG-DNA. /evidence=ECO:0000250|UniProtKB:Q2EEY0 179..181 0/1 (0%)
LRR 6 198..221 7/22 (32%)
LRR_8 200..254 CDD:290566 12/53 (23%)
leucine-rich repeat 201..221 CDD:275380 5/19 (26%)
leucine-rich repeat 222..245 CDD:275380 3/22 (14%)
LRR 7 223..242 2/18 (11%)
LRR 8 243..268 6/24 (25%)
leucine-rich repeat 246..285 CDD:275380 8/38 (21%)
LRR 9 283..306 5/22 (23%)
LRR_8 284..344 CDD:290566 20/59 (34%)
leucine-rich repeat 286..307 CDD:275380 5/20 (25%)
LRR 10 308..332 8/23 (35%)
leucine-rich repeat 310..335 CDD:275380 10/24 (42%)
LRR 11 333..356 9/22 (41%)
leucine-rich repeat 336..365 CDD:275380 8/28 (29%)
LRR 12 363..386 0/22 (0%)
leucine-rich repeat 366..392 CDD:275380 4/25 (16%)
LRR 13 390..413 10/22 (45%)
leucine-rich repeat 393..416 CDD:275380 10/22 (45%)
LRR 14 415..440 8/24 (33%)
leucine-rich repeat 417..472 CDD:275380 16/56 (29%)
LRR 15 470..494 10/23 (43%)
LRR_RI 476..739 CDD:238064 93/484 (19%)
leucine-rich repeat 476..497 CDD:275380 8/20 (40%)
LRR_8 496..555 CDD:290566 26/112 (23%)
LRR 16 496..519 9/45 (20%)
leucine-rich repeat 498..522 CDD:275380 9/46 (20%)
LRR 17 520..543 10/45 (22%)
leucine-rich repeat 523..546 CDD:275380 13/45 (29%)
LRR 18 545..572 8/34 (24%)
leucine-rich repeat 547..599 CDD:275380 11/59 (19%)
LRR 19 574..598 4/23 (17%)
LRR_8 598..665 CDD:290566 29/234 (12%)
leucine-rich repeat 600..629 CDD:275380 11/45 (24%)
LRR 20 600..622 8/27 (30%)
LRR 21 627..650 10/22 (45%)
leucine-rich repeat 630..654 CDD:275380 12/174 (7%)
LRR 22 652..675 6/173 (3%)
leucine-rich repeat 655..678 CDD:275380 5/22 (23%)
LRR 23 676..699 12/22 (55%)
leucine-rich repeat 679..702 CDD:275380 11/22 (50%)
LRR_8 701..762 CDD:290566 15/60 (25%)
LRR 24 701..723 5/21 (24%)
leucine-rich repeat 703..726 CDD:275380 5/22 (23%)
LRR 25 724..747 5/22 (23%)
leucine-rich repeat 727..748 CDD:275380 5/20 (25%)
LRR 26 749..772 8/22 (36%)
leucine-rich repeat 752..770 CDD:275380 6/17 (35%)
TIR_2 870..1009 CDD:304906 39/138 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
43.780

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