Protein Alignment Tollo and CG18249

DIOPT Version :10

• Sequence 1: NP_524757.1
• Gene: Tollo / 44497
• FlyBaseID: FBgn0029114
• Length: 1346
• Species: Drosophila melanogaster
• Sequence 2: NP_001163549.1
• Gene: CG18249 / 40964
• FlyBaseID: FBgn0037553
• Length: 559
• Species: Drosophila melanogaster
• Alignment Length: 472
• Identity: 120/472 - (25%)
• Similarity: 213/472 - (45%)
• Gaps: 85/472 - (18%)

  Fly   207 VCGST----LQSLDLSA--NKMVSLPTAMLSALGRLT-------------HL-NMAKNSMSFLAD 251
            :||.|    |...|.|.  |...|.|.:..|...|..             || |.::.|:::|..
  Fly    11 ICGLTVSDALAVYDASGRFNLSASCPDSFCSLSDRPVAYSATPALQLRELHLRNCSRQSITWLVL 75

  Fly   252 RAFEGLLSLRVVDLSANRLT--SLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLA 314
            :...||.:|.:.:.:...::  ||.|     .:.|..:.::..|:.||...||..:..|.:|.|:
  Fly    76 QLTPGLRTLVIRNCATYHISKESLRP-----VENLTSLQMQGTSLGVLRDQIFNAVPRLEILQLS 135

  Fly   315 SNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADL 379
            .|.:::  ::.|.|.||.:|.:|.|..|.|:.:.:....||..|..|.|..|.:..||..|||..
  Fly   136 QNFIHT--VHVAAFQGLSKLRLLGLQGNAIAEILSSTLDPLMELVHLDLSRNELTTLPQNIFAKN 198

  Fly   380 TNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVP 444
            ..|.||:|:.|.:.::....|..|.||.:  ||....:.::..:| |.:.:|:|.|..:.|.::
  Fly   199 KKLQTLLLNGNPLRILMPDVLGSLPNLRL--LDLGHAAELEVMTL-NLTNVQNLVLEGSSLSSL- 259

  Fly   445 EALAHVQLLKTLDVGENMISQIE---NTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNL 506
              :.:...:| |..|.|.::.::   .:|:.::: |:|..:..|....:.||    |.:||.|:|
  Fly   260 --VINGGFIK-LQAGNNELNHLQVGNKSSVIEMD-LHGNLLNGNDTAALLRG----MWNLQRLDL 316

  Fly   507 SQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQ 571
            |:|:::::.    |..|.|.|   .|.|...|      ||:|.:||::.|:|.:     :|....
  Fly   317 SKNRIEALP----QHGSGLDA---SGTQELLI------LPSLKFLNLANNQLVR-----LPPESP 363

  Fly   572 WLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEV---LYLNDNQISKIQPY 633
            .|..|                  ||..|.|:||:..:.. :|..|:.|   ||:..|:::.|...
  Fly   364 ILSSR------------------LSYLDLSHNLMLTLDV-AILRSLSVLKGLYVEGNRLNTINYQ 409

  Fly   634 TFFKK-PNLTRVDLVRN 649
            ...:: |:|:.:.|..|
  Fly   410 KLHEEHPDLSELGLHDN 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR	54..400	CDD:443914	57/214 (27%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		leucine-rich repeat	212..235	CDD:275380	7/24 (29%)
		leucine-rich repeat	236..259	CDD:275380	7/36 (19%)
		LRR	239..634	CDD:443914	104/403 (26%)
		leucine-rich repeat	260..283	CDD:275380	4/24 (17%)
		leucine-rich repeat	284..307	CDD:275380	6/22 (27%)
		leucine-rich repeat	308..333	CDD:275380	8/24 (33%)
		leucine-rich repeat	334..357	CDD:275380	7/22 (32%)
		leucine-rich repeat	358..381	CDD:275380	9/22 (41%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..429	CDD:275380	5/22 (23%)
		leucine-rich repeat	430..452	CDD:275380	4/21 (19%)
		leucine-rich repeat	453..500	CDD:275380	11/49 (22%)
		leucine-rich repeat	501..521	CDD:275380	6/19 (32%)
		leucine-rich repeat	525..547	CDD:275380	6/21 (29%)
		leucine-rich repeat	548..573	CDD:275380	6/24 (25%)
		leucine-rich repeat	604..640	CDD:275380	8/39 (21%)
		LRR_8	616..>660	CDD:404697	10/38 (26%)
		leucine-rich repeat	641..688	CDD:275380	3/9 (33%)
		leucine-rich repeat	689..816	CDD:275380
		LRR	<794..>920	CDD:443914
		leucine-rich repeat	817..864	CDD:275380
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380	5/22 (23%)
		LRR	105..433	CDD:443914	98/373 (26%)
		leucine-rich repeat	105..128	CDD:275380	6/22 (27%)
		leucine-rich repeat	129..152	CDD:275380	8/24 (33%)
		leucine-rich repeat	153..176	CDD:275380	7/22 (32%)
		leucine-rich repeat	177..200	CDD:275380	9/22 (41%)
		leucine-rich repeat	201..224	CDD:275380	7/22 (32%)
		leucine-rich repeat	225..258	CDD:275380	9/35 (26%)
		leucine-rich repeat	259..310	CDD:275380	11/59 (19%)
		leucine-rich repeat	311..344	CDD:275380	14/45 (31%)
		leucine-rich repeat	345..368	CDD:275380	7/27 (26%)
		leucine-rich repeat	369..390	CDD:275380	7/21 (33%)
		leucine-rich repeat	393..417	CDD:275380	4/23 (17%)