DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Tlr1

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	XP_038947853.1	Gene:	Tlr1 / 305354	RGDID:	1309975	Length:	808	Species:	Rattus norvegicus

Alignment Length:	965	Identity:	230/965 - (23%)
Similarity:	366/965 - (37%)	Gaps:	300/965 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 LDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQ 401
            ||:|.|.||.|:......|:.|::..:..|.:..|...:|...|.|..|.||.|.:.:|......
  Rat    66 LDVSQNNISELQTSDILLLSKLRVFIMSYNRLQYLNISVFKFNTELEYLDLSHNELRLISCHATA 130

  Fly   402 GLKNLLVLSLDFNRISRMD-QRSLVNCSQLQDLHLNDNKLQ-AVPEALAHVQLLKTLDVGENMIS 464
            .||:   |.|.||....:. .:...|.||||.|.|:.:::| :..:.:||:.:.|.|.|
  Rat   131 DLKH---LDLSFNAFDALPICKEFGNLSQLQFLGLSGSQIQNSSVQLIAHLNISKVLLV------ 186

  Fly   465 QIENTSITQLESLYGLRMTENSLTHIRRG----VFDR---------MS-----SLQILNLS---Q 508
                     |...||.:.....|.||...    ||..         ||     ||::.|:.   :
  Rat   187 ---------LGDTYGEKEDPKCLQHISTETLHIVFPSKREFHFLLDMSVSTAISLELSNIKCVLE 242

  Fly   509 NKLKSIEAGSLQRNSQLQAI-RLDGNQLKSIAGLFTELPNLVW------LNISGNRLE------K 560
            :|..|...|:|:|..:.|.: .|..|.:.:....|..:..|||      .:||..:|:      :
  Rat   243 DKNCSYFLGTLERLRKTQRLSNLTLNNVDTTWNSFINILQLVWHTPVKSFSISNVKLKGHFNFRR 307

  Fly   561 FDYSHIPIGLQWLDVRANRITQL---------GNYFEIESELSLSTFDASYNLLTEITASSIPNS 616
            |.||.       ..:||..|.|:         .|.:.|.|.:::.:|..|.   |.:.....|:.
  Rat   308 FHYSD-------TSLRALSIHQVVTDVFSFPQSNIYSIFSNMNIQSFTVSG---TRMVHMLCPDQ 362

  Fly   617 VE-VLYLN--DNQISKIQPYTFFKKPNLTR---VDLVRNRLTTLEPNALRLSPIAEDREIPEFYI 675
            :. .|||:  ||.::.|   .|....||.|   :.|.:|:|.||| |.:.:|
  Rat   363 ISPFLYLDFTDNLLTDI---VFEDCRNLIRLKTLSLQKNQLKTLE-NIILMS------------- 410

  Fly   676 GHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCF 740
                               ...|..|.:|:.|...|.:.|                    .|.|
  Rat   411 -------------------MEMTSLQKLDISQNSLRYSDA--------------------GSPC- 435

  Fly   741 ALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRE 805
                                       |||.:::..:       |.|::..||.        ||.
  Rat   436 ---------------------------SWTQSLLVLN-------LSSNMLTDSV--------FRC 458

  Fly   806 LQSHAFIGRKRLKVLHLNHSRI-----EVLHNRTFYGLLELEVLQLQSNQLKALNG-NEFQGLDN 864
            |.       .::|||.|:::||     :|.|      |..|:.|.:.||.|..|.| ..|..
  Rat   459 LP-------PKVKVLDLHNNRIVSISKDVTH------LQALQELNVASNFLTDLPGCGAFSS--- 507

  Fly   865 LQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLPSYLN--ELRLASNPWTCSCE 927
                                    |.:|.:|||:: |....:|..|..|  .:...:||:.|:||
  Rat   508 ------------------------LSVLVIDHNSV-SHPSSDFFQSCQNIRSITAGNNPFRCTCE 547

  Fly   928 FIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNY 992
                ||:::..               .|.:::::|    .|.|.|   .:|            :|
  Rat   548 ----LREFVKN---------------IGQASREVV----EGWPDS---YRC------------DY 574

  Fly   993 AEQAGGENASNATSTKMILNQPPKLDYIPILVAI-----LTAFIFVMICISLVFIFRQEMRV--- 1049
            .:...|      |..:.....|...|.|.:.|.|     |.|.|...:|  |.|.....:|:
  Rat   575 PDSIKG------TPLQDFHMSPLSCDTILLTVTIGATLLLLAAIGASLC--LYFDLPWYLRMLWQ 631

  Fly  1050 WCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDF 1114
            |..:|...|     ...:::.:|...|.||||||..|..:|..||.|.||..:.|  :|||:|:|
  Rat   632 WTQTRHRAR-----NIPLEELQRNLQFHAFVSYSGHDSAWVKNELLPNLEKDDIR--VCLHERNF 689

  Fly  1115 PVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKE 1179
            ..|..:.|.|:..|:.|.::|.|:|.:||:||||.:|...||.::..:....||:|:|..:||..
  Rat   690 VPGKSIVENIIHFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPIPQYS 754

  Fly  1180 LDPD---LRLYLKTNTYLQWGDK-----LFWQKLRFALPDVSSSQRSNVAGQSCH 1226
            :..:   |:..:...|||:|..:     |||..||.::    :.:..|.|..:|:
  Rat   755 IPTNYHKLKTLMARRTYLEWPTEKSKHGLFWANLRASI----NVKLVNQAEATCY 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	95/369 (26%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380
		LRR_RI	276..558	CDD:238064	65/250 (26%)
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..333	CDD:275380
		leucine-rich repeat	334..357	CDD:275380	8/19 (42%)
		leucine-rich repeat	358..381	CDD:275380	4/22 (18%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..429	CDD:275380	5/23 (22%)
		leucine-rich repeat	430..452	CDD:275380	7/22 (32%)
		leucine-rich repeat	453..500	CDD:275380	13/64 (20%)
		leucine-rich repeat	501..521	CDD:275380	6/22 (27%)
		leucine-rich repeat	525..547	CDD:275380	4/22 (18%)
		leucine-rich repeat	548..573	CDD:275380	9/36 (25%)
		leucine-rich repeat	604..640	CDD:275380	9/38 (24%)
		leucine-rich repeat	641..688	CDD:275380	10/49 (20%)
		leucine-rich repeat	689..816	CDD:275380	18/126 (14%)
		LRR_8	815..875	CDD:290566	17/65 (26%)
		leucine-rich repeat	817..864	CDD:275380	17/52 (33%)
		LRR_8	864..921	CDD:290566	9/58 (16%)
		leucine-rich repeat	865..888	CDD:275380	0/22 (0%)
		leucine-rich repeat	889..910	CDD:275380	7/20 (35%)
		TIR	1076..1211	CDD:214587	53/142 (37%)
Tlr1	XP_038947853.1	PRK15370	<51..>146	CDD:185268	25/82 (30%)
		leucine-rich repeat	63..86	CDD:275378	8/19 (42%)
		leucine-rich repeat	87..110	CDD:275378	4/22 (18%)
		leucine-rich repeat	111..125	CDD:275378	5/13 (38%)
		leucine-rich repeat	132..156	CDD:275378	7/26 (27%)
		leucine-rich repeat	157..169	CDD:275378	4/11 (36%)
		PRK15370	<313..>500	CDD:185268	61/301 (20%)
		leucine-rich repeat	368..389	CDD:275380	8/23 (35%)
		leucine-rich repeat	390..415	CDD:275380	8/57 (14%)
		leucine-rich repeat	416..440	CDD:275380	10/71 (14%)
		leucine-rich repeat	441..462	CDD:275380	7/42 (17%)
		leucine-rich repeat	463..485	CDD:275380	9/27 (33%)
		leucine-rich repeat	486..507	CDD:275380	8/20 (40%)
		leucine-rich repeat	508..531	CDD:275380	8/23 (35%)
		LRRCT	540..594	CDD:214507	17/97 (18%)
		TIR	652..795	CDD:214587	53/148 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920