DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tollo and CD180

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_005573.2 Gene:CD180 / 4064 HGNCID:6726 Length:661 Species:Homo sapiens


Alignment Length:644 Identity:152/644 - (23%)
Similarity:257/644 - (39%) Gaps:143/644 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   136 WSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASL 200
            |..|.:|..:|   :....|.|.||     .|||.:.   .:.:.|..|:|.:..|.|..||..:
Human    24 WDQMCIEKEAN---KTYNCENLGLS-----EIPDTLP---NTTEFLEFSFNFLPTIHNRTFSRLM 77

  Fly   201 SSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLR---V 262
            :          |..|||:..::..:......:..:|:.|.:..|.:.|:|:.:..|..||:   :
Human    78 N----------LTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFL 132

  Fly   263 VDLSANRLTSLPPELFAETKQLQEIYLRNNSI-NVLAPGIFGELAELLVLDLASNELNSQWINAA 326
            :....:.|..:|..   ..:.|:.:||.:|.| ::..|..| ....|.|||..:|.::  :|:..
Human   133 IQTGISNLEFIPVH---NLENLESLYLGSNHISSIKFPKDF-PARNLKVLDFQNNAIH--YISRE 191

  Fly   327 TFVGLKRLMMLDLSAN-------KISRLEAHIFRPL-----ASLQIL--KLEDNYIDQLPGGIFA 377
            ....|::.:.|.|:.|       ::...::.||:.|     .:|.::  .|:::....|..|.|.
Human   192 DMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFE 256

  Fly   378 DLTNLHTLILSRNRISVIEQRTLQGLKNLLV--LSLDFNRISRMDQRSLVNCSQLQDLHLNDNKL 440
            |:.:           ..|....|:||..:.|  |:|..:|.|.:...:....:|||:|.|....|
Human   257 DIDD-----------EDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHL 310

  Fly   441 QAVPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTEN-SLTHIRRGVFDRMSSLQIL 504
            :.:|..:..:.|||.|.:..|...|:...|.....||..|.:..| ...|:..|..:::.:||.|
Human   311 KGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTL 375

  Fly   505 NLSQNKLKSIEAGSLQ-RN-SQLQAIRLDGNQ---LKSIAGLFTELPNLVWLNISGNRLE----- 559
            :||.|.:::.:..||| :| |.||.:.|..|:   |:|.|  |.|.|.|..|:::..||.     
Human   376 DLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQA--FKECPQLELLDLAFTRLHINAPQ 438

  Fly   560 ------------KFDY-------SHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASY--- 602
                        ...|       .|:..||..|    ..:...||:|:          |.:.   
Human   439 SPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVL----RHLNLKGNHFQ----------DGTITKT 489

  Fly   603 NLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLT--------------- 652
            |||..:      .|:|||.|:...:..|....|.....::.|||..|.||               
Human   490 NLLQTV------GSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYL 548

  Fly   653 TLEPNAL-----RLSPIAEDREIPEFYIGHNAYECDCN----LDW----LQKVNRESRT 698
            .|..|::     ||.||...:.  ...:.||..:|.|:    |.|    |.|:.....|
Human   549 NLAANSINIISPRLLPILSQQS--TINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEET 605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 32/147 (22%)
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380 3/7 (43%)
LRR_8 152..222 CDD:290566 18/69 (26%)
leucine-rich repeat 154..177 CDD:275380 7/22 (32%)
leucine-rich repeat 178..201 CDD:275380 7/22 (32%)
LRR 210..656 CDD:227223 120/513 (23%)
leucine-rich repeat 212..235 CDD:275380 4/22 (18%)
leucine-rich repeat 236..259 CDD:275380 6/22 (27%)
leucine-rich repeat 260..283 CDD:275380 3/25 (12%)
LRR_RI 276..558 CDD:238064 78/304 (26%)
leucine-rich repeat 284..307 CDD:275380 7/23 (30%)
leucine-rich repeat 308..333 CDD:275380 7/24 (29%)
leucine-rich repeat 334..357 CDD:275380 6/34 (18%)
leucine-rich repeat 358..381 CDD:275380 6/24 (25%)
leucine-rich repeat 382..405 CDD:275380 4/22 (18%)
leucine-rich repeat 406..429 CDD:275380 5/24 (21%)
leucine-rich repeat 430..452 CDD:275380 6/21 (29%)
leucine-rich repeat 453..500 CDD:275380 12/47 (26%)
leucine-rich repeat 501..521 CDD:275380 9/20 (45%)
leucine-rich repeat 525..547 CDD:275380 9/24 (38%)
leucine-rich repeat 548..573 CDD:275380 8/48 (17%)
leucine-rich repeat 604..640 CDD:275380 9/35 (26%)
leucine-rich repeat 641..688 CDD:275380 17/70 (24%)
leucine-rich repeat 689..816 CDD:275380 3/10 (30%)
LRR_8 815..875 CDD:290566
leucine-rich repeat 817..864 CDD:275380
LRR_8 864..921 CDD:290566
leucine-rich repeat 865..888 CDD:275380
leucine-rich repeat 889..910 CDD:275380
TIR 1076..1211 CDD:214587
CD180NP_005573.2 leucine-rich repeat 38..57 CDD:275380 7/26 (27%)
LRR 1 54..75 6/20 (30%)
leucine-rich repeat 58..78 CDD:275380 7/19 (37%)
LRR 2 78..99 4/30 (13%)
leucine-rich repeat 79..102 CDD:275380 4/22 (18%)
LRR_8 102..161 CDD:290566 14/61 (23%)
LRR 3 102..123 5/20 (25%)
leucine-rich repeat 103..126 CDD:275380 6/22 (27%)
LRR 4 126..147 4/23 (17%)
leucine-rich repeat 127..150 CDD:275380 3/25 (12%)
LRR 5 150..171 7/21 (33%)
leucine-rich repeat 151..174 CDD:275380 7/23 (30%)
LRR 6 174..195 6/22 (27%)
leucine-rich repeat 175..195 CDD:275380 6/21 (29%)
leucine-rich repeat 196..234 CDD:275380 7/37 (19%)
LRR 7 201..221 3/19 (16%)
leucine-rich repeat 235..275 CDD:275380 10/50 (20%)
LRR 8 275..296 5/20 (25%)
leucine-rich repeat 276..299 CDD:275380 5/22 (23%)
LRR 9 299..320 7/20 (35%)
leucine-rich repeat 300..322 CDD:275380 6/21 (29%)
LRR 10 322..343 7/20 (35%)
LRR_8 323..382 CDD:290566 18/58 (31%)
leucine-rich repeat 323..371 CDD:275380 12/47 (26%)
LRR_RI 327..541 CDD:238064 59/235 (25%)
LRR 11 346..366 6/19 (32%)
LRR_8 371..432 CDD:290566 23/62 (37%)
LRR 12 371..391 7/19 (37%)
leucine-rich repeat 372..397 CDD:275380 10/24 (42%)
LRR 13 397..418 8/22 (36%)
leucine-rich repeat 398..421 CDD:275380 9/24 (38%)
LRR_8 420..481 CDD:290566 12/64 (19%)
LRR 14 421..442 4/20 (20%)
leucine-rich repeat 422..446 CDD:275380 4/23 (17%)
LRR 15 446..466 2/19 (11%)
leucine-rich repeat 447..470 CDD:275380 4/22 (18%)
LRR 16 470..493 7/36 (19%)
leucine-rich repeat 471..497 CDD:275380 8/45 (18%)
LRR_8 497..555 CDD:290566 15/57 (26%)
LRR 17 497..518 7/20 (35%)
leucine-rich repeat 498..521 CDD:275380 6/22 (27%)
LRR 18 521..544 6/22 (27%)
leucine-rich repeat 522..543 CDD:275380 6/20 (30%)
LRR 19 546..564 4/17 (24%)
TPKR_C2 577..626 CDD:301599 8/29 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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