Protein Alignment Tollo and tsku

DIOPT Version :10

• Sequence 1: NP_524757.1
• Gene: Tollo / 44497
• FlyBaseID: FBgn0029114
• Length: 1346
• Species: Drosophila melanogaster
• Sequence 2: NP_001011330.1
• Gene: tsku / 496792
• XenbaseID: XB-GENE-493206
• Length: 350
• Species: Xenopus tropicalis
• Alignment Length: 299
• Identity: 83/299 - (27%)
• Similarity: 125/299 - (41%)
• Gaps: 54/299 - (18%)

  Fly   215 LDLSANKMVSLPTAMLSALG--RLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPEL 277
            ||||||.:..:..::||..|  .|.:||::.|.:..::...|..|..|..:|||.|.|.:||...
 Frog    64 LDLSANGIKRINESVLSGPGYTTLINLNLSHNQIVRISFSTFSKLRYLESLDLSHNLLETLPDGS 128

  Fly   278 FAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSAN 342
            |                      ::..|.|   |||:||:|....|.|.|.....|.|.::|..|
 Frog   129 F----------------------LYSRLTE---LDLSSNKLLEVGIGAFTLKSQGRSMTINLGNN 168

  Fly   343 KISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTN--LHTLILSRNRISVIEQRTLQGLKN 405
            .|..:.....||:.::..|.|..|.:..:|     ||..  |..|.|.||.::.||:.:..||:.
 Frog   169 NIRSIHRGAERPVPNIHSLTLSGNDLLSVP-----DLHGIPLRHLDLDRNPLAKIEKESFLGLEG 228

  Fly   406 LLVLSL-DFNRISRMDQRSLVNCSQLQDLHLNDN---------------KLQAVPEALAHVQLLK 454
            |..||| |...:..:...|......|.||.|:.|               .||.:..|.:.|..|.
 Frog   229 LTHLSLSDLPNLREVSPYSFKTLPSLLDLDLSSNPQLKSLSSDMFFGLDSLQELNLAYSGVAALP 293

  Fly   455 TLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRG 493
            . |:..|:.|.   .|||..|::...:..:.|..|.::|
 Frog   294 K-DIMLNLPSM---KSITWGENIRCSKTVKESPFHAQKG 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR	54..400	CDD:443914	55/188 (29%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		leucine-rich repeat	212..235	CDD:275380	9/21 (43%)
		leucine-rich repeat	236..259	CDD:275380	6/22 (27%)
		LRR	239..634	CDD:443914	73/273 (27%)
		leucine-rich repeat	260..283	CDD:275380	9/22 (41%)
		leucine-rich repeat	284..307	CDD:275380	1/22 (5%)
		leucine-rich repeat	308..333	CDD:275380	9/24 (38%)
		leucine-rich repeat	334..357	CDD:275380	6/22 (27%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	382..405	CDD:275380	9/22 (41%)
		leucine-rich repeat	406..429	CDD:275380	6/23 (26%)
		leucine-rich repeat	430..452	CDD:275380	9/36 (25%)
		leucine-rich repeat	453..500	CDD:275380	11/41 (27%)
		leucine-rich repeat	501..521	CDD:275380
		leucine-rich repeat	525..547	CDD:275380
		leucine-rich repeat	548..573	CDD:275380
		leucine-rich repeat	604..640	CDD:275380
		LRR_8	616..>660	CDD:404697
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380
		LRR	<794..>920	CDD:443914
		leucine-rich repeat	817..864	CDD:275380
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
tsku	NP_001011330.1	LRRNT	21..63	CDD:214470
		LRR 1	60..81		7/16 (44%)
		leucine-rich repeat	61..86	CDD:275380	9/21 (43%)
		LRR	<62..>236	CDD:443914	61/201 (30%)
		LRR 2	86..107		5/20 (25%)
		leucine-rich repeat	87..110	CDD:275380	6/22 (27%)
		LRR 3	110..131		9/42 (21%)
		leucine-rich repeat	111..133	CDD:275380	9/43 (21%)
		LRR 4	133..154		10/23 (43%)
		leucine-rich repeat	134..159	CDD:275380	11/27 (41%)
		LRR 5	159..180		5/20 (25%)
		leucine-rich repeat	160..183	CDD:275380	6/22 (27%)
		LRR 6	183..203		6/24 (25%)
		leucine-rich repeat	184..203	CDD:275380	6/23 (26%)
		LRR 7	204..225		7/20 (35%)
		LRR_8	205..286	CDD:404697	22/80 (28%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		LRR 8	228..250		6/21 (29%)
		leucine-rich repeat	229..278	CDD:275380	11/48 (23%)
		LRR 9	253..275		5/21 (24%)
		LRR 10	278..299		6/21 (29%)
		leucine-rich repeat	279..302	CDD:275380	7/23 (30%)