DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and tlr2

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	XP_005170910.1	Gene:	tlr2 / 403125	ZFINID:	ZDB-GENE-040219-6	Length:	818	Species:	Danio rerio

Alignment Length:	1087	Identity:	247/1087 - (22%)
Similarity:	378/1087 - (34%)	Gaps:	358/1087 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 IWLIPDGM----VCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVS 224
            ::::..|:    .|....:...|.|.|.:..:.              ...|.:..||||.|::.|
Zfish    44 MFILAQGLECSQTCKCDQMYFCNCSSNNLHQVP--------------TVPSDVLGLDLSFNQIES 94

  Fly   225 LPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYL 289
            :....||:...|..||:.||.:..:...||:...:|.|:|||.|.|.:|.|..|.:.|.||::.|
Zfish    95 INMTDLSSYNELIILNLHKNKLRHIHRDAFKSQHNLEVLDLSLNNLNNLSPSWFHKLKSLQQLNL 159

  Fly   290 RNNSINVLAPG-IFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFR 353
            ..|..:.:.|. ||..|..|..|.|.|..|.
Zfish   160 VGNPYSTVGPAPIFKSLVNLRTLHLGSPSLR---------------------------------- 190

  Fly   354 PLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISR 418
                    :|..|.:|.        ||:|..:....:.:...|..:|:..:.:..:||....:..
Zfish   191 --------ELHKNGLDV--------LTHLDEMTFFGSNLRSYENGSLKAARPIGSVSLSLQNLFE 239

  Fly   419 MDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQ--LLKTLDVGE--NMISQIENTSITQLESLYG 479
            .|. .||: ..|||:        :.||.|..::  .:||....|  .|:.:....|:|...|
Zfish   240 SDP-ELVS-KVLQDV--------SHPETLLIIKDVTMKTNTSTEPFKMVKEGGTKSLTFQNS--- 291

  Fly   480 LRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTE 544
             ..|:.:||          |.|:.                          :||:.|.     |..
Zfish   292 -STTDQALT----------SFLEF--------------------------MDGSPLS-----FIG 314

  Fly   545 LPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEIT 609
            |.::.::.|  ...:|..|:|..         :.|...|.| .|||.....|:......||....
Zfish   315 LEDIQFVGI--GEWQKAKYTHHD---------SLRTAYLRN-IEIEGFFGFSSMIELGFLLKHFH 367

  Fly   610 ASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFY 674
            ..|:.|:.         :..|...|.|...||..:||.:|.||.|...             |..|
Zfish   368 NVSVINAT---------VFVIPKETTFLLKNLEYMDLSQNLLTDLTIQ-------------PTLY 410

  Fly   675 IGHNAYECDCNLDWL---QKVNRE----SRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFL 732
            .|..||:   ||:.|   |.|.:.    ||....|..|..:.  |:|   :|.||:
Zfish   411 TGSGAYQ---NLNMLNVSQNVLKSLGLMSRLVTNLKKLKYLD--LSY---NSFVSM--------- 458

  Fly   733 CKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSW--TSNVVDCSRASYEQTLPSHIPMDSTQ 795
                                     |::|      ||  |...::.|.... .||...:|...|.
Zfish   459 -------------------------PEKC------SWPVTLRFLNLSSTKL-STLTPCLPSSLTV 491

  Fly   796 LYLDGNNFRELQSHAFIGR-KRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEF 859
            |.|..|:.:     ||..| ..|..|.|..:|:..|.:...:.  .|..|.:|.|.|:..|.:..
Zfish   492 LDLSENDLK-----AFKQRFPHLTTLILTGNRLMKLPDGKLFP--SLNTLLIQRNALRMFNQSSL 549

  Fly   860 QGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLPSYLNELRLASNPWTC 924
            :....|  |||:..|                                             |.:.|
Zfish   550 RSFKTL--LYLEAGA---------------------------------------------NNFVC 567

  Fly   925 SCEFID----KLRDYI----NRHEYVVDKLKMKCD---VISGNSTQQMVIYPGSGEPASLPVVQC 978
            ||:|:.    .:.|.|    .|..||       |:   .:.||:.          :...|.|.:|
Zfish   568 SCKFVSFFKKDVEDLITLQDGRQNYV-------CNTPFTLRGNAI----------DSVRLSVFEC 615

  Fly   979 SQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAF-IFVMICISL-VF 1041
             ..:|                    |.|.              :...|:||. :.|:.|..| |.
Zfish   616 -YMIP--------------------AVSV--------------LCFGIITALGLVVLTCHKLHVI 645

  Fly  1042 IFRQEMRVWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYK 1106
            .:.|..:.|..::        .:..|.:...|..:|||||||..|..:|.|.|...||..:..:.
Zfish   646 WYLQMTKAWIQAK--------RKPAVGRLPEELRYDAFVSYSQHDAEWVEEILVAELEDTQPSFS 702

  Fly  1107 LCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIV 1171
            ||||:|||..|.::.:.|:.:|:.|.||:.|:||:|:.|||||:|...:|..:: |......|:|
Zfish   703 LCLHKRDFRPGRWIVDNIIDSIEKSYRTLFVLSEHFVSSEWCRYELDFSHFRIM-DEHNDSAVLV 766

  Fly  1172 LGEVPQKELDP----DLRLYLKTNTYLQW---GDKL--FWQKLRFAL 1209
            |.|..:||..|    .||..:.:.|||:|   .||.  ||..||.||
Zfish   767 LLEPIKKETIPKRFCKLRKIMNSRTYLEWPEDEDKRDEFWSNLRAAL 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	31/120 (26%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566	11/61 (18%)
		leucine-rich repeat	154..177	CDD:275380	2/16 (13%)
		leucine-rich repeat	178..201	CDD:275380	3/22 (14%)
		LRR	210..656	CDD:227223	102/450 (23%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..259	CDD:275380	7/22 (32%)
		leucine-rich repeat	260..283	CDD:275380	10/22 (45%)
		LRR_RI	276..558	CDD:238064	52/286 (18%)
		leucine-rich repeat	284..307	CDD:275380	8/23 (35%)
		leucine-rich repeat	308..333	CDD:275380	5/24 (21%)
		leucine-rich repeat	334..357	CDD:275380	0/22 (0%)
		leucine-rich repeat	358..381	CDD:275380	4/22 (18%)
		leucine-rich repeat	382..405	CDD:275380	3/22 (14%)
		leucine-rich repeat	406..429	CDD:275380	5/22 (23%)
		leucine-rich repeat	430..452	CDD:275380	6/23 (26%)
		leucine-rich repeat	453..500	CDD:275380	10/48 (21%)
		leucine-rich repeat	501..521	CDD:275380	1/19 (5%)
		leucine-rich repeat	525..547	CDD:275380	5/21 (24%)
		leucine-rich repeat	548..573	CDD:275380	4/24 (17%)
		leucine-rich repeat	604..640	CDD:275380	7/35 (20%)
		leucine-rich repeat	641..688	CDD:275380	14/46 (30%)
		leucine-rich repeat	689..816	CDD:275380	28/136 (21%)
		LRR_8	815..875	CDD:290566	15/59 (25%)
		leucine-rich repeat	817..864	CDD:275380	11/46 (24%)
		LRR_8	864..921	CDD:290566	5/56 (9%)
		leucine-rich repeat	865..888	CDD:275380	5/22 (23%)
		leucine-rich repeat	889..910	CDD:275380	0/20 (0%)
		TIR	1076..1211	CDD:214587	59/143 (41%)
tlr2	XP_005170910.1	leucine-rich repeat	85..105	CDD:275378	8/19 (42%)
		leucine-rich repeat	106..129	CDD:275378	7/22 (32%)
		LRR_8	108..163	CDD:290566	20/54 (37%)
		leucine-rich repeat	130..153	CDD:275378	10/22 (45%)
		leucine-rich repeat	154..178	CDD:275378	8/23 (35%)
		leucine-rich repeat	179..192	CDD:275378	5/54 (9%)
		LRR_RI	<390..501	CDD:238064	39/177 (22%)
		leucine-rich repeat	390..418	CDD:275380	12/43 (28%)
		LRR_8	418..478	CDD:290566	20/104 (19%)
		leucine-rich repeat	419..444	CDD:275380	7/24 (29%)
		leucine-rich repeat	445..467	CDD:275380	10/66 (15%)
		leucine-rich repeat	468..488	CDD:275380	4/20 (20%)
		leucine-rich repeat	489..508	CDD:275380	7/23 (30%)
		leucine-rich repeat	509..530	CDD:275380	5/22 (23%)
		leucine-rich repeat	531..554	CDD:275380	6/22 (27%)
		TIR	671..814	CDD:214587	59/144 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7248
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820