Protein Alignment Tollo and kek6

DIOPT Version :10

• Sequence 1: NP_524757.1
• Gene: Tollo / 44497
• FlyBaseID: FBgn0029114
• Length: 1346
• Species: Drosophila melanogaster
• Sequence 2: NP_001263151.1
• Gene: kek6 / 43729
• FlyBaseID: FBgn0039862
• Length: 843
• Species: Drosophila melanogaster
• Alignment Length: 757
• Identity: 165/757 - (21%)
• Similarity: 268/757 - (35%)
• Gaps: 222/757 - (29%)

  Fly   742 LCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYE-QTLPSHIPMDSTQLYLDGNNFRE 805
            ||......|.|..:.|...|:|    .||:.......:|.: .|:|:.:..:...|.|:.|:...
  Fly    23 LCLVAWTVADDWSLSCASNCTC----KWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPY 83

  Fly   806 LQSHAF--IGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQEL 868
            |....|  :|...|:.::|..|.::.:|..:|..|..|..:.|..|:|:.|:.:.|.|.|.|:.|
  Fly    84 LNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRIL 148

  Fly   869 YLQHN------------------------AIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFL- 908
            ||..|                        .|:.||.::..:|..|:.|.|.:|.:.|.:.:.|.
  Fly   149 YLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSEYVFQH 213

  Fly   909 PSYLNELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISG------------------ 955
            .:.|..|.|..|||.|:|    |||.:  |..||..:|.....|..|
  Fly   214 MANLKTLSLEENPWQCNC----KLRKF--RGWYVNSRLSSVSLVCKGPPAQKDRTWDSVDDELFG 272

  Fly   956 --------------------NSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNN----------- 989
                                |:|...::|   |:|  ||.|.......: |||:
  Fly   273 CPPRVEIFNNEEVQNIDIGSNTTFSCLVY---GDP--LPEVAWELNGKI-LDNDNVLFESESIAS 331

  Fly   990 ---------FNYAEQAGGENASNATST----------------KMILNQPPKLDYIPILVAILTA 1029
                     ||......|..|...:::                :.:|.:.|:..:...|:..:..
  Fly   332 DKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLSEIVQHVLEKTPETFWYFGLIMGIFG 396

  Fly  1030 FIFVMICIS-LVFIFRQEMRVWCH-SRFGVRLFYNAQKDVDKNERE-KLFDAFVSYSSKDE---- 1087
            .:|::|.|| :|.:.::..|...| ::.||:      ..|..|::| ||.|:.|:.::.|.
  Fly   397 TVFLLISISFVVCLCKRTTRQHRHANKAGVK------SSVSFNDQEKKLLDSSVTTTTNDRGDSY 455

  Fly  1088 LFVNEELAPMLEMGE----------------HRYKLCL-----HQRDFPVGGYLPETIVQAIDSS 1131
            ...|:..:..:..|:                ||:...|     .|:....||.:.:.::|..||:
  Fly   456 GIDNQPTSIGMNKGDSAGMGFNQIEIHAVESHRHGSMLVQQQPQQQQVAGGGGMRQQLMQVKDST 520

  Fly  1132 RRTIMV--------------VSENFIKS--------EWCRFEFKSAHQSVLRDRRRRLIVIVLGE 1174
            ...:.|              :||.|..:        |:|        .:::.:......:.:...
  Fly   521 CGMMSVPTSMAGHAHSHPAQISEEFPLNVGVFPPPPEFC--------SNIVPNPAFGGNIFIRVS 577

  Fly  1175 VPQKELD-PDLRLYLKTNTYLQWGDKLFWQKLRFALPDVSSSQRSNVA---GQSCHVPINHASYH 1235
            |.|..|| .||.:|         .|.|...|   .:.||..|....||   ||...:|
  Fly   578 VTQDMLDGADLNMY---------PDLLNIPK---RMQDVQESGAGAVAVPEGQFATLP------- 623

  Fly  1236 HHHHVHQQAMPLPHSVHHHQQQFMLPPPPQQPGSFRRQPSLHQQQQQQQQIRGNNNTTQQQQQQQ 1300
             .|...:..:....|:...|||             .:|...||||||||||:...:...|||.|.
  Fly   624 -RHTARRGILKKDTSLQQQQQQ-------------HQQQHQHQQQQQQQQIQQQQHQQLQQQHQP 674

  Fly  1301 AALLMGGGSV--GGPAPQMIPLAGGIQQQSLPLPPNQQPTPA 1340
            :.|......|  ...|....|...|....::.||| ..|.||
  Fly   675 SGLYTHDEIVTYNLEASGYDPHQSGYHSNAMELPP-PPPPPA 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR	54..400	CDD:443914
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		LRR	239..634	CDD:443914
		leucine-rich repeat	260..283	CDD:275380
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..333	CDD:275380
		leucine-rich repeat	334..357	CDD:275380
		leucine-rich repeat	358..381	CDD:275380
		leucine-rich repeat	382..405	CDD:275380
		leucine-rich repeat	406..429	CDD:275380
		leucine-rich repeat	430..452	CDD:275380
		leucine-rich repeat	453..500	CDD:275380
		leucine-rich repeat	501..521	CDD:275380
		leucine-rich repeat	525..547	CDD:275380
		leucine-rich repeat	548..573	CDD:275380
		leucine-rich repeat	604..640	CDD:275380
		LRR_8	616..>660	CDD:404697
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380	18/76 (24%)
		LRR	<794..>920	CDD:443914	38/152 (25%)
		leucine-rich repeat	817..864	CDD:275380	13/46 (28%)
		leucine-rich repeat	865..888	CDD:275380	9/46 (20%)
		leucine-rich repeat	889..910	CDD:275380	6/21 (29%)
		TIR	1076..1211	CDD:214587	30/182 (16%)
kek6	NP_001263151.1	LRR	<56..>226	CDD:443914	41/169 (24%)
		leucine-rich repeat	71..96	CDD:275380	6/24 (25%)
		LRR_8	96..155	CDD:404697	19/58 (33%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		leucine-rich repeat	169..216	CDD:275380	10/46 (22%)
		LRRCT	225..274	CDD:214507	14/54 (26%)
		Ig	286..360	CDD:472250	15/79 (19%)
		Ig strand B	294..298	CDD:409353	1/3 (33%)
		Ig strand C	307..310	CDD:409353	1/2 (50%)
		Ig strand E	336..340	CDD:409353	0/3 (0%)
		Ig strand F	350..355	CDD:409353	1/4 (25%)