DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tollo and Lrig3

DIOPT Version :10

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_796126.4 Gene:Lrig3 / 320398 MGIID:2443955 Length:1117 Species:Mus musculus


Alignment Length:1351 Identity:275/1351 - (20%)
Similarity:460/1351 - (34%) Gaps:456/1351 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   107 YCKLGNLTDGSFRGLQELRNLTIRTHNGDWSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGM 171
            :| ||:|.|.|.|.|..|.:..     ..|.|                 |||||.|.:..|....
Mouse    52 HC-LGDLLDCSRRRLVRLPDPL-----PAWVT-----------------RLDLSHNRLSFIQTSS 93

  Fly   172 VCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRL 236
            :..|:|||.:..:.|:::.|.|.              ||      :|||               :
Mouse    94 LSHLQSLQEVKLNNNELETIPNL--------------GS------ISAN---------------I 123

  Fly   237 THLNMAKNSMSFLADRAFEGLLSLRVVDLSANRL----TSLPPELFAETKQLQEIYLRNNSINVL 297
            ..|::|.|::..:.....|...||..:|||.|.:    |:.||      .||:.:|:.||.::.:
Mouse   124 RQLSLAGNAIDKILPEQLEAFQSLETLDLSNNNISELRTAFPP------LQLKYLYINNNRVSSM 182

  Fly   298 APGIFGELAE-LLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQIL 361
            .||.|..||. ||||.|..|.:::  |....| .|.:|..|:|:.|||..::...|:.|.:|:.|
Mouse   183 EPGYFDNLASTLLVLKLNRNRISA--IPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSL 244

  Fly   362 KLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVN 426
            |::.|.:.:|..|.|                        .||.|:.||.||.|.::.:.:..|..
Mouse   245 KMQRNGVTKLMDGAF------------------------WGLSNMEVLQLDHNNLTEITKGWLYG 285

  Fly   427 CSQLQDLHLNDNKLQAV-PEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHI 490
            ...|::|||:.|.:..: |:|....|.|..||:..|.:|:::::|...|..|..|.:..|.:::|
Mouse   286 LLMLRELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNALHIGNNKVSYI 350

  Fly   491 RRGVFDRMSSLQILNLSQNKLK-SIE--AGSLQRNSQLQAIRLDGNQLKSIA-GLFTELPNLVWL 551
            ....|..::||:.|:|..|::. :||  :|:.....:|:.:.|.||:::||. ..|..|..|..|
Mouse   351 ADCAFRGLTSLKTLDLRNNEISWTIEDMSGAFSGLDRLRQLILQGNRIRSITKKAFAGLDTLEHL 415

  Fly   552 NISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNS 616
            ::|||.:              :.:::|..:|:                               ..
Mouse   416 DLSGNAI--------------MSLQSNAFSQM-------------------------------KK 435

  Fly   617 VEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYE 681
            ::.|:||.:.:.                                                     
Mouse   436 LQQLHLNTSSLL----------------------------------------------------- 447

  Fly   682 CDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCC 746
            |||.|.||.:...|:..| ..::....|.:|...|     |:.....|.|:|.            
Mouse   448 CDCQLRWLPQWVAENNFQ-SFVNASCAHPQLLKGR-----SIFTVSPDGFVCD------------ 494

  Fly   747 DFQACDCKMECPDRCSCY--HDQSWTSNVVDCSRASYEQTLPSHIPM------DSTQLYLDGNNF 803
            ||......:: |:..|..  .|.|:|     ||.||     .|..||      |:..|     ..
Mouse   495 DFPKPQITVQ-PETQSAIKGSDVSFT-----CSAAS-----SSDSPMTFAWKKDNEAL-----QD 543

  Fly   804 RELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALN--GNEFQGLDNL- 865
            .|::::|          ||.....|::...|...|..:|.......|....|  |:.:.....| 
Mouse   544 AEMENYA----------HLRAQGGELMEYTTILRLRNVEFTSEGKYQCVISNHFGSSYSVKAKLT 598

  Fly   866 -----------QELYLQHNAIATIDTLTFTH------------------------------LYHL 889
                       .:|.::..|:|.::.....|                              ::.:
Mouse   599 INMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFI 663

  Fly   890 KILRLDHNAITSFAVWNFLPSYLNELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVIS 954
            ..::::...:.|....|...|      :::|......|....||..::|.....:...::|  |:
Mouse   664 VDVKIEDIGVYSCTAQNSAGS------VSANATLTVLETPSFLRPLLDRTVTKGETAVLQC--IA 720

  Fly   955 GNSTQQMVIYPGSGEPASLPVVQ-----CSQTLPLGLDNNFNYAEQAGGENASNATSTK------ 1008
            |.|....:.:.....|  |.|.:     ....|.:.:|::.:.|.:...| .||...|:      
Mouse   721 GGSPPPRLNWTKDDSP--LVVTERHFFAAGNQLLIIVDSDVSDAGKYTCE-MSNTLGTERGNVRL 782

  Fly  1009 MILNQP---------PKLD---YIPILVAILTAFIFVMICI---SLVFIFRQEMRVWCHSRFGVR 1058
            .::..|         |.||   :..:.|.|    |.|:.|:   |||::              |.
Mouse   783 SVIPTPTCDSPHMTAPSLDGDGWATVGVVI----IAVVCCVVGTSLVWV--------------VI 829

  Fly  1059 LFYNAQKDVD---KNEREKLFDAFV-SY-SSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGG 1118
            :::..:::.|   .|..|....|.: || ||:..|...::.....|.|.|      ||.....||
Mouse   830 IYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYISSESGSH------HQFVTSSGG 888

  Fly  1119 --YLPE----TIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQ 1177
              :||:    ......|||...:...|:.|:    |.|                  |...|.|  
Mouse   889 GFFLPQHDGAGTCHFDDSSEADVEAASDPFL----CPF------------------VGSTGPV-- 929

  Fly  1178 KELDPDLRLYLKTNTYLQWGDKLFWQKLRFALPDVSSSQRSNVAGQSCHVPINHASYHHHHHVHQ 1242
                     ||:.|.|..       ......||..||..|:.:        ::|.          
Mouse   930 ---------YLQGNLYSP-------DPFEVYLPGCSSDPRTAL--------MDHC---------- 960

  Fly  1243 QAMPLPHSVHHHQQQFMLPPPPQQP--GSFRRQPSLHQQQQQQQQIRGNNNTTQQQQQQQAALLM 1305
                  .|.:..|.:|....|.::|  .|.:..|..|.::........|...|.|      .|.:
Mouse   961 ------ESSYVKQDRFSCARPSEEPCERSLKSIPWPHSRKLTDSTYPPNEGHTVQ------TLCL 1013

  Fly  1306 GGGSVG---GPAPQMIPLAGGIQQ--------------QSLPLPPNQQPTP 1339
            ...||.   ||.|.....:.....              .|...||:.||.|
Mouse  1014 NKSSVDFSTGPEPGSATSSNSFMGTFGKPLRRPHLDAFSSSAQPPDCQPRP 1064

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR 54..400 CDD:443914 77/297 (26%)
leucine-rich repeat 100..123 CDD:275380 8/15 (53%)
leucine-rich repeat 124..144 CDD:275380 3/19 (16%)
leucine-rich repeat 154..177 CDD:275380 8/22 (36%)
leucine-rich repeat 178..201 CDD:275380 5/22 (23%)
leucine-rich repeat 212..235 CDD:275380 3/22 (14%)
leucine-rich repeat 236..259 CDD:275380 4/22 (18%)
LRR 239..634 CDD:443914 102/404 (25%)
leucine-rich repeat 260..283 CDD:275380 8/26 (31%)
leucine-rich repeat 284..307 CDD:275380 8/22 (36%)
leucine-rich repeat 308..333 CDD:275380 9/24 (38%)
leucine-rich repeat 334..357 CDD:275380 8/22 (36%)
leucine-rich repeat 358..381 CDD:275380 7/22 (32%)
leucine-rich repeat 382..405 CDD:275380 2/22 (9%)
leucine-rich repeat 406..429 CDD:275380 6/22 (27%)
leucine-rich repeat 430..452 CDD:275380 7/22 (32%)
leucine-rich repeat 453..500 CDD:275380 12/46 (26%)
leucine-rich repeat 501..521 CDD:275380 7/22 (32%)
leucine-rich repeat 525..547 CDD:275380 8/22 (36%)
leucine-rich repeat 548..573 CDD:275380 5/24 (21%)
leucine-rich repeat 604..640 CDD:275380 3/35 (9%)
LRR_8 616..>660 CDD:404697 3/43 (7%)
leucine-rich repeat 641..688 CDD:275380 4/46 (9%)
leucine-rich repeat 689..816 CDD:275380 28/134 (21%)
LRR <794..>920 CDD:443914 20/169 (12%)
leucine-rich repeat 817..864 CDD:275380 9/48 (19%)
leucine-rich repeat 865..888 CDD:275380 5/64 (8%)
leucine-rich repeat 889..910 CDD:275380 2/20 (10%)
TIR 1076..1211 CDD:214587 30/142 (21%)
Lrig3NP_796126.4 LRRNT 46..74 CDD:214470 9/27 (33%)
LRR 1 75..98 9/39 (23%)
leucine-rich repeat 76..99 CDD:275378 9/39 (23%)
LRR 77..421 CDD:443914 116/428 (27%)
LRR 2 99..120 8/40 (20%)
leucine-rich repeat 100..146 CDD:275378 14/80 (18%)
LRR 3 122..143 4/35 (11%)
LRR 4 146..168 9/27 (33%)
leucine-rich repeat 147..168 CDD:275380 8/26 (31%)
leucine-rich repeat 169..192 CDD:275380 8/22 (36%)
LRR 5 169..189 7/19 (37%)
LRR 6 193..214 8/23 (35%)
leucine-rich repeat 194..216 CDD:275380 9/24 (38%)
LRR 7 216..237 7/20 (35%)
leucine-rich repeat 217..240 CDD:275380 8/22 (36%)
LRR 8 240..261 7/44 (16%)
leucine-rich repeat 241..264 CDD:275380 9/46 (20%)
LRR 9 264..285 7/20 (35%)
leucine-rich repeat 265..288 CDD:275380 6/22 (27%)
LRR 10 288..309 7/20 (35%)
leucine-rich repeat 289..312 CDD:275380 7/22 (32%)
LRR 11 312..333 6/20 (30%)
leucine-rich repeat 313..336 CDD:275380 7/22 (32%)
LRR 12 336..357 5/20 (25%)
leucine-rich repeat 337..360 CDD:275380 5/22 (23%)
LRR 13 360..382 8/21 (38%)
leucine-rich repeat 361..385 CDD:275380 7/23 (30%)
LRR 14 387..408 7/20 (35%)
leucine-rich repeat 388..411 CDD:275380 8/22 (36%)
LRR 15 411..432 6/34 (18%)
leucine-rich repeat 412..433 CDD:275380 6/34 (18%)
PCC 416..>494 CDD:188093 22/181 (12%)
Ig_3 498..585 CDD:464046 23/112 (21%)
IgI_LRIG1-like 604..694 CDD:409420 8/95 (8%)
Ig strand A 604..607 CDD:409420 0/2 (0%)
Ig strand A' 611..615 CDD:409420 1/3 (33%)
Ig strand B 618..627 CDD:409420 2/8 (25%)
Ig strand C 633..638 CDD:409420 0/4 (0%)
Ig strand C' 641..643 CDD:409420 0/1 (0%)
Ig strand D 651..655 CDD:409420 0/3 (0%)
Ig strand E 659..666 CDD:409420 0/6 (0%)
Ig strand F 672..680 CDD:409420 1/7 (14%)
Ig strand G 683..694 CDD:409420 2/16 (13%)
I-set 697..784 CDD:400151 17/91 (19%)
Ig strand B 714..718 CDD:409544 0/3 (0%)
Ig strand C 727..731 CDD:409544 0/3 (0%)
Ig strand E 750..754 CDD:409544 1/3 (33%)
Ig strand F 764..769 CDD:409544 1/5 (20%)
Ig strand G 777..780 CDD:409544 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1019..1093 9/46 (20%)

Return to query results.
Submit another query.