DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tollo and NRROS

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_940967.1 Gene:NRROS / 375387 HGNCID:24613 Length:692 Species:Homo sapiens


Alignment Length:898 Identity:191/898 - (21%)
Similarity:315/898 - (35%) Gaps:261/898 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 FYF--------SASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLA 250
            |:|        |.:.::....||.....:.|.....:.|:|:::......||   :..|.:..|.
Human    12 FHFLTVGWRNRSGTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHARMLT---LDANPLKTLW 73

  Fly   251 DRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINV----------LAPGIFGEL 305
            :.:.:....|..:.|.:..|..:....|.|...|:.:.|.:|.::.          ..||     
Human    74 NHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPG----- 133

  Fly   306 AELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQ 370
              |..|||:.|.|... :.|.....|..|..:.|:.|.|.||:..:|..|..|:.|.|:.|||.:
Human   134 --LRRLDLSGNALTED-MAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFE 195

  Fly   371 LPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHL 435
            :.||.|..|..|..|.|:.|.:..|..   .||..|.||::.:|.:............:|:.|.|
Human   196 IEGGAFDGLAELRHLNLAFNNLPCIVD---FGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDL 257

  Fly   436 NDNKLQAVPEALAHVQLLKTLDVGENMIS---QIENTSITQLESLYGLRMTENSLTHIRR-GVFD 496
            :.|:|...| .|.....|:||.:.:|.:.   .:.||| :..|.:....:.:.::|:|.. .:::
Human   258 SHNQLLFFP-LLPQYSKLRTLLLRDNNMGFYRDLYNTS-SPREMVAQFLLVDGNVTNITTVSLWE 320

  Fly   497 RMSS-----LQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGN 556
            ..||     |:.|::|||:.:.:..|.|::                       :|:|..||:..|
Human   321 EFSSSDLADLRFLDMSQNQFQYLPDGFLRK-----------------------MPSLSHLNLHQN 362

  Fly   557 RLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEI----TASSIPNSV 617
                        .|..|.:|           |.|...:|:..|.|:|.|:|:    ..:|...|:
Human   363 ------------CLMTLHIR-----------EHEPPGALTELDLSHNQLSELHLAPGLASCLGSL 404

  Fly   618 EVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYEC 682
            .:..|:.||:..:.|..|....|:|.:|:..|::      :|...|.|.||..|...:       
Human   405 RLFNLSSNQLLGVPPGLFANARNITTLDMSHNQI------SLCPLPAASDRVGPPSCV------- 456

  Fly   683 DCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCD 747
                        :.|....|..|....|.|.            |..|                |.
Human   457 ------------DFRNMASLRSLSLEGCGLG------------ALPD----------------CP 481

  Fly   748 FQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFI 812
            ||....         .|.|.|....|::.|.|..:...|                          
Human   482 FQGTSL---------TYLDLSSNWGVLNGSLAPLQDVAP-------------------------- 511

  Fly   813 GRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIAT 877
               .|:||.|.:..   ||: :|..|                   :|.|..||::|.|..|.:.|
Human   512 ---MLQVLSLRNMG---LHS-SFMAL-------------------DFSGFGNLRDLDLSGNCLTT 550

  Fly   878 IDTLTFTHLYHLKILRLDHNAITSF---AVWNFLPSYLNELRLASNPWTCSCEFIDKLRDYINRH 939
            ..  .|.....|:.|.|..|::|:.   ||...|...|..:.|:.||:.| |. :|.. ..:...
Human   551 FP--RFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDC-CG-VDGW-GALQHG 610

  Fly   940 EYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCS-QTLPLGLDNNFNYAEQAGGENASN 1003
            :.|.|...:.|::.|  ...::...|| |.|.     .|. :.|.|||                 
Human   611 QTVADWAMVTCNLSS--KIIRVTELPG-GVPR-----DCKWERLDLGL----------------- 650

  Fly  1004 ATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFR----QEMRVWCH 1052
                         |..:.||.:.||   .::.|..:|..|:    |.::..||
Human   651 -------------LYLVLILPSCLT---LLVACTVIVLTFKKPLLQVIKSRCH 687

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 16/94 (17%)
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380
LRR_8 152..222 CDD:290566 6/35 (17%)
leucine-rich repeat 154..177 CDD:275380
leucine-rich repeat 178..201 CDD:275380 3/14 (21%)
LRR 210..656 CDD:227223 107/468 (23%)
leucine-rich repeat 212..235 CDD:275380 3/22 (14%)
leucine-rich repeat 236..259 CDD:275380 4/22 (18%)
leucine-rich repeat 260..283 CDD:275380 5/22 (23%)
LRR_RI 276..558 CDD:238064 75/300 (25%)
leucine-rich repeat 284..307 CDD:275380 5/32 (16%)
leucine-rich repeat 308..333 CDD:275380 8/24 (33%)
leucine-rich repeat 334..357 CDD:275380 8/22 (36%)
leucine-rich repeat 358..381 CDD:275380 10/22 (45%)
leucine-rich repeat 382..405 CDD:275380 7/22 (32%)
leucine-rich repeat 406..429 CDD:275380 4/22 (18%)
leucine-rich repeat 430..452 CDD:275380 7/21 (33%)
leucine-rich repeat 453..500 CDD:275380 10/50 (20%)
leucine-rich repeat 501..521 CDD:275380 7/19 (37%)
leucine-rich repeat 525..547 CDD:275380 0/21 (0%)
leucine-rich repeat 548..573 CDD:275380 5/24 (21%)
leucine-rich repeat 604..640 CDD:275380 9/39 (23%)
leucine-rich repeat 641..688 CDD:275380 9/46 (20%)
leucine-rich repeat 689..816 CDD:275380 17/126 (13%)
LRR_8 815..875 CDD:290566 15/59 (25%)
leucine-rich repeat 817..864 CDD:275380 10/46 (22%)
LRR_8 864..921 CDD:290566 17/59 (29%)
leucine-rich repeat 865..888 CDD:275380 6/22 (27%)
leucine-rich repeat 889..910 CDD:275380 8/23 (35%)
TIR 1076..1211 CDD:214587
NRROSNP_940967.1 leucine-rich repeat 42..61 CDD:275380 3/18 (17%)
LRR 1. /evidence=ECO:0000255 58..79 4/23 (17%)
leucine-rich repeat 62..82 CDD:275380 4/22 (18%)
LRR_RI 76..>285 CDD:238064 58/220 (26%)
LRR_8 81..144 CDD:290566 15/69 (22%)
LRR 2. /evidence=ECO:0000255 82..103 4/20 (20%)
leucine-rich repeat 83..106 CDD:275380 5/22 (23%)
LRR 3. /evidence=ECO:0000255 106..127 3/20 (15%)
leucine-rich repeat 107..133 CDD:275380 3/25 (12%)
LRR 4. /evidence=ECO:0000255 133..155 8/29 (28%)
leucine-rich repeat 134..158 CDD:275380 8/24 (33%)
LRR_8 157..217 CDD:290566 22/59 (37%)
LRR 5. /evidence=ECO:0000255 158..179 7/20 (35%)
leucine-rich repeat 159..182 CDD:275380 8/22 (36%)
LRR 6. /evidence=ECO:0000255 182..203 9/20 (45%)
leucine-rich repeat 183..206 CDD:275380 10/22 (45%)
LRR 7. /evidence=ECO:0000255 206..227 7/23 (30%)
leucine-rich repeat 207..227 CDD:275380 7/22 (32%)
leucine-rich repeat 228..251 CDD:275380 4/22 (18%)
LRR 8. /evidence=ECO:0000255 228..239 4/10 (40%)
LRR 9. /evidence=ECO:0000255 251..272 7/21 (33%)
leucine-rich repeat 252..273 CDD:275380 7/21 (33%)
LRR 10. /evidence=ECO:0000255 273..294 5/20 (25%)
LRR 11. /evidence=ECO:0000255 329..350 7/20 (35%)
LRR_8 330..388 CDD:290566 21/103 (20%)
leucine-rich repeat 330..353 CDD:275380 7/45 (16%)
LRR 12. /evidence=ECO:0000255 353..374 8/43 (19%)
leucine-rich repeat 354..377 CDD:275380 9/45 (20%)
LRR_RI 357..594 CDD:238064 75/375 (20%)
LRR 13. /evidence=ECO:0000255 377..398 6/20 (30%)
LRR_8 378..438 CDD:290566 17/59 (29%)
leucine-rich repeat 378..403 CDD:275380 7/24 (29%)
LRR 14. /evidence=ECO:0000255 403..424 6/20 (30%)
leucine-rich repeat 404..427 CDD:275380 5/22 (23%)
LRR 15. /evidence=ECO:0000255 427..447 6/25 (24%)
leucine-rich repeat 428..463 CDD:275380 10/59 (17%)
LRR 16. /evidence=ECO:0000255 463..484 8/48 (17%)
leucine-rich repeat 464..486 CDD:275380 9/49 (18%)
LRR 17. /evidence=ECO:0000255 486..507 6/29 (21%)
leucine-rich repeat 487..512 CDD:275380 7/62 (11%)
LRR 18. /evidence=ECO:0000255 512..534 9/44 (20%)
LRR_8 513..570 CDD:290566 21/81 (26%)
leucine-rich repeat 513..537 CDD:275380 10/46 (22%)
LRR 19. /evidence=ECO:0000255 537..558 7/22 (32%)
leucine-rich repeat 538..559 CDD:275380 6/22 (27%)
LRR 20. /evidence=ECO:0000255 559..580 7/20 (35%)
LRR 21. /evidence=ECO:0000255 585..594 2/8 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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