DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tollo and Toll-4

DIOPT Version :10

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster


Alignment Length:1264 Identity:270/1264 - (21%)
Similarity:454/1264 - (35%) Gaps:463/1264 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 TINSELENTNFSVIQPQNTVRLRLECNDALFFQSSLSPDS--FRSLVELRDLTIEYCKLGNLTDG 116
            |:||.:.| |:......||.::::..::. |.:::|:.:.  |....::..|.....|:..||:.
  Fly   218 TVNSVITN-NYIRKTMNNTEKIKIYYHNT-FEKTTLTMEKNIFHGKNKMSALIFNGLKIKGLTNN 280

  Fly   117 SFRGLQELRNLT-----------IRTHNGDWSTMSLEMA-----------SNSFVEFRQLERLDL 159
            :|..|..|..|.           :|:     ||:...:.           ..||.:|..||.:::
  Fly   281 TFENLTSLNTLIFDNVFLKDLSFLRS-----STLQSSLTYCIMKVDNMVDLKSFEKFTNLEIIEV 340

  Fly   160 S-------------------------LNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSAS 199
            |                         :|.:       .||||    .|.|||:  |.|..     
  Fly   341 SQYKGFKNFTAFICEPYKSHCKFTLGINEV-------ACPLK----CNCSYNR--DKSQL----- 387

  Fly   200 LSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVD 264
                          .:|.....:.::|:..:...|. :.|....|.::.|.|.:.||..:|:.:|
  Fly   388 --------------EIDCWQKNLTTIPSLPVPKKGS-SALVFQSNLLAELPDNSLEGYHNLKSLD 437

  Fly   265 LSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFV 329
            :|.|:||||......|:  |..:.:|:|.|..|:|    ::.|.|......|:..::|   :.:.
  Fly   438 VSYNQLTSLSVSQLPES--LHYLDIRHNKITTLSP----QVVEYLYSVNVFNQYGNKW---SIYC 493

  Fly   330 GLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFAD---LTNLHTLILSRNR 391
            ....|........|:.|::...|:.:.         .||:....|.|.:   :.|:..|.|..|.
  Fly   494 DEYHLQEFFWYKAKLLRIKTSKFQTIM---------EYIELSSKGSFVENFFVQNIDQLYLEANE 549

  Fly   392 ISVIEQ----------RTLQGLKNLL-VLSLDFNRISRMDQRS-----------------LVNCS 428
            ..:|:.          :.::.|.:.: :.|.:|:.|......|                 |:||.
  Fly   550 DEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCR 614

  Fly   429 QLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRG 493
            .|        .|...|.....:....||.:..|.|.::.||     |||                
  Fly   615 NL--------SLDIYPRLPNSIPYKTTLYLDRNEIRKLTNT-----ESL---------------- 650

  Fly   494 VFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRL 558
            |....:|:..|::|||.|:                               |||    |::     
  Fly   651 VVAGHASIHKLHMSQNLLR-------------------------------ELP----LHL----- 675

  Fly   559 EKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLN 623
                   :|..:.:||||.|.:.                                       ||:
  Fly   676 -------LPENITYLDVRNNLLK---------------------------------------YLD 694

  Fly   624 DNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCN--- 685
            |..|:.::     .:.|:|:::|                             ..|.:||:|.   
  Fly   695 DGVIAFLE-----YRENITKIEL-----------------------------SGNPWECNCKAKA 725

  Fly   686 -LDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQ 749
             |.:|:      |.:|  |:.:.:..|:..             :||                   
  Fly   726 FLSFLR------RHEP--MEYETVLRRVEI-------------TDD------------------- 750

  Fly   750 ACDCKMECPDRCSCYHDQSWTSN------VVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQS 808
                  :||:.|.|..|   |||      |||||....     |.||...|..|           
  Fly   751 ------KCPEDCICCVD---TSNSDSLAYVVDCSGKEL-----SEIPQLPTPTY----------- 790

  Fly   809 HAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHN 873
                |:                           ..|..:.|.||....:...|..::...||.||
  Fly   791 ----GQ---------------------------TTLVFERNSLKKWPSSLLPGYSSVTRFYLAHN 824

  Fly   874 AIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLPSYLN----ELRLASNPWTCSCEFIDKLRD 934
            .::.||.|. ..|.:|.|...:.:|:.. .|..||...:|    :|.|..|||||.||  ||  |
  Fly   825 RLSDIDQLP-DKLEYLDISNNNFSALDD-RVRGFLQKRMNSSQLQLSLFGNPWTCRCE--DK--D 883

  Fly   935 YINRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYAEQAGGE 999
            ::   .:|.::.|                     ..|:...:||..|                |.
  Fly   884 FL---VFVKEQAK---------------------NIANASAIQCIDT----------------GR 908

  Fly  1000 NASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISL---VFI-FRQEMRVWCHSRFGVRLF 1060
            :......|          |..|.::...|:....::.|:|   ||| |||.:.:|.:.. .:.|.
  Fly   909 SLIEVEET----------DICPSVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYEH-EICLS 962

  Fly  1061 YNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPETIV 1125
            ..|::::|:   :|.:|||:|::.|||..: ||....||.|.|:::||.:.||:.||..:|:.|.
  Fly   963 LAARRELDE---DKKYDAFLSFTHKDEDLI-EEFVDRLENGRHKFRLCFYLRDWLVGESIPDCIN 1023

  Fly  1126 QAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQ-KELDPDLRLYLK 1189
            |::..|||.|:::::||:||.|.|.||:.|..:..|||.:||||::..:|.. .:||.:||.|:.
  Fly  1024 QSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMV 1088

  Fly  1190 TNTYLQWGDKLFWQKLRFALPDVSSSQRS 1218
            .||||...:..||.||.:::|..|..:||
  Fly  1089 LNTYLDRNNPNFWNKLMYSMPHASHLKRS 1117

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR 54..400 CDD:443914 79/407 (19%)
leucine-rich repeat 100..123 CDD:275380 6/22 (27%)
leucine-rich repeat 124..144 CDD:275380 5/30 (17%)
leucine-rich repeat 154..177 CDD:275380 7/47 (15%)
leucine-rich repeat 178..201 CDD:275380 6/22 (27%)
leucine-rich repeat 212..235 CDD:275380 2/22 (9%)
leucine-rich repeat 236..259 CDD:275380 6/22 (27%)
LRR 239..634 CDD:443914 79/425 (19%)
leucine-rich repeat 260..283 CDD:275380 9/22 (41%)
leucine-rich repeat 284..307 CDD:275380 6/22 (27%)
leucine-rich repeat 308..333 CDD:275380 3/24 (13%)
leucine-rich repeat 334..357 CDD:275380 4/22 (18%)
leucine-rich repeat 358..381 CDD:275380 4/25 (16%)
leucine-rich repeat 382..405 CDD:275380 5/32 (16%)
leucine-rich repeat 406..429 CDD:275380 7/40 (18%)
leucine-rich repeat 430..452 CDD:275380 3/21 (14%)
leucine-rich repeat 453..500 CDD:275380 10/46 (22%)
leucine-rich repeat 501..521 CDD:275380 5/19 (26%)
leucine-rich repeat 525..547 CDD:275380 2/21 (10%)
leucine-rich repeat 548..573 CDD:275380 2/24 (8%)
leucine-rich repeat 604..640 CDD:275380 4/35 (11%)
LRR_8 616..>660 CDD:404697 7/43 (16%)
leucine-rich repeat 641..688 CDD:275380 7/50 (14%)
leucine-rich repeat 689..816 CDD:275380 26/132 (20%)
LRR <794..>920 CDD:443914 25/129 (19%)
leucine-rich repeat 817..864 CDD:275380 5/46 (11%)
leucine-rich repeat 865..888 CDD:275380 8/22 (36%)
leucine-rich repeat 889..910 CDD:275380 6/20 (30%)
TIR 1076..1211 CDD:214587 56/135 (41%)
Toll-4NP_523519.2 LRR 210..>470 CDD:443914 61/293 (21%)
leucine-rich repeat 264..287 CDD:275380 6/22 (27%)
leucine-rich repeat 288..308 CDD:275380 3/24 (13%)
leucine-rich repeat 309..334 CDD:275380 3/24 (13%)
leucine-rich repeat 335..386 CDD:275380 13/63 (21%)
PRK15370 <381..>482 CDD:185268 29/128 (23%)
leucine-rich repeat 388..408 CDD:275380 2/19 (11%)
leucine-rich repeat 412..432 CDD:275378 6/19 (32%)
LRR <416..591 CDD:443914 41/192 (21%)
leucine-rich repeat 433..454 CDD:275378 8/20 (40%)
leucine-rich repeat 455..478 CDD:275378 8/26 (31%)
leucine-rich repeat 479..490 CDD:275378 2/13 (15%)
leucine-rich repeat 632..657 CDD:275378 10/45 (22%)
leucine-rich repeat 658..679 CDD:275378 10/67 (15%)
leucine-rich repeat 680..706 CDD:275378 9/69 (13%)
PCC 684..>771 CDD:188093 31/208 (15%)
leucine-rich repeat 707..719 CDD:275378 3/40 (8%)
leucine-rich repeat 771..791 CDD:275380 10/39 (26%)
PRK15370 <793..>877 CDD:185268 25/85 (29%)
leucine-rich repeat 793..815 CDD:275378 5/21 (24%)
leucine-rich repeat 816..835 CDD:275378 7/19 (37%)
leucine-rich repeat 836..859 CDD:275378 7/23 (30%)
TIR 974..1110 CDD:214587 56/136 (41%)

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