DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Tlr7

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	XP_017457568.1	Gene:	Tlr7 / 317468	RGDID:	1563357	Length:	1068	Species:	Rattus norvegicus

Alignment Length:	1277	Identity:	284/1277 - (22%)
Similarity:	475/1277 - (37%)	Gaps:	374/1277 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 RWSGGGEHDITLVCHLRTINSELENTNFSVIQ--------------PQNTVRLRLECNDALFFQS 87
            ||     :..||.|.:     .|::||..||.              |.||..|.|..|..    .
  Rat    46 RW-----YPKTLPCDV-----SLDSTNTHVIVDCTDKHLTEIPEGIPTNTTNLTLTINHI----P 96

  Fly    88 SLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQELRNLTIRTHNGDWSTMSLEMASNSFVEFR 152
            |:|||||..|                                                      :
  Rat    97 SISPDSFHRL------------------------------------------------------K 107

  Fly   153 QLERLDLSLN--NIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSL 215
            .||.|||..|  .|.|.....|| .|.||....|::.:.|:.:.|...:......:...|:||.|
  Rat   108 HLEELDLRCNCVPILLGSKANVC-TKRLQIRPGSFSGLSDLKSLYLDGNQLLEIPQDLPSSLQLL 171

  Fly   216 DLSANKMVSLPTAMLSALGRLTHLNMAKN-------SMSFLADR-AFEGLLSLRVVDLSANRLTS 272
            .|.||.:.|:....||.|..:..|.:.:|       ::|:..:: ||..:.:|:|:.|..|.:|:
  Rat   172 SLEANNIFSITKENLSELVNIESLYLGQNCYYRNPCNVSYSIEKDAFLVMKNLKVLSLKDNNVTA 236

  Fly   273 ----LPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASN--------------ELN 319
                |||.|.       |:||.||.|..:....|.:|::|.||||:.|              |.|
  Rat   237 VPTILPPNLL-------ELYLYNNIIKRIQEHDFNKLSQLQVLDLSGNCPRCYNVPYPCTPCENN 294

  Fly   320 SQWINAATFVGLKRLMMLDLSANKISRLEAH--IFRPLASLQILKLEDNYIDQLPGGIFADLTNL 382
            |.                         |:.|  .|..|..|::|:|..|.:..:|...|.:::||
  Rat   295 SP-------------------------LQIHDNAFDSLTELKVLRLHSNSLQHVPAEWFKNMSNL 334

  Fly   383 HTLILSRNRIS--VIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPE 445
            ..|.||:|.::  :.|.:.|..|.||:.|.|.||             .:||..|.:    ..:|.
  Rat   335 QELDLSQNYLAREIEEAKFLNSLPNLVQLDLSFN-------------YELQVYHAS----ITLPH 382

  Fly   446 ALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIR---RGVFDRMSSLQILNLS 507
            :|:.:..||.|.:...:..:::::|::.|.:|..|.:.:.....|:   ..:|.:..:|:.::||
  Rat   383 SLSSLTKLKNLYIKGYVFKELKDSSLSVLHNLSNLEVLDLGTNFIKIADLNIFQQFENLKFIDLS 447

  Fly   508 QNKL----KSIEAGSLQRNSQLQAIRLDGNQLKSIAGLF-------------TELPNLVWLN--- 552
            .||:    :|.|.| |..|:| .::...|.|:......|             .|.|..:.||
  Rat   448 VNKISPSEESREVG-LCPNAQ-TSVDWHGPQVLEALHYFRYDEYARSCRFKNKEPPTFLPLNADC 510

  Fly   553 --------ISGNR---LEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLT 606
                    :|.|.   ::..|:.|:.. |:.|::..|.|.|..|..|::....|...|.|.|.|.
  Rat   511 HTYGKTLDLSRNNIFFIKPSDFKHLSF-LKCLNLSGNAIGQTLNGSELQPLRELRYLDFSNNRLD 574

  Fly   607 EI--TASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDRE 669
            .:  ||.....::|:|.|:.|.       .:|:...:|.:.....:|..||      ..:..|.:
  Rat   575 LLYSTAFEELQNLEILDLSSNS-------HYFQAEGITHMLNFTKKLRHLE------KLMMNDND 626

  Fly   670 IPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCK 734
            |                         |.:..:.|:.:.:  |:...|| :|:.::....|:....
  Rat   627 I-------------------------STSASRTMESESL--RVLEFRG-NHLDVLWRDGDNRYLD 663

  Fly   735 YASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLP---SHIPMDSTQL 796
            :..:...|                             ..:|.||.|.....|   ..:|.:.|.|
  Rat   664 FFKNLLNL-----------------------------EELDISRNSLNSVPPGVFEGMPPNLTTL 699

  Fly   797 YLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQG 861
            .|..|..|..........|.||.|.|:|:::..:..|.......|..|.|..||::.|.....:.
  Rat   700 SLAKNGLRSFSWGRLQLLKHLKNLDLSHNQLTTVPARLANCSKSLTKLILNHNQIRQLTKYFLED 764

  Fly   862 LDNLQELYLQHNAIATIDTLTFTH--LYHLKILRLDHNAITSFAVWNFLPSYLNELRLASNPWTC 924
            ...|:.|.:..|.|..|...:|..  |.:|.:|.|.||        .||               |
  Rat   765 ALQLRYLDISSNKIQVIQKTSFPENVLNNLNMLLLHHN--------RFL---------------C 806

  Fly   925 SCE---FIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGS--GEPA-SLPVVQCSQTLP 983
            :|:   |:    .::|..:..:..|          :|......||:  |:.. ||.:..|...|
  Rat   807 NCDAVWFV----WWVNHTDVTIPYL----------ATDVTCAGPGAHKGQSVISLDLYTCELDL- 856

  Fly   984 LGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFRQEMR 1048
                                   |.:||           ....:::.:|:||.::...:|..:|
  Rat   857 -----------------------TNLIL-----------FSVSISSVLFLMIVMTTSHLFFWDM- 886

  Fly  1049 VWCHSRFGVRLFYNAQ-KDVDK-NEREKLFDAFVSYSSKDEL---FVNEELAPMLE-MGEHRYKL 1107
             |.     :..|:.|: |.... ...|..:|||:.|.:|:..   :|.:||...|| ..|..:.|
  Rat   887 -WY-----IYYFWKAKIKGYQHLQSMESCYDAFIVYDTKNSAVTEWVLQELVVKLEDPREKHFNL 945

  Fly  1108 CLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVL 1172
            ||.:||:..|..:.|.:.|:|..||:|:.|:::.:.|:|..:..|..:||.::.::...:|:|.|
  Rat   946 CLEERDWLPGQPVLENLSQSIQLSRKTVFVMTQKYAKTESFKMAFYLSHQRLMDEKVDVIILIFL 1010

  Fly  1173 GEVPQKELDPDLRLYLKTNTYLQW-----GDKLFWQKLRFAL 1209
            .:..||.....||..|.:::.|:|     ....|||.|:.||
  Rat  1011 EKPLQKSKFLQLRKRLCSSSVLEWPTNPQAHPYFWQCLKNAL 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	48/209 (23%)
		leucine-rich repeat	100..123	CDD:275380	0/22 (0%)
		leucine-rich repeat	124..144	CDD:275380	0/19 (0%)
		LRR_8	152..222	CDD:290566	23/71 (32%)
		leucine-rich repeat	154..177	CDD:275380	10/24 (42%)
		leucine-rich repeat	178..201	CDD:275380	5/22 (23%)
		LRR	210..656	CDD:227223	125/511 (24%)
		leucine-rich repeat	212..235	CDD:275380	10/22 (45%)
		leucine-rich repeat	236..259	CDD:275380	5/30 (17%)
		leucine-rich repeat	260..283	CDD:275380	9/26 (35%)
		LRR_RI	276..558	CDD:238064	77/333 (23%)
		leucine-rich repeat	284..307	CDD:275380	8/22 (36%)
		leucine-rich repeat	308..333	CDD:275380	9/38 (24%)
		leucine-rich repeat	334..357	CDD:275380	4/24 (17%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	382..405	CDD:275380	8/24 (33%)
		leucine-rich repeat	406..429	CDD:275380	5/22 (23%)
		leucine-rich repeat	430..452	CDD:275380	5/21 (24%)
		leucine-rich repeat	453..500	CDD:275380	9/49 (18%)
		leucine-rich repeat	501..521	CDD:275380	9/23 (39%)
		leucine-rich repeat	525..547	CDD:275380	4/34 (12%)
		leucine-rich repeat	548..573	CDD:275380	7/38 (18%)
		leucine-rich repeat	604..640	CDD:275380	8/37 (22%)
		leucine-rich repeat	641..688	CDD:275380	6/46 (13%)
		leucine-rich repeat	689..816	CDD:275380	19/129 (15%)
		LRR_8	815..875	CDD:290566	16/59 (27%)
		leucine-rich repeat	817..864	CDD:275380	12/46 (26%)
		LRR_8	864..921	CDD:290566	14/58 (24%)
		leucine-rich repeat	865..888	CDD:275380	7/24 (29%)
		leucine-rich repeat	889..910	CDD:275380	7/20 (35%)
		TIR	1076..1211	CDD:214587	45/143 (31%)
Tlr7	XP_017457568.1	leucine-rich repeat	66..87	CDD:275380	4/20 (20%)
		LRR_8	93..157	CDD:290566	24/122 (20%)
		leucine-rich repeat	109..146	CDD:275380	14/37 (38%)
		leucine-rich repeat	147..191	CDD:275380	12/43 (28%)
		leucine-rich repeat	192..223	CDD:275380	5/30 (17%)
		LRR_8	222..277	CDD:290566	22/61 (36%)
		LRR_RI	223..472	CDD:238064	76/299 (25%)
		leucine-rich repeat	224..244	CDD:275380	7/19 (37%)
		leucine-rich repeat	245..268	CDD:275380	9/29 (31%)
		leucine-rich repeat	269..309	CDD:275380	13/64 (20%)
		LRR_8	308..368	CDD:290566	19/59 (32%)
		leucine-rich repeat	310..333	CDD:275380	6/22 (27%)
		leucine-rich repeat	334..359	CDD:275380	8/24 (33%)
		leucine-rich repeat	370..389	CDD:275380	5/22 (23%)
		leucine-rich repeat	390..416	CDD:275380	6/25 (24%)
		leucine-rich repeat	417..440	CDD:275380	3/22 (14%)
		LRR_8	515..573	CDD:290566	15/58 (26%)
		leucine-rich repeat	515..537	CDD:275380	4/21 (19%)
		LRR_RI	532..778	CDD:238064	61/316 (19%)
		leucine-rich repeat	538..562	CDD:275380	7/23 (30%)
		LRR_8	561..627	CDD:290566	17/78 (22%)
		leucine-rich repeat	563..586	CDD:275380	7/22 (32%)
		leucine-rich repeat	587..616	CDD:275380	7/35 (20%)
		leucine-rich repeat	617..639	CDD:275380	6/52 (12%)
		LRR_8	639..706	CDD:290566	16/98 (16%)
		leucine-rich repeat	640..670	CDD:275380	5/32 (16%)
		leucine-rich repeat	671..695	CDD:275380	7/52 (13%)
		LRR_8	694..754	CDD:290566	16/59 (27%)
		leucine-rich repeat	696..719	CDD:275380	5/22 (23%)
		leucine-rich repeat	720..743	CDD:275380	6/22 (27%)
		leucine-rich repeat	768..786	CDD:275380	5/17 (29%)
		TIR	909..1054	CDD:214587	45/144 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.780