DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tollo and Tlr3

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_942086.2 Gene:Tlr3 / 364594 RGDID:735171 Length:905 Species:Rattus norvegicus


Alignment Length:1087 Identity:257/1087 - (23%)
Similarity:401/1087 - (36%) Gaps:277/1087 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   210 STLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLP 274
            |.:..|:|:.|::..||.|..:...:|..|:...||:|.|.....:.|..|:|::|..|.|:.:.
  Rat    52 SNITVLNLTHNQLRGLPPANFTRYSQLALLDAGFNSISKLEPELCQILPLLKVLNLQHNELSQIS 116

  Fly   275 PELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDL 339
            .:.||....|.|::|.:|||..:....|.....|:.|||:.|.|:|  ....|.|.|:.|..|.|
  Rat   117 DQTFAFCTNLTELHLMSNSIRKIKSNPFKNQKSLIKLDLSRNGLSS--TKLGTGVQLENLQELLL 179

  Fly   340 SANKI--SRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISV-IEQRTLQ 401
            :.|||  .|.|...|...:|||.|.|..|.:.:...|.|..:..|..|:|:..:::: :.::...
  Rat   180 AKNKIFALRSEELDFLGNSSLQKLDLSSNPLKEFSPGCFHAIGKLFVLLLNNAQLNLNLTEKLCW 244

  Fly   402 GLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQI 466
            .|.|                      :.:|:|.|.:|            |||.|   ..:..|.:
  Rat   245 ELSN----------------------TSIQNLSLANN------------QLLAT---SNSTFSGL 272

  Fly   467 ENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLD 531
            :.|::|.|:..|      |||.::....|..:..|:.|:|..|.::|:...|.:..|.|:.:.|.
  Rat   273 KQTNLTSLDLSY------NSLRYVGNDAFSWLPHLKYLSLEYNNIQSLTPHSFRGLSNLRYLSLK 331

  Fly   532 GNQLKSIAGLFTELPNL-----VWLNISGNRLE--KFDYSHIPIGLQWLDVRANRITQLGNYFEI 589
            ....|....|.:. ||:     .||..    ||  ..|.:.||      .:::|..|.|.:.   
  Rat   332 RAFTKQSVALASH-PNIDDFSFQWLKC----LEHLNMDDNTIP------GIKSNTFTGLVSL--- 382

  Fly   590 ESELSLS-TFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDL----VRN 649
             ..|||| ||.....|..|...|...:.:..|.|..|.||||...||.....|..:||    :..
  Rat   383 -KYLSLSKTFTGLQTLTNETFVSLTHSPLLTLNLTKNHISKIASGTFSWLGQLRILDLGLNEIEQ 446

  Fly   650 RLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAY 714
            .||..|...|        ..|.|.|:.:|.|        ||..::.....|.|.       ||..
  Rat   447 ELTGQEWRGL--------GNIFEIYLSYNKY--------LQLTSKSFTLVPSLQ-------RLML 488

  Fly   715 ARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRA 779
            .|       :..||                                             ||.|.:
  Rat   489 RR-------VALKS---------------------------------------------VDISPS 501

  Fly   780 SYEQTLPSHIPM-DSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRT--------F 835
            .:.       |: :.|.|.|..||...|......|.:.|::|...|:.:..|....        .
  Rat   502 PFR-------PLYNLTILDLSNNNIANLNEDLLEGLENLEILDFQHNNLARLWKHANPGGPVNFL 559

  Fly   836 YGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAIT 900
            .||..|.:|.|:||.|..:....|:.|..|:.:.|..|.:.|:....|.....|:.|.|..|.||
  Rat   560 KGLSHLHILNLESNGLDEIPVKVFKNLFELKSINLGLNNLNTLLPSIFDDQTSLRSLNLQKNLIT 624

  Fly   901 SFAVWNFLPSY--LNELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMK--CDVISGNSTQQM 961
            |.....|.|::  ||.|.::.||:.|:||.|.....::|:....:.:|...  |     |:.|: 
  Rat   625 SVEKSVFGPAFHNLNSLDMSFNPFDCTCESIAWFVTWLNQTHTNIPELSTHYLC-----NTPQR- 683

  Fly   962 VIYPGSGEPASLPV-----VQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIP 1021
              |.|      |||     ..|..:.|..|                     ..|:|         
  Rat   684 --YHG------LPVKLFDTSSCKDSAPFQL---------------------LFIIN--------- 710

  Fly  1022 ILVAILTAFIFVMICISLVFIFRQEMRVWCHSRFGVRLFYNAQ-------KDVDKNEREKLFDAF 1079
              .:.|..||..::.|        ....|     .:..::|..       |::|....:..:.|:
  Rat   711 --TSTLLTFILAVLLI--------HFEGW-----RISFYWNVSVHRILGFKEIDAQGEQFEYTAY 760

  Fly  1080 VSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIK 1144
            :.::.||..:|.|..:||.|. :...|.||.:|||..|....|.||.:|..||:.|.|::.:.:|
  Rat   761 IIHAQKDRDWVWEHFSPMEEQ-DQSLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITHHLLK 824

  Fly  1145 SEWC-RFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDPDL---RLYLKTNTYLQWGDKLFWQKL 1205
            ...| ||:...|.|..:......:|:|.|..:|..:|:..|   |...|::..|.|         
  Rat   825 DPLCRRFKVHHAVQQAIEQNLDSIILIFLQNIPDYKLNHALCLRRGMFKSHCILNW--------- 880

  Fly  1206 RFALPDVSSSQRSNVAGQSCHVPINHASYHHHHHVHQQAMPLPHSVH 1252
                                  ||.....:..||..|.|:...:|.|
  Rat   881 ----------------------PIQKERINAFHHKLQVALGSRNSAH 905

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 21/70 (30%)
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380
LRR_8 152..222 CDD:290566 4/11 (36%)
leucine-rich repeat 154..177 CDD:275380
leucine-rich repeat 178..201 CDD:275380
LRR 210..656 CDD:227223 123/460 (27%)
leucine-rich repeat 212..235 CDD:275380 6/22 (27%)
leucine-rich repeat 236..259 CDD:275380 7/22 (32%)
leucine-rich repeat 260..283 CDD:275380 7/22 (32%)
LRR_RI 276..558 CDD:238064 73/289 (25%)
leucine-rich repeat 284..307 CDD:275380 7/22 (32%)
leucine-rich repeat 308..333 CDD:275380 10/24 (42%)
leucine-rich repeat 334..357 CDD:275380 9/24 (38%)
leucine-rich repeat 358..381 CDD:275380 7/22 (32%)
leucine-rich repeat 382..405 CDD:275380 4/23 (17%)
leucine-rich repeat 406..429 CDD:275380 0/22 (0%)
leucine-rich repeat 430..452 CDD:275380 4/21 (19%)
leucine-rich repeat 453..500 CDD:275380 11/46 (24%)
leucine-rich repeat 501..521 CDD:275380 6/19 (32%)
leucine-rich repeat 525..547 CDD:275380 4/21 (19%)
leucine-rich repeat 548..573 CDD:275380 7/31 (23%)
leucine-rich repeat 604..640 CDD:275380 12/35 (34%)
leucine-rich repeat 641..688 CDD:275380 12/50 (24%)
leucine-rich repeat 689..816 CDD:275380 20/127 (16%)
LRR_8 815..875 CDD:290566 17/67 (25%)
leucine-rich repeat 817..864 CDD:275380 14/54 (26%)
LRR_8 864..921 CDD:290566 17/58 (29%)
leucine-rich repeat 865..888 CDD:275380 5/22 (23%)
leucine-rich repeat 889..910 CDD:275380 8/20 (40%)
TIR 1076..1211 CDD:214587 39/138 (28%)