DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Slitrk3

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001101153.1	Gene:	Slitrk3 / 310519	RGDID:	1310506	Length:	979	Species:	Rattus norvegicus

Alignment Length:	1057	Identity:	219/1057 - (20%)
Similarity:	353/1057 - (33%)	Gaps:	385/1057 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 RLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQ 397
            |...|.|..|.:.:|..:.|..|.:...:.|.:|.:..:..|.|..|..|..|.|..|::.|...
  Rat    78 RPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRN 142

  Fly   398 RTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENM 462
            .|..||::|..|..|:|.|.|::..:..|.|:|:.|.||||.:..:|..|.....|..||:..|
  Rat   143 DTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPVLPTNLFKAVSLTHLDLRGN- 206

  Fly   463 ISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQA 527
                      :|:.|:...|    |.||.|       ||..|.|.:|..          |...:.
  Rat   207 ----------RLKVLFYRGM----LDHIGR-------SLMELQLEENPW----------NCTCEI 240

  Fly   528 IRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHI--------PIGLQWLDVRANRITQLG 584
            :     ||||            |       ||:..|:.:        |......|:|..:.|:|.
  Rat   241 V-----QLKS------------W-------LERIPYTALVGDITCETPFHFHGKDLREIKKTELC 281

  Fly   585 NYF---EIESELSLSTFDASYNLLTEITASSIPNSV-----EVLYLNDNQISKIQPYTFFKKPNL 641
            ...   |:|:.|.:....:|.........||:.:||     .|.|.:.|:    ||     ||
  Rat   282 PLLSDSEVEASLGIPHLSSSKENAWPTKPSSMLSSVHFTASSVEYKSSNK----QP-----KP-- 335

  Fly   642 TRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLD 706
                       |.:|...|  |.:..:.:   |.|.|           |......:|:|.:
  Rat   336 -----------TKQPRTPR--PPSTSQAL---YPGPN-----------QPPIAPYQTRPPI---- 369

  Fly   707 QIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSC---YHDQS 768
                                                           .:.||..|:|   .:|..
  Rat   370 -----------------------------------------------PIICPTGCTCNLHINDLG 387

  Fly   769 WTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNR 833
            .|.|..:....:..:.||.  |:::.:|||..|..:::....|.....|.:|||.::||..:.:.
  Rat   388 LTVNCKERGFNNISELLPR--PLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDG 450

  Fly   834 TFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNA 898
            .|..|..|:.|.|..|.::.|....|:||.:|..||.:.|.|..|....|:.:.:||:|.|::|.
  Rat   451 AFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNL 515

  Fly   899 I----------TSFAVWN-------FLP-----SYLN---ELRLASNPWTCSCEFIDKLRDYINR 938
            :          ||.|..|       :||     .:||   ::.|..|||.|:|:.: ..:.:|.
  Rat   516 LRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLV-PFKQWIE- 578

  Fly   939 HEYVVDKLKMKCDVI---SGNSTQQMVIYPGSGE-----PASLPVVQCSQTLPLGLDNNFNYAEQ 995
               .:..:.:..||:   ..|.|.:.|   .:.|     |..|.:.|...:.|           |
  Rat   579 ---TISSVSVVGDVLCRTPENLTHRDV---RTIELEVLCPEMLHIAQPGPSPP-----------Q 626

  Fly   996 AGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIF----------------- 1043
            :|..:.:...::....:..|....:|:.|.||:   .:::..|.||:.
  Rat   627 SGDYHPNGGPTSASPYDFSPPGGPVPLSVLILS---LLVLFFSAVFVAAGLFAYVLRRRRKKLPF 688

  Fly  1044 ---RQE------MRVWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLE 1099
               |||      :::.||     |||.::..           ....|.|.......:.|.||
  Rat   689 RSKRQEGVDLTGIQMQCH-----RLFEDSGG-----------SGGGSGSGGRPTLSSPEKAP--- 734

  Fly  1100 MGEHRYKLCLHQRDFPVG---GYLPETIVQ---------------AIDSSRRT------------ 1134
                           |||   .|:|..:.|               |..:::.|
  Rat   735 ---------------PVGHVYEYIPHPVTQMCNNPIYKPREEEEVAASAAQDTGATDRGGPGTQP 784

  Fly  1135 -----IMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDPDLRLYLKTNTYL 1194
                 :::.||.|                              .|.| ||...:.|..|:...
  Rat   785 PGMGEVLLGSEQF------------------------------AETP-KENHSNYRTLLEKEK-- 816

  Fly  1195 QWGDKLFWQKLRFALPDVSSSQRSNVAGQSCHVPINHASYHHHHHVHQQAMPLPHSV-------- 1251
            :|           ||. ||:||.:.:      |.:|    |||.|.|..|:.....|
  Rat   817 EW-----------ALA-VSNSQLNTI------VTVN----HHHPHPHHSAVGGVSGVGGGTGGDL 859

  Fly  1252 ---HHHQQQ---FMLPP 1262
               .||::.   .:.||
  Rat   860 AGFRHHEKNGGVVLFPP 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	82/338 (24%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380
		LRR_RI	276..558	CDD:238064	58/224 (26%)
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..333	CDD:275380	219/1057 (21%)
		leucine-rich repeat	334..357	CDD:275380	6/22 (27%)
		leucine-rich repeat	358..381	CDD:275380	5/22 (23%)
		leucine-rich repeat	382..405	CDD:275380	8/22 (36%)
		leucine-rich repeat	406..429	CDD:275380	7/22 (32%)
		leucine-rich repeat	430..452	CDD:275380	8/21 (38%)
		leucine-rich repeat	453..500	CDD:275380	11/46 (24%)
		leucine-rich repeat	501..521	CDD:275380	4/19 (21%)
		leucine-rich repeat	525..547	CDD:275380	4/21 (19%)
		leucine-rich repeat	548..573	CDD:275380	5/32 (16%)
		leucine-rich repeat	604..640	CDD:275380	10/40 (25%)
		leucine-rich repeat	641..688	CDD:275380	7/46 (15%)
		leucine-rich repeat	689..816	CDD:275380	18/129 (14%)
		LRR_8	815..875	CDD:290566	20/59 (34%)
		leucine-rich repeat	817..864	CDD:275380	16/46 (35%)
		LRR_8	864..921	CDD:290566	21/81 (26%)
		leucine-rich repeat	865..888	CDD:275380	7/22 (32%)
		leucine-rich repeat	889..910	CDD:275380	11/42 (26%)
		TIR	1076..1211	CDD:214587	25/169 (15%)
Slitrk3	NP_001101153.1	leucine-rich repeat	81..102	CDD:275380	6/20 (30%)
		leucine-rich repeat	103..126	CDD:275380	5/22 (23%)
		LRR_8	105..161	CDD:290566	17/55 (31%)
		leucine-rich repeat	127..150	CDD:275380	8/22 (36%)
		LRR_8	150..208	CDD:290566	20/68 (29%)
		leucine-rich repeat	151..174	CDD:275380	7/22 (32%)
		leucine-rich repeat	175..197	CDD:275380	8/21 (38%)
		leucine-rich repeat	198..402	CDD:275380	62/348 (18%)
		LRRCT	232..>270	CDD:214507	11/71 (15%)
		leucine-rich repeat	403..433	CDD:275380	8/31 (26%)
		LRR_8	432..492	CDD:290566	20/59 (34%)
		LRR_4	433..473	CDD:289563	13/39 (33%)
		leucine-rich repeat	434..457	CDD:275380	8/22 (36%)
		LRR_4	456..497	CDD:289563	14/40 (35%)
		leucine-rich repeat	458..481	CDD:275380	8/22 (36%)
		leucine-rich repeat	482..501	CDD:275380	6/18 (33%)
		leucine-rich repeat	506..528	CDD:275380	5/21 (24%)
		leucine-rich repeat	529..553	CDD:275380	5/23 (22%)
		LRRCT	562..>597	CDD:214507	8/39 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3875
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.050