Protein Alignment Tollo and LOC4577388

DIOPT Version :10

• Sequence 1: NP_524757.1
• Gene: Tollo / 44497
• FlyBaseID: FBgn0029114
• Length: 1346
• Species: Drosophila melanogaster
• Sequence 2: XP_061501804.1
• Gene: LOC4577388 / 4577388
• VectorBaseID: AGAMI1_011116
• Length: 472
• Species: Anopheles gambiae
• Alignment Length: 553
• Identity: 141/553 - (25%)
• Similarity: 213/553 - (38%)
• Gaps: 149/553 - (26%)

  Fly     9 YVLIATCVIPIF------GA------------ALSKTVLYQAPD---ECRWSGGGEHDITLV--- 49
            :|::..||..:|      ||            .|.|.|.....|   |.|    .|...:::
Mosquito     9 FVILTHCVASLFLLTVANGAIIRLNCDTVDDKCLLKNVFASEDDRFKEIR----NERYQSIIEFF 69

  Fly    50 -CHLRT------INS---------ELENTNFSVIQPQNTVRLRLECNDALFFQSSLSPDSFRSLV 98
             ||:.|      ||.         .:|...||.|...:....||.         .:|..:|....
Mosquito    70 DCHIHTLPPIPYINKVKANAINLVRIEENTFSTIHRLDVSYNRLR---------EISTKAFEYPE 125

  Fly    99 ELRDLTIEYCKLGNLTDGSFRGLQELRNLTIRTHNGDWSTMSLEMA---SNSFVEFRQLERLDLS 160
            ||.:|.:.    ||.|...|..|.:|..|    .:.|.:.|.||:.   .|:|....:|..|::|
Mosquito   126 ELLELNLN----GNPTLKDFAFLSKLTGL----RSLDMADMKLELELLDINTFAGMSELSTLNMS 182

  Fly   161 LNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSL 225
            .|.|..||.||..||..|..|:.|.|.|..|::..|:.:
Mosquito   183 DNRITSIPVGMFSPLVGLTDLDLSRNSITKIASGTFAIA-------------------------- 221

  Fly   226 PTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLR 290
                      .||        |:|.|..:...|:.   |||:|.::.:....|...   .::.||
Mosquito   222 ----------TTH--------SYLRDGIYHQALNF---DLSSNNVSIIENNAFLHA---SKVNLR 262

  Fly   291 NNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKIS--RLEAHIFR 353
            ||.:..:....|.....|..|||:.|:   |..|......|:.|..||:|....|  .:..:||.
Mosquito   263 NNKLIGIGQYAFDNQTALEHLDLSGND---QLKNFDFLHNLRALHYLDMSHMNFSFDGVPRNIFD 324

  Fly   354 PLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLV--LSLDFNRI 416
            .|.||..|.|.:|.|.::|.||||:|.:|:.:.|..|.||.||..|....|..|:  :.|.:|.|
Mosquito   325 DLDSLTTLDLSNNRILEIPIGIFAELQSLNFINLRHNSISHIEFGTFSMRKYDLIDEIDLSYNNI 389

  Fly   417 SRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLR 481
            ..:                  |.|..||     ::.||||.:..|.||.:....:|:.:|||...
Mosquito   390 KEL------------------NFLVFVP-----LKYLKTLLLHGNKISYVNAKQLTRNKSLYNFG 431

  Fly   482 MTENSLTHIR-RGVFDRMSSLQILNLSQNKLKS 513
            : :||  ::| ..:.|.:.||::: |..|:..|
Mosquito   432 I-QNS--NVRCYDLIDLLGSLKLV-LEPNEFIS 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR	54..400	CDD:443914	96/365 (26%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		leucine-rich repeat	124..144	CDD:275380	6/19 (32%)
		leucine-rich repeat	154..177	CDD:275380	11/22 (50%)
		leucine-rich repeat	178..201	CDD:275380	7/22 (32%)
		leucine-rich repeat	212..235	CDD:275380	0/22 (0%)
		leucine-rich repeat	236..259	CDD:275380	5/22 (23%)
		LRR	239..634	CDD:443914	79/280 (28%)
		leucine-rich repeat	260..283	CDD:275380	5/22 (23%)
		leucine-rich repeat	284..307	CDD:275380	5/22 (23%)
		leucine-rich repeat	308..333	CDD:275380	8/24 (33%)
		leucine-rich repeat	334..357	CDD:275380	8/24 (33%)
		leucine-rich repeat	358..381	CDD:275380	11/22 (50%)
		leucine-rich repeat	382..405	CDD:275380	8/22 (36%)
		leucine-rich repeat	406..429	CDD:275380	4/24 (17%)
		leucine-rich repeat	430..452	CDD:275380	4/21 (19%)
		leucine-rich repeat	453..500	CDD:275380	15/47 (32%)
		leucine-rich repeat	501..521	CDD:275380	4/13 (31%)
		leucine-rich repeat	525..547	CDD:275380
		leucine-rich repeat	548..573	CDD:275380
		leucine-rich repeat	604..640	CDD:275380
		LRR_8	616..>660	CDD:404697
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380
		LRR	<794..>920	CDD:443914
		leucine-rich repeat	817..864	CDD:275380
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
LOC4577388	XP_061501804.1	None