DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Tl

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster

Alignment Length:	1219	Identity:	293/1219 - (24%)
Similarity:	507/1219 - (41%)	Gaps:	290/1219 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 RWSGG---------GEHDITLVCHLRTINSE--------LENTNFSV-IQPQNTVRLRLECNDAL 83
            :|.|.         .|..|..:|....|.||        .||..|.: |||::.|::.....|..
  Fly    21 QWPGSEASFGRDACSEMSIDGLCQCAPIMSEYEIICPANAENPTFRLTIQPKDYVQIMCNLTDTT 85

  Fly    84 FFQSSLSPDSFRSLVELRDLTIEYCKL-GNLTDGS---FRGLQELRNLTIRTHNGDWSTMSLEMA 144
            .:|.  .|...| :.|:..:.:..|.| |:....|   :.|:.....|...:.|     :.:.:.
  Fly    86 DYQQ--LPKKLR-IGEVDRVQMRRCMLPGHTPIASILDYLGIVSPTTLIFESDN-----LGMNIT 142

  Fly   145 SNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCG 209
            .........|:|...:...:..||..::..:::|.||....| |:::.:..|...
  Fly   143 RQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHLELRAN-IEEMPSHLFDDL---------- 196

  Fly   210 STLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLP 274
            ..|:|::..:||:..:|..:...:.:|..||:..|.:..|....|||..|:..:|:..|.:..||
  Fly   197 ENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLP 261

  Fly   275 PELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDL 339
            .::||....:.:|.|..|....|..|:|.....|..:.|.:|.:
  Fly   262 HDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRV--------------------- 305

  Fly   340 SANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLK 404
               .::.|.:.:|.....||||:|... :..|||.:|...|
  Fly   306 ---PLATLPSRLFANQPELQILRLRAE-LQSLPGDLFEHST------------------------ 342

  Fly   405 NLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQL-LKTLDVGENMISQIEN 468
                                    |:.::.|.||.|:.:|..|...|: |.:||:..|.::.:.:
  Fly   343 ------------------------QITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPD 383

  Fly   469 TSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGN 533
            :......:|..||:.:|.||.|...:|..:.:|..|.:|:|:|::|::.:....:.|:.:.||.|
  Fly   384 SLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHN 448

  Fly   534 QLKSIAGLFTELPNL-VWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLST 597
            .:.      .:.|.| :.|....|  ..|.|.|   ||..|::|.|.|..:.|.:: .:.|.|..
  Fly   449 DID------LQQPLLDIMLQTQIN--SPFGYMH---GLLTLNLRNNSIIFVYNDWK-NTMLQLRE 501

  Fly   598 FDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLS 662
            .|.|||.::.:      ...::.:|:.|::          ..|:|.             |.:|..
  Fly   502 LDLSYNNISSL------GYEDLAFLSQNRL----------HVNMTH-------------NKIRRI 537

  Fly   663 PIAEDREIPEFY--------IGHNAYECDCNLDW----LQKVNRESRTQPQLMDLDQIHCRLAYA 715
            .:.||..:.|.|        :..|...|||.:.|    ::.|::...::...:..|::.|.....
  Fly   538 ALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNV 602

  Fly   716 RGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCY---HDQSWTSNVVDCS 777
            ...:.|..||.::  .:|.           .||.....:.:||..|:|:   :|::.   |::|.
  Fly   603 LEGTPVRQIEPQT--LICP-----------LDFSDDPRERKCPRGCNCHVRTYDKAL---VINCH 651

  Fly   778 RASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELE 842
            ..:.     :|:|                         ||..||.|               ::|.
  Fly   652 SGNL-----THVP-------------------------RLPNLHKN---------------MQLM 671

  Fly   843 VLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTF-THLYHLKILRLDHNAITSFAVWN 906
            .|.|::|.|..|......|.:::..|:|..|.:.:||.... |:|.||.| ..:|..:.:..|..
  Fly   672 ELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDI-SWNHLQMLNATVLG 735

  Fly   907 FLPSYL--NELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGE 969
            ||...:  ..::|:.|||.|.|.....|....:..|.:.|:.:|.|                  .
  Fly   736 FLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMC------------------V 782

  Fly   970 PASLP--VVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIF 1032
            .|.:|  :|:.|       .|:...||                     |..:|.:.|.|....:.
  Fly   783 NAEMPTRMVELS-------TNDICPAE---------------------KGVFIALAVVIALTGLL 819

  Fly  1033 VMICISLVFIFRQEMRVWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPM 1097
            .....:|.:.|:.|:::|.::. .:.|::..::|:||   :|.||||:|||.||:.|:.:.|.|.
  Fly   820 AGFTAALYYKFQTEIKIWLYAH-NLLLWFVTEEDLDK---DKKFDAFISYSHKDQSFIEDYLVPQ 880

  Fly  1098 LEMGEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRD 1162
            ||.|..:::||:|:||:.|||::||.|::::..|||||:|:|:|||||||.|.||::||:|.|.:
  Fly   881 LEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNE 945

  Fly  1163 RRRRLIVIVLGEVPQKE-LDPDLRLYLKTNTYLQWGDKLFWQKLRFALP 1210
            .|.|:|||:..::...| ||.:|:.|||.||||:|||..||.|||||||
  Fly   946 GRSRIIVIIYSDIGDVEKLDEELKAYLKMNTYLKWGDPWFWDKLRFALP 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	41/199 (21%)
		leucine-rich repeat	100..123	CDD:275380	5/26 (19%)
		leucine-rich repeat	124..144	CDD:275380	2/19 (11%)
		LRR_8	152..222	CDD:290566	13/69 (19%)
		leucine-rich repeat	154..177	CDD:275380	4/22 (18%)
		leucine-rich repeat	178..201	CDD:275380	6/22 (27%)
		LRR	210..656	CDD:227223	95/447 (21%)
		leucine-rich repeat	212..235	CDD:275380	5/22 (23%)
		leucine-rich repeat	236..259	CDD:275380	8/22 (36%)
		leucine-rich repeat	260..283	CDD:275380	6/22 (27%)
		LRR_RI	276..558	CDD:238064	57/283 (20%)
		leucine-rich repeat	284..307	CDD:275380	6/22 (27%)
		leucine-rich repeat	308..333	CDD:275380	3/24 (13%)
		leucine-rich repeat	334..357	CDD:275380	2/22 (9%)
		leucine-rich repeat	358..381	CDD:275380	9/22 (41%)
		leucine-rich repeat	382..405	CDD:275380	0/22 (0%)
		leucine-rich repeat	406..429	CDD:275380	0/22 (0%)
		leucine-rich repeat	430..452	CDD:275380	6/21 (29%)
		leucine-rich repeat	453..500	CDD:275380	12/46 (26%)
		leucine-rich repeat	501..521	CDD:275380	6/19 (32%)
		leucine-rich repeat	525..547	CDD:275380	4/21 (19%)
		leucine-rich repeat	548..573	CDD:275380	8/25 (32%)
		leucine-rich repeat	604..640	CDD:275380	2/35 (6%)
		leucine-rich repeat	641..688	CDD:275380	11/54 (20%)
		leucine-rich repeat	689..816	CDD:275380	18/129 (14%)
		LRR_8	815..875	CDD:290566	15/59 (25%)
		leucine-rich repeat	817..864	CDD:275380	11/46 (24%)
		LRR_8	864..921	CDD:290566	15/59 (25%)
		leucine-rich repeat	865..888	CDD:275380	7/23 (30%)
		leucine-rich repeat	889..910	CDD:275380	6/20 (30%)
		TIR	1076..1211	CDD:214587	75/136 (55%)
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	15/69 (22%)
		leucine-rich repeat	176..198	CDD:275380	6/32 (19%)
		leucine-rich repeat	199..222	CDD:275380	5/22 (23%)
		LRR_RI	216..542	CDD:238064	92/439 (21%)
		LRR_8	221..281	CDD:290566	18/59 (31%)
		leucine-rich repeat	223..270	CDD:275380	15/46 (33%)
		leucine-rich repeat	271..294	CDD:275380	6/22 (27%)
		leucine-rich repeat	295..320	CDD:275380	5/48 (10%)
		leucine-rich repeat	321..343	CDD:275380	10/70 (14%)
		LRR_8	342..402	CDD:290566	17/107 (16%)
		leucine-rich repeat	344..367	CDD:275380	7/22 (32%)
		leucine-rich repeat	368..391	CDD:275380	4/22 (18%)
		LRR_8	390..450	CDD:290566	18/59 (31%)
		leucine-rich repeat	392..415	CDD:275380	8/22 (36%)
		leucine-rich repeat	416..439	CDD:275380	6/22 (27%)
		leucine-rich repeat	440..474	CDD:275380	11/44 (25%)
		leucine-rich repeat	475..498	CDD:275380	6/23 (26%)
		LRR_8	477..534	CDD:290566	16/86 (19%)
		leucine-rich repeat	499..520	CDD:275380	5/26 (19%)
		leucine-rich repeat	523..552	CDD:275380	9/51 (18%)
		LRRCT	561..619	CDD:214507	11/59 (19%)
		LRRNT	631..667	CDD:214470	13/68 (19%)
		leucine-rich repeat	664..693	CDD:275380	10/43 (23%)
		LRR_8	669..726	CDD:290566	17/57 (30%)
		leucine-rich repeat	694..715	CDD:275380	5/20 (25%)
		leucine-rich repeat	716..737	CDD:275380	6/21 (29%)
		LRRCT	751..800	CDD:214507	15/73 (21%)
		TIR	858..996	CDD:214587	75/137 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453666
Domainoid	1	1.000	44	1.000	Domainoid score	I4673
eggNOG	1	0.900	-	-		E2759_KOG4641
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	125	1.000	Inparanoid score	I1937
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24216
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
	8	7.800