DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tollo and CG7896

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_651754.1 Gene:CG7896 / 43552 FlyBaseID:FBgn0039728 Length:1392 Species:Drosophila melanogaster


Alignment Length:1464 Identity:329/1464 - (22%)
Similarity:552/1464 - (37%) Gaps:426/1464 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 QSSLSPDSFRSL-VELRDLTIEYCKLGNLTDGSFRGLQ----ELR---NLTIRTHNGDWSTMSLE 142
            |..|...:|..| :.:.:|.:.|..:..:.:.:|.||:    |||   ||.....|..:||..|.
  Fly    93 QQVLPAQTFGQLKLTIEELDLSYNLIRRIPEKAFDGLKDSLNELRLANNLLGDNLNPIFSTAELH 157

  Fly   143 MASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARV 207
            :..|       |..||||.|.|.||.:|:   ||.          ..|:..||            
  Fly   158 VLKN-------LRLLDLSGNKIKLIEEGL---LKG----------CMDLKEFY------------ 190

  Fly   208 CGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSM-SFLADRAFEGLLSLRVVDLSANRLT 271
                     :..|.:.|:||..|:....|.||::.:|.: |.||| :|.....|.::||..|.:.
  Fly   191 ---------IDRNSLTSVPTNSLNGPSALRHLSLRQNQIGSLLAD-SFNAQRQLEIIDLRHNVIR 245

  Fly   272 SLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNS-QWINAATFVGLKRLM 335
            |:....|...::::||.|..|.|:.|...:|.:|..|..|||:.|.... ..:..|...|||.  
  Fly   246 SIDSLAFKGLQKIREIKLAGNRISHLNSDVFEKLQSLQKLDLSENFFGQFPTVALAAVPGLKH-- 308

  Fly   336 MLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTL 400
             |:||:|.:.:|:....:.:.||:.|.:..|.|..:..|.|.::..|..|.||.|.:..||...|
  Fly   309 -LNLSSNMLQQLDYTHMQVVRSLESLDISRNTITTITPGTFREMGALKYLDLSLNSLRTIEDDAL 372

  Fly   401 QGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAV-PEALAHVQL--LKTLDVGENM 462
            :||.:|..|.:..|.|..:...:|....||..|.|:.|::.|: .|.|..:|.  :.||.:..|:
  Fly   373 EGLDSLQTLIIKDNNILLVPGSALGRLPQLTSLQLDYNRVAALSAEILGSLQAGDITTLSLSRNV 437

  Fly   463 ISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRM-SSLQILNLSQNKLKSIEAGSLQRNSQLQ 526
            |.::...|.....||:.|.::.|||..|....|..: |:|..|.||||:|..: .|:.....:|:
  Fly   438 IRELPPGSFQMFSSLHTLDLSGNSLAVINADTFAGLESTLMALKLSQNRLTGL-GGAPWVLPELR 501

  Fly   527 AIRLDGNQLKSI-AGLFTELPNLVWLNISGNRLEKFDYSHI-PIG-LQWLDVRANRITQLGNYFE 588
            ::.|.||.|..: :.:|.||.|:..||:|||.|.....:.. |:. ||.:|:....|.|:     
  Fly   502 SLDLSGNTLTELPSTIFEELENVQSLNLSGNHLTPLTGALFKPLDRLQVIDLSGCNIRQI----- 561

  Fly   589 IESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTT 653
                        |.:||..:      ..::.:||||||:.::|..:|....|::.:||..||:.:
  Fly   562 ------------SGDLLAGL------QDLKHIYLNDNQLQELQDGSFVNLWNISSIDLSNNRIGS 608

  Fly   654 LEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRES-----------RTQPQLMDLDQ 707
            :...|.                        .|:..|||::...           .|...:.:||.
  Fly   609 IRSGAF------------------------VNVMKLQKLDLHGNQLSAFKGEYFNTGTGIEELDI 649

  Fly   708 IHCRLAYARGSS---HVSLIEAKSDDFLCKYASHCFALCHCCDFQA-CDCKMECPDRCSCYHDQS 768
            ...:|:|...||   |..|.|.::       |::.|:.     |.| ....::..:.....|:|.
  Fly   650 SDNQLSYLFPSSFRIHPRLREIRA-------ANNKFSF-----FPAELISTLQYLEHIDLSHNQL 702

  Fly   769 WTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSH-AFIGRKRLKVLHLNHSRIEVLHN 832
            .|...:|.:|      ||      ..::.|..||..::.|. ||....:|::|.|.|:.::.:..
  Fly   703 KTIEELDFAR------LP------RLRVLLVANNQLDMVSEMAFHNSTQLQILDLAHNNLDRIGE 755

  Fly   833 RTFYGLLELEVLQLQSNQLKALNGNEFQ--GLDNLQELYLQHNA---------------IATIDT 880
            |||.||:.||.|.|:.|:|..|:...|:  .|..|:.:.|.||.               ::::| 
  Fly   756 RTFEGLVRLEQLNLEGNRLSELSDGVFERTKLQMLENINLAHNRFEYAPLNALQRQFFFVSSVD- 819

  Fly   881 LTFTH------------LYHLKILRLDHNAITSFAVWNFL--PSYLNELRLASNPWTCSCEFIDK 931
              .:|            :.::|.:.|..|.::|.||.|.|  |..:.||.||..    ..|.::.
  Fly   820 --LSHNKIKELPGDDSIMVNIKRIDLSFNPLSSKAVHNVLNEPKTVRELSLAGT----GIENLEL 878

  Fly   932 LR----DYINRHEYVVDKLK-MKCDV-----------ISGNSTQQMVIYPGSGEPASL--PVVQC 978
            |.    .::|...   :||| :|.:|           :|.|..:.:       |..|:  |.:|.
  Fly   879 LETPFLQFLNLSH---NKLKNVKPEVFQRVTLLETLDLSSNQLESL-------EDLSMAWPQLQV 933

  Fly   979 SQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAI-LTAFIFVMICISLVFI 1042
            .|:|.:. :|:|....|      ||....:|:  :..:|.::|....| ..||..:...:||   
  Fly   934 LQSLDVS-NNSFEIVSQ------SNFGKLEML--RSLRLSHLPQCTRIEKNAFKQLPNLVSL--- 986

  Fly  1043 FRQEMRVWCHSRFGVRL--FYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPM-------L 1098
                      ..:.:.|  :.:.|..::.....::.|..|    ||....:|::.|:       |
  Fly   987 ----------EAYDLPLLGYLDLQGILELLPGLEVLDIEV----KDSSIGSEQIQPLKHPRLKSL 1037

  Fly  1099 EMGEHRYK--------------LCLHQRDFPVGGYLPETIVQA---------IDSSRRTIMVVSE 1140
            .:...|.|              |.:..|:..:....|..:...         ::.|:.|::|.  
  Fly  1038 GIRGDRLKSISSGTLAGLKSNDLSVQLRNTSLNALPPALLFPVPRSSHLSLNVEGSKITVLVP-- 1100

  Fly  1141 NFIKSEWCRFEFKSAHQSVLRDRR----------------------------------------- 1164
                      :|.:|    |.|||                                         
  Fly  1101 ----------QFLNA----LEDRRASLQLQGLASNPIVCDCNARALRRWLPSSGMPDVTCASPAY 1151

  Fly  1165 ---RRLIVIVLGEVPQKELDPDLRL--------------YLKTNTYLQWGDK-------LFW--- 1202
               |:||     ||...||..|.|.              .|||::.|.....       :.|   
  Fly  1152 LLNRKLI-----EVGDDELTCDARRMTSSTSRPTASVPHLLKTSSQLVTRSSSTTEEPLIIWSLE 1211

  Fly  1203 -------QKLRFALP------DVSSSQRSNVAG--------------QSCHVPINHASYHHHHHV 1240
                   :|::...|      .:.|:..:.:.|              ..|.:.:..::..:..:.
  Fly  1212 PTQPPSLKKMKTKAPLMKAQSPIISNDDTLIIGIVGGVVAFIAILIIIICIIRLRMSNAEYQQNA 1276

  Fly  1241 HQQAMPLPHSVHHHQQQF---------MLPPPPQQPGSFRRQPSLHQQQQ---QQQQIRGNNNTT 1293
            ....:|....:..|...:         :...||.......:..|:||..|   |:||        
  Fly  1277 TMIGIPAGMQMGAHNAAYNYKNGAGAALYAVPPYHATLPHKAASIHQSSQNLSQRQQ-------- 1333

  Fly  1294 QQQQQQQAALL---------------MGGGSVGG 1312
            |||||||.|..               .|||:..|
  Fly  1334 QQQQQQQVAAAAAAYSTMSRMSYFSGAGGGNGDG 1367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 54/203 (27%)
leucine-rich repeat 100..123 CDD:275380 5/26 (19%)
leucine-rich repeat 124..144 CDD:275380 8/22 (36%)
LRR_8 152..222 CDD:290566 16/69 (23%)
leucine-rich repeat 154..177 CDD:275380 11/22 (50%)
leucine-rich repeat 178..201 CDD:275380 3/22 (14%)
LRR 210..656 CDD:227223 132/454 (29%)
leucine-rich repeat 212..235 CDD:275380 5/22 (23%)
leucine-rich repeat 236..259 CDD:275380 9/23 (39%)
leucine-rich repeat 260..283 CDD:275380 6/22 (27%)
LRR_RI 276..558 CDD:238064 90/287 (31%)
leucine-rich repeat 284..307 CDD:275380 8/22 (36%)
leucine-rich repeat 308..333 CDD:275380 8/25 (32%)
leucine-rich repeat 334..357 CDD:275380 5/22 (23%)
leucine-rich repeat 358..381 CDD:275380 6/22 (27%)
leucine-rich repeat 382..405 CDD:275380 10/22 (45%)
leucine-rich repeat 406..429 CDD:275380 5/22 (23%)
leucine-rich repeat 430..452 CDD:275380 7/22 (32%)
leucine-rich repeat 453..500 CDD:275380 13/47 (28%)
leucine-rich repeat 501..521 CDD:275380 8/19 (42%)
leucine-rich repeat 525..547 CDD:275380 8/22 (36%)
leucine-rich repeat 548..573 CDD:275380 9/26 (35%)
leucine-rich repeat 604..640 CDD:275380 10/35 (29%)
leucine-rich repeat 641..688 CDD:275380 6/46 (13%)
leucine-rich repeat 689..816 CDD:275380 30/142 (21%)
LRR_8 815..875 CDD:290566 22/76 (29%)
leucine-rich repeat 817..864 CDD:275380 18/48 (38%)
LRR_8 864..921 CDD:290566 19/85 (22%)
leucine-rich repeat 865..888 CDD:275380 6/49 (12%)
leucine-rich repeat 889..910 CDD:275380 8/22 (36%)
TIR 1076..1211 CDD:214587 37/245 (15%)
CG7896NP_651754.1 LRR_8 109..172 CDD:290566 21/69 (30%)
leucine-rich repeat 109..132 CDD:275380 5/22 (23%)
LRR_RI <132..338 CDD:238064 70/250 (28%)
leucine-rich repeat 133..161 CDD:275380 9/27 (33%)
LRR_8 160..220 CDD:290566 25/100 (25%)
leucine-rich repeat 162..185 CDD:275380 12/35 (34%)
leucine-rich repeat 186..209 CDD:275380 7/43 (16%)
leucine-rich repeat 210..233 CDD:275380 9/23 (39%)
LRR_8 232..290 CDD:290566 18/57 (32%)
leucine-rich repeat 234..257 CDD:275380 6/22 (27%)
leucine-rich repeat 258..281 CDD:275380 8/22 (36%)
LRR_RI 273..535 CDD:238064 83/265 (31%)
LRR_8 281..338 CDD:290566 17/59 (29%)
leucine-rich repeat 282..329 CDD:275380 14/49 (29%)
LRR_8 328..388 CDD:290566 20/59 (34%)
leucine-rich repeat 330..353 CDD:275380 6/22 (27%)
leucine-rich repeat 354..377 CDD:275380 10/22 (45%)
leucine-rich repeat 378..401 CDD:275380 5/22 (23%)
leucine-rich repeat 402..425 CDD:275380 7/22 (32%)
leucine-rich repeat 428..451 CDD:275380 5/22 (23%)
LRR_8 429..487 CDD:290566 20/57 (35%)
leucine-rich repeat 452..473 CDD:275380 7/20 (35%)
leucine-rich repeat 477..497 CDD:275378 8/20 (40%)
LRR_8 498..558 CDD:290566 19/59 (32%)
leucine-rich repeat 500..523 CDD:275380 8/22 (36%)
LRR_RI 502..769 CDD:238064 80/337 (24%)
leucine-rich repeat 524..547 CDD:275380 7/22 (32%)
leucine-rich repeat 548..571 CDD:275380 8/45 (18%)
LRR_8 572..630 CDD:290566 18/81 (22%)
leucine-rich repeat 572..595 CDD:275380 8/22 (36%)
leucine-rich repeat 596..619 CDD:275380 6/46 (13%)
LRR_8 619..678 CDD:290566 14/65 (22%)
leucine-rich repeat 620..643 CDD:275380 4/22 (18%)
leucine-rich repeat 644..667 CDD:275380 7/22 (32%)
LRR_8 666..726 CDD:290566 16/83 (19%)
leucine-rich repeat 668..691 CDD:275380 6/34 (18%)
leucine-rich repeat 692..715 CDD:275380 7/34 (21%)
LRR_8 714..774 CDD:290566 21/65 (32%)
leucine-rich repeat 716..739 CDD:275380 6/22 (27%)
leucine-rich repeat 740..761 CDD:275380 7/20 (35%)
leucine-rich repeat 764..789 CDD:275380 9/24 (38%)
leucine-rich repeat 790..810 CDD:275380 4/19 (21%)
leucine-rich repeat 818..850 CDD:275380 5/34 (15%)
leucine-rich repeat 863..883 CDD:275378 6/23 (26%)
LRR_RI <878..1070 CDD:238064 41/227 (18%)
LRR_8 884..944 CDD:290566 15/70 (21%)
LRR_4 884..925 CDD:289563 9/50 (18%)
leucine-rich repeat 884..907 CDD:275380 6/25 (24%)
leucine-rich repeat 908..933 CDD:275380 5/31 (16%)
leucine-rich repeat 934..955 CDD:275380 7/27 (26%)
leucine-rich repeat 958..982 CDD:275380 5/25 (20%)
leucine-rich repeat 983..1055 CDD:275380 13/88 (15%)
leucine-rich repeat 1009..1033 CDD:275380 6/27 (22%)
leucine-rich repeat 1058..1085 CDD:275380 3/26 (12%)
TPKR_C2 1121..1168 CDD:301599 7/51 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453660
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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