DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Slitrk1

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001100753.1	Gene:	Slitrk1 / 306147	RGDID:	1308858	Length:	696	Species:	Rattus norvegicus

Alignment Length:	639	Identity:	162/639 - (25%)
Similarity:	249/639 - (38%)	Gaps:	147/639 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   518 SLQR----NSQLQAIRLDGNQL-KSIAGLFTELPNLVWLNISGNRLEKFDYSHIP---IGLQW-- 572
            ||||    .||...:.|.||.| :.....|....|.|.|::..|.|.:.    :|   :|||.
  Rat    49 SLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEI----VPGAFLGLQLVK 109

  Fly   573 -LDVRANRITQLGNYFEIESELSLSTFD---ASYNLLTEITASSIP--NSVEVLYLNDNQISKIQ 631
             |.:..|:|..    |..::.|.|...:   |.:|||.:|...:..  |.:|||.||||.||.:
  Rat   110 RLHINNNKIKS----FRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTL- 169

  Fly   632 PYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDRE----IPEFYIGHNAYECDCNL----DW 688
            |...|:...:|.:||..|||.||        |..|..|    |.|..:..|.::|.|:|    :|
  Rat   170 PANVFQYVPITHLDLRGNRLKTL--------PYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEW 226

  Fly   689 LQKVNR---------ESRTQPQLMDL----DQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCF 740
            |:.:.:         |:.|:.|..||    :|..|.|. .|..|.:....|:.:.|........|
  Rat   227 LENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLK-NRVDSSLPAPPAQEETFAPGPLPTPF 290

  Fly   741 AL-------------------------------------------CHCCDFQACDCKMECPDRCS 762
            .:                                           .|         .:.||..||
  Rat   291 KINGQDEHATPGAVPNGGTKIPGNWQLKIKPTPPIATGSARNKPPVH---------GLPCPGGCS 346

  Fly   763 CYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQ-LYLDGNNFRELQSHAFIGRKRLKVLHLNHSR 826
            |.|... :...::|:..:..........:.:.| |:|..|....::...|:..|.|.:|.|.::.
  Rat   347 CDHIPG-SGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRRSHFVDYKNLILLDLGNNN 410

  Fly   827 IEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKI 891
            |..:.|.||..||:|..|.:.||.|..|:..:|.||.||:.|.:::|||..|...||..:..|:|
  Rat   411 IANIENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRI 475

  Fly   892 LRLDHNAITSFAV-----------------WNFLP--------SYLNELRLASNPWTCSCEFIDK 931
            |.|::|.:.|..|                 :.:||        :.:.::.|..|||.|||..: .
  Rat   476 LILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIV-P 539

  Fly   932 LRDYINR--HEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYAE 994
            .:.:..|  .|.::..||.:..|   |..::..:...:.|.......:.|.||.....|:...||
  Rat   540 FKQWAERLGSEVLMSDLKCETPV---NFFRKDFMLLSNDEICPQLYAKISPTLTSHSKNSTGLAE 601

  Fly   995 QAGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFRQEMR 1048
            .....|:...||...|....|.|    :||.:.:||..|.:   ||||.|...|
  Rat   602 TGTHSNSYLDTSRVSISVLVPGL----LLVFVTSAFTVVGM---LVFILRNRKR 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	51/153 (33%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380
		LRR_RI	276..558	CDD:238064	15/44 (34%)
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..333	CDD:275380
		leucine-rich repeat	334..357	CDD:275380
		leucine-rich repeat	358..381	CDD:275380
		leucine-rich repeat	382..405	CDD:275380
		leucine-rich repeat	406..429	CDD:275380
		leucine-rich repeat	430..452	CDD:275380
		leucine-rich repeat	453..500	CDD:275380
		leucine-rich repeat	501..521	CDD:275380	2/2 (100%)
		leucine-rich repeat	525..547	CDD:275380	5/22 (23%)
		leucine-rich repeat	548..573	CDD:275380	8/30 (27%)
		leucine-rich repeat	604..640	CDD:275380	15/37 (41%)
		leucine-rich repeat	641..688	CDD:275380	17/54 (31%)
		leucine-rich repeat	689..816	CDD:275380	27/183 (15%)
		LRR_8	815..875	CDD:290566	23/59 (39%)
		leucine-rich repeat	817..864	CDD:275380	18/46 (39%)
		LRR_8	864..921	CDD:290566	19/81 (23%)
		leucine-rich repeat	865..888	CDD:275380	8/22 (36%)
		leucine-rich repeat	889..910	CDD:275380	9/45 (20%)
		TIR	1076..1211	CDD:214587
Slitrk1	NP_001100753.1	leucine-rich repeat	39..60	CDD:275380	5/10 (50%)
		leucine-rich repeat	62..83	CDD:275380	5/20 (25%)
		leucine-rich repeat	84..107	CDD:275380	7/26 (27%)
		LRR_8	108..166	CDD:290566	19/61 (31%)
		leucine-rich repeat	108..131	CDD:275380	6/26 (23%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		LRR_8	155..213	CDD:290566	24/66 (36%)
		leucine-rich repeat	156..177	CDD:275380	11/21 (52%)
		TPKR_C2	212..>250	CDD:301599	9/37 (24%)
		leucine-rich repeat	356..372	CDD:275380	1/15 (7%)
		leucine-rich repeat	377..400	CDD:275380	5/22 (23%)
		leucine-rich repeat	401..424	CDD:275380	8/22 (36%)
		LRR_8	425..483	CDD:290566	23/57 (40%)
		leucine-rich repeat	425..448	CDD:275380	9/22 (41%)
		leucine-rich repeat	449..472	CDD:275380	8/22 (36%)
		LRR_8	471..530	CDD:290566	10/58 (17%)
		leucine-rich repeat	473..495	CDD:275380	7/21 (33%)
		leucine-rich repeat	496..520	CDD:275380	2/23 (9%)
		TPKR_C2	529..579	CDD:301599	13/53 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3875
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050