DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tollo and rdo

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_001286024.1 Gene:rdo / 35077 FlyBaseID:FBgn0243486 Length:757 Species:Drosophila melanogaster


Alignment Length:622 Identity:151/622 - (24%)
Similarity:252/622 - (40%) Gaps:137/622 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 YVLIATCVIPIFGAALSKTVLYQAPDECRWSGGGEHDITLVCHLRTINSELE----NTNFSVI-- 67
            ::|.:.|::|    |:......:.|.||:.|.........:|....:||.|.    :.:..||  
  Fly     5 WLLFSLCIMP----AMFSNTKRKCPTECQCSMDDLDRYQAICTKGGLNSLLSPNELDVDVKVIII 65

  Fly    68 -QPQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQELRNLTIRT 131
             .|:|::              ::.| :.|..::|..|.|....|..:...||.||:.||      
  Fly    66 RGPRNSI--------------TIGP-ALRQFMKLEILRITDSNLPAIGAESFWGLKYLR------ 109

  Fly   132 HNGDWSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYF 196
                                    .||||.|||                .|.:.|..:...|   
  Fly   110 ------------------------ILDLSKNNI----------------TNITENNFRGQDN--- 131

  Fly   197 SASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLR 261
                           |..||||.||::.:.::....|..|..||:|.||:..|..|.|..|..|:
  Fly   132 ---------------LLELDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLK 181

  Fly   262 VVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAA 326
            .:|||.|.|..|.|::|.:..:|:.:..||..:..:.|.::..|..|..|||..||.  ::::..
  Fly   182 YLDLSGNPLQDLQPDVFRDVPELKVLKCRNCQLKKINPQMYNLLPLLSELDLGRNEF--KFLDKD 244

  Fly   327 TFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNR 391
            .|..:|||..:.|..|::|.:...:||...||..|.|..|.:.::|...|..||||..|.||.|:
  Fly   245 EFRDVKRLTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNK 309

  Fly   392 ISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSL------------VNCSQLQDLHLNDNKLQAVP 444
            :..:|.::::.|.|||.|::..|.:  ||.|.:            :.||:|        ..|.:|
  Fly   310 LVRLEPQSIRSLSNLLTLNISGNVL--MDLREMRETFEPLIYYFFLTCSKL--------FFQLIP 364

  Fly   445 EALAHVQL--LKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLS 507
            : |.|:.:  :.|:.||          .:...:.|..|.::.|||.:....|.|....|:.|:||
  Fly   365 Q-LTHLAIADMGTMPVG----------LLHPFKQLRYLNISGNSLNNTALEVIDPCRELEFLDLS 418

  Fly   508 QNKLKSIEAGSLQRNSQLQAIRLDGNQL----KSIAGLFTELPNLVWLNISGNRLEKFDYSHIPI 568
            :|:|..|...::.|...::.:|||.|.|    ..:..|...:..|.|      :.:.:....:|.
  Fly   419 RNQLHGISEDTVLRIQGIRNVRLDNNPLICDECHMGKLINVVRQLQW------KWDTYPICFLPK 477

  Fly   569 GLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLL 605
            .|:..::....|..|.......::...:....|||.|
  Fly   478 SLRGAEINNLDINGLHTCLTFITDEEQNAASTSYNFL 514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 49/195 (25%)
leucine-rich repeat 100..123 CDD:275380 8/22 (36%)
leucine-rich repeat 124..144 CDD:275380 2/19 (11%)
LRR_8 152..222 CDD:290566 16/69 (23%)
leucine-rich repeat 154..177 CDD:275380 7/22 (32%)
leucine-rich repeat 178..201 CDD:275380 3/22 (14%)
LRR 210..656 CDD:227223 113/414 (27%)
leucine-rich repeat 212..235 CDD:275380 8/22 (36%)
leucine-rich repeat 236..259 CDD:275380 10/22 (45%)
leucine-rich repeat 260..283 CDD:275380 9/22 (41%)
LRR_RI 276..558 CDD:238064 79/299 (26%)
leucine-rich repeat 284..307 CDD:275380 5/22 (23%)
leucine-rich repeat 308..333 CDD:275380 7/24 (29%)
leucine-rich repeat 334..357 CDD:275380 6/22 (27%)
leucine-rich repeat 358..381 CDD:275380 7/22 (32%)
leucine-rich repeat 382..405 CDD:275380 7/22 (32%)
leucine-rich repeat 406..429 CDD:275380 8/34 (24%)
leucine-rich repeat 430..452 CDD:275380 5/21 (24%)
leucine-rich repeat 453..500 CDD:275380 10/46 (22%)
leucine-rich repeat 501..521 CDD:275380 7/19 (37%)
leucine-rich repeat 525..547 CDD:275380 6/25 (24%)
leucine-rich repeat 548..573 CDD:275380 4/24 (17%)
leucine-rich repeat 604..640 CDD:275380 1/2 (50%)
leucine-rich repeat 641..688 CDD:275380
leucine-rich repeat 689..816 CDD:275380
LRR_8 815..875 CDD:290566
leucine-rich repeat 817..864 CDD:275380
LRR_8 864..921 CDD:290566
leucine-rich repeat 865..888 CDD:275380
leucine-rich repeat 889..910 CDD:275380
TIR 1076..1211 CDD:214587
rdoNP_001286024.1 leucine-rich repeat 84..107 CDD:275380 8/22 (36%)
leucine-rich repeat 108..131 CDD:275380 11/68 (16%)
LRR_8 131..190 CDD:290566 24/76 (32%)
leucine-rich repeat 132..155 CDD:275380 8/22 (36%)
LRR_RI 151..422 CDD:238064 87/293 (30%)
leucine-rich repeat 156..179 CDD:275380 10/22 (45%)
LRR_8 178..262 CDD:290566 26/85 (31%)
leucine-rich repeat 180..203 CDD:275380 9/22 (41%)
leucine-rich repeat 204..251 CDD:275380 12/48 (25%)
leucine-rich repeat 252..275 CDD:275380 6/22 (27%)
LRR_8 274..334 CDD:290566 22/59 (37%)
leucine-rich repeat 276..299 CDD:275380 7/22 (32%)
LRR_4 298..342 CDD:289563 17/45 (38%)
leucine-rich repeat 300..323 CDD:275380 7/22 (32%)
leucine-rich repeat 388..411 CDD:275380 7/22 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453667
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.740

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