DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tollo and CG4168

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_001285953.1 Gene:CG4168 / 34889 FlyBaseID:FBgn0028888 Length:1330 Species:Drosophila melanogaster


Alignment Length:1046 Identity:246/1046 - (23%)
Similarity:400/1046 - (38%) Gaps:293/1046 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LYVLIATCVIPIFGAALSKTVLYQAPDEC-RWSGGGEH--------------------------- 44
            ||:::.:|::              :...| ::.|||.|                           
  Fly     3 LYLVLISCLV--------------SSSHCWQFDGGGGHRRPRNSGRGPPSSSGGRGSAALLGSQQ 53

  Fly    45 -DITLVCHLRTI--NSELENTNFSVIQPQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIE 106
             ||...|.|.::  .:.|.|...::|:        :.||:...::   .|:...|.|  |.:.:.
  Fly    54 QDILYACPLNSMCQCAGLPNETSTLIE--------INCNEVALYK---FPEFMHSSV--RYIEMS 105

  Fly   107 YCKLGNLTDGSFRGLQ---------ELRNLTIRTHNGDWSTMSLEMASNSFVEFRQLERLDLSLN 162
            ...|.::.|.:|:||:         ||::::.|:    :|||:           ..|..||:|.|
  Fly   106 NTHLQSVDDETFQGLRLKTLKLIDNELQDISERS----FSTMT-----------HSLMTLDISGN 155

  Fly   163 NIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMV---- 223
            .:..:|...:..|.||..|.|..|.|..:...:.:..          .||:||.||.|.:.    
  Fly   156 KMQHLPLDALQRLHSLSRLVAQRNHITTLDGNWDAQH----------DTLRSLHLSDNDITEVAP 210

  Fly   224 --------------SLPTAMLSALGRLTHLNMAKNSMSFLADRA-----FEGLLSLRVVDLSANR 269
                          |.|:::.:...||...|..........||.     ||.|..|..:|||.||
  Fly   211 GGGSIEVVSQNDNSSQPSSLAAVQTRLETSNSIYPPSPSSGDRTTGGRPFEQLQKLLWLDLSNNR 275

  Fly   270 L-----TSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNS-QWINAATF 328
            :     ..||       :.|..:.|.:|.:.|....:|.:|.||.::.|..|.:.| ||......
  Fly   276 IYHVAGNYLP-------RSLVTMDLSSNLLTVFPQQLFEQLPELRIVSLRDNLIRSVQWKELQVR 333

  Fly   329 VGLKRLMMLDLSANKISRLEAHIFRPLAS---LQILKLEDNYIDQLPGGIFADLTNLHTLILSRN 390
            .....|..|||..|.|..||:..|:...|   |:.|.||.|::.|||..:| ..|.:..|:|:.|
  Fly   334 PLRMHLERLDLGQNCIENLESDYFQQNYSDVHLRALNLEQNFVTQLPEAVF-KATGIAHLVLAFN 397

  Fly   391 RISVIEQRTLQGL-----------------------------------------------KNLLV 408
            .||.:.....:||                                               :||.|
  Fly   398 AISRVHPSAFEGLTETLEYLDLERNRLTTVPVALSSLHHLKYLYLTSNQISQLNNLPSFTENLRV 462

  Fly   409 LSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQL----LKTLDVGENMISQIENT 469
            |||..|..|.:....|.|.:||..|::..|.:..:||.:..|..    |:|:.:..|.|:.:...
  Fly   463 LSLSGNNFSMIPVLGLKNYTQLSYLNMGYNSITDIPEGIFAVDSWGSNLQTILLRNNKITHLHLG 527

  Fly   470 SITQLESLYGLRMTENSLTHIRRGVFDRMS-SLQILNLS-----QNKLKSIE-AGSLQRNSQLQA 527
            |...||.:..:.::.|.:|.....||:.:| :|:||.||     ...|:|:: ..:|...|||..
  Fly   528 SFAGLEQIQEISLSFNDITIHHPLVFENVSRTLKILELSFAVFPARSLESLDPLDALLPLSQLIW 592

  Fly   528 IRLDGNQLKSIAG-LFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIES 591
            :.||.|.||.::. .|.::..|.::|:|.|:|:.     :|.||                |:.::
  Fly   593 LGLDNNNLKQVSNESFAQMRELSYINLSFNQLKT-----LPRGL----------------FQSDA 636

  Fly   592 ELSLSTFDASYNLLTEITASSIPN--SVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTL 654
            ...|...|.|||.|..:.|.:..:  .::.|.|..|::..|..:.|.....|..:||..|||.. 
  Fly   637 HSHLVEIDLSYNGLERLEAQTFHSLGDLQTLNLQSNRLRTIARHAFHNLEFLRYLDLSYNRLVN- 700

  Fly   655 EPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSS 719
                                |.|.|:                ...|.|..||.:|.:|.      
  Fly   701 --------------------ISHGAF----------------TVLPNLAALDLMHNQLC------ 723

  Fly   720 HVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQT 784
               .:..||  ||  |.|:                ...|.|.:..|:..          ||:...
  Fly   724 ---SLSLKS--FL--YVSN----------------TTTPLRLNVSHNHI----------ASFYDE 755

  Fly   785 LPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSN 849
            |.|:  |...||.:..|:..:..|...:. ..|:.|:|.|:::..|.:..|..|..||:|.:..|
  Fly   756 LSSY--MYIYQLDISHNHVTKSDSFTNLA-NTLRFLNLAHNQLGSLQSHAFGDLEFLEILNVAHN 817

  Fly   850 QLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLPSYLNE 914
            .|.:|....||||::||||.|.||.:..:....|::|..|:|||::.|.:.:.....|:.:.|..
  Fly   818 NLTSLRRRSFQGLNSLQELDLSHNQLDQLQVEQFSNLRKLRILRINSNRLRALPREVFMNTRLEF 882

  Fly   915 LRLASN 920
            |.:|.|
  Fly   883 LDIAEN 888

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 53/232 (23%)
leucine-rich repeat 100..123 CDD:275380 6/31 (19%)
leucine-rich repeat 124..144 CDD:275380 5/19 (26%)
LRR_8 152..222 CDD:290566 20/69 (29%)
leucine-rich repeat 154..177 CDD:275380 7/22 (32%)
leucine-rich repeat 178..201 CDD:275380 5/22 (23%)
LRR 210..656 CDD:227223 138/538 (26%)
leucine-rich repeat 212..235 CDD:275380 8/40 (20%)
leucine-rich repeat 236..259 CDD:275380 7/27 (26%)
leucine-rich repeat 260..283 CDD:275380 8/27 (30%)
LRR_RI 276..558 CDD:238064 90/344 (26%)
leucine-rich repeat 284..307 CDD:275380 6/22 (27%)
leucine-rich repeat 308..333 CDD:275380 6/25 (24%)
leucine-rich repeat 334..357 CDD:275380 9/22 (41%)
leucine-rich repeat 358..381 CDD:275380 9/22 (41%)
leucine-rich repeat 382..405 CDD:275380 7/69 (10%)
leucine-rich repeat 406..429 CDD:275380 9/22 (41%)
leucine-rich repeat 430..452 CDD:275380 6/21 (29%)
leucine-rich repeat 453..500 CDD:275380 12/47 (26%)
leucine-rich repeat 501..521 CDD:275380 8/25 (32%)
leucine-rich repeat 525..547 CDD:275380 7/22 (32%)
leucine-rich repeat 548..573 CDD:275380 8/24 (33%)
leucine-rich repeat 604..640 CDD:275380 7/37 (19%)
leucine-rich repeat 641..688 CDD:275380 9/46 (20%)
leucine-rich repeat 689..816 CDD:275380 24/126 (19%)
LRR_8 815..875 CDD:290566 24/59 (41%)
leucine-rich repeat 817..864 CDD:275380 17/46 (37%)
LRR_8 864..921 CDD:290566 19/57 (33%)
leucine-rich repeat 865..888 CDD:275380 9/22 (41%)
leucine-rich repeat 889..910 CDD:275380 6/20 (30%)
TIR 1076..1211 CDD:214587
CG4168NP_001285953.1 leucine-rich repeat 99..118 CDD:275380 4/20 (20%)
LRR_8 121..181 CDD:290566 18/74 (24%)
LRR_RI 122..350 CDD:238064 62/259 (24%)
leucine-rich repeat 122..146 CDD:275380 6/38 (16%)
leucine-rich repeat 147..170 CDD:275380 7/22 (32%)
leucine-rich repeat 171..194 CDD:275380 5/32 (16%)
leucine-rich repeat 195..214 CDD:275380 6/18 (33%)
leucine-rich repeat 215..236 CDD:275380 2/20 (10%)
LRR_8 265..322 CDD:290566 18/63 (29%)
leucine-rich repeat 266..287 CDD:275380 8/27 (30%)
leucine-rich repeat 288..311 CDD:275380 6/22 (27%)
leucine-rich repeat 312..338 CDD:275380 6/25 (24%)
LRR_RI 315..546 CDD:238064 57/231 (25%)
leucine-rich repeat 339..365 CDD:275380 10/25 (40%)
LRR_8 365..424 CDD:290566 17/59 (29%)
leucine-rich repeat 366..388 CDD:275380 9/22 (41%)
leucine-rich repeat 389..412 CDD:275380 7/22 (32%)
LRR_8 413..470 CDD:290566 7/56 (13%)
leucine-rich repeat 414..436 CDD:275380 0/21 (0%)
leucine-rich repeat 437..459 CDD:275380 0/21 (0%)
leucine-rich repeat 460..483 CDD:275380 9/22 (41%)
LRR_8 482..545 CDD:290566 15/62 (24%)
leucine-rich repeat 484..510 CDD:275380 6/25 (24%)
leucine-rich repeat 511..534 CDD:275380 6/22 (27%)
leucine-rich repeat 535..589 CDD:275380 13/53 (25%)
LRR_RI 588..891 CDD:238064 99/401 (25%)
LRR_8 588..650 CDD:290566 23/82 (28%)
leucine-rich repeat 590..613 CDD:275380 7/22 (32%)
leucine-rich repeat 614..639 CDD:275380 9/45 (20%)
LRR_8 638..698 CDD:290566 16/59 (27%)
leucine-rich repeat 640..663 CDD:275380 7/22 (32%)
leucine-rich repeat 664..687 CDD:275380 5/22 (23%)
LRR_8 688..749 CDD:290566 24/126 (19%)
leucine-rich repeat 688..711 CDD:275380 9/59 (15%)
leucine-rich repeat 712..735 CDD:275380 10/35 (29%)
leucine-rich repeat 740..783 CDD:275380 11/55 (20%)
LRR_8 784..843 CDD:290566 24/58 (41%)
leucine-rich repeat 785..808 CDD:275380 7/22 (32%)
leucine-rich repeat 809..832 CDD:275380 10/22 (45%)
LRR_RI <827..1053 CDD:238064 23/62 (37%)
LRR_8 832..890 CDD:290566 19/57 (33%)
leucine-rich repeat 833..856 CDD:275380 9/22 (41%)
leucine-rich repeat 857..879 CDD:275380 6/21 (29%)
leucine-rich repeat 880..900 CDD:275380 4/9 (44%)
LRR_8 904..963 CDD:290566
leucine-rich repeat 905..928 CDD:275380
leucine-rich repeat 929..952 CDD:275380
leucine-rich repeat 953..977 CDD:275380
leucine-rich repeat 978..1020 CDD:275380
LRR_8 1019..1074 CDD:290566
leucine-rich repeat 1045..1068 CDD:275380
leucine-rich repeat 1069..1090 CDD:275380
leucine-rich repeat 1091..1114 CDD:275380
leucine-rich repeat 1115..1161 CDD:275380
leucine-rich repeat 1162..1190 CDD:275380
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453612
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR45617
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.940

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