DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tollo and Tlr12

DIOPT Version :10

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_991392.1 Gene:Tlr12 / 384059 MGIID:3045221 Length:906 Species:Mus musculus


Alignment Length:1130 Identity:255/1130 - (22%)
Similarity:407/1130 - (36%) Gaps:313/1130 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 LDLSLNNIW-----LIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASLS----SRKARVCGSTL 212
            |.|.|...|     |:.:|...||.|.......::|:.     :.:|.||    ::...|...|:
Mouse    12 LSLPLVTGWSTSNCLVTEGSRLPLVSRYFTFCRHSKLS-----FLAACLSVSNLTQTLEVVPRTV 71

  Fly   213 QSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFL--ADRAFEGLLSLRVVDLSANRLTSLPP 275
            :.|.|.......||.| .||...|..|.::.:....|  |.|....|.||...|....|...|||
Mouse    72 EGLCLGGTVSTLLPDA-FSAFPGLKVLALSLHLTQLLPGALRGLGQLQSLSFFDSPLRRSLFLPP 135

  Fly   276 ELFAETKQLQEIYLRNNSINV-----LAPGIFGELAELLVLDLASNELNSQWINAATF----VGL 331
            :.|::...||.:::....::.     |.||:                   ||:.....    ||.
Mouse   136 DAFSDLISLQRLHISGPCLDKKAGIRLPPGL-------------------QWLGVTLSCIQDVGE 181

  Fly   332 KRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIE 396
            ...|..||.....||:.       .:||.|.|..|:                       ::.:..
Mouse   182 LAGMFPDLVQGSSSRVS-------WTLQKLDLSSNW-----------------------KLKMAS 216

  Fly   397 QRTLQGLKNLLVLSLDFNRISRMDQRSL--VNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVG 459
            ..:||||:   |..||..| :.:|...|  :...:|..|:......:...||:||.: |:.|.|.
Mouse   217 PGSLQGLQ---VEILDLTR-TPLDAVWLKGLGLQKLDVLYAQTATAELAAEAVAHFE-LQGLIVK 276

  Fly   460 ENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQ 524
            |:.|..|...::....||..|.::...||.:..|....|..||.|.||.|              |
Mouse   277 ESKIGSISQEALASCHSLKTLGLSSTGLTKLPPGFLTAMPRLQRLELSGN--------------Q 327

  Fly   525 LQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFD---YSHIPIGLQWLDVRANRITQLGNY 586
            ||:..|..|:...::||.|       |::|||||....   :|.:| .|:.|.:|.|::..|..|
Mouse   328 LQSAVLCMNETGDVSGLTT-------LDLSGNRLRILPPAAFSCLP-HLRELLLRYNQLLSLEGY 384

  Fly   587 -FEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNR 650
             |:...:|.....|.:                .:|:|..|.::.:        |.||.:.|:..:
Mouse   385 LFQELQQLETLKLDGN----------------PLLHLGKNWLAAL--------PALTTLSLLDTQ 425

  Fly   651 LTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQ--IHCRLA 713
                    :|:||      .|.|:...|.:.....|..|        ..|.::.|..  ....|.
Mouse   426 --------IRMSP------EPGFWGAKNLHTLSLKLPAL--------PAPAVLFLPMYLTSLELH 468

  Fly   714 YARGSS-HVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCS-----CYHDQSWTSN 772
            .|.|:: |.:|..|            .|.............|::...:.:     .....|...|
Mouse   469 IASGTTEHWTLSPA------------IFPSLETLTISGGGLKLKLGSQNASGVFPALQKLSLLKN 521

  Fly   773 VVD--CSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTF 835
            .:|  ||:.:....|.....:.|.:::..||:.|..........:.||:..|.            
Mouse   522 SLDAFCSQGTSNLFLWQLPKLQSLRVWGAGNSSRPCLITGLPSLRELKLASLQ------------ 574

  Fly   836 YGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAIT 900
                  .:.|.:|.||:.|.|:    |..||.|.|....:.::....|..|:.|::|.|:     
Mouse   575 ------SITQPRSVQLEELVGD----LPQLQALVLSSTGLKSLSAAAFQRLHSLQVLVLE----- 624

  Fly   901 SFAVWNFLPSYLNELRLASNPWTCSCEFIDKLRDY---INRHEYVVDKLKMKCDVISG------- 955
                      |..:|.|.           |.||:|   :..:.|:::. .:.|...:.       
Mouse   625 ----------YEKDLMLQ-----------DSLREYSPQMPHYIYILES-NLACHCANAWMEPWVK 667

  Fly   956 NSTQQMV------IYPGS---GEPASLPVV---QCSQTLPLGLDNNFNYAEQAGGENASNATSTK 1008
            .||:..:      :.||.   ....|||..   .|.|||.|.|            ..||:|....
Mouse   668 RSTKTYIYIRDNRLCPGQDRLSARGSLPSFLWDHCPQTLELKL------------FLASSALVFM 720

  Fly  1009 MI---LNQPPKLDYIPILVAILTAFIFVMICISLVFIFRQEMRVWCHSRFGVRLFYNAQKDVDKN 1070
            :|   |.|..:..:||.|.|:                    .|||..   |:|         .|.
Mouse   721 LIALPLLQEARNSWIPYLQAL--------------------FRVWLQ---GLR---------GKG 753

  Fly  1071 EREK--LFDAFVSYSSKDELFVNEELAPMLE------MGEHRYKLCLHQRDFPVGGYLPETIVQA 1127
            ::.|  |||.|||:..:|:.:|.|||.|.||      :|   .:|||.:|||..|..:.:.:|.:
Mouse   754 DKGKRFLFDVFVSHCRQDQGWVIEELLPALEGFLPAGLG---LRLCLPERDFEPGKDVVDNVVDS 815

  Fly  1128 IDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIV-LGEVPQKELDPDLRL--YLK 1189
            :.|||.|:.|:|...:.:..||.|.:.|...:|......::::| |..:.:.:|....||  .|:
Mouse   816 MLSSRTTLCVLSGQALCNPRCRLELRLATSLLLAAPSPPVLLLVFLEPISRHQLPGYHRLARLLR 880

  Fly  1190 TNTYLQWGDKL-----FWQKLRFAL 1209
            ...|..|.::.     ||..||..|
Mouse   881 RGDYCLWPEEEERKSGFWTWLRSRL 905

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR 54..400 CDD:443914 55/262 (21%)
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380
leucine-rich repeat 154..177 CDD:275380 8/24 (33%)
leucine-rich repeat 178..201 CDD:275380 2/22 (9%)
leucine-rich repeat 212..235 CDD:275380 7/22 (32%)
leucine-rich repeat 236..259 CDD:275380 6/24 (25%)
LRR 239..634 CDD:443914 95/411 (23%)
leucine-rich repeat 260..283 CDD:275380 7/22 (32%)
leucine-rich repeat 284..307 CDD:275380 5/27 (19%)
leucine-rich repeat 308..333 CDD:275380 4/28 (14%)
leucine-rich repeat 334..357 CDD:275380 5/22 (23%)
leucine-rich repeat 358..381 CDD:275380 5/22 (23%)
leucine-rich repeat 382..405 CDD:275380 4/22 (18%)
leucine-rich repeat 406..429 CDD:275380 6/24 (25%)
leucine-rich repeat 430..452 CDD:275380 6/21 (29%)
leucine-rich repeat 453..500 CDD:275380 13/46 (28%)
leucine-rich repeat 501..521 CDD:275380 6/19 (32%)
leucine-rich repeat 525..547 CDD:275380 7/21 (33%)
leucine-rich repeat 548..573 CDD:275380 9/27 (33%)
leucine-rich repeat 604..640 CDD:275380 3/35 (9%)
LRR_8 616..>660 CDD:404697 7/43 (16%)
leucine-rich repeat 641..688 CDD:275380 10/46 (22%)
leucine-rich repeat 689..816 CDD:275380 21/136 (15%)
LRR <794..>920 CDD:443914 25/125 (20%)
leucine-rich repeat 817..864 CDD:275380 10/46 (22%)
leucine-rich repeat 865..888 CDD:275380 6/22 (27%)
leucine-rich repeat 889..910 CDD:275380 3/20 (15%)
TIR 1076..1211 CDD:214587 46/148 (31%)
Tlr12NP_991392.1 LRR 56..482 CDD:443914 125/548 (23%)
LRR 1 91..114 5/22 (23%)
leucine-rich repeat 94..116 CDD:275380 5/21 (24%)
LRR 2 115..140 9/24 (38%)
leucine-rich repeat 117..143 CDD:275380 9/25 (36%)
LRR 3 142..170 7/46 (15%)
leucine-rich repeat 144..191 CDD:275380 12/65 (18%)
LRR 4 198..222 6/53 (11%)
leucine-rich repeat 201..224 CDD:275380 8/45 (18%)
LRR 5 224..247 6/26 (23%)
leucine-rich repeat 225..247 CDD:275380 6/22 (27%)
leucine-rich repeat 248..293 CDD:275380 12/45 (27%)
LRR 6 267..290 7/23 (30%)
LRR 7 291..314 6/22 (27%)
leucine-rich repeat 294..317 CDD:275380 6/22 (27%)
LRR 8 316..338 11/35 (31%)
leucine-rich repeat 318..343 CDD:275380 11/38 (29%)
LRR 9 341..364 9/29 (31%)
leucine-rich repeat 344..367 CDD:275380 10/30 (33%)
LRR 10 366..388 8/22 (36%)
leucine-rich repeat 368..391 CDD:275380 7/22 (32%)
LRR 11 389..412 5/38 (13%)
leucine-rich repeat 392..415 CDD:275380 5/46 (11%)
LRR 12 414..436 9/35 (26%)
leucine-rich repeat 416..436 CDD:275380 8/33 (24%)
LRR 439..>625 CDD:443914 42/242 (17%)
leucine-rich repeat 440..512 CDD:275380 12/91 (13%)
LRR 13 462..484 6/33 (18%)
LRR 14 485..508 1/22 (5%)
LRR 15 510..533 5/22 (23%)
leucine-rich repeat 513..564 CDD:275380 10/50 (20%)
LRR 16 562..586 7/41 (17%)
leucine-rich repeat 565..593 CDD:275380 10/49 (20%)
LRR 17 591..614 6/22 (27%)
leucine-rich repeat 594..617 CDD:275380 6/22 (27%)
TIR 761..902 CDD:214587 43/143 (30%)
Blue background indicates that the domain is not in the aligned region.

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