DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Tlr11

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001138251.2	Gene:	Tlr11 / 498491	RGDID:	1564460	Length:	932	Species:	Rattus norvegicus

Alignment Length:	1238	Identity:	274/1238 - (22%)
Similarity:	427/1238 - (34%)	Gaps:	450/1238 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 HDITLVCHLRTINSELENTNFSVIQPQNTVRLRLECNDALFFQSSLSP-------DSFRSLVELR 101
            |.:....:::.||..||..      |:||..|.|:         .:.|       |.|.||..||
  Rat    66 HLLASCSNVKNINQTLEKV------PRNTEVLCLQ---------GMVPTLPANAFDGFYSLQLLR 115

  Fly   102 DLTIEYCKLG--NLTDGSFRGLQELRNLTIRTHNGDWSTMSLEMASNSFVEFRQLERLDLSLNNI 164
                  .:||  |:|..:|:||.:|:.|....|    :...|                     ::
  Rat   116 ------LQLGTTNITSRTFQGLDQLQYLFFEHH----APCCL---------------------SL 149

  Fly   165 WLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSLPTAM 229
            :|.||.    |:||:.|                :|||          .|...|:.:..:.|||.
  Rat   150 FLPPDS----LESLRSL----------------SSLS----------FQGYCLTYSHSIYLPTT- 183

  Fly   230 LSALGRLTHLNMAKNSMSFLAD--RAFEGLL--------------SLRVVDLSANRLTSLPPELF 278
                  |.||.|..:.::.|.:  |.|..||              .|.|:|||.|
  Rat   184 ------LRHLTMRNSCLTKLQELQRLFPDLLLGASSTPNTKPRTPFLEVLDLSYN---------- 232

  Fly   279 AETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANK 343
               .||::..:|:         ::|.....|:||...                  |..|||:::
  Rat   233 ---LQLKQAGIRD---------LYGLTLHSLILDGTP------------------LRALDLTSS- 266

  Fly   344 ISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRI-SVIEQRTLQGLKNLL 407
                      .|..|..|.|....|::||..: ...:.|..|.|.:|:| :::....:.|||.|.
  Rat   267 ----------GLLHLHFLSLVGTGIEKLPASV-TGFSELCALDLGKNQIQNILGNGDILGLKALK 320

  Fly   408 VLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSIT 472
            .|||..|.:..:..|.|....|||.|:|:.|||..:            |::.|.:.|    |::|
  Rat   321 FLSLHDNHLQSLPVRFLRTLPQLQKLNLSMNKLGPI------------LELPEGLFS----TNLT 369

  Fly   473 QLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKS 537
            .|:      ::.|.|..|.||.|..:|.||.|.||.|.:.|:...|||....|:.:.|..||:|.
  Rat   370 VLD------LSHNQLCEIPRGNFSFLSQLQELWLSGNNISSLSNESLQGLRWLRTLDLSWNQIKV 428

  Fly   538 I-AGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIE-------SELS 594
            : .|..:.||.|..||:.|..||     ||. |.|....:..|..|||::..:|       ..||
  Rat   429 LKPGWLSHLPALTTLNLLGTYLE-----HIS-GTQLQGPKMLRHLQLGSFPTLEIYRLWFPMLLS 487

  Fly   595 LSTFDASYNLLTEITASS-----IPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTL 654
            |           ||.|.:     :|:.              :|:.|.:  ||           ||
  Rat   488 L-----------EIQAETYIQFMVPSG--------------EPFLFLE--NL-----------TL 514

  Fly   655 EPNALRLSPIAEDREIPEF----YIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYA 715
            |.:.|.|.|.......|..    ..|::.:        |.....:|...|||..|:..   ..:.
  Rat   515 ETSNLLLEPKTTTIHFPSLRRLTLRGYSIF--------LSTSQLQSFFPPQLPLLEYF---FVWC 568

  Fly   716 RGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRAS 780
            |....|.|              |.|               |.|           ...|::....:
  Rat   569 RNDDAVDL--------------HLF---------------EMP-----------RLRVLELGNLN 593

  Fly   781 --YE------QTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYG 837
              ||      :.|.:.:|                         :|:||.|:|..::.|...:|.|
  Rat   594 FFYESSTVKLEMLLNEVP-------------------------QLQVLALSHLNLKNLSVSSFKG 633

  Fly   838 LLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSF 902
            |..|::|.|.|.:...:|       .|||||..|
  Rat   634 LQSLKLLLLNSERALEMN-------SNLQELIPQ------------------------------- 660

  Fly   903 AVWNFLPSYLNELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGS 967
                 :|.|   :..:...:.|.|| ...|..:..|
  Rat   661 -----IPQY---VYFSDVTFACQCE-TSWLESWATR----------------------------- 687

  Fly   968 GEPASLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMI----LNQPPKLDYIPILVAILT 1028
                      ...|...||:.....|      |||:.:.|.:.    .|.|...::    ...||
  Rat   688 ----------APNTFVYGLEKPICMA------NASDYSKTLLFSFLATNCPHGTEF----WGFLT 732

  Fly  1029 AFIFVMICISLVFIFRQEMRVWCHSRFGVRLFYNAQKDVDKNEREKLF--DAFVSYSSKDELFVN 1091
            :|..:::.|.|..|...:.. |.|..:  .||:.....:..:.....|  |.|:||..:|:.:|.
  Rat   733 SFSLLLLLIILPLISCHKWS-WLHHLW--TLFHTCWWKLGGHRLRGQFNYDVFISYCEEDQDWVL 794

  Fly  1092 EELAPMLEM----GEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEF 1152
            |||.|:||.    || ..:|||..|||.:|....|:::.::..||..:.|::...:.|.||..|.
  Rat   795 EELVPVLEKAPPEGE-GLRLCLPARDFGIGNDRMESMIASMGKSRAILCVLTGQALASPWCNLEL 858

  Fly  1153 KSA-HQSVLRDRRRRLIVIVLGEVPQKELDPDLRL--YLKTNTYLQWGD-KLFW--------QKL 1205
            :.| :..:.|.....|:::.|..:.:::|....||  :|:...|..... |:.|        |:|
  Rat   859 RLATYHLIARPGTTCLLLLFLEPLDRQKLHSYHRLSRWLQKEDYFDLSQGKMEWNTFCEQLKQRL 923

  Fly  1206 RFA 1208
            |.|
  Rat   924 RKA 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	48/220 (22%)
		leucine-rich repeat	100..123	CDD:275380	9/24 (38%)
		leucine-rich repeat	124..144	CDD:275380	4/19 (21%)
		LRR_8	152..222	CDD:290566	12/69 (17%)
		leucine-rich repeat	154..177	CDD:275380	4/22 (18%)
		leucine-rich repeat	178..201	CDD:275380	3/22 (14%)
		LRR	210..656	CDD:227223	120/475 (25%)
		leucine-rich repeat	212..235	CDD:275380	5/22 (23%)
		leucine-rich repeat	236..259	CDD:275380	9/38 (24%)
		leucine-rich repeat	260..283	CDD:275380	6/22 (27%)
		LRR_RI	276..558	CDD:238064	76/283 (27%)
		leucine-rich repeat	284..307	CDD:275380	3/22 (14%)
		leucine-rich repeat	308..333	CDD:275380	3/24 (13%)
		leucine-rich repeat	334..357	CDD:275380	5/22 (23%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	382..405	CDD:275380	7/23 (30%)
		leucine-rich repeat	406..429	CDD:275380	7/22 (32%)
		leucine-rich repeat	430..452	CDD:275380	7/21 (33%)
		leucine-rich repeat	453..500	CDD:275380	12/46 (26%)
		leucine-rich repeat	501..521	CDD:275380	9/19 (47%)
		leucine-rich repeat	525..547	CDD:275380	7/22 (32%)
		leucine-rich repeat	548..573	CDD:275380	10/24 (42%)
		leucine-rich repeat	604..640	CDD:275380	6/40 (15%)
		leucine-rich repeat	641..688	CDD:275380	9/50 (18%)
		leucine-rich repeat	689..816	CDD:275380	18/134 (13%)
		LRR_8	815..875	CDD:290566	20/59 (34%)
		leucine-rich repeat	817..864	CDD:275380	14/46 (30%)
		LRR_8	864..921	CDD:290566	8/56 (14%)
		leucine-rich repeat	865..888	CDD:275380	5/22 (23%)
		leucine-rich repeat	889..910	CDD:275380	0/20 (0%)
		TIR	1076..1211	CDD:214587	45/151 (30%)
Tlr11	NP_001138251.2	leucine-rich repeat	111..133	CDD:275380	10/27 (37%)
		LRR_RI	<179..427	CDD:238064	86/328 (26%)
		leucine-rich repeat	224..246	CDD:275380	9/43 (21%)
		leucine-rich repeat	248..270	CDD:275380	8/50 (16%)
		LRR_8	270..329	CDD:290566	19/59 (32%)
		leucine-rich repeat	271..293	CDD:275380	6/22 (27%)
		leucine-rich repeat	294..318	CDD:275380	7/23 (30%)
		LRR_8	319..378	CDD:290566	22/80 (28%)
		leucine-rich repeat	319..342	CDD:275380	7/22 (32%)
		leucine-rich repeat	343..367	CDD:275380	10/39 (26%)
		LRR_8	366..426	CDD:290566	23/65 (35%)
		leucine-rich repeat	368..391	CDD:275380	8/28 (29%)
		leucine-rich repeat	392..415	CDD:275380	10/22 (45%)
		LRR_8	416..471	CDD:290566	21/60 (35%)
		leucine-rich repeat	416..437	CDD:275380	6/20 (30%)
		leucine-rich repeat	440..463	CDD:275380	10/28 (36%)
		leucine-rich repeat	533..583	CDD:275380	14/100 (14%)
		leucine-rich repeat	584..612	CDD:275380	5/52 (10%)
		leucine-rich repeat	613..633	CDD:275380	7/19 (37%)
		TIR_2	781..>861	CDD:290400	28/80 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820