DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tollo and TLR8

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_057694.2 Gene:TLR8 / 51311 HGNCID:15632 Length:1059 Species:Homo sapiens


Alignment Length:1300 Identity:289/1300 - (22%)
Similarity:480/1300 - (36%) Gaps:404/1300 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 LVCHLRTINSELE---NTNFSVIQPQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIEYCK 109
            |.|....|:...|   ..|||...|         |::.....|.::..|.|.|.|:.....:|..
Human    29 LTCIFLLISGSCELCAEENFSRSYP---------CDEKKQNDSVIAECSNRRLQEVPQTVGKYVT 84

  Fly   110 --------LGNLTDGSFRGLQEL------RNLTIRTHNGDWSTMS--LEMASNSFVEFRQLERLD 158
                    :.::|:.||:|||.|      .|..::..||:....|  |.:...:|:..:.|..|.
Human    85 ELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELL 149

  Fly   159 LSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDIS-----------------NFYFSASLSSRKAR 206
            |..|.:..||.|:.   :||..|:...|.|.:|:                 |.||:        :
Human   150 LEDNQLPQIPSGLP---ESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFN--------K 203

  Fly   207 VCGST------------LQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLS 259
            ||..|            |:.|.||.|.:..:|..:.|:|.:|.   ::...:.::::..|:||::
Human   204 VCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLF---LSNTQIKYISEEDFKGLIN 265

  Fly   260 LRVVDLSAN--RLTSLP-PEL--------------FAETKQLQEIYLRNNSINVLAPGIFGELAE 307
            |.::|||.|  |..:.| |.:              |....||:.:.|.:.|:..:....|..:..
Human   266 LTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPH 330

  Fly   308 LLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKI-SRLEAHI-----FRPLASLQILKL--- 363
            |.||||..|.|..:..:.|....|.||.:||||.|.| .....||     |..|.||:.|.|   
Human   331 LKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGY 395

  Fly   364 ------EDNY--IDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRM- 419
                  ||::  :.|||        ||.|:.|..|.|..|:.:..|...||.::.|..||||.: 
Human   396 VFQELREDDFQPLMQLP--------NLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLV 452

  Fly   420 --DQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSITQLE---SLYG 479
              .::|..|.|..|                .|::..::.|...:..|...:.:...::   :.||
Human   453 KDTRQSYANSSSFQ----------------RHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYG 501

  Fly   480 --LRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLF 542
              |.::.||:..|....|:.:..:..||||.|.           |:|:    |.|.:       |
Human   502 KALDLSLNSIFFIGPNQFENLPDIACLNLSANS-----------NAQV----LSGTE-------F 544

  Fly   543 TELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYN---- 603
            :.:|::.:|:::.|||: ||             .|:.:|:|.:         |...|.|||    
Human   545 SAIPHVKYLDLTNNRLD-FD-------------NASALTELSD---------LEVLDLSYNSHYF 586

  Fly   604 LLTEIT--ASSIPN--SVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVR-----NRLTTLEPNAL 659
            .:..:|  ...|.|  :::||.|:.|.|     ||...|.||....||.     |||..|     
Human   587 RIAGVTHHLEFIQNFTNLKVLNLSHNNI-----YTLTDKYNLESKSLVELVFSGNRLDIL----- 641

  Fly   660 RLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLI 724
                                        |....||                         ::|:.
Human   642 ----------------------------WNDDDNR-------------------------YISIF 653

  Fly   725 EAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHI 789
            :...                                                             
Human   654 KGLK------------------------------------------------------------- 657

  Fly   790 PMDSTQLYLDGNNFRELQSHAFIG-RKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKA 853
              :.|:|.|..|..:.:.:.||:. ...|..||:|.:.::..:.........||:|.|:.|:|..
Human   658 --NLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLF 720

  Fly   854 LNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHN---AITSFAVWNFLPSYLNEL 915
            |..:......:|:.|.|.||.|:.:.:...:.:..||.|.|..|   .|...|:.....:.|:.|
Human   721 LTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSML 785

  Fly   916 RLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQ 980
            .|..||:.|:|: |...|.:::.|..|  |:....|||..:        ||              
Human   786 ELHGNPFECTCD-IGDFRRWMDEHLNV--KIPRLVDVICAS--------PG-------------- 825

  Fly   981 TLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFRQ 1045
                         :|.|....|...:|.:       .|...:::...|.||..|:.::.:     
Human   826 -------------DQRGKSIVSLELTTCV-------SDVTAVILFFFTFFITTMVMLAAL----- 865

  Fly  1046 EMRVWCHSRF--GVRLFYNAQKDVDKNER-----EKLFDAFVSYSSKD----ELFVNEELAPMLE 1099
                 .|..|  .|...||......|..|     :..:||::||.:||    :..:||....:.|
Human   866 -----AHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEE 925

  Fly  1100 MGEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAH----QSVL 1160
            ..:....|||.:||:..|..:.:.::|:|:.|::|:.|:::.:.|| |   .||:|.    |.::
Human   926 SRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKS-W---NFKTAFYLALQRLM 986

  Fly  1161 RDRRRRLIVIVLGEVPQKELDPDLRLYLKTNTYLQWGDK-----LFWQKLRFALPDVSSSQRSNV 1220
            .:....:|.|:|..|.|......||..:..::.|||.|.     ||||.||..:...:.|:.:|:
Human   987 DENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRYNNM 1051

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 59/257 (23%)
leucine-rich repeat 100..123 CDD:275380 6/30 (20%)
leucine-rich repeat 124..144 CDD:275380 6/27 (22%)
LRR_8 152..222 CDD:290566 24/98 (24%)
leucine-rich repeat 154..177 CDD:275380 7/22 (32%)
leucine-rich repeat 178..201 CDD:275380 8/39 (21%)
LRR 210..656 CDD:227223 130/512 (25%)
leucine-rich repeat 212..235 CDD:275380 8/22 (36%)
leucine-rich repeat 236..259 CDD:275380 4/22 (18%)
leucine-rich repeat 260..283 CDD:275380 9/39 (23%)
LRR_RI 276..558 CDD:238064 78/320 (24%)
leucine-rich repeat 284..307 CDD:275380 4/22 (18%)
leucine-rich repeat 308..333 CDD:275380 9/24 (38%)
leucine-rich repeat 334..357 CDD:275380 11/28 (39%)
leucine-rich repeat 358..381 CDD:275380 8/33 (24%)
leucine-rich repeat 382..405 CDD:275380 7/22 (32%)
leucine-rich repeat 406..429 CDD:275380 8/25 (32%)
leucine-rich repeat 430..452 CDD:275380 2/21 (10%)
leucine-rich repeat 453..500 CDD:275380 9/51 (18%)
leucine-rich repeat 501..521 CDD:275380 5/19 (26%)
leucine-rich repeat 525..547 CDD:275380 3/21 (14%)
leucine-rich repeat 548..573 CDD:275380 6/24 (25%)
leucine-rich repeat 604..640 CDD:275380 11/39 (28%)
leucine-rich repeat 641..688 CDD:275380 7/51 (14%)
leucine-rich repeat 689..816 CDD:275380 9/127 (7%)
LRR_8 815..875 CDD:290566 16/59 (27%)
leucine-rich repeat 817..864 CDD:275380 11/46 (24%)
LRR_8 864..921 CDD:290566 16/59 (27%)
leucine-rich repeat 865..888 CDD:275380 6/22 (27%)
leucine-rich repeat 889..910 CDD:275380 7/23 (30%)
TIR 1076..1211 CDD:214587 44/147 (30%)
TLR8NP_057694.2 LRR_8 83..155 CDD:290566 17/71 (24%)
leucine-rich repeat 83..106 CDD:275380 5/22 (23%)
leucine-rich repeat 107..144 CDD:275380 7/36 (19%)
leucine-rich repeat 145..165 CDD:275380 7/22 (32%)
leucine-rich repeat 166..189 CDD:275380 5/22 (23%)
leucine-rich repeat 190..220 CDD:275380 6/37 (16%)
leucine-rich repeat 221..241 CDD:275380 6/19 (32%)
LRR_8 240..317 CDD:290566 18/79 (23%)
leucine-rich repeat 242..265 CDD:275380 5/25 (20%)
leucine-rich repeat 266..306 CDD:275380 9/39 (23%)
LRR_8 305..367 CDD:290566 21/61 (34%)
leucine-rich repeat 307..330 CDD:275380 4/22 (18%)
leucine-rich repeat 331..356 CDD:275380 9/24 (38%)
leucine-rich repeat 387..413 CDD:275380 8/33 (24%)
LRR_8 412..>449 CDD:290566 14/44 (32%)
leucine-rich repeat 414..437 CDD:275380 7/22 (32%)
LRR_8 502..560 CDD:290566 18/79 (23%)
LRR_RI <504..719 CDD:238064 68/385 (18%)
leucine-rich repeat 504..524 CDD:275380 5/19 (26%)
leucine-rich repeat 525..549 CDD:275380 10/45 (22%)
LRR_8 548..614 CDD:290566 22/88 (25%)
leucine-rich repeat 550..573 CDD:275380 9/36 (25%)
leucine-rich repeat 574..603 CDD:275380 8/28 (29%)
leucine-rich repeat 604..658 CDD:275380 20/179 (11%)
LRR_8 657..718 CDD:290566 15/123 (12%)
leucine-rich repeat 659..683 CDD:275380 6/23 (26%)
leucine-rich repeat 684..707 CDD:275380 4/22 (18%)
LRR_8 706..766 CDD:290566 18/59 (31%)
leucine-rich repeat 708..730 CDD:275380 7/21 (33%)
leucine-rich repeat 732..755 CDD:275380 6/22 (27%)
leucine-rich repeat 756..775 CDD:275380 7/18 (39%)
LRRCT 790..835 CDD:214507 16/82 (20%)
TIR 898..1040 CDD:214587 44/145 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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