DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and kek6

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster

Alignment Length:	757	Identity:	165/757 - (21%)
Similarity:	268/757 - (35%)	Gaps:	222/757 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   742 LCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYE-QTLPSHIPMDSTQLYLDGNNFRE 805
            ||......|.|..:.|...|:|    .||:.......:|.: .|:|:.:..:...|.|:.|:...
  Fly    23 LCLVAWTVADDWSLSCASNCTC----KWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPY 83

  Fly   806 LQSHAF--IGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQEL 868
            |....|  :|...|:.::|..|.::.:|..:|..|..|..:.|..|:|:.|:.:.|.|.|.|:.|
  Fly    84 LNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRIL 148

  Fly   869 YLQHN------------------------AIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFL- 908
            ||..|                        .|:.||.::..:|..|:.|.|.:|.:.|.:.:.|.
  Fly   149 YLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSEYVFQH 213

  Fly   909 PSYLNELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISG------------------ 955
            .:.|..|.|..|||.|:|    |||.:  |..||..:|.....|..|
  Fly   214 MANLKTLSLEENPWQCNC----KLRKF--RGWYVNSRLSSVSLVCKGPPAQKDRTWDSVDDELFG 272

  Fly   956 --------------------NSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNN----------- 989
                                |:|...::|   |:|  ||.|.......: |||:
  Fly   273 CPPRVEIFNNEEVQNIDIGSNTTFSCLVY---GDP--LPEVAWELNGKI-LDNDNVLFESESIAS 331

  Fly   990 ---------FNYAEQAGGENASNATST----------------KMILNQPPKLDYIPILVAILTA 1029
                     ||......|..|...:::                :.:|.:.|:..:...|:..:..
  Fly   332 DKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLSEIVQHVLEKTPETFWYFGLIMGIFG 396

  Fly  1030 FIFVMICIS-LVFIFRQEMRVWCH-SRFGVRLFYNAQKDVDKNERE-KLFDAFVSYSSKDE---- 1087
            .:|::|.|| :|.:.::..|...| ::.||:      ..|..|::| ||.|:.|:.::.|.
  Fly   397 TVFLLISISFVVCLCKRTTRQHRHANKAGVK------SSVSFNDQEKKLLDSSVTTTTNDRGDSY 455

  Fly  1088 LFVNEELAPMLEMGE----------------HRYKLCL-----HQRDFPVGGYLPETIVQAIDSS 1131
            ...|:..:..:..|:                ||:...|     .|:....||.:.:.::|..||:
  Fly   456 GIDNQPTSIGMNKGDSAGMGFNQIEIHAVESHRHGSMLVQQQPQQQQVAGGGGMRQQLMQVKDST 520

  Fly  1132 RRTIMV--------------VSENFIKS--------EWCRFEFKSAHQSVLRDRRRRLIVIVLGE 1174
            ...:.|              :||.|..:        |:|        .:::.:......:.:...
  Fly   521 CGMMSVPTSMAGHAHSHPAQISEEFPLNVGVFPPPPEFC--------SNIVPNPAFGGNIFIRVS 577

  Fly  1175 VPQKELD-PDLRLYLKTNTYLQWGDKLFWQKLRFALPDVSSSQRSNVA---GQSCHVPINHASYH 1235
            |.|..|| .||.:|         .|.|...|   .:.||..|....||   ||...:|
  Fly   578 VTQDMLDGADLNMY---------PDLLNIPK---RMQDVQESGAGAVAVPEGQFATLP------- 623

  Fly  1236 HHHHVHQQAMPLPHSVHHHQQQFMLPPPPQQPGSFRRQPSLHQQQQQQQQIRGNNNTTQQQQQQQ 1300
             .|...:..:....|:...|||             .:|...||||||||||:...:...|||.|.
  Fly   624 -RHTARRGILKKDTSLQQQQQQ-------------HQQQHQHQQQQQQQQIQQQQHQQLQQQHQP 674

  Fly  1301 AALLMGGGSV--GGPAPQMIPLAGGIQQQSLPLPPNQQPTPA 1340
            :.|......|  ...|....|...|....::.||| ..|.||
  Fly   675 SGLYTHDEIVTYNLEASGYDPHQSGYHSNAMELPP-PPPPPA 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380
		LRR_RI	276..558	CDD:238064
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..333	CDD:275380
		leucine-rich repeat	334..357	CDD:275380
		leucine-rich repeat	358..381	CDD:275380
		leucine-rich repeat	382..405	CDD:275380
		leucine-rich repeat	406..429	CDD:275380
		leucine-rich repeat	430..452	CDD:275380
		leucine-rich repeat	453..500	CDD:275380
		leucine-rich repeat	501..521	CDD:275380
		leucine-rich repeat	525..547	CDD:275380
		leucine-rich repeat	548..573	CDD:275380
		leucine-rich repeat	604..640	CDD:275380
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380	18/76 (24%)
		LRR_8	815..875	CDD:290566	19/83 (23%)
		leucine-rich repeat	817..864	CDD:275380	13/46 (28%)
		LRR_8	864..921	CDD:290566	18/81 (22%)
		leucine-rich repeat	865..888	CDD:275380	9/46 (20%)
		leucine-rich repeat	889..910	CDD:275380	6/21 (29%)
		TIR	1076..1211	CDD:214587	30/182 (16%)
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	6/24 (25%)
		LRR_8	96..155	CDD:290566	19/58 (33%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR_4	144..186	CDD:289563	8/41 (20%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		leucine-rich repeat	169..216	CDD:275380	10/46 (22%)
		LRRCT	225..274	CDD:214507	14/54 (26%)
		Ig	295..367	CDD:143165	14/77 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453656
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930