Protein Alignment Tollo and tril

DIOPT Version :10

• Sequence 1: NP_524757.1
• Gene: Tollo / 44497
• FlyBaseID: FBgn0029114
• Length: 1346
• Species: Drosophila melanogaster
• Sequence 2: XP_009292463.1
• Gene: tril / 448885
• ZFINID: ZDB-GENE-131218-1
• Length: 758
• Species: Danio rerio
• Alignment Length: 440
• Identity: 110/440 - (25%)
• Similarity: 187/440 - (42%)
• Gaps: 107/440 - (24%)

  Fly   191 ISN-FYFSASLSSRKARVCGSTLQSLD-------LSANK-MVSLPTA----------MLSALGRL 236
            :|| |.|.:.|....|.||....:..|       |.||: :.::|.|          :||..|..
Zfish     5 LSNLFLFGSGLLLFFAPVCAICPERCDCQHAQHILCANRGLRAVPKAPQVEHAEDVRVLSLAGNF 69

  Fly   237 THLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGI 301
            .|...|.:.|.:       |  .|..::|..|::.|:.||.|.:..:|:|::|.||.|:.:.||.
Zfish    70 IHNISAFDFMRY-------G--DLMRLNLQFNQIRSIHPESFKKLSKLEELFLGNNLISTIQPGT 125

  Fly   302 FGELAELLVLDLASNELNS----------------------QWINAATFVGLKRLMMLDLSANKI 344
            ...|.:|.:|...:||:|.                      :.:..:.|.||..||.|.|.:|.:
Zfish   126 LQSLKKLTILYSNNNEINECIPKSFTHLNSLVKLRLDGNSIEVLKESVFEGLPNLMFLHLESNHL 190

  Fly   345 SRLEAHIFRPLASLQILKLEDNYIDQLPG-GIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLV 408
            .|::.:.|..|:.||.|.|.||...:|.. .:|:||.:|.||:::.|:|..:.....|.||.|..
Zfish   191 RRIDRNAFLRLSKLQFLNLSDNKQTELQDVFMFSDLKSLKTLLIAGNQIRHVGNHVFQSLKKLSK 255

  Fly   409 LSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSITQ 473
            |||..|:||::...:.....::::..::.|:|..:|..|                       :..
Zfish   256 LSLSHNKISKLGNEAFKGLGRVREFMIDRNELTEIPAGL-----------------------LDP 297

  Fly   474 LESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGN----- 533
            ||.:..|..::|.::.:.:|.|..:|.|:||.|..|:|.::.......|..|..:.|:||
Zfish   298 LERIEHLDFSDNHISLVDQGAFGHLSHLKILKLKNNRLMNLSGSIFASNGGLFHVELNGNNWTCD 362

  Fly   534 ----QLKS-----------------------IAGLFTE-LPNLVWLNISG 555
                :|||                       :||.:.: :.||...|:||
Zfish   363 CRMEKLKSWMTHAHSQGKLLTVFVRCLHPPVLAGKYLDYVSNLQLKNMSG 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR	54..400	CDD:443914	68/250 (27%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380	4/10 (40%)
		leucine-rich repeat	212..235	CDD:275380	8/40 (20%)
		leucine-rich repeat	236..259	CDD:275380	4/22 (18%)
		LRR	239..634	CDD:443914	92/373 (25%)
		leucine-rich repeat	260..283	CDD:275380	7/22 (32%)
		leucine-rich repeat	284..307	CDD:275380	9/22 (41%)
		leucine-rich repeat	308..333	CDD:275380	8/46 (17%)
		leucine-rich repeat	334..357	CDD:275380	8/22 (36%)
		leucine-rich repeat	358..381	CDD:275380	10/23 (43%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..429	CDD:275380	7/22 (32%)
		leucine-rich repeat	430..452	CDD:275380	4/21 (19%)
		leucine-rich repeat	453..500	CDD:275380	6/46 (13%)
		leucine-rich repeat	501..521	CDD:275380	6/19 (32%)
		leucine-rich repeat	525..547	CDD:275380	9/54 (17%)
		leucine-rich repeat	548..573	CDD:275380	4/8 (50%)
		leucine-rich repeat	604..640	CDD:275380
		LRR_8	616..>660	CDD:404697
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380
		LRR	<794..>920	CDD:443914
		leucine-rich repeat	817..864	CDD:275380
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
tril	XP_009292463.1	LRRNT	25..56	CDD:214470	6/30 (20%)
		leucine-rich repeat	60..83	CDD:275380	7/31 (23%)
		LRR	<83..>242	CDD:443914	47/158 (30%)
		leucine-rich repeat	84..107	CDD:275380	7/22 (32%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		leucine-rich repeat	156..179	CDD:275380	3/22 (14%)
		leucine-rich repeat	180..203	CDD:275380	8/22 (36%)
		leucine-rich repeat	204..228	CDD:275380	10/23 (43%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		LRR_8	259..311	CDD:404697	11/74 (15%)
		leucine-rich repeat	277..298	CDD:275380	4/43 (9%)
		LRR_8	300..358	CDD:404697	15/57 (26%)
		leucine-rich repeat	301..324	CDD:275380	4/22 (18%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		FN3	546..614	CDD:214495