DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and tlr20f

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	XP_009303059.3	Gene:	tlr20f / 403141	ZFINID:	ZDB-GENE-040220-7	Length:	956	Species:	Danio rerio

Alignment Length:	1266	Identity:	268/1266 - (21%)
Similarity:	467/1266 - (36%)	Gaps:	385/1266 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LATTHMLYVLIATCVIPIFGAALSKTVLYQAPDECRWSGGGEHDITLVCHLRTINSELENTNFSV 66
            |.|:::|..:...||........:....|          .|:.:|.....:..|..:|...
Zfish    28 LKTSYVLSWIPGKCVFYSDMEGFTSASTY----------AGQTNIAKCVSVTDIKEDLRGL---- 78

  Fly    67 IQPQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQELRNLTIRT 131
              |.|.:.|.::.:  |.....|||:||.:|..|..|.|..| ...:...:|.||..|.:|||.:
Zfish    79 --PANVLNLYIKMD--LHSHGVLSPNSFSNLAXLEYLEITGC-FSEIPPKAFSGLPHLTSLTISS 138

  Fly   132 HNGD-WSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFY 195
            .:.: |..::|:     |.....|..|.:|..::.|:...:             :.||..:.|.|
Zfish   139 FSSENWCEVALD-----FSHLPSLTSLSISYYSLSLLEPNV-------------FEKIPQLQNLY 185

  Fly   196 FSASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSL 260
            .                  :|:....|..:       |.|||::...|....|     .:.|..|
Zfish   186 L------------------IDVRLKNMSEI-------LCRLTNIKKLKQFNLF-----DDALTHL 220

  Fly   261 RVVDLSANRLTSLPPELFAETKQLQEIYLRN-NSINVLAPGIFGELAELLVLDLASNELNSQWIN 324
            :..:.|...::.:..|...|   ..::||.| ..::..|..:||   :|..::..|   |:.::.
Zfish   221 QKPNCSVFNISDISTEFNIE---YADLYLNNVEHVDEGALKVFG---KLFCINFGS---NTDFLR 276

  Fly   325 AATFVGLKRL--MMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLIL 387
            ..:.:|:.::  :.:|:....::.|       ..:.::..:|         .||||   ..|:.|
Zfish   277 YLSLIGVHKISSLYVDVDVLNVNDL-------CTAAKLYSIE---------SIFAD---YKTINL 322

  Fly   388 SRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLV----NCSQLQ-DLHL-NDNKLQAVPEA 446
            .:.:.::.|  ..:.:|| :||:..|| .:.:|..|:|    |.:.:: .||: ..:..|::..:
Zfish   323 PQTQTNISE--GCRKIKN-IVLNKHFN-ANILDVNSVVQLFSNLTSIKIFLHMFRSDDFQSLCAS 383

  Fly   447 LAH-VQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNK 510
            ..| |:.:..:.:|. .|..|.:...|...:|..|.:..|.:.:|....|..::.|:.|.||.||
Zfish   384 KPHAVKQISVMSLGP-YIDFIVSFQFTCFTNLIILELFNNQIYNIEDFAFVGLNKLEELYLSGNK 447

  Fly   511 LKSIEAGSLQRNSQLQAIRLDGNQL-----KSIAGLFTELPNLVW--LNISGNRLEKFDYSHIPI 568
            |..|...:.....:|..:.|.||.:     ||. |.|..:..|:.  ||.|.      |.|.|.:
Zfish   448 LSYIHQHTFSGLHELMVLDLQGNHIIYIEPKSF-GHFMNITTLLLGDLNFSP------DMSLIKV 505

  Fly   569 GLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPY 633
            .|.                           |..|         .||.::..|:|:    |.::|
Zfish   506 NLS---------------------------DIFY---------GIPCNLSNLFLS----SGLRP- 529

  Fly   634 TFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRT 698
                      :.||....|||. |.|.|      |...::.|..     |||...|..|
Zfish   530 ----------MHLVMGSNTTLN-NGLNL------RITGQYVIVE-----DCNNLLLTSV------ 566

  Fly   699 QPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSC 763
                         ::....:::||.    .::|:.||.                     |...|.
Zfish   567 -------------VSLQINAAYVSC----ENEFIGKYV---------------------PSVVSL 593

  Fly   764 YHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIE 828
            .....::.|:.|.  |...|.:  |:    ..|.|:..:|:                  |...:.
Zfish   594 EFHSKFSDNIGDL--AVINQLV--HL----KTLKLEDIDFK------------------NQPNLA 632

  Fly   829 VLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYL-QHNAIATIDTLTFTHLYHLKIL 892
            ::    |:.|.:|:.|.|.:.::..|:|:..:.|..|::|.| ..|.:..:.|.. .||..|:.:
Zfish   633 IM----FHNLTKLQTLILANCRIFFLDGSLTKDLTALRKLILIPTNTVNILQTFV-EHLTDLEYV 692

  Fly   893 RLDHNAITSFAVWNFLPSYLNELRLASNPWTCSCE---FIDKLRDYINRHEYVVDKLKMKCDVIS 954
                              |...|.|     .|||:   .:..::|  ||          |.:|..
Zfish   693 ------------------YFEGLGL-----YCSCDDAWLVSWVKD--NR----------KVEVSM 722

  Fly   955 GNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDY 1019
            .|.|.|              .:||                              :|.|:..:|::
Zfish   723 FNPTMQ--------------DLQC------------------------------LIENEVDQLNF 743

  Fly  1020 IP------------ILVAILTAFIFVMICISLVFIF-RQEMRVWCHSRFG-----VRLFYNAQKD 1066
            :.            :..|....|:.:.|.:.|::.| .|..:.:.|...|     :|:
Zfish   744 VSFVKENCSFDIEFVFFASTAVFLCIFIVVVLMYKFVGQYFKPFFHIASGWFREVLRM------- 801

  Fly  1067 VDKNEREKLFDAFVSYSSKDELFVNEELAPMLEM-GEHRYKLCLHQRDFPVGGYLPETIVQAIDS 1130
              |.:::..:|.|||||||||.:|.|||.|.||. |....::|||.|||.:|..:.|.|..:|.:
Zfish   802 --KKKQQYRYDVFVSYSSKDEHWVMEELLPNLEQRGPPFLRICLHSRDFQLGHDIVENITDSIYA 864

  Fly  1131 SRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDPDLRL--YLKTNTY 1193
            ||||:.:||:|::.|.||..|.:.|...:..:.|..||::.|..:|.:.|....||  .:||.||
Zfish   865 SRRTLCLVSQNYLGSNWCSLEMQLATYRLQVEHRDILILVFLETIPSRLLSSHHRLARLVKTRTY 929

  Fly  1194 LQW-----GDKLFWQKLRFALPDVSSSQRSN 1219
            |.|     ..:.||.:|...|    ||.::|
Zfish   930 LDWPHDPERHEAFWHRLWCKL----SSSKAN 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	40/196 (20%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		leucine-rich repeat	124..144	CDD:275380	6/20 (30%)
		LRR_8	152..222	CDD:290566	9/69 (13%)
		leucine-rich repeat	154..177	CDD:275380	4/22 (18%)
		leucine-rich repeat	178..201	CDD:275380	4/22 (18%)
		LRR	210..656	CDD:227223	94/462 (20%)
		leucine-rich repeat	212..235	CDD:275380	3/22 (14%)
		leucine-rich repeat	236..259	CDD:275380	5/22 (23%)
		leucine-rich repeat	260..283	CDD:275380	4/22 (18%)
		LRR_RI	276..558	CDD:238064	66/298 (22%)
		leucine-rich repeat	284..307	CDD:275380	6/23 (26%)
		leucine-rich repeat	308..333	CDD:275380	4/24 (17%)
		leucine-rich repeat	334..357	CDD:275380	2/24 (8%)
		leucine-rich repeat	358..381	CDD:275380	5/22 (23%)
		leucine-rich repeat	382..405	CDD:275380	3/22 (14%)
		leucine-rich repeat	406..429	CDD:275380	8/26 (31%)
		leucine-rich repeat	430..452	CDD:275380	5/24 (21%)
		leucine-rich repeat	453..500	CDD:275380	9/46 (20%)
		leucine-rich repeat	501..521	CDD:275380	8/19 (42%)
		leucine-rich repeat	525..547	CDD:275380	8/26 (31%)
		leucine-rich repeat	548..573	CDD:275380	8/26 (31%)
		leucine-rich repeat	604..640	CDD:275380	6/35 (17%)
		leucine-rich repeat	641..688	CDD:275380	13/46 (28%)
		leucine-rich repeat	689..816	CDD:275380	17/126 (13%)
		LRR_8	815..875	CDD:290566	13/60 (22%)
		leucine-rich repeat	817..864	CDD:275380	9/46 (20%)
		LRR_8	864..921	CDD:290566	11/57 (19%)
		leucine-rich repeat	865..888	CDD:275380	7/23 (30%)
		leucine-rich repeat	889..910	CDD:275380	1/20 (5%)
		TIR	1076..1211	CDD:214587	58/142 (41%)
tlr20f	XP_009303059.3	LRR_8	<96..138	CDD:316378	17/42 (40%)
		leucine-rich repeat	108..130	CDD:275380	7/22 (32%)
		leucine-rich repeat	131..180	CDD:275380	13/66 (20%)
		leucine-rich repeat	181..206	CDD:275380	8/49 (16%)
		leucine-rich repeat	207..238	CDD:275380	6/35 (17%)
		leucine-rich repeat	239..262	CDD:275380	7/28 (25%)
		leucine-rich repeat	263..324	CDD:275380	13/82 (16%)
		leucine-rich repeat	325..380	CDD:275380	14/58 (24%)
		LRR_8	412..472	CDD:316378	17/59 (29%)
		leucine-rich repeat	414..437	CDD:275378	5/22 (23%)
		leucine-rich repeat	438..461	CDD:275378	8/22 (36%)
		leucine-rich repeat	462..485	CDD:275378	8/23 (35%)
		leucine-rich repeat	486..497	CDD:275378	3/10 (30%)
		leucine-rich repeat	521..589	CDD:275380	24/138 (17%)
		leucine-rich repeat	590..614	CDD:275380	5/27 (19%)
		leucine-rich repeat	615..640	CDD:275380	6/50 (12%)
		leucine-rich repeat	641..664	CDD:275380	6/22 (27%)
		TIR	808..946	CDD:214587	56/137 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010