Protein Alignment Tollo and tlr2

DIOPT Version :10

• Sequence 1: NP_524757.1
• Gene: Tollo / 44497
• FlyBaseID: FBgn0029114
• Length: 1346
• Species: Drosophila melanogaster
• Sequence 2: XP_005170910.2
• Gene: tlr2 / 403125
• ZFINID: ZDB-GENE-040219-6
• Length: 818
• Species: Danio rerio
• Alignment Length: 1138
• Identity: 227/1138 - (19%)
• Similarity: 376/1138 - (33%)
• Gaps: 460/1138 - (40%)

  Fly   164 IWLIPDGM----VCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVS 224
            ::::..|:    .|....:...|.|.|.:..:.              ...|.:..||||.|::.|
Zfish    44 MFILAQGLECSQTCKCDQMYFCNCSSNNLHQVP--------------TVPSDVLGLDLSFNQIES 94

  Fly   225 LPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYL 289
            :....||:...|..||:.||.:..:...||:...:|.|:|||.|.|.:|.|..|.:.|.||::.|
Zfish    95 INMTDLSSYNELIILNLHKNKLRHIHRDAFKSQHNLEVLDLSLNNLNNLSPSWFHKLKSLQQLNL 159

  Fly   290 RNNSINVLAPG-IFGELAELLVLDLAS---NELNSQWINAATFVGLKRLMMLDLSANKISRLEAH 350
            ..|..:.:.|. ||..|..|..|.|.|   .||:...::..|.:........:|.:.:...|:|
Zfish   160 VGNPYSTVGPAPIFSSLVNLRTLHLGSPSLRELHKNGLDVLTHLDEMTFFGSNLRSYENGSLKA- 223

  Fly   351 IFRPLASLQILKLEDNYID--QLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLVL---- 409
             .||:.|:. |.|::.:..  :|...:..|:::..||::    |..:..:|....:...|:
Zfish   224 -ARPIGSVS-LSLQNLFESDPELVSKVLQDVSHPETLLI----IKDVTMKTNTSTEPFKVVKEGG 282

  Fly   410 --SLDFNRISRMDQR-----SLVNCSQLQDLHLNDNKLQAVPE----ALAHVQLLKT-------- 455
              ||.|...|..||.     ..::.|.|..:.|.|.:...:.|    ...|...|:|
Zfish   283 TKSLTFQNSSTTDQALTSFLEFMDGSPLSFIGLEDIQFVGIGEWQKAKYTHHDSLRTAYLRNIEI 347

  Fly   456 ---------LDVGENMISQIENTSITQ-------------LESLYGLRMTENSLTHIR------- 491
                     :::| .::....|.|:..             |::|..:.:::|.||.:.
Zfish   348 EGFFGFSSMIELG-FLLKHFHNVSVINATVFVIPKETTFLLKNLEYMDLSQNLLTDLTIQPTLYT 411

  Fly   492 -RGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISG 555
             .|.:   .:|.:||:|||.|||:  |.:.|                   |.|.|..|.:|::|.
Zfish   412 GSGAY---QNLNMLNVSQNVLKSL--GLMSR-------------------LVTNLKKLKYLDLSH 452

  Fly   556 NRL----EKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNS 616
            |..    ||..:   |:.|::|::.:.:::.|                          ...:|:|
Zfish   453 NSFVSMPEKCSW---PVTLRFLNLSSTKLSTL--------------------------TPCLPSS 488

  Fly   617 VEVLYLNDNQISKIQPYTFFKK--PNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNA 679
            :.||.|::|.:..      ||:  |:||.:.|..|||
Zfish   489 LTVLDLSENDLKA------FKQRFPHLTTLILTGNRL---------------------------- 519

  Fly   680 YECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCH 744
                                                                             
Zfish   520 ----------------------------------------------------------------- 519

  Fly   745 CCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSH 809
                      |:.||                      .:..||
Zfish   520 ----------MKLPD----------------------GKLFPS---------------------- 530

  Fly   810 AFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNA 874
                                           |..|.:|.|.|:..|.:..:....|  |||:..|
Zfish   531 -------------------------------LSTLLIQRNALRMFNQSSLRSFKTL--LYLEAGA 562

  Fly   875 IATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLPSYLNELRLASNPWTCSCEFID----KLRDY 935
                                                         |.:.|||:|:.    .:.|.
Zfish   563 ---------------------------------------------NNFVCSCKFVSFFKKDVEDL 582

  Fly   936 I----NRHEYVVDKLKMKCD---VISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYA 993
            |    .|..||       |:   .:.||:.          :...|.|.:|..
Zfish   583 ITLQDGRQNYV-------CNTPFTLRGNAI----------DSVRLSVFECYM------------- 617

  Fly   994 EQAGGENASNATSTKMILNQPPKLDYIPILVA-ILTAF-IFVMICISL-VFIFRQEMRVWCHSRF 1055
                                   :..:.:|.: |:||. :.|:.|..| |..:.|..:.|..::
Zfish   618 -----------------------IPAVSVLCSGIITALGLVVLTCHKLHVIWYLQMTKAWIQAK- 658

  Fly  1056 GVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYL 1120
                   .:..|.:...|..:|||||||..|..:|.|.|...||..:..:.||||:|||..|.::
Zfish   659 -------RKPAVGRLPEELRYDAFVSYSQHDAEWVEEILVAELEDTQPSFSLCLHKRDFRPGRWI 716

  Fly  1121 PETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDP--- 1182
            .:.|:.:|:.|.||:.|:||:|:.|||||:|...:|..:: |......|:||.|..:||..|
Zfish   717 VDNIIDSIEKSYRTLFVLSEHFVSSEWCRYELDFSHFRIM-DEHNDSAVLVLLEPIKKETIPKRF 780

  Fly  1183 -DLRLYLKTNTYLQW---GDKL--FWQKLRFAL 1209
             .||..:.:.|||:|   .||.  ||..||.||
Zfish   781 CKLRKIMNSRTYLEWPEDEDKRDEFWSNLRAAL 813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR	54..400	CDD:443914	60/245 (24%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		leucine-rich repeat	154..177	CDD:275380	2/16 (13%)
		leucine-rich repeat	178..201	CDD:275380	3/22 (14%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..259	CDD:275380	7/22 (32%)
		LRR	239..634	CDD:443914	100/457 (22%)
		leucine-rich repeat	260..283	CDD:275380	10/22 (45%)
		leucine-rich repeat	284..307	CDD:275380	8/23 (35%)
		leucine-rich repeat	308..333	CDD:275380	7/27 (26%)
		leucine-rich repeat	334..357	CDD:275380	5/22 (23%)
		leucine-rich repeat	358..381	CDD:275380	4/24 (17%)
		leucine-rich repeat	382..405	CDD:275380	4/22 (18%)
		leucine-rich repeat	406..429	CDD:275380	7/33 (21%)
		leucine-rich repeat	430..452	CDD:275380	5/25 (20%)
		leucine-rich repeat	453..500	CDD:275380	11/84 (13%)
		leucine-rich repeat	501..521	CDD:275380	10/19 (53%)
		leucine-rich repeat	525..547	CDD:275380	3/21 (14%)
		leucine-rich repeat	548..573	CDD:275380	8/28 (29%)
		leucine-rich repeat	604..640	CDD:275380	8/37 (22%)
		LRR_8	616..>660	CDD:404697	14/45 (31%)
		leucine-rich repeat	641..688	CDD:275380	6/46 (13%)
		leucine-rich repeat	689..816	CDD:275380	5/126 (4%)
		LRR	<794..>920	CDD:443914	11/125 (9%)
		leucine-rich repeat	817..864	CDD:275380	6/46 (13%)
		leucine-rich repeat	865..888	CDD:275380	5/22 (23%)
		leucine-rich repeat	889..910	CDD:275380	0/20 (0%)
		TIR	1076..1211	CDD:214587	59/143 (41%)
tlr2	XP_005170910.2	None