DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Slitrk5

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001100754.1	Gene:	Slitrk5 / 306152	RGDID:	1310957	Length:	958	Species:	Rattus norvegicus

Alignment Length:	1012	Identity:	212/1012 - (20%)
Similarity:	346/1012 - (34%)	Gaps:	340/1012 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 LSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGL 403
            ||.|.::||..:.|.......||.|..|.|..:..|.|..|..|..|.|:.|::.::...|..||
  Rat    88 LSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGL 152

  Fly   404 KNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIEN 468
            :||..|.:|:|.||.::..:......||.|.||||.|..:|..|.....|..||:..|.:..:..
  Rat   153 ENLEYLQVDYNYISVIEPNAFGKLHMLQVLILNDNLLSGLPNNLFRFVPLTHLDLRGNRLKLLPY 217

  Fly   469 TSITQ-LESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDG 532
            ..:.| ::.:..|::.||...          .|.::::| ::.|.||...:|
  Rat   218 VGLLQHMDKVVELQLEENPWN----------CSCELISL-KDWLDSISYSAL------------- 258

  Fly   533 NQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLST 597
                 :..:..|.|    ..:.|..|::       :..|.|..|     :|.:.:|:..:..|||
  Rat   259 -----VGDVVCETP----FRLHGRDLDE-------VSKQELCPR-----KLISDYEMRPQTPLST 302

  Fly   598 FDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLS 662
              ..|...|..:.:|:..|...:|         :|.  .|.|..||           :||..|:.
  Rat   303 --TGYLHTTPASVNSVATSSSAVY---------KPP--LKPPKGTR-----------QPNKPRVR 343

  Fly   663 PIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAK 727
            |.:..   |...:|::.|                  .|.          :||          :.|
  Rat   344 PTSRQ---PSKDLGYSNY------------------GPS----------IAY----------QTK 367

  Fly   728 SDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYE---QTLPSHI 789
            |                       ...:|||..|:|....|.....|:|.....|   :..|.
  Rat   368 S-----------------------PVPLECPTACTCNLQISDLGLNVNCQERKIESIAELQPK-- 407

  Fly   790 PMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKAL 854
            |.:..::||..|....::...|:....|.:|||.::||.::.:|.|..|..|..|.|..|:::.|
  Rat   408 PYNPKKMYLTENYITVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLGNLRRLYLNGNRIERL 472

  Fly   855 NGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDH----------------------- 896
            :...|.||.:||.|:||:|.|..|.:.||..:.:|::|.|::
  Rat   473 SPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNQLQAMPSGVFSGLTLLRLNLRS 537

  Fly   897 NAITSFAVWNFLP--SYLNELRLASNPWTCSCE------FIDKLRDYINRHEYVVD--------- 944
            |:.||..|...|.  :.|.::.|..|||.|:||      :|::|:..:...|.:..
  Rat   538 NSFTSLPVSGVLDQLTSLIQIDLHDNPWDCTCEVVGMKLWIEQLKVGVLVDEVICKAPKKFAETY 602

  Fly   945 ----KLKMKC----DVISGNSTQQMVIYPGSGEPASLPVVQCSQT-LPLGLDNNFNYAEQAGGEN 1000
                |.::.|    ||:....|...:..|.....|:.|.|:.:.| .|.||         ..|..
  Rat   603 MRSIKSELLCPDYSDVVVSTPTPSSIQLPSRTNAAATPAVKLNSTGTPAGL---------GAGTG 658

  Fly  1001 ASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFRQEMRVWCHSRFGVRLFYNAQK 1065
            ||:                :|:.|.||:   .:::.|..||:             ...||....|
  Rat   659 ASS----------------VPLSVLILS---LLLVFIMSVFV-------------AAGLFVLVMK 691

  Fly  1066 DVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMG------EHRYKLCLHQRDFPVGGYLPETI 1124
            ...||:.:     ..|.::.|....|.:.:.....|      .|.:   :|.|    |..||:..
  Rat   692 RRKKNQSD-----HTSTNNSDVSSFNMQYSVYGGGGGGGGGHPHAH---VHHR----GSALPKVK 744

  Fly  1125 VQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDPDLRLYLK 1189
            ..|                                             |.|.:....|
  Rat   745 TPA---------------------------------------------GHVYEYIPHP------- 757

  Fly  1190 TNTYLQWGDKLFWQKLRFALPDVSSSQRSNVAGQSCHVPINHA----SYHHHHHVHQQAMPLPHS 1250
                                           .|..|..||..:    |...:..:|:  :.:.:|
  Rat   758 -------------------------------LGHMCKNPIYRSREGNSVEDYKDLHE--LKVTYS 789

  Fly  1251 VHHHQQQFMLPPPPQQPGSFRRQPSLHQQQQQQQQIR 1287
            .:||.|| ..|||||||   ::||....|.|..::.|
  Rat   790 SNHHLQQ-QQPPPPQQP---QQQPPPQLQLQPGEEER 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	74/317 (23%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380
		LRR_RI	276..558	CDD:238064	55/219 (25%)
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..333	CDD:275380
		leucine-rich repeat	334..357	CDD:275380	6/17 (35%)
		leucine-rich repeat	358..381	CDD:275380	8/22 (36%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..429	CDD:275380	6/22 (27%)
		leucine-rich repeat	430..452	CDD:275380	10/21 (48%)
		leucine-rich repeat	453..500	CDD:275380	8/47 (17%)
		leucine-rich repeat	501..521	CDD:275380	5/19 (26%)
		leucine-rich repeat	525..547	CDD:275380	1/21 (5%)
		leucine-rich repeat	548..573	CDD:275380	3/24 (13%)
		leucine-rich repeat	604..640	CDD:275380	6/35 (17%)
		leucine-rich repeat	641..688	CDD:275380	9/46 (20%)
		leucine-rich repeat	689..816	CDD:275380	20/129 (16%)
		LRR_8	815..875	CDD:290566	23/59 (39%)
		leucine-rich repeat	817..864	CDD:275380	17/46 (37%)
		LRR_8	864..921	CDD:290566	20/81 (25%)
		leucine-rich repeat	865..888	CDD:275380	10/22 (45%)
		leucine-rich repeat	889..910	CDD:275380	8/45 (18%)
		TIR	1076..1211	CDD:214587	14/140 (10%)
Slitrk5	NP_001100754.1	leucine-rich repeat	62..79	CDD:275380
		leucine-rich repeat	83..106	CDD:275380	6/17 (35%)
		LRR_8	84..141	CDD:290566	18/52 (35%)
		leucine-rich repeat	107..130	CDD:275380	8/22 (36%)
		LRR_8	129..189	CDD:290566	21/59 (36%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		LRR_8	179..236	CDD:290566	17/56 (30%)
		leucine-rich repeat	179..200	CDD:275380	10/20 (50%)
		leucine-rich repeat	202..226	CDD:275380	5/23 (22%)
		LRRCT	235..>273	CDD:214507	9/70 (13%)
		LRR_8	433..493	CDD:290566	23/59 (39%)
		LRR_4	433..474	CDD:289563	14/40 (35%)
		leucine-rich repeat	435..458	CDD:275380	9/22 (41%)
		LRR_4	458..498	CDD:289563	16/39 (41%)
		leucine-rich repeat	459..482	CDD:275380	8/22 (36%)
		leucine-rich repeat	483..528	CDD:275380	13/44 (30%)
		leucine-rich repeat	530..554	CDD:275380	5/23 (22%)
		TPKR_C2	563..>599	CDD:301599	9/35 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3875
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050