DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and tlr3

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001013287.2	Gene:	tlr3 / 403126	ZFINID:	ZDB-GENE-040219-7	Length:	903	Species:	Danio rerio

Alignment Length:	1086	Identity:	253/1086 - (23%)
Similarity:	412/1086 - (37%)	Gaps:	254/1086 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 FY--FSA----SLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLAD- 251
            ||  |||    :.::||: .|.......|.|...:.::||.:.:   .:|.|:::.|.:..|:.
Zfish    12 FYACFSAHCAGTTNARKS-ACMIKNAKADCSHMNLDAIPTDLPT---NITTLDVSHNRLKTLSSL 72

  Fly   252 RAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASN 316
            ..:..|::   :|.|.|.|..:..:|......||.:.:::|.:.:::.........|..|||:.|
Zfish    73 HMYTNLVN---IDASYNSLAGIEKDLCLSLPHLQFLNVQHNQVYLISEKNLKNCFHLTQLDLSDN 134

  Fly   317 ELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTN 381
            :|..|   ...|..||.|..||:|.||::..:.                        |....|.|
Zfish   135 KLKLQ---GEPFSLLKNLTWLDVSRNKLTSAKL------------------------GTEPQLPN 172

  Fly   382 LHTLILSRNRISVIEQRTLQGLKN---LLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKL--- 440
            |.||:||.|.|:::::.....|.|   ..||.|....:.:::.........|.||.|:.:||
Zfish   173 LVTLVLSGNNINILQENDFSFLSNSSSFRVLILSSLILKKVENGCFKAIDTLSDLVLDSSKLTSQ 237

  Fly   441 -------QAVPEALAHVQLLKT--LDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFD 496
                   :....||.::.|..|  :.:.......:|.|.||.|:      ::||.::.|..|.|.
Zfish   238 FTTSLFEELADTALRNLSLKSTEQVTLSNTTFQGLEKTKITVLD------LSENRISKIVDGAFQ 296

  Fly   497 RMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKF 561
            .:..|:.|:|..|.::.:...|......|:.:.|....:||.|.|..              ::.|
Zfish   297 WLPQLEFLSLEHNTIRHLTNDSFSGLGNLRQLNLRKALIKSHASLPV--------------IDDF 347

  Fly   562 DYSHIPIGLQWLDVRANRITQLGNYFEIESEL-SLSTFDASYNL-----LTEITASSIPNS--VE 618
            .:.|: :.|::|.:......:|..  :|.|.| :|.|.|.|:::     :|..|.:.:..|  ::
Zfish   348 SFQHL-VQLEYLCMANTAFRELTE--QIFSGLRNLKTLDLSWSITGIKTVTNKTFAGLQESPLLQ 409

  Fly   619 VLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLT-TLEPNALRLSPIAEDREIPEFYIGHNAYEC 682
            .|.|....|:|::|..|....||:.:.:.||.:. .|:.|              ||....|..|.
Zfish   410 TLNLTGMGINKLEPGAFSSLGNLSNLLMSRNFINQQLQGN--------------EFKGLSNIKEI 460

  Fly   683 DCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCD 747
            |      ..:|::|                        :||..|
Zfish   461 D------MSINQQS------------------------ISLTNA--------------------- 474

  Fly   748 FQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTL-----PSHIPMDSTQLYLDGNNFRELQ 807
                          |..|..  |...:...|| .:.||     |....::.|.|.|..||...:.
Zfish   475 --------------SFVHVS--TLRTLKLGRA-LKGTLDMEPSPFRPLVNLTILDLSNNNIANIN 522

  Fly   808 SHAFIGRKRLKVLHLNHSRIEVLHNRTFYG--------LLELEVLQLQSNQLKALNGNEFQGLDN 864
            :....|...|||:.:.|:.:..|......|        ...|..|.|..|.:..:..|.|:|...
Zfish   523 ADLLEGLYNLKVVKMQHNNLARLWKMANPGGPVLFLKDATNLSYLNLDYNGIDEIPPNAFRGFSE 587

  Fly   865 LQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSF--AVWNFLPSYLNELRLASNPWTCSCE 927
            |.||.|:.|.:..:....|..|..||.|.|..|.|||.  |.:....|.|.||.:..||:.|:||
Zfish   588 LHELSLRGNLLDQLHASVFDDLNSLKYLHLQKNLITSVQRATFGVPLSKLKELNMDHNPFDCTCE 652

  Fly   928 FIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNY 992
            .|....:::                   |||...|    .|.|.|   ..|
Zfish   653 SILWFSEWL-------------------NSTNTSV----PGFPQS---YIC-------------- 677

  Fly   993 AEQAGGENASNATSTKMILNQPPK--LDYIPI--LVAILTAFIFVMICISLVFIFRQEMRVWCHS 1053
                   |..||.....::|..|.  .|..|.  |..:.:..:.:::.||.:..| |..|:..:.
Zfish   678 -------NTPNAYFNHSVMNFDPLSCKDMTPFKALYILSSTAVLMLLFISFLVHF-QGWRIQFYW 734

  Fly  1054 RFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGG 1118
            ...|.....:.||....|....|||::.::.:|:.:|...|   |.:.:........|||...|.
Zfish   735 NIMVNRMLGSLKDAKVTEGRFQFDAYIIHAGEDKSWVERSL---LSLEDKDLNFFYEQRDSTPGH 796

  Fly  1119 YLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAH--QSVLRDRRRRLIVIVLGEVPQKELD 1181
            ...||||..:..||:.|.|::|..:|..||| :||:.|  ..|:.|.|..||:|.|.:|....|:
Zfish   797 SRLETIVDNMVYSRKIIFVITEMLLKDPWCR-QFKAHHALHHVMEDNRDSLILIFLEDVTDYNLN 860

  Fly  1182 PDLRL---YLKTNTYLQW---GDKL--FWQKLRFALPDVSSSQRSN 1219
            ..|.|   .||....|.|   .:::  |.||||.||   :|:.:.|
Zfish   861 RSLHLRRGMLKPKCVLYWPLHKERIPAFHQKLRSAL---ASTNKVN 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	22/93 (24%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566	10/33 (30%)
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380	5/12 (42%)
		LRR	210..656	CDD:227223	105/470 (22%)
		leucine-rich repeat	212..235	CDD:275380	4/22 (18%)
		leucine-rich repeat	236..259	CDD:275380	5/23 (22%)
		leucine-rich repeat	260..283	CDD:275380	5/22 (23%)
		LRR_RI	276..558	CDD:238064	66/296 (22%)
		leucine-rich repeat	284..307	CDD:275380	3/22 (14%)
		leucine-rich repeat	308..333	CDD:275380	9/24 (38%)
		leucine-rich repeat	334..357	CDD:275380	6/22 (27%)
		leucine-rich repeat	358..381	CDD:275380	2/22 (9%)
		leucine-rich repeat	382..405	CDD:275380	8/22 (36%)
		leucine-rich repeat	406..429	CDD:275380	3/22 (14%)
		leucine-rich repeat	430..452	CDD:275380	8/31 (26%)
		leucine-rich repeat	453..500	CDD:275380	11/48 (23%)
		leucine-rich repeat	501..521	CDD:275380	5/19 (26%)
		leucine-rich repeat	525..547	CDD:275380	6/21 (29%)
		leucine-rich repeat	548..573	CDD:275380	3/24 (13%)
		leucine-rich repeat	604..640	CDD:275380	9/42 (21%)
		leucine-rich repeat	641..688	CDD:275380	10/47 (21%)
		leucine-rich repeat	689..816	CDD:275380	19/131 (15%)
		LRR_8	815..875	CDD:290566	18/67 (27%)
		leucine-rich repeat	817..864	CDD:275380	13/54 (24%)
		LRR_8	864..921	CDD:290566	20/58 (34%)
		leucine-rich repeat	865..888	CDD:275380	7/22 (32%)
		leucine-rich repeat	889..910	CDD:275380	9/22 (41%)
		TIR	1076..1211	CDD:214587	49/144 (34%)
tlr3	NP_001013287.2	LRR_RI	<49..183	CDD:238064	40/166 (24%)
		leucine-rich repeat	57..77	CDD:275380	4/19 (21%)
		leucine-rich repeat	78..101	CDD:275380	6/25 (24%)
		leucine-rich repeat	102..125	CDD:275380	3/22 (14%)
		LRR_8	125..183	CDD:290566	25/84 (30%)
		leucine-rich repeat	126..148	CDD:275380	9/24 (38%)
		leucine-rich repeat	149..172	CDD:275380	8/46 (17%)
		leucine-rich repeat	173..276	CDD:275380	23/102 (23%)
		LRR_8	275..331	CDD:290566	15/61 (25%)
		leucine-rich repeat	278..300	CDD:275380	7/27 (26%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..354	CDD:275380	8/43 (19%)
		leucine-rich repeat	355..378	CDD:275380	6/24 (25%)
		leucine-rich repeat	379..404	CDD:275380	6/24 (25%)
		LRR_8	406..466	CDD:290566	17/79 (22%)
		leucine-rich repeat	408..431	CDD:275380	6/22 (27%)
		leucine-rich repeat	432..456	CDD:275380	7/37 (19%)
		leucine-rich repeat	457..507	CDD:275380	15/117 (13%)
		leucine-rich repeat	482..498	CDD:275380	4/16 (25%)
		leucine-rich repeat	508..531	CDD:275380	6/22 (27%)
		leucine-rich repeat	532..563	CDD:275380	6/30 (20%)
		LRR_8	562..622	CDD:290566	19/59 (32%)
		leucine-rich repeat	564..587	CDD:275380	7/22 (32%)
		leucine-rich repeat	588..611	CDD:275380	7/22 (32%)
		leucine-rich repeat	612..630	CDD:275380	9/17 (53%)
		LRRCT	645..>683	CDD:214507	16/84 (19%)
		TIR	756..898	CDD:214587	49/148 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20696
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.780