DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tollo and CG5819

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster

Alignment Length:	615	Identity:	144/615 - (23%)
Similarity:	256/615 - (41%)	Gaps:	138/615 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 LDLSLNNIWLIPD--GMVCP--------LKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGST 211
            |:|:|..:.:|..  .:.||        :.|| :.:.|...:|...||             .|..
  Fly     5 LELALLVLGVISSCRAVNCPWPCRCTWVVDSL-YADCSRRSLQTYPNF-------------DGIP 55

  Fly   212 LQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTS---- 272
            ::.||||.||.:..|| :.:.:..|.:|:::.|.:|.:..:...|..|||.:.|:.|.:.|
  Fly    56 VEHLDLSGNKFLEFPT-LYADIDSLIYLDLSSNYISSIGAKTLIGFTSLRTLLLANNSIDSWESL 119

  Fly   273 LPPELFAETKQLQEIYLRNNSINVLAPGIF--GELAELLV------LDLASNELNS----QWINA 325
            .|.|.|.....|:.:.|..|.:     |.|  ||..|||.      |.|:|..::|    |.:|.
  Fly   120 SPNEAFKYAPSLKRLGLDGNRL-----GSFGNGESFELLTSSSLTDLGLSSCGISSIGGDQMVNQ 179

  Fly   326 ATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRN 390
                 |..|..|:|:.|:::::.|   .|..:|::|.|.:..|..|.|.....:.||..|.||||
  Fly   180 -----LPNLERLNLANNQLAQIAA---LPSRTLRVLDLSNCSIKNLSGFFLDAMQNLEALNLSRN 236

  Fly   391 RISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKT 455
            .....:..:...:...::..||.: ...:|...|....||.::.|..|             ||:.
  Fly   237 TELQFDSLSEDPILTYMLRKLDVS-YCNLDSIELSGLPQLTEVRLQGN-------------LLRV 287

  Fly   456 LDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQ 520
            :||     :...|.|:.::..|     ::|.|.||.:..|.::..|:.|||:.|::..::...::
  Fly   288 VDV-----NTFANNSMLEVVDL-----SQNVLRHIGQDAFAKLKRLKELNLAFNEIARLDRNFIR 342

  Fly   521 RNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKF----DYSHIPIGLQWLDVRANRIT 581
            .|..                       ||.||:|.|.|:|.    ..|...|.:.|.::.:...|
  Fly   343 NNDV-----------------------LVELNLSRNVLQKLTKIVSNSVRTINMSWCEITSIEST 384

  Fly   582 QLGNYFEIESELS-LSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVD 645
            .|       |.|| :...|.|.||:|::.......:::.|.|.:.:::.::..||.:.|.|..:.
  Fly   385 AL-------SSLSVIQKLDLSNNLITDMPTFMRSETLQQLNLANCRLTTVRNNTFREFPELADLH 442

  Fly   646 LVRNRLTT-LEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDL-DQI 708
            |..||||: :.||.     ...::.:.:.::|.|.:.|||:             .|..:|. |.:
  Fly   443 LNGNRLTSPIPPNY-----FDGNKFLDQLWLGDNPWICDCH-------------SPLFVDFYDYL 489

  Fly   709 HCRLAYARGSSHV-----SLIEAKSDDFLC 733
            ..:.|..:..:|:     ::...|..:|.|
  Fly   490 TAKPAKIKDRNHLRCAAPAVFYGKLWEFAC 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	35/137 (26%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566	18/74 (24%)
		leucine-rich repeat	154..177	CDD:275380	6/29 (21%)
		leucine-rich repeat	178..201	CDD:275380	5/22 (23%)
		LRR	210..656	CDD:227223	116/467 (25%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..259	CDD:275380	5/22 (23%)
		leucine-rich repeat	260..283	CDD:275380	8/26 (31%)
		LRR_RI	276..558	CDD:238064	70/293 (24%)
		leucine-rich repeat	284..307	CDD:275380	7/24 (29%)
		leucine-rich repeat	308..333	CDD:275380	9/34 (26%)
		leucine-rich repeat	334..357	CDD:275380	6/22 (27%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	382..405	CDD:275380	6/22 (27%)
		leucine-rich repeat	406..429	CDD:275380	4/22 (18%)
		leucine-rich repeat	430..452	CDD:275380	3/21 (14%)
		leucine-rich repeat	453..500	CDD:275380	11/46 (24%)
		leucine-rich repeat	501..521	CDD:275380	5/19 (26%)
		leucine-rich repeat	525..547	CDD:275380	0/21 (0%)
		leucine-rich repeat	548..573	CDD:275380	10/28 (36%)
		leucine-rich repeat	604..640	CDD:275380	6/35 (17%)
		leucine-rich repeat	641..688	CDD:275380	13/47 (28%)
		leucine-rich repeat	689..816	CDD:275380	8/51 (16%)
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	8/22 (36%)
		LRR_RI	<58..236	CDD:238064	56/191 (29%)
		LRR_8	78..141	CDD:290566	17/62 (27%)
		leucine-rich repeat	79..102	CDD:275380	5/22 (23%)
		leucine-rich repeat	103..130	CDD:275380	8/26 (31%)
		leucine-rich repeat	131..155	CDD:275380	10/28 (36%)
		LRR_8	156..214	CDD:290566	16/65 (25%)
		leucine-rich repeat	158..182	CDD:275380	7/28 (25%)
		LRR_8	202..285	CDD:290566	21/96 (22%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		leucine-rich repeat	254..274	CDD:275380	4/20 (20%)
		LRR_8	273..333	CDD:290566	21/82 (26%)
		leucine-rich repeat	275..298	CDD:275380	8/40 (20%)
		LRR_RI	277..>471	CDD:238064	55/251 (22%)
		leucine-rich repeat	299..322	CDD:275380	6/27 (22%)
		LRR_8	321..402	CDD:290566	25/110 (23%)
		leucine-rich repeat	323..346	CDD:275380	6/22 (27%)
		leucine-rich repeat	347..391	CDD:275380	15/50 (30%)
		leucine-rich repeat	392..413	CDD:275380	5/20 (25%)
		LRR_8	393..448	CDD:290566	13/54 (24%)
		leucine-rich repeat	414..437	CDD:275380	4/22 (18%)
		LRRCT	471..517	CDD:214507	10/58 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010