DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tollo and CG4781

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_611951.1	Gene:	CG4781 / 37943	FlyBaseID:	FBgn0035043	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	333	Identity:	93/333 - (27%)
Similarity:	149/333 - (44%)	Gaps:	78/333 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 LLSLRV--VDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELN 319
            ||.|.:  :|||.|.|.|:|  :|. :..|.::.||:|:|:.|..|.|.:|..|       .||.
  Fly    83 LLPLYIDSLDLSWNALDSVP--IFT-SDSLHQLNLRHNNISQLVSGNFKQLTSL-------RELY 137

  Fly   320 SQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHT 384
            ..|                   |.|.:||:..|..|..||:|.|..|.:..|||.:||.|..|.|
  Fly   138 LGW-------------------NSIGKLESGSFDGLPHLQVLDLAHNNLHLLPGHLFAPLLVLGT 183

  Fly   385 LILSRNR---ISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEA 446
            |.:|.||   .|..:..|..|: |..:.:|..:..|..|....|| :.|::|.|..|:|:.:|..
  Fly   184 LDISWNRRFNESGGDLYTGLGV-NWKLSTLRLDACSLNDLHLPVN-APLKELSLRRNQLKRIPTQ 246

  Fly   447 LAHVQLLKTLDVGENMISQI---ENTSITQLESLY------GLRMTENSLTHIRRGVFDRMSSLQ 502
            |.  :.|..||:.:|::.::   :..::||:..|:      ..|:..|||||:     |.:.:|.
  Fly   247 LP--ETLLRLDISDNLLEELLPEDTANLTQVRQLFIEDMPVLQRVVANSLTHV-----DVLETLS 304

  Fly   503 ILNLSQNKLKSIEAGSL-------QRNSQLQAIRLDGNQLK----SIAGLFTELP---------- 546
            ..|..|  |..::|.:.       .:...|:::...|..|:    ::|.:||:|.
  Fly   305 FQNSRQ--LSHLDAEAFGPIMTTPTKKRALRSLSFRGTMLRTFNSTLAPIFTQLAELDLNGLPLQ 367

  Fly   547 ---NLVWL 551
               .||||
  Fly   368 CDCELVWL 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	11/25 (44%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	93/333 (28%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380	1/1 (100%)
		leucine-rich repeat	260..283	CDD:275380	9/24 (38%)
		LRR_RI	276..558	CDD:238064	83/312 (27%)
		leucine-rich repeat	284..307	CDD:275380	9/22 (41%)
		leucine-rich repeat	308..333	CDD:275380	4/24 (17%)
		leucine-rich repeat	334..357	CDD:275380	6/22 (27%)
		leucine-rich repeat	358..381	CDD:275380	11/22 (50%)
		leucine-rich repeat	382..405	CDD:275380	9/25 (36%)
		leucine-rich repeat	406..429	CDD:275380	5/22 (23%)
		leucine-rich repeat	430..452	CDD:275380	7/21 (33%)
		leucine-rich repeat	453..500	CDD:275380	14/55 (25%)
		leucine-rich repeat	501..521	CDD:275380	5/26 (19%)
		leucine-rich repeat	525..547	CDD:275380	7/38 (18%)
		leucine-rich repeat	548..573	CDD:275380	4/4 (100%)
		leucine-rich repeat	604..640	CDD:275380
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
CG4781	NP_611951.1	leucine-rich repeat	90..108	CDD:275380	8/20 (40%)
		LRR_8	108..167	CDD:290566	24/84 (29%)
		leucine-rich repeat	109..132	CDD:275380	9/22 (41%)
		LRR_RI	<121..>261	CDD:238064	51/169 (30%)
		leucine-rich repeat	133..156	CDD:275380	10/48 (21%)
		leucine-rich repeat	157..180	CDD:275380	11/22 (50%)
		leucine-rich repeat	181..208	CDD:275380	10/27 (37%)
		leucine-rich repeat	230..253	CDD:275380	8/24 (33%)
		leucine-rich repeat	254..274	CDD:275380	3/19 (16%)
		leucine-rich repeat	275..299	CDD:275380	7/28 (25%)
		leucine-rich repeat	300..319	CDD:275380	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010