DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and TLR7

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_057646.1	Gene:	TLR7 / 51284	HGNCID:	15631	Length:	1049	Species:	Homo sapiens

Alignment Length:	1233	Identity:	278/1233 - (22%)
Similarity:	455/1233 - (36%)	Gaps:	355/1233 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIEYCK-----LGNLTDGSFRGLQELRNLT 128
            |.||..|.|..|..    ..:||.||..|..|.::... |.     ||:..:...:.||    :.
Human    64 PTNTTNLTLTINHI----PDISPASFHRLDHLVEIDFR-CNCVPIPLGSKNNMCIKRLQ----IK 119

  Fly   129 IRTHNGDWSTMSLEMASNSFVEFRQ-----LERLDLSLNNIWLIPDGMVCPLKSLQHL----NAS 184
            .|:.:|.....||.:..|..:|..|     |:.|.|..|||:.|....:..|.:::.|    |..
Human   120 PRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCY 184

  Fly   185 YNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFL 249
            |.     :..|.|.|: .:.|.:..:.|:.|.|..|.:.::||.:.|.   ||.|.:..|.::.:
Human   185 YR-----NPCYVSYSI-EKDAFLNLTKLKVLSLKDNNVTAVPTVLPST---LTELYLYNNMIAKI 240

  Fly   250 ADRAFEGLLSLRVVDLSA-----------------NRLTSLPPELFAETKQLQEIYLRNNSINVL 297
            .:..|..|..|:::|||.                 |....:|...|....:|:.:.|.:||:..:
Human   241 QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHV 305

  Fly   298 APGIFGELAELLVLDLASNELNSQWINAATFVG-LKRLMMLDLSAN------------------- 342
            .|..|..:.:|..|||:.|.|..: |..|.|:. |..|:.||||.|
Human   306 PPRWFKNINKLQELDLSQNFLAKE-IGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSL 369

  Fly   343 ---KISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLK 404
               ||.|:..::|:.|.|..:..|.             :|.||..|.|..|.|.:......:..|
Human   370 KSLKILRIRGYVFKELKSFNLSPLH-------------NLQNLEVLDLGTNFIKIANLSMFKQFK 421

  Fly   405 NLLVLSLDFNRISRMDQRSLVN-CSQLQDLHLNDNKLQAV----PEALAHVQLLKTLDVGENMIS 464
            .|.|:.|..|:||.....|.|. ||         |...:|    |:.|..:...:......:...
Human   422 RLKVIDLSVNKISPSGDSSEVGFCS---------NARTSVESYEPQVLEQLHYFRYDKYARSCRF 477

  Fly   465 QIENTSITQL-ESLY----GLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQ 524
            :.:..|...: ||.|    .|.:::||:..::...|..:|.|:.||||.|.:..
Human   478 KNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQ----------- 531

  Fly   525 LQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLE-----KFDYSHIPIGLQWLDVRANRITQLG 584
                .|:|::       |..|..|.:|:.|.|||:     .|:..|   .|:.||:.:|     .
Human   532 ----TLNGSE-------FQPLAELRYLDFSNNRLDLLHSTAFEELH---KLEVLDISSN-----S 577

  Fly   585 NYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRN 649
            :||:.|....:..|..:..:|            :.|.:|||.||.                   :
Human   578 HYFQSEGITHMLNFTKNLKVL------------QKLMMNDNDISS-------------------S 611

  Fly   650 RLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLD--WLQKVNRESRTQPQLMDLDQIHCRL 712
            ...|:|..:||..         ||...|        ||  |.:..||..:....|:.|:::.
Human   612 TSRTMESESLRTL---------EFRGNH--------LDVLWREGDNRYLQLFKNLLKLEELD--- 656

  Fly   713 AYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCS 777
                       |...|..||                                     .|.|.|
Human   657 -----------ISKNSLSFL-------------------------------------PSGVFD-- 671

  Fly   778 RASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELE 842
                      .:|.:...|.|..|..:..........|.|:.|.|:|:::..:..|.......|:
Human   672 ----------GMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLK 726

  Fly   843 VLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTH--LYHLKILRLDHNAI--TSFA 903
            .|.|::||:::|.....|....|:.|.|..|.|..|...:|..  |.:||:|.|.||..  |..|
Human   727 NLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDA 791

  Fly   904 VWNFLPSYLNELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGS- 967
            || |:             |            ::|..|..:..|          :|....:.||:
Human   792 VW-FV-------------W------------WVNHTEVTIPYL----------ATDVTCVGPGAH 820

  Fly   968 -GEPA-SLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAF 1030
             |:.. ||.:..|...|                        |.:||..      :.|.|::   |
Human   821 KGQSVISLDLYTCELDL------------------------TNLILFS------LSISVSL---F 852

  Fly  1031 IFVMICISLVFIFRQEMRVWCHSRFGVRLFYNAQKDVDKNER----EKLFDAFVSYSSKD----E 1087
            :.||:..|.::.:    .||       .:::..:..:...:|    :..:|||:.|.:||    |
Human   853 LMVMMTASHLYFW----DVW-------YIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTE 906

  Fly  1088 LFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEF 1152
            ..:.|.:|.:.:..|..:.|||.:||:..|..:.|.:.|:|..|::|:.|:::.:.|:|..:..|
Human   907 WVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAF 971

  Fly  1153 KSAHQSVLRDRRRRLIVIVLGEVP-QKELDPDLRLYLKTNTYLQW-----GDKLFWQKLRFAL 1209
            ..:||. |.|.:..:|:::..|.| ||.....||..|..::.|:|     ....|||.|:.||
Human   972 YLSHQR-LMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNAL 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	53/226 (23%)
		leucine-rich repeat	100..123	CDD:275380	5/27 (19%)
		leucine-rich repeat	124..144	CDD:275380	4/19 (21%)
		LRR_8	152..222	CDD:290566	20/78 (26%)
		leucine-rich repeat	154..177	CDD:275380	8/22 (36%)
		leucine-rich repeat	178..201	CDD:275380	6/26 (23%)
		LRR	210..656	CDD:227223	114/500 (23%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	236..259	CDD:275380	6/22 (27%)
		leucine-rich repeat	260..283	CDD:275380	7/39 (18%)
		LRR_RI	276..558	CDD:238064	75/314 (24%)
		leucine-rich repeat	284..307	CDD:275380	6/22 (27%)
		leucine-rich repeat	308..333	CDD:275380	10/25 (40%)
		leucine-rich repeat	334..357	CDD:275380	11/44 (25%)
		leucine-rich repeat	358..381	CDD:275380	2/22 (9%)
		leucine-rich repeat	382..405	CDD:275380	5/22 (23%)
		leucine-rich repeat	406..429	CDD:275380	9/23 (39%)
		leucine-rich repeat	430..452	CDD:275380	4/25 (16%)
		leucine-rich repeat	453..500	CDD:275380	8/51 (16%)
		leucine-rich repeat	501..521	CDD:275380	6/19 (32%)
		leucine-rich repeat	525..547	CDD:275380	4/21 (19%)
		leucine-rich repeat	548..573	CDD:275380	9/29 (31%)
		leucine-rich repeat	604..640	CDD:275380	7/35 (20%)
		leucine-rich repeat	641..688	CDD:275380	9/48 (19%)
		leucine-rich repeat	689..816	CDD:275380	15/126 (12%)
		LRR_8	815..875	CDD:290566	17/59 (29%)
		leucine-rich repeat	817..864	CDD:275380	12/46 (26%)
		LRR_8	864..921	CDD:290566	19/60 (32%)
		leucine-rich repeat	865..888	CDD:275380	8/24 (33%)
		leucine-rich repeat	889..910	CDD:275380	11/22 (50%)
		TIR	1076..1211	CDD:214587	45/144 (31%)
TLR7	NP_057646.1	leucine-rich repeat	598..651	CDD:275380	20/100 (20%)
		LRR 21	619..644		10/41 (24%)
		leucine-rich repeat	621..643	CDD:275380	10/38 (26%)
		LRR 22	649..672		9/85 (11%)
		leucine-rich repeat	652..676	CDD:275380	9/86 (10%)
		LRR 23	674..697		4/22 (18%)
		leucine-rich repeat	677..700	CDD:275380	3/22 (14%)
		LRR 24	698..721		6/22 (27%)
		leucine-rich repeat	701..724	CDD:275380	5/22 (23%)
		LRR 25	723..745		6/21 (29%)
		leucine-rich repeat	725..748	CDD:275380	7/22 (32%)
		LRR 26	746..769		7/22 (32%)
		leucine-rich repeat	749..767	CDD:275380	6/17 (35%)
		PCC	753..>837	CDD:188093	28/119 (24%)
		LRR 27	772..795		11/23 (48%)
		TIR	890..>993	CDD:214587	30/103 (29%)
		LRR 1	43..64		278/1233 (23%)
		leucine-rich repeat	48..69	CDD:275380	3/4 (75%)
		LRR 2	65..87		9/25 (36%)
		LRR_8	75..139	CDD:404697	17/72 (24%)
		leucine-rich repeat	91..128	CDD:275380	8/41 (20%)
		LRR 3	110..126		3/19 (16%)
		LRR 4	127..149		5/21 (24%)
		leucine-rich repeat	129..173	CDD:275380	13/43 (30%)
		LRR 5	151..170		6/18 (33%)
		LRR 6	171..195		6/28 (21%)
		PLN00113	191..>711	CDD:215061	146/687 (21%)
		LRR 7	203..226		6/22 (27%)
		leucine-rich repeat	206..225	CDD:275380	6/18 (33%)
		leucine-rich repeat	227..250	CDD:275380	6/22 (27%)
		LRR 8	228..247		4/18 (22%)
		LRR 9	248..275		5/26 (19%)
		leucine-rich repeat	251..291	CDD:275380	7/39 (18%)
		LRR 10	289..312		6/22 (27%)
		leucine-rich repeat	292..315	CDD:275380	6/22 (27%)
		LRR 11	314..337		9/23 (39%)
		leucine-rich repeat	316..341	CDD:275380	10/25 (40%)
		LRR 12	339..368		7/28 (25%)
		leucine-rich repeat	342..371	CDD:275380	6/28 (21%)
		LRR 13	369..392		6/22 (27%)
		leucine-rich repeat	372..398	CDD:275380	8/38 (21%)
		LRR 14	396..419		7/22 (32%)
		leucine-rich repeat	399..422	CDD:275380	5/22 (23%)
		LRR 15	421..443		8/21 (38%)
		LRR	<488..775	CDD:227223	87/427 (20%)
		LRR 16	492..515		5/22 (23%)
		leucine-rich repeat	496..518	CDD:275380	4/21 (19%)
		LRR 17	516..540		10/45 (22%)
		leucine-rich repeat	519..543	CDD:275380	10/45 (22%)
		LRR 18	541..564		8/22 (36%)
		leucine-rich repeat	544..567	CDD:275380	8/25 (32%)
		LRR 19	566..588		8/29 (28%)
		leucine-rich repeat	568..597	CDD:275380	8/33 (24%)
		LRR 20	595..618		8/53 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.780