Protein Alignment Tollo and Gp150

DIOPT Version :10

• Sequence 1: NP_524757.1
• Gene: Tollo / 44497
• FlyBaseID: FBgn0029114
• Length: 1346
• Species: Drosophila melanogaster
• Sequence 2: NP_477049.2
• Gene: Gp150 / 37549
• FlyBaseID: FBgn0013272
• Length: 1076
• Species: Drosophila melanogaster
• Alignment Length: 584
• Identity: 139/584 - (23%)
• Similarity: 235/584 - (40%)
• Gaps: 167/584 - (28%)

  Fly    89 LSPDSFRSL-------VELRDLTIEYCKLGNLTDGSFRGLQELR--NLTIRTHNGDWSTMSLEMA 144
            :.|:.|::|       :::.:.|:||     |...:|.||.||.  |||
  Fly   306 MGPNFFQNLGLKNVASIKIANCTLEY-----LHAEAFHGLNELYAVNLT---------------- 349

  Fly   145 SNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCG 209
                       .:.|::.|    ||..| ..|.|:.|..|.|.:..:|:.::....||
  Fly   350 -----------DVGLAIIN----PDTFV-GNKKLRMLTISGNDLSVMSSIHYLLKSSS------- 391

  Fly   210 STLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLP 274
              ::.||.|.|.::.|.....|.|..:.::|:::||:..|.::|||.:..|..:|||.|.||.||
  Fly   392 --IEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNSLTELP 454

  Fly   275 PELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDL 339
            .::|..| .|..::|:.|:.|       |:|                      ..|.|.|..|||
  Fly   455 RDIFNGT-TLSILHLKYNTFN-------GDL----------------------HFGTKDLQQLDL 489

  Fly   340 SANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLK 404
            |.|.|.::...:|                |::||     ||||:   |..|.|..|:..:...||
  Fly   490 SFNSIVQVHHSMF----------------DKMPG-----LTNLN---LKGNGIKKIQPDSFLTLK 530

  Fly   405 NLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDN-KLQAVPE----ALAHVQLLKTLDVGENMIS 464
            ||..:.|..|.:.::........|:|..:.|||| :|..:|.    :.:....:..||:....|.
  Fly   531 NLRHIDLSINDLDQISGMLFFKNSELDVIRLNDNPRLSQLPTDGFLSYSGEFTVYYLDISNCAIG 595

  Fly   465 QIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIR 529
            .:.:.:.:.:..|..|::..|::.|:.|.:|..:..|..|:||.|.:..::......|.:|..:.
  Fly   596 PLGHKAFSTMPHLTTLKLAWNNINHLPREIFTGLHKLIDLDLSNNLITRMDDLIFMDNGELTKLS 660

  Fly   530 LDGNQLKSIA-GLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRIT------QLGNYF 587
            |.||.:..:: .||..|..                      |:.|||....:|      .||..:
  Fly   661 LAGNPISRLSVRLFLPLHQ----------------------LRCLDVNDCELTTLLSDRDLGAGY 703

  Fly   588 EIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRL 651
            :|..  ||.:|:||.||:.:|::..:.:                    ||  ||..:|:..|.|
  Fly   704 KIFD--SLRSFNASGNLIKKISSEDVKS--------------------FK--NLRSLDITNNPL 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR	54..400	CDD:443914	80/319 (25%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		leucine-rich repeat	124..144	CDD:275380	4/21 (19%)
		leucine-rich repeat	154..177	CDD:275380	5/22 (23%)
		leucine-rich repeat	178..201	CDD:275380	5/22 (23%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	236..259	CDD:275380	7/22 (32%)
		LRR	239..634	CDD:443914	97/406 (24%)
		leucine-rich repeat	260..283	CDD:275380	11/22 (50%)
		leucine-rich repeat	284..307	CDD:275380	6/22 (27%)
		leucine-rich repeat	308..333	CDD:275380	1/24 (4%)
		leucine-rich repeat	334..357	CDD:275380	8/22 (36%)
		leucine-rich repeat	358..381	CDD:275380	4/22 (18%)
		leucine-rich repeat	382..405	CDD:275380	6/22 (27%)
		leucine-rich repeat	406..429	CDD:275380	3/22 (14%)
		leucine-rich repeat	430..452	CDD:275380	7/26 (27%)
		leucine-rich repeat	453..500	CDD:275380	9/46 (20%)
		leucine-rich repeat	501..521	CDD:275380	5/19 (26%)
		leucine-rich repeat	525..547	CDD:275380	7/22 (32%)
		leucine-rich repeat	548..573	CDD:275380	1/24 (4%)
		leucine-rich repeat	604..640	CDD:275380	4/35 (11%)
		LRR_8	616..>660	CDD:404697	7/36 (19%)
		leucine-rich repeat	641..688	CDD:275380	4/11 (36%)
		leucine-rich repeat	689..816	CDD:275380
		LRR	<794..>920	CDD:443914
		leucine-rich repeat	817..864	CDD:275380
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
Gp150	NP_477049.2	LRR	341..758	CDD:443914	129/544 (24%)
		leucine-rich repeat	343..366	CDD:275380	9/54 (17%)
		leucine-rich repeat	367..391	CDD:275380	5/23 (22%)
		leucine-rich repeat	393..415	CDD:275380	7/21 (33%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..483	CDD:275380	18/72 (25%)
		leucine-rich repeat	463..481	CDD:275380	6/46 (13%)
		leucine-rich repeat	484..507	CDD:275380	9/38 (24%)
		leucine-rich repeat	508..531	CDD:275380	9/25 (36%)
		leucine-rich repeat	532..569	CDD:275380	10/36 (28%)
		leucine-rich repeat	556..583	CDD:275380	7/26 (27%)
		leucine-rich repeat	570..607	CDD:275380	4/36 (11%)
		leucine-rich repeat	608..631	CDD:275380	6/22 (27%)
		leucine-rich repeat	632..655	CDD:275380	6/22 (27%)
		leucine-rich repeat	656..674	CDD:275380	4/17 (24%)
		leucine-rich repeat	733..745	CDD:275378	4/11 (36%)