Protein Alignment Tollo and Toll-9

DIOPT Version :10

• Sequence 1: NP_524757.1
• Gene: Tollo / 44497
• FlyBaseID: FBgn0029114
• Length: 1346
• Species: Drosophila melanogaster
• Sequence 2: XP_565221.3
• Gene: Toll-9 / 3290281
• VectorBaseID: AGAMI1_015050
• Length: 817
• Species: Anopheles gambiae
• Alignment Length: 864
• Identity: 203/864 - (23%)
• Similarity: 336/864 - (38%)
• Gaps: 248/864 - (28%)

  Fly   430 LQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQI-ENTSIT-----QLESLYGLRMTENSLT 488
            |...|...:..|..||.|        |....|.:..: |:..:|     ....|..||::::.:.
Mosquito   113 LSAFHAGASTQQGQPECL--------LGTANNYLPWVTEDGRLTVRPGPHALDLSSLRLSDHGVQ 169

  Fly   489 HIRRGVFDRMSSLQILNLS--QNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWL 551
            .:.:||...:...::|:||  :|:|..:.:.:|::...::.:.|.||       .|||..|
Mosquito   170 GLVQGVSALIPLEEVLHLSIARNELTLVPSPTLKKFQNVRLLSLSGN-------FFTEFSN---- 223

  Fly   552 NISGNRLEKFDYSHIPI--GLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIP 614
                   :..:::.:|:  .|:.||:|               ..||.|.
Mosquito   224 -------DTAEHNRLPLLTKLRVLDMR---------------NCSLRTL---------------- 250

  Fly   615 NSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNA 679
                             |..||:..||..:.|..||:|||            ..||  ||...:.
Mosquito   251 -----------------PEAFFRNVNLEYLFLSHNRITTL------------PAEI--FYPLRSL 284

  Fly   680 YECD-CNLDWLQKVNRESRTQP-------------------QLMDLDQIHCRLAYARGSSHVSLI 724
            ...| .|:| .::...|....|                   .|:.||..:.||.|.      :.|
Mosquito   285 LHLDLSNMD-TRRTGEERIENPFMKLIAGVDLHQDIFFPLISLVFLDLSNTRLEYQ------AFI 342

  Fly   725 EAKSDDFLCKYASHC-FALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSH 788
            ..:|..:..:|.|:| ..|....|:.....|:...|                   .||...:...
Mosquito   343 ALRSVQWRVQYVSYCNIGLPAIVDYLFVSKKIAMLD-------------------ISYNVGVAQS 388

  Fly   789 IPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKA 853
            :...|..|..|.                |:||:...|.::.|:  ....|..|.||.|:.|.|:.
Mosquito   389 LHSASFTLLADS----------------LEVLYFKDSMVQQLN--WLVPLQRLRVLNLRGNILRM 435

  Fly   854 LNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAI---TSFAVWNFLPSYLNEL 915
            |....|..|.:|::|.|.:|.|:..:....|....|:.:.|.:|:|   |:..:::|  |.|:.:
Mosquito   436 LQRESFANLTHLEQLDLSYNYISAWNQQILTTTTALQSVNLRNNSIVILTTDMLYDF--SRLSAM 498

  Fly   916 RLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCD-VISGNSTQQMVIYPGSG---EPASLPVV 976
            .|..|...|||.::..||:.::....|.....:..: :|.|..        |||   ...||..|
Mosquito   499 GLGGNTIQCSCNYVKFLRNILHNRTDVAGAYTISAEPLIVGRR--------GSGTISNKLSLQHV 555

  Fly   977 Q----------C-----SQTL-PLGLDN---------NFNYAEQAGGE--NASNATSTKMILNQP 1014
            |          |     :|.| ||.|.:         |.:..|:...|  :|.|.|
Mosquito   556 QLFDYEESEYLCMNFTSNQKLDPLELQDCMIPEDELINSDIPEEGEDEPAHAKNHT--------- 611

  Fly  1015 PKLDYIPILVAILTAFIFVMICISLVFIFRQEMRVWCHSRF--------GVRLFYNAQK-DVDKN 1070
                .:.|||::..:|: ::..:.|.:       .|.|.::        .|..|:|.:| .:||:
Mosquito   612 ----LVYILVSVAVSFL-ILTGVGLFY-------YWFHIKYFFKIMKNSAVLSFFNDEKLYLDKS 664

  Fly  1071 ----EREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPETIVQAIDSS 1131
                |.:..:|.|||||:.|..:|.:.|.|.:| |..:..||||:|||.||..:.|.|:..:|.|
Mosquito   665 GLLKEADFHYDVFVSYSNADRSWVLDHLLPNME-GVSQINLCLHERDFEVGYGILENIISCMDRS 728

  Fly  1132 RRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDPDLRLYLKTNTYLQW 1196
            |..:::|||:|:.|.||:||...|...:|...|..||:::|.::|:::....|...|||.||::|
Mosquito   729 RCLMLIVSESFLLSHWCQFEMHLAQHRLLETCRDELILVLLEDIPRRKCPKTLSYLLKTKTYIKW 793

  Fly  1197 GDK------LFWQKLRFAL 1209
            ..|      |||::|...|
Mosquito   794 PTKSVHEQALFWKRLHKTL 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR	54..400	CDD:443914
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		LRR	239..634	CDD:443914	37/213 (17%)
		leucine-rich repeat	260..283	CDD:275380
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..333	CDD:275380
		leucine-rich repeat	334..357	CDD:275380
		leucine-rich repeat	358..381	CDD:275380
		leucine-rich repeat	382..405	CDD:275380
		leucine-rich repeat	406..429	CDD:275380
		leucine-rich repeat	430..452	CDD:275380	6/21 (29%)
		leucine-rich repeat	453..500	CDD:275380	9/52 (17%)
		leucine-rich repeat	501..521	CDD:275380	6/21 (29%)
		leucine-rich repeat	525..547	CDD:275380	6/21 (29%)
		leucine-rich repeat	548..573	CDD:275380	2/26 (8%)
		leucine-rich repeat	604..640	CDD:275380	3/35 (9%)
		LRR_8	616..>660	CDD:404697	11/43 (26%)
		leucine-rich repeat	641..688	CDD:275380	13/47 (28%)
		leucine-rich repeat	689..816	CDD:275380	22/146 (15%)
		LRR	<794..>920	CDD:443914	32/128 (25%)
		leucine-rich repeat	817..864	CDD:275380	15/46 (33%)
		leucine-rich repeat	865..888	CDD:275380	6/22 (27%)
		leucine-rich repeat	889..910	CDD:275380	6/23 (26%)
		TIR	1076..1211	CDD:214587	55/140 (39%)
Toll-9	XP_565221.3	None