DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tollo and alrm

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_651393.1 Gene:alrm / 43074 FlyBaseID:FBgn0039332 Length:471 Species:Drosophila melanogaster


Alignment Length:476 Identity:114/476 - (23%)
Similarity:200/476 - (42%) Gaps:87/476 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   257 LLSLRVVDLSANRLTSLPPELFAETK-----QLQEIYLRNN-SINVLAPGIFGELAELLVLDLAS 315
            ||||:||.:       |||.....|.     ||:.::|::: |..:....:.|. ::.::|    
  Fly     7 LLSLQVVLI-------LPPSYHLATPSSGSGQLRRLWLQDHCSAGICTNVVIGR-SDYVIL---- 59

  Fly   316 NELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLT 380
                    :.|...|...|..|:.|..||..|   :|.....||:|::|:              .
  Fly    60 --------SQAPIGGTTMLTFLNSSIAKIPHL---LFDTFPDLQVLRMEN--------------C 99

  Fly   381 NLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPE 445
            :|.|          .|:...:|..||:.|.|.:||:..:.:...:....|..|||..|:|:.:..
  Fly   100 SLET----------FEKPQFEGASNLMSLFLGYNRLKDIPKNIFLGADNLATLHLQGNQLKQLGN 154

  Fly   446 ALAH-VQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQN 509
            ...| ::.:|.|.:.||.:.||.....:.:..|..|.:..|.|..:.||||||..:|..|||::|
  Fly   155 HSFHALKEVKELSLAENQLEQISLGVFSGMRKLMDLNLAGNRLDALPRGVFDRNLNLTKLNLARN 219

  Fly   510 KLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLD 574
            :..:.|:..|:.......:.:.||..:.:...||.|...:..:....||..:...|      .||
  Fly   220 RFTAFESELLKLQPVFTQLDISGNIFQELTLNFTMLDVAIAHSCDLRRLTVYGVIH------ELD 278

  Fly   575 VRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQ-PYTFFKK 638
            :..|.:.::.:   |....::|:.|.|:|.|..:..:.:.....:|.||.:.....: |...|||
  Fly   279 LHNNSLREMPH---IPLAANVSSLDLSHNPLGNLQGNPLRRFTSLLRLNLSATGAHELPEGLFKK 340

  Fly   639 -PNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQK-----VNR--- 694
             .:|..:|:..|.:     .:|:::.....:.:..||...|.:.|    |:||.     |.|   
  Fly   341 QSHLQMLDISGNSI-----YSLKITIFDSLKALQYFYFQQNNWNC----DFLQLLMSSFVKRKDI 396

  Fly   695 ---ESRTQPQLMD--LDQIHC 710
               |..|.|:|:|  :|.|.|
  Fly   397 SFMEDITAPELVDDYVDGIAC 417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 9/23 (39%)
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380
LRR_8 152..222 CDD:290566
leucine-rich repeat 154..177 CDD:275380
leucine-rich repeat 178..201 CDD:275380
LRR 210..656 CDD:227223 96/407 (24%)
leucine-rich repeat 212..235 CDD:275380
leucine-rich repeat 236..259 CDD:275380 1/1 (100%)
leucine-rich repeat 260..283 CDD:275380 7/27 (26%)
LRR_RI 276..558 CDD:238064 65/288 (23%)
leucine-rich repeat 284..307 CDD:275380 4/23 (17%)
leucine-rich repeat 308..333 CDD:275380 3/24 (13%)
leucine-rich repeat 334..357 CDD:275380 7/22 (32%)
leucine-rich repeat 358..381 CDD:275380 4/22 (18%)
leucine-rich repeat 382..405 CDD:275380 4/22 (18%)
leucine-rich repeat 406..429 CDD:275380 5/22 (23%)
leucine-rich repeat 430..452 CDD:275380 7/22 (32%)
leucine-rich repeat 453..500 CDD:275380 16/46 (35%)
leucine-rich repeat 501..521 CDD:275380 7/19 (37%)
leucine-rich repeat 525..547 CDD:275380 5/21 (24%)
leucine-rich repeat 548..573 CDD:275380 3/24 (13%)
leucine-rich repeat 604..640 CDD:275380 8/37 (22%)
leucine-rich repeat 641..688 CDD:275380 8/46 (17%)
leucine-rich repeat 689..816 CDD:275380 12/35 (34%)
LRR_8 815..875 CDD:290566
leucine-rich repeat 817..864 CDD:275380
LRR_8 864..921 CDD:290566
leucine-rich repeat 865..888 CDD:275380
leucine-rich repeat 889..910 CDD:275380
TIR 1076..1211 CDD:214587
alrmNP_651393.1 LRR_RI 84..354 CDD:238064 72/302 (24%)
LRR_8 91..149 CDD:290566 19/81 (23%)
leucine-rich repeat 91..114 CDD:275380 8/46 (17%)
leucine-rich repeat 115..138 CDD:275380 5/22 (23%)
LRR_8 138..197 CDD:290566 16/58 (28%)
leucine-rich repeat 139..162 CDD:275380 7/22 (32%)
leucine-rich repeat 163..186 CDD:275380 6/22 (27%)
LRR_8 185..243 CDD:290566 17/57 (30%)
leucine-rich repeat 187..210 CDD:275380 10/22 (45%)
leucine-rich repeat 211..283 CDD:275380 17/77 (22%)
leucine-rich repeat 284..319 CDD:275380 6/37 (16%)
LRR_8 318..377 CDD:290566 13/63 (21%)
leucine-rich repeat 320..343 CDD:275380 7/22 (32%)
leucine-rich repeat 344..365 CDD:275380 4/25 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR45617
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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