DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and tlr20.2

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001170914.2	Gene:	tlr20.2 / 403140	ZFINID:	ZDB-GENE-040220-6	Length:	950	Species:	Danio rerio

Alignment Length:	1304	Identity:	277/1304 - (21%)
Similarity:	445/1304 - (34%)	Gaps:	499/1304 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 CRWSGGGEHDITLVCHLRTINSELENTNFSVIQP--QNTVRLR------------------LECN 80
            |.|..|       .||   |.|:.|..:||...|  :||...|                  |...
Zfish    26 CSWLAG-------KCH---IESDGEEFSFSTSSPRKRNTTVCRSVTDMKEDLRGLPANLQNLIVQ 80

  Fly    81 DALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQELRNLTIRTHNGDWSTMSLEMAS 145
            ..|.:...|:|:||.....|.:|.|..| |..:...:|.||..:..||:     ..|....|:|.
Zfish    81 TDLGYHGVLAPNSFLRFGSLENLEIVGC-LSEVPPEAFNGLTNVTTLTL-----SCSQQCTEVAF 139

  Fly   146 NSFVEFRQLERLDLSLNNIWLIPDG-----------------------MVCPLKSLQHL------ 181
            : |.....|..|.||..::.|:|..                       ::|.||:::.|
Zfish   140 D-FSRLTSLTSLSLSDYSLSLLPSNVFEKIPQLRWLHLCSECLKDLSEVLCRLKNVKSLKYLGLG 203

  Fly   182 NASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSM 246
            |....::|..:...|:.|..|.|..:     :..||...|:..:....|...|:|:.|....:|.
Zfish   204 NTMLTRLQYPNCSVFNVSEISTKFNI-----ERADLLLGKLEHVDEGALKVFGKLSRLYFTVSSK 263

  Fly   247 SFLADRAFEG------------------------LLSLRVVDLSANRLT-SLPPELFAETKQLQE 286
            :||.|.:..|                        |.|::.||:..:.:. ||..::....||:..
Zfish   264 NFLRDLSLIGVHQISVIIATVDVLNVDDLCVAAKLYSVKSVDVDYDTINLSLTSKISDGCKQIGY 328

  Fly   287 IYLRNNSINVLAPGIFGELAELLVLDLASNELNS--QWINAATFVGLKRLMMLDLSANKISRLEA 349
            |.|.||        |||:...||       ::||  |..:..|.|.:.:.:   |.:|....|.|
Zfish   329 IMLENN--------IFGKTVNLL-------DVNSLFQIFSNLTSVTIDKHV---LRSNDFQSLCA 375

  Fly   350 HIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFN 414
            ...:.:..:..:.|....||::....|....||.||.|:.::.||||.....||..|..|:|..|
Zfish   376 SFPQTVKKISDMVLRIIRIDKIVSHQFMCFVNLKTLKLAMSKFSVIEDFAFIGLNKLKELNLHSN 440

  Fly   415 RISRMDQRSLVNCSQLQDLHLNDNKLQAV-PEALAHVQLLKTLDVGENMISQIENTSITQLESLY 478
            :||.:.|.:.....:|:.|.||:|.|..: ||:..|:..|:||.:|:  ::...|.|:.:|.
Zfish   441 KISSIHQHTFSGLHELRVLDLNENPLFHIEPESFRHLINLRTLLLGD--LNFPPNMSLIKLH--- 500

  Fly   479 GLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFT 543
                    |:.|.|.:...:|::.|                  :|.|:.:.|       :.|..|
Zfish   501 --------LSDIFREIPRNLSNVFI------------------SSGLRPMHL-------VIGSNT 532

  Fly   544 ELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEI 608
            .|.|  .||:           ||.                |.|..:|        |.:..|||.:
Zfish   533 TLNN--GLNL-----------HIK----------------GQYVIVE--------DCNSLLLTSV 560

  Fly   609 TASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEF 673
                                                       .||:.||
Zfish   561 -------------------------------------------VTLQINA--------------- 567

  Fly   674 YIGHNAYE-CDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYAS 737
                 ||. |:                                             ::|:.||.
Zfish   568 -----AYMICE---------------------------------------------NEFIGKYV- 581

  Fly   738 HCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNN 802
                                |...|...:..::.|:.|.|..:
Zfish   582 --------------------PSVVSLKFESMFSDNIGDLSVIN---------------------- 604

  Fly   803 FRELQSHAFIGRKRLKVLHLNHSRIE--VLHNR-----TFYGLLELEVLQLQSNQLKALNGNEFQ 860
                           :::||...::|  .|.|:     .|:.|.:||.|.|.:.:|..|:|:..:
Zfish   605 ---------------QLVHLKTLKLENIDLTNQPNTGIMFHNLTKLETLILANCRLLFLDGSLTK 654

  Fly   861 GLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLPSYLNELRLASNPWTCS 925
            .|..|..|.|...     ||:.....:.:.:::|:      |..:..|..|            ||
Zfish   655 DLKALTTLVLLPK-----DTVNILQTFAVHLIQLE------FVCFYRLGLY------------CS 696

  Fly   926 CE---FIDKLRDYINRHEYVVDKLKMKCDVIS----------GNSTQQMVIYPGSGEPASLPVVQ 977
            |:   .:..:||  ||        |::.|:.:          ||...|:
Zfish   697 CDNAWLVSWIRD--NR--------KVEVDMSNPSMHDLQCFFGNEFDQL---------------- 735

  Fly   978 CSQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFI 1042
                      |..:||:    ||.|.            .||::....:.:...||:::.:...|:
Zfish   736 ----------NFVSYAK----ENCSF------------DLDFVFFACSSVFLCIFIVVVLMYKFV 774

  Fly  1043 --------------FRQEMRVWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEE 1093
                          ||:.:|:                   |.:::..:|||||||.|||.:|.||
Zfish   775 GQYFKPFYHIANGWFREALRM-------------------KEKQQYRYDAFVSYSGKDEHWVIEE 820

  Fly  1094 LAPMLEM-GEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQ 1157
            |.|.||. |....:||||.|||.:|..:.|.|..:|.:||||:.:||.|::.|.||..|.:.|..
Zfish   821 LLPNLEQRGPPFLRLCLHSRDFQLGHDIVENITDSIYASRRTLCLVSRNYLNSNWCSLEMQLATY 885

  Fly  1158 SVLRDRRRRLIVIVLGEVPQKELDPDLRL--YLKTNTYLQWGDK-----LFWQKLRFALPDVSSS 1215
            .:..:.|..||::.|..:|.:.|....||  .:||.|||.|..:     .||.:|...|    ||
Zfish   886 RLQVEHRDILILVFLENIPSRLLSSHHRLARLVKTRTYLDWPQEPEMHDAFWDRLWCKL----SS 946

  Fly  1216 QRSN 1219
            .::|
Zfish   947 NKAN 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	52/249 (21%)
		leucine-rich repeat	100..123	CDD:275380	8/22 (36%)
		leucine-rich repeat	124..144	CDD:275380	4/19 (21%)
		LRR_8	152..222	CDD:290566	18/98 (18%)
		leucine-rich repeat	154..177	CDD:275380	8/45 (18%)
		leucine-rich repeat	178..201	CDD:275380	5/28 (18%)
		LRR	210..656	CDD:227223	101/473 (21%)
		leucine-rich repeat	212..235	CDD:275380	4/22 (18%)
		leucine-rich repeat	236..259	CDD:275380	8/46 (17%)
		leucine-rich repeat	260..283	CDD:275380	4/23 (17%)
		LRR_RI	276..558	CDD:238064	72/284 (25%)
		leucine-rich repeat	284..307	CDD:275380	7/22 (32%)
		leucine-rich repeat	308..333	CDD:275380	7/26 (27%)
		leucine-rich repeat	334..357	CDD:275380	4/22 (18%)
		leucine-rich repeat	358..381	CDD:275380	4/22 (18%)
		leucine-rich repeat	382..405	CDD:275380	10/22 (45%)
		leucine-rich repeat	406..429	CDD:275380	7/22 (32%)
		leucine-rich repeat	430..452	CDD:275380	9/22 (41%)
		leucine-rich repeat	453..500	CDD:275380	10/46 (22%)
		leucine-rich repeat	501..521	CDD:275380	1/19 (5%)
		leucine-rich repeat	525..547	CDD:275380	5/21 (24%)
		leucine-rich repeat	548..573	CDD:275380	4/24 (17%)
		leucine-rich repeat	604..640	CDD:275380	3/35 (9%)
		leucine-rich repeat	641..688	CDD:275380	7/47 (15%)
		leucine-rich repeat	689..816	CDD:275380	8/126 (6%)
		LRR_8	815..875	CDD:290566	18/66 (27%)
		leucine-rich repeat	817..864	CDD:275380	15/53 (28%)
		LRR_8	864..921	CDD:290566	9/56 (16%)
		leucine-rich repeat	865..888	CDD:275380	5/22 (23%)
		leucine-rich repeat	889..910	CDD:275380	3/20 (15%)
		TIR	1076..1211	CDD:214587	59/142 (42%)
tlr20.2	NP_001170914.2	leucine-rich repeat	358..383	CDD:275380	5/27 (19%)
		LRR_8	407..466	CDD:290566	23/58 (40%)
		leucine-rich repeat	408..431	CDD:275380	10/22 (45%)
		LRR_4	431..471	CDD:289563	13/39 (33%)
		leucine-rich repeat	432..455	CDD:275380	7/22 (32%)
		leucine-rich repeat	456..479	CDD:275380	9/22 (41%)
		leucine-rich repeat	496..539	CDD:275380	13/80 (16%)
		leucine-rich repeat	540..583	CDD:275380	19/206 (9%)
		leucine-rich repeat	584..608	CDD:275380	4/60 (7%)
		leucine-rich repeat	609..634	CDD:275380	6/24 (25%)
		leucine-rich repeat	635..658	CDD:275380	8/22 (36%)
		TIR	802..940	CDD:214587	57/137 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3549
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24216
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.870