DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tollo and tlr3

DIOPT Version :10

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_001013287.2 Gene:tlr3 / 403126 ZFINID:ZDB-GENE-040219-7 Length:903 Species:Danio rerio


Alignment Length:1086 Identity:253/1086 - (23%)
Similarity:412/1086 - (37%) Gaps:254/1086 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 FY--FSA----SLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLAD- 251
            ||  |||    :.::||: .|.......|.|...:.::||.:.:   .:|.|:::.|.:..|:. 
Zfish    12 FYACFSAHCAGTTNARKS-ACMIKNAKADCSHMNLDAIPTDLPT---NITTLDVSHNRLKTLSSL 72

  Fly   252 RAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASN 316
            ..:..|::   :|.|.|.|..:..:|......||.:.:::|.:.:::.........|..|||:.|
Zfish    73 HMYTNLVN---IDASYNSLAGIEKDLCLSLPHLQFLNVQHNQVYLISEKNLKNCFHLTQLDLSDN 134

  Fly   317 ELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTN 381
            :|..|   ...|..||.|..||:|.||::..:.                        |....|.|
Zfish   135 KLKLQ---GEPFSLLKNLTWLDVSRNKLTSAKL------------------------GTEPQLPN 172

  Fly   382 LHTLILSRNRISVIEQRTLQGLKN---LLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKL--- 440
            |.||:||.|.|:::::.....|.|   ..||.|....:.:::.........|.||.|:.:||   
Zfish   173 LVTLVLSGNNINILQENDFSFLSNSSSFRVLILSSLILKKVENGCFKAIDTLSDLVLDSSKLTSQ 237

  Fly   441 -------QAVPEALAHVQLLKT--LDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFD 496
                   :....||.::.|..|  :.:.......:|.|.||.|:      ::||.::.|..|.|.
Zfish   238 FTTSLFEELADTALRNLSLKSTEQVTLSNTTFQGLEKTKITVLD------LSENRISKIVDGAFQ 296

  Fly   497 RMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKF 561
            .:..|:.|:|..|.::.:...|......|:.:.|....:||.|.|..              ::.|
Zfish   297 WLPQLEFLSLEHNTIRHLTNDSFSGLGNLRQLNLRKALIKSHASLPV--------------IDDF 347

  Fly   562 DYSHIPIGLQWLDVRANRITQLGNYFEIESEL-SLSTFDASYNL-----LTEITASSIPNS--VE 618
            .:.|: :.|::|.:......:|..  :|.|.| :|.|.|.|:::     :|..|.:.:..|  ::
Zfish   348 SFQHL-VQLEYLCMANTAFRELTE--QIFSGLRNLKTLDLSWSITGIKTVTNKTFAGLQESPLLQ 409

  Fly   619 VLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLT-TLEPNALRLSPIAEDREIPEFYIGHNAYEC 682
            .|.|....|:|::|..|....||:.:.:.||.:. .|:.|              ||....|..|.
Zfish   410 TLNLTGMGINKLEPGAFSSLGNLSNLLMSRNFINQQLQGN--------------EFKGLSNIKEI 460

  Fly   683 DCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCD 747
            |      ..:|::|                        :||..|                     
Zfish   461 D------MSINQQS------------------------ISLTNA--------------------- 474

  Fly   748 FQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTL-----PSHIPMDSTQLYLDGNNFRELQ 807
                          |..|..  |...:...|| .:.||     |....::.|.|.|..||...:.
Zfish   475 --------------SFVHVS--TLRTLKLGRA-LKGTLDMEPSPFRPLVNLTILDLSNNNIANIN 522

  Fly   808 SHAFIGRKRLKVLHLNHSRIEVLHNRTFYG--------LLELEVLQLQSNQLKALNGNEFQGLDN 864
            :....|...|||:.:.|:.:..|......|        ...|..|.|..|.:..:..|.|:|...
Zfish   523 ADLLEGLYNLKVVKMQHNNLARLWKMANPGGPVLFLKDATNLSYLNLDYNGIDEIPPNAFRGFSE 587

  Fly   865 LQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSF--AVWNFLPSYLNELRLASNPWTCSCE 927
            |.||.|:.|.:..:....|..|..||.|.|..|.|||.  |.:....|.|.||.:..||:.|:||
Zfish   588 LHELSLRGNLLDQLHASVFDDLNSLKYLHLQKNLITSVQRATFGVPLSKLKELNMDHNPFDCTCE 652

  Fly   928 FIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNY 992
            .|....:::                   |||...|    .|.|.|   ..|              
Zfish   653 SILWFSEWL-------------------NSTNTSV----PGFPQS---YIC-------------- 677

  Fly   993 AEQAGGENASNATSTKMILNQPPK--LDYIPI--LVAILTAFIFVMICISLVFIFRQEMRVWCHS 1053
                   |..||.....::|..|.  .|..|.  |..:.:..:.:::.||.:..| |..|:..:.
Zfish   678 -------NTPNAYFNHSVMNFDPLSCKDMTPFKALYILSSTAVLMLLFISFLVHF-QGWRIQFYW 734

  Fly  1054 RFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGG 1118
            ...|.....:.||....|....|||::.::.:|:.:|...|   |.:.:........|||...|.
Zfish   735 NIMVNRMLGSLKDAKVTEGRFQFDAYIIHAGEDKSWVERSL---LSLEDKDLNFFYEQRDSTPGH 796

  Fly  1119 YLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAH--QSVLRDRRRRLIVIVLGEVPQKELD 1181
            ...||||..:..||:.|.|::|..:|..||| :||:.|  ..|:.|.|..||:|.|.:|....|:
Zfish   797 SRLETIVDNMVYSRKIIFVITEMLLKDPWCR-QFKAHHALHHVMEDNRDSLILIFLEDVTDYNLN 860

  Fly  1182 PDLRL---YLKTNTYLQW---GDKL--FWQKLRFALPDVSSSQRSN 1219
            ..|.|   .||....|.|   .:::  |.||||.||   :|:.:.|
Zfish   861 RSLHLRRGMLKPKCVLYWPLHKERIPAFHQKLRSAL---ASTNKVN 903

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR 54..400 CDD:443914 51/212 (24%)
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380
leucine-rich repeat 154..177 CDD:275380
leucine-rich repeat 178..201 CDD:275380 5/12 (42%)
leucine-rich repeat 212..235 CDD:275380 4/22 (18%)
leucine-rich repeat 236..259 CDD:275380 5/23 (22%)
LRR 239..634 CDD:443914 94/418 (22%)
leucine-rich repeat 260..283 CDD:275380 5/22 (23%)
leucine-rich repeat 284..307 CDD:275380 3/22 (14%)
leucine-rich repeat 308..333 CDD:275380 9/24 (38%)
leucine-rich repeat 334..357 CDD:275380 6/22 (27%)
leucine-rich repeat 358..381 CDD:275380 2/22 (9%)
leucine-rich repeat 382..405 CDD:275380 8/22 (36%)
leucine-rich repeat 406..429 CDD:275380 3/22 (14%)
leucine-rich repeat 430..452 CDD:275380 8/31 (26%)
leucine-rich repeat 453..500 CDD:275380 11/48 (23%)
leucine-rich repeat 501..521 CDD:275380 5/19 (26%)
leucine-rich repeat 525..547 CDD:275380 6/21 (29%)
leucine-rich repeat 548..573 CDD:275380 3/24 (13%)
leucine-rich repeat 604..640 CDD:275380 9/42 (21%)
LRR_8 616..>660 CDD:404697 13/46 (28%)
leucine-rich repeat 641..688 CDD:275380 10/47 (21%)
leucine-rich repeat 689..816 CDD:275380 19/131 (15%)
LRR <794..>920 CDD:443914 39/135 (29%)
leucine-rich repeat 817..864 CDD:275380 13/54 (24%)
leucine-rich repeat 865..888 CDD:275380 7/22 (32%)
leucine-rich repeat 889..910 CDD:275380 9/22 (41%)
TIR 1076..1211 CDD:214587 49/144 (34%)
tlr3NP_001013287.2 LRR <54..436 CDD:443914 98/437 (22%)
leucine-rich repeat 57..77 CDD:275380 4/19 (21%)
leucine-rich repeat 78..101 CDD:275380 6/25 (24%)
leucine-rich repeat 102..125 CDD:275380 3/22 (14%)
leucine-rich repeat 126..148 CDD:275380 9/24 (38%)
leucine-rich repeat 149..172 CDD:275380 8/46 (17%)
leucine-rich repeat 173..276 CDD:275380 23/102 (23%)
leucine-rich repeat 278..300 CDD:275380 7/27 (26%)
leucine-rich repeat 301..324 CDD:275380 5/22 (23%)
leucine-rich repeat 325..354 CDD:275380 8/43 (19%)
leucine-rich repeat 355..378 CDD:275380 6/24 (25%)
LRR 368..>666 CDD:443914 89/400 (22%)
leucine-rich repeat 379..404 CDD:275380 6/24 (25%)
leucine-rich repeat 408..431 CDD:275380 6/22 (27%)
leucine-rich repeat 432..456 CDD:275380 7/37 (19%)
leucine-rich repeat 457..507 CDD:275380 15/117 (13%)
leucine-rich repeat 482..498 CDD:275380 4/16 (25%)
leucine-rich repeat 508..531 CDD:275380 6/22 (27%)
leucine-rich repeat 532..563 CDD:275380 6/30 (20%)
leucine-rich repeat 564..587 CDD:275380 7/22 (32%)
leucine-rich repeat 588..611 CDD:275380 7/22 (32%)
leucine-rich repeat 612..630 CDD:275380 9/17 (53%)
Tlr3_TMD 698..730 CDD:465595 7/32 (22%)
TIR 756..898 CDD:214587 49/148 (33%)
Blue background indicates that the domain is not in the aligned region.

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