DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Tlr10

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001139507.1	Gene:	Tlr10 / 305355	RGDID:	1311569	Length:	811	Species:	Rattus norvegicus

Alignment Length:	930	Identity:	210/930 - (22%)
Similarity:	358/930 - (38%)	Gaps:	220/930 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 ELNSQWINAATFVGLKRL--------MMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPG 373
            ||.|.:.|.|    |:::        .:||||.|.:.:.::..|...:.|:.|.|..|.|.||..
  Rat    29 ELISNYSNMA----LRKVPPDVTPATTILDLSYNLLYQFQSSDFHSFSKLRFLILCHNSIQQLDT 89

  Fly   374 GIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDN 438
            .||.....|..|.||.||:..|...:|..|::|.:...||:.:...::  :.|...|:.|.|:..
  Rat    90 KIFDLNKELSYLDLSYNRLQSITWSSLVDLRHLDLSFNDFDTLPACEE--IGNMRHLETLGLSGA 152

  Fly   439 KLQAVP-EALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQ 502
            |:|... :.:|::| ..|:.:|.|.:|..|..|:..|.:         ::.||   |....::..
  Rat   153 KIQRSDLQKIANLQ-FSTVFIGLNTLSHYEEGSLPVLNT---------TVLHI---VLPMAANFW 204

  Fly   503 ILNLSQNKL-KSIEAGSLQRNSQLQAIR----LDGNQLKSIAGLFTELPNLVWLNISGNRLEKFD 562
            :|.....|. |.:|..::...||..:..    |.....|:...:|.:: :|:|.::    |..|.
  Rat   205 VLLCDGMKTSKVVEMSNIGGKSQFVSYETPRTLSVENTKASTLIFHKV-DLLWDDL----LHVFQ 264

  Fly   563 YSHIPIGLQW-LDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQ 626
            :       .| ..|...:|..|  .|...:....|:||.|..::..:...||  ...:.::..|:
  Rat   265 F-------VWQTSVECFQIQDL--TFGGMASRDHSSFDYSNTVMKAVILESI--HFRIFFIPQNK 318

  Fly   627 ISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQK 691
            |     |.||     |::||  ..||..:.....|...:..:........:|....|...:.:|
  Rat   319 I-----YLFF-----TQMDL--ENLTISDAQMPHLLFPSHPQSFQHLNFANNILTDDLFKNPIQ- 370

  Fly   692 VNRESRTQPQLMDL----DQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACD 752
                   .|.|..|    :|:......:..::|.||:.......|.::.:
  Rat   371 -------MPYLKTLVLRGNQLETLSLVSLFANHTSLLHLDLSQNLLQHGN--------------- 413

  Fly   753 CKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRL 817
                 .::|      .|...::..:.:|.:               .||:.||.|.       |.:
  Rat   414 -----GEKC------MWPDTLILLNLSSNK---------------FDGSVFRCLP-------KSI 445

  Fly   818 KVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLT 882
            :.|.||:::|..:.....|                         |.:|:||.:..|.:.  |...
  Rat   446 QTLDLNNNKIRAVPKEIIY-------------------------LKSLRELSIAFNFLT--DLPG 483

  Fly   883 FTHLYHLKILRLDHNAITSFAVWNFLPS--YLNELRLASNPWTCSCEFIDKLRDYI--NRHEYVV 943
            ..|...|..|.::.|.|.|.:: :|..|  .:..|....||:.|.|||    ||:|  .:|..
  Rat   484 CDHFKRLSSLNIEMNLILSPSL-DFFQSCQEVKTLNAGRNPFRCICEF----RDFIWLEKHSK-- 541

  Fly   944 DKLKMKCDVISGNSTQQMVIYPGS--GEPAS---LPVVQCSQTLPLGLDNNFNYAEQAGGENASN 1003
                   .::|.........||.|  |.|..   ||.:.|:.||.:
  Rat   542 -------GLMSEWPDSYACEYPLSLKGTPLKDVYLPELACNTTLLI------------------- 580

  Fly  1004 ATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFRQEMRVWCHSRFGVRLFYNAQKDV- 1067
                            :.|::.||...:.|..|| |.|.....:||....   :|..:..:|.|
  Rat   581 ----------------VTIVLVILVLGLVVAFCI-LKFDMLWYLRVLAQC---IRTQHRVRKTVR 625

  Fly  1068 DKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPETIVQAIDSSR 1132
            ::.:|...|.||:||::.|.::|..||.|.||..:....|||.:|:|.....:.|.|:...:.|.
  Rat   626 EERKRSVQFHAFISYAAHDSVWVKNELIPNLETEDGSVLLCLPERNFDPDRSIAENIISCTEKSY 690

  Fly  1133 RTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELD---PDLRLYLKTNTYL 1194
            ::|.|:|.||:::.||..|...||.:..||....:|.|:|..:|...:.   |.|:..|:...||
  Rat   691 KSIFVLSPNFVQNGWCHNELYLAHHNPFRDNYDYIIPILLEPIPSYCVPTKFPKLKALLEKKVYL 755

  Fly  1195 QW-GDK----LFWQKLRFAL 1209
            :| .|:    |||..||.|:
  Rat   756 EWPKDRRKHGLFWANLRAAI 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	85/353 (24%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380
		LRR_RI	276..558	CDD:238064	62/254 (24%)
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..333	CDD:275380	6/15 (40%)
		leucine-rich repeat	334..357	CDD:275380	6/30 (20%)
		leucine-rich repeat	358..381	CDD:275380	9/22 (41%)
		leucine-rich repeat	382..405	CDD:275380	9/22 (41%)
		leucine-rich repeat	406..429	CDD:275380	4/22 (18%)
		leucine-rich repeat	430..452	CDD:275380	6/22 (27%)
		leucine-rich repeat	453..500	CDD:275380	10/46 (22%)
		leucine-rich repeat	501..521	CDD:275380	4/20 (20%)
		leucine-rich repeat	525..547	CDD:275380	3/25 (12%)
		leucine-rich repeat	548..573	CDD:275380	5/25 (20%)
		leucine-rich repeat	604..640	CDD:275380	7/35 (20%)
		leucine-rich repeat	641..688	CDD:275380	8/46 (17%)
		leucine-rich repeat	689..816	CDD:275380	17/130 (13%)
		LRR_8	815..875	CDD:290566	11/59 (19%)
		leucine-rich repeat	817..864	CDD:275380	6/46 (13%)
		LRR_8	864..921	CDD:290566	14/58 (24%)
		leucine-rich repeat	865..888	CDD:275380	6/22 (27%)
		leucine-rich repeat	889..910	CDD:275380	6/20 (30%)
		TIR	1076..1211	CDD:214587	49/142 (35%)
Tlr10	NP_001139507.1	LRR_RI	<39..167	CDD:238064	36/130 (28%)
		leucine-rich repeat	50..73	CDD:275378	6/22 (27%)
		LRR_8	72..129	CDD:290566	19/56 (34%)
		leucine-rich repeat	74..97	CDD:275378	9/22 (41%)
		leucine-rich repeat	98..118	CDD:275378	8/19 (42%)
		leucine-rich repeat	119..143	CDD:275378	5/25 (20%)
		leucine-rich repeat	144..155	CDD:275378	4/10 (40%)
		LRR_RI	<324..481	CDD:238064	36/241 (15%)
		leucine-rich repeat	350..373	CDD:275380	3/30 (10%)
		LRR_8	372..455	CDD:290566	20/130 (15%)
		leucine-rich repeat	374..398	CDD:275380	4/23 (17%)
		leucine-rich repeat	399..422	CDD:275380	4/48 (8%)
		leucine-rich repeat	423..444	CDD:275380	6/42 (14%)
		LRR_8	443..500	CDD:290566	16/83 (19%)
		leucine-rich repeat	445..467	CDD:275380	6/46 (13%)
		leucine-rich repeat	468..489	CDD:275380	6/22 (27%)
		leucine-rich repeat	490..513	CDD:275380	7/23 (30%)
		TPKR_C2	522..574	CDD:301599	18/64 (28%)
		TIR	633..775	CDD:214587	48/141 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010