DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Slitrk2

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001101057.1	Gene:	Slitrk2 / 309349	RGDID:	1561361	Length:	846	Species:	Rattus norvegicus

Alignment Length:	884	Identity:	185/884 - (20%)
Similarity:	321/884 - (36%)	Gaps:	240/884 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   409 LSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAV-PEALAHVQLLKTLDVGENMISQIENTSIT 472
            |.|:.|.::|:.....||.|....|||.:|.||.: |.|.:.::.||.|.:..|.:..:...:..
  Rat    67 LFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRPGAFSGLKTLKRLHLNNNKLEVLREDTFL 131

  Fly   473 QLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLK- 536
            .||||..|:...|.::.|..|.|.:::.|::|.|:.|.|.|:.: ::.|...|..:.|.||:||
  Rat   132 GLESLEYLQADYNYISTIEAGAFSKLNKLKVLILNDNLLLSLPS-NVFRFVLLTHLDLRGNRLKV 195

  Fly   537 -SIAGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDA 600
             ..||:...:..::.:.:..|.. ......:|: ..|||.    ||........|:...|...|
  Rat   196 MPFAGVLEHIGGIMEIQLEENPW-NCTCDLLPL-KAWLDT----ITVFVGEIVCETPFRLHGKD- 253

  Fly   601 SYNLLTEIT-------ASSIPNSVEVLYLNDNQISKIQP-----YTFFKKPNLTRVDLVRNRLTT 653
                :|::|       .|:..:|.:....:|..:.::.|     ....:.|..:|...:|||.|
  Rat   254 ----VTQLTRQDLCPRKSASGDSSQRSSHSDTHVQRLSPTMNPALNPTRAPKASRPPKMRNRPT- 313

  Fly   654 LEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGS 718
              |..    .:::||:                                               ..
  Rat   314 --PRV----TVSKDRQ-----------------------------------------------SF 325

  Fly   719 SHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQ 783
            ..:.:.:.||                       ...:.||..|.|....|.....|:|....:
  Rat   326 GPIMVYQTKS-----------------------PVALTCPSSCVCTSQSSDNGLNVNCQERKF-- 365

  Fly   784 TLPSHI---PMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQ 845
            |..|.:   |....:|||.||..:.:..:..:....|.:|||.::||.|:....|..|..|..|.
  Rat   366 TNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYTSLDLLHLGNNRIAVIQEGAFTNLTSLRRLY 430

  Fly   846 LQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSF-------- 902
            |..|.|:.|..:.|.||.:||.|||::|.|..|..|||..|.:|::|.|::|.:.|.
  Rat   431 LNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGT 495

  Fly   903 ------------------AVWNFLPSYLNELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMK 949
                              .|.:.||::: ::.|..|||.|:|:.:. |:|:.......|...::.
  Rat   496 ALTRLNLRNNHFSHLPVKGVLDQLPAFI-QIDLQENPWDCTCDIMG-LKDWTEHANSPVIINEVT 558

  Fly   950 CDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILN-- 1012
            |:..:.::.:   |....|..|..|            ||          .|.|:.|...|..|
  Rat   559 CESPAKHAGE---ILKFLGREAICP------------DN----------PNLSDGTVLSMNHNTD 598

  Fly  1013 QPPKLDYIP--------------ILVAILTAFIFVMICIS---LVFIFRQEMRVWCHSRFGVRL- 1059
            .|..|...|              :::.:|..|| :.:|..   .||:.::...|....|....|
  Rat   599 TPRSLSVSPSSYPELHTEVPLSVLILGLLVVFI-LSVCFGAGLFVFVLKRRKGVPSVPRSATNLD 662

  Fly  1060 ---------FYNAQKDVDKNERE--KLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRD 1113
                     .||.:.: ||.:..  ......|....::.:::.:|..|:.     .|:   :.:|
  Rat   663 VSSFQLQYGSYNTETN-DKTDGHVYNYIPPPVGQMCQNPIYMQKEGDPVA-----YYR---NLQD 718

  Fly  1114 FPVG------------GYL---------------PETIVQAIDSSRRTIMVVSENFIKSEWC--- 1148
            |..|            .|.               ||.:.|.|  :.|...:.|...:...:|
  Rat   719 FSYGNLEEKKEEPATLAYTISATELLEKQATPKEPELLYQNI--AERAKELPSAGLVHYNFCTLP 781

  Fly  1149 RFEFKSAHQSVLRDRRRRLIVIVLGEVPQK----ELDPD 1183
            :.:|..:::| .|..:.|:...||...|:|    :..||
  Rat   782 KRQFAPSYES-RRQNQDRINKTVLYGTPRKCFVGQSKPD 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	65/261 (25%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380
		LRR_RI	276..558	CDD:238064	44/151 (29%)
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..333	CDD:275380
		leucine-rich repeat	334..357	CDD:275380
		leucine-rich repeat	358..381	CDD:275380
		leucine-rich repeat	382..405	CDD:275380
		leucine-rich repeat	406..429	CDD:275380	6/19 (32%)
		leucine-rich repeat	430..452	CDD:275380	8/22 (36%)
		leucine-rich repeat	453..500	CDD:275380	13/46 (28%)
		leucine-rich repeat	501..521	CDD:275380	6/19 (32%)
		leucine-rich repeat	525..547	CDD:275380	8/23 (35%)
		leucine-rich repeat	548..573	CDD:275380	2/24 (8%)
		leucine-rich repeat	604..640	CDD:275380	6/47 (13%)
		leucine-rich repeat	641..688	CDD:275380	8/46 (17%)
		leucine-rich repeat	689..816	CDD:275380	17/129 (13%)
		LRR_8	815..875	CDD:290566	24/59 (41%)
		leucine-rich repeat	817..864	CDD:275380	18/46 (39%)
		LRR_8	864..921	CDD:290566	21/82 (26%)
		leucine-rich repeat	865..888	CDD:275380	12/22 (55%)
		leucine-rich repeat	889..910	CDD:275380	7/46 (15%)
		TIR	1076..1211	CDD:214587	25/142 (18%)
Slitrk2	NP_001101057.1	leucine-rich repeat	67..87	CDD:275378	6/19 (32%)
		LRR_8	86..146	CDD:404697	19/59 (32%)
		leucine-rich repeat	90..111	CDD:275380	8/20 (40%)
		leucine-rich repeat	112..135	CDD:275380	5/22 (23%)
		LRR_8	135..193	CDD:404697	18/58 (31%)
		leucine-rich repeat	136..159	CDD:275380	6/22 (27%)
		leucine-rich repeat	160..182	CDD:275380	7/22 (32%)
		leucine-rich repeat	183..207	CDD:275380	8/23 (35%)
		leucine-rich repeat	208..370	CDD:275380	35/251 (14%)
		TPKR_C2	216..>252	CDD:417692	9/41 (22%)
		PPP1R42	358..531	CDD:411060	49/175 (28%)
		leucine-rich repeat	371..401	CDD:275380	6/29 (21%)
		LRR_8	400..460	CDD:404697	24/59 (41%)
		leucine-rich repeat	402..425	CDD:275380	9/22 (41%)
		leucine-rich repeat	426..449	CDD:275380	9/22 (41%)
		leucine-rich repeat	450..469	CDD:275380	10/18 (56%)
		leucine-rich repeat	474..492	CDD:275380	5/17 (29%)
		leucine-rich repeat	497..510	CDD:275378	0/12 (0%)
		leucine-rich repeat	522..534	CDD:275378	4/12 (33%)
		LRRCT	530..580	CDD:214507	12/53 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3875
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.050