DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tollo and 18w

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster


Alignment Length:1405 Identity:501/1405 - (35%)
Similarity:774/1405 - (55%) Gaps:151/1405 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLATTHMLYVL-IATCVIPIFGAALSKTVLYQAPDECRWSGGGEHDITLV---CHLRTINSELEN 61
            |.||:.::.:: :|.|::.:...|       .|..:|.|    ::.:|.:   |.:|.:.|. ..
  Fly     1 MPATSSIITIIAVAACLLLLVADA-------HAQQQCNW----QYGLTTMDIRCSVRALESG-TG 53

  Fly    62 TNFSVIQPQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQELRN 126
            |...:...:...||.|:|:..|...|.|:|..||.|.:|.:|.|:.|||..:...:|.||..|:.
  Fly    54 TPLDLQVAEAAGRLDLQCSQELLHASELAPGLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKR 118

  Fly   127 LTIRTHNGDWST-MSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQD 190
            ||:.:||..|.. .:||:...||...::|..|.|..|||..:|:|:.|.:.|||.||.:.|:|:.
  Fly   119 LTLESHNAVWGPGKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRS 183

  Fly   191 ISNFYFS------ASLSSRKARVC-GSTLQSLDLSANKMVSLPTAM-LSALGRLTHLNMAKNSMS 247
            .....||      ::||:....|. ||.||:||:|.|::.|||.|. .|.|.||..|::..|::|
  Fly   184 AEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNIS 248

  Fly   248 FLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLD 312
            .||..|..||.||||:::|.|.|.|||.|.||..|:|:|::|:.|.:..|..|:...|.:|||||
  Fly   249 TLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLD 313

  Fly   313 LASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFA 377
            |:.|:|.|..::.:||.||.||::|:||.|.::|:.:..|:.|..||||.:.:|.|..:..|.|.
  Fly   314 LSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFL 378

  Fly   378 DLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQA 442
            .|.|||||.|:.||:..::.|...||..|..|:|:.|.:|.::.::..|||.|::|.|:.|:|..
  Fly   379 PLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTE 443

  Fly   443 VPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLS 507
            ||||:..:.:|||||:|||.||:.:|.:...|..|.|||:.:|.:.:|..|:|..:..|.:|||:
  Fly   444 VPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLA 508

  Fly   508 QNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQW 572
            :|:::|||.|:..:|::::|||||.|.|..|.|:|..|.:|:|||:|.|.|..|||:.||..|:|
  Fly   509 KNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKW 573

  Fly   573 LDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFK 637
            ||:..|.|..||||::::.|:.::|.|||:|.:|||.|.|:|||:|:|::|:|.|.:||..||..
  Fly   574 LDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVD 638

  Fly   638 KPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNR-ESRTQPQ 701
            |..|.||||..|.|:.:..||||::|::.::.:||||:|.|.:||||:::|||::|. .:|..|.
  Fly   639 KTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPH 703

  Fly   702 LMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHD 766
            ::||..|.|.:.::|.:....|....:.||:|||.|||...||||:::.|:|::.||..|||:||
  Fly   704 VVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHD 768

  Fly   767 QSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLH 831
            .:|.:|:|||.|... ..||:.||.|.:.|||||||..||:.....||:.|:.|:||.|.:..|.
  Fly   769 ATWATNIVDCGRQDL-AALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQ 832

  Fly   832 NRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDH 896
            |.:...|:.|.||.|::|:|.||.|.||:.|..|:||||.:|.:..|...||..|..|::||||:
  Fly   833 NGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDN 897

  Fly   897 NAITSFAVWNFLPSYLNELRLASNPWTCSCEFIDKLRDYINRHEYVV-DKLKMKCDVISGNSTQQ 960
            |.::|.....:..| |..|.|..|.|:|.|:.:.:|..:::.:..|| |...:.| :.:|...:.
  Fly   898 NRLSSLPHLQYRHS-LQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYC-LDAGIKREL 960

  Fly   961 MVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVA 1025
            .:|    |..|:.|  .||..|.....|..:..:.|||..                   :|:|.|
  Fly   961 ELI----GNLANGP--DCSDLLDASASNISSSQDLAGGYR-------------------LPLLAA 1000

  Fly  1026 ILTAFIFVMICISLVFIFRQEMRVWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFV 1090
            :| ..||:::.:.:||:||:.:|:|..:.:|||:.....:|..     ||:||.:.:|.||..||
  Fly  1001 VL-VLIFLVVVLIIVFVFRESVRMWLFAHYGVRVCEPRFEDAG-----KLYDAIILHSEKDYEFV 1059

  Fly  1091 NEELAPMLEMGEHRYKLCLHQRDFPVGGYLPET----IVQAIDSSRRTIMVVSENFIKSEWCRFE 1151
            ...:|..||.|...::||:.|||.|     |:.    :|:...:||:.|:|::.|.:.:||.|.|
  Fly  1060 CRNIAAELEHGRPPFRLCIQQRDLP-----PQASHLQLVEGARASRKIILVLTRNLLATEWNRIE 1119

  Fly  1152 FKSAHQSVLRDRRRRLIVIVLGEVPQKELD-PDLRLYLKT--NTYLQWGDKLFWQKLRFALPDVS 1213
            |::|....||...::|::|....|..:..| .:|..|||:  :..|...|:.||:|||:|:| :.
  Fly  1120 FRNAFHESLRGLAQKLVIIEETSVSAEAEDVAELSPYLKSVPSNRLLTCDRYFWEKLRYAIP-IE 1183

  Fly  1214 SSQRSNVAGQSCHVPINHASYHHHHH--------VHQQAMPLP-------HSVHHHQQQFMLPPP 1263
            .|.|.|          |:...||...        :.:||.|.|       ...::.......|.|
  Fly  1184 LSPRGN----------NYTLDHHERFKQPVSPGMIFRQAPPPPAYYCTEEMEANYSSATTATPSP 1238

  Fly  1264 -PQQPGSF----------RRQPSLH-------------------------QQQQQQQQIRGNNNT 1292
             |.:||..          .|.||.|                         ..|.||||:|.:.  
  Fly  1239 RPTRPGGAARIVDSMPMPMRPPSEHIYHSIESEYSAYDQHEALSMIPTGLMHQHQQQQLRLHQ-- 1301

  Fly  1293 TQQQQQQQAALLMGGGSVGGPAPQMIPLAGGIQQQSLPLP 1332
             |||||||..||.             |....:.||::|.|
  Fly  1302 -QQQQQQQQRLLQ-------------PQFRAMPQQAIPAP 1327

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 83/204 (41%)
leucine-rich repeat 100..123 CDD:275380 9/22 (41%)
leucine-rich repeat 124..144 CDD:275380 8/20 (40%)
LRR_8 152..222 CDD:290566 29/76 (38%)
leucine-rich repeat 154..177 CDD:275380 9/22 (41%)
leucine-rich repeat 178..201 CDD:275380 8/28 (29%)
LRR 210..656 CDD:227223 197/446 (44%)
leucine-rich repeat 212..235 CDD:275380 12/23 (52%)
leucine-rich repeat 236..259 CDD:275380 9/22 (41%)
leucine-rich repeat 260..283 CDD:275380 12/22 (55%)
LRR_RI 276..558 CDD:238064 117/281 (42%)
leucine-rich repeat 284..307 CDD:275380 7/22 (32%)
leucine-rich repeat 308..333 CDD:275380 13/24 (54%)
leucine-rich repeat 334..357 CDD:275380 8/22 (36%)
leucine-rich repeat 358..381 CDD:275380 9/22 (41%)
leucine-rich repeat 382..405 CDD:275380 10/22 (45%)
leucine-rich repeat 406..429 CDD:275380 7/22 (32%)
leucine-rich repeat 430..452 CDD:275380 9/21 (43%)
leucine-rich repeat 453..500 CDD:275380 20/46 (43%)
leucine-rich repeat 501..521 CDD:275380 9/19 (47%)
leucine-rich repeat 525..547 CDD:275380 11/21 (52%)
leucine-rich repeat 548..573 CDD:275380 13/24 (54%)
leucine-rich repeat 604..640 CDD:275380 18/35 (51%)
leucine-rich repeat 641..688 CDD:275380 22/46 (48%)
leucine-rich repeat 689..816 CDD:275380 54/127 (43%)
LRR_8 815..875 CDD:290566 26/59 (44%)
leucine-rich repeat 817..864 CDD:275380 20/46 (43%)
LRR_8 864..921 CDD:290566 21/56 (38%)
leucine-rich repeat 865..888 CDD:275380 10/22 (45%)
leucine-rich repeat 889..910 CDD:275380 7/20 (35%)
TIR 1076..1211 CDD:214587 48/141 (34%)
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 11/24 (46%)
leucine-rich repeat 92..115 CDD:275380 9/22 (41%)
LRR_8 115..181 CDD:290566 25/65 (38%)
leucine-rich repeat 116..146 CDD:275380 10/29 (34%)
leucine-rich repeat 147..170 CDD:275380 9/22 (41%)
leucine-rich repeat 171..201 CDD:275380 9/29 (31%)
LRR_RI 210..464 CDD:238064 111/253 (44%)
leucine-rich repeat 212..236 CDD:275380 12/23 (52%)
LRR_8 235..295 CDD:290566 28/59 (47%)
leucine-rich repeat 237..260 CDD:275380 9/22 (41%)
leucine-rich repeat 261..284 CDD:275380 12/22 (55%)
LRR_8 283..345 CDD:290566 27/61 (44%)
leucine-rich repeat 285..308 CDD:275380 7/22 (32%)
leucine-rich repeat 309..334 CDD:275380 13/24 (54%)
LRR_8 334..393 CDD:290566 25/58 (43%)
leucine-rich repeat 335..358 CDD:275380 8/22 (36%)
leucine-rich repeat 359..382 CDD:275380 9/22 (41%)
LRR_8 382..441 CDD:290566 23/58 (40%)
leucine-rich repeat 383..406 CDD:275380 10/22 (45%)
leucine-rich repeat 407..430 CDD:275380 7/22 (32%)
LRR_8 431..488 CDD:290566 26/56 (46%)
leucine-rich repeat 431..451 CDD:275380 9/19 (47%)
leucine-rich repeat 454..477 CDD:275380 12/22 (55%)
LRR_8 477..559 CDD:290566 35/81 (43%)
leucine-rich repeat 478..499 CDD:275380 8/20 (40%)
leucine-rich repeat 502..525 CDD:275380 10/22 (45%)
leucine-rich repeat 526..548 CDD:275380 11/21 (52%)
leucine-rich repeat 590..617 CDD:275380 12/26 (46%)
leucine-rich repeat 618..641 CDD:275380 10/22 (45%)
leucine-rich repeat 642..689 CDD:275380 22/46 (48%)
LRRCT 679..736 CDD:214507 19/56 (34%)
leucine-rich repeat 775..796 CDD:275380 9/21 (43%)
LRR_8 797..852 CDD:290566 24/54 (44%)
leucine-rich repeat 797..817 CDD:275380 11/19 (58%)
leucine-rich repeat 818..841 CDD:275380 8/22 (36%)
LRR_8 841..900 CDD:290566 28/58 (48%)
leucine-rich repeat 842..865 CDD:275380 12/22 (55%)
LRR_4 866..907 CDD:289563 17/40 (43%)
leucine-rich repeat 866..889 CDD:275380 10/22 (45%)
leucine-rich repeat 890..911 CDD:275380 7/20 (35%)
TIR 1045..1183 CDD:214587 49/143 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453662
Domainoid 1 1.000 44 1.000 Domainoid score I4673
eggNOG 1 0.900 - - E2759_KOG4641
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 219 1.000 Inparanoid score I3549
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D12592at6656
OrthoFinder 1 1.000 - - FOG0006722
OrthoInspector 1 1.000 - - otm24216
orthoMCL 1 0.900 - - OOG6_104126
Panther 1 1.100 - - P PTHR45617
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
1110.800

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