DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Tlr6

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_997487.1	Gene:	Tlr6 / 305353	RGDID:	1303030	Length:	806	Species:	Rattus norvegicus

Alignment Length:	993	Identity:	239/993 - (24%)
Similarity:	379/993 - (38%)	Gaps:	297/993 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 VVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAA 326
            |||.|...||.:|.:|...||.|.   |..|||:.|.......|:||.||.|:.|.:..  ::..
  Rat    46 VVDYSNKNLTHVPKDLSPSTKSLS---LSQNSISDLQMSDISFLSELRVLRLSHNRIRR--LDFG 105

  Fly   327 TFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNR 391
            .|:..:.|..||:|.|::..:..   .|:.:|:.|.|..|..:.||  ::.:..||..|
  Rat   106 VFLLNRDLEYLDVSHNQLQNISC---CPMVNLKHLDLSFNDFEVLP--VYKEFGNLRKL------ 159

  Fly   392 ISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTL 456
                   :..||.......||...||                ||:   |..|...|.:.|:..
  Rat   160 -------SFLGLSAAKFRQLDLLPIS----------------HLH---LSCVLLDLVNYQIKD-- 196

  Fly   457 DVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVF--DRMSSLQILNLSQNKLKSIEAGSL 519
              ||....|:.||::..|                   ||  :.:.|:|: |:|.|.|     |.|
  Rat   197 --GETESLQVPNTNVLHL-------------------VFHPNSLFSVQV-NISVNAL-----GCL 234

  Fly   520 QRNSQLQAIRLDGNQLKSIAGLFTELP------NLVWLNISGN-----RLEKFDYSHIPIGLQWL 573
                ||..|:|:....:|:....:||.      ||...:|..|     ||.:|.:   |..:::|
  Rat   235 ----QLSNIKLNDENCQSLIIFLSELTRGPTLLNLTLQHIETNWKCFVRLLQFLW---PRPVEYL 292

  Fly   574 DVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKK 638
            ::....||:         .:|..||.....:|..:....:.|.| .|::.|      ..|:.|.:
  Rat   293 NIYNLTITE---------SISRETFIYVETVLKSLKIEHVTNQV-FLFVKD------ALYSVFAE 341

  Fly   639 PNLTRVDLVRNRLTTLE--PNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRES----- 696
            .|:        |:.||.  |....:.|     |.|..:    |:     |::.|.|..:|
  Rat   342 MNI--------RMLTLSDTPFIHMVCP-----EFPSTF----AF-----LNFTQNVFTDSIFQGC 384

  Fly   697 ----RTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMEC 757
                |.:..::..:.:......|..:..:|.:|. .|..|....||.:
  Rat   385 STLKRLETLILQRNGLKNLFKVALMTKTMSSLET-LDVSLNSLNSHVY----------------- 431

  Fly   758 PDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHL 822
             || :|    :|..::       ....|.|::..||.        ||.|.       .::|||.|
  Rat   432 -DR-TC----AWAESI-------RVLNLSSNVLSDSV--------FRCLP-------PKVKVLDL 468

  Fly   823 NHSRI-----EVLHNRTFYGLLELEVLQLQSNQLKALNG-NEFQGLDNLQELYLQHNAIATIDTL 881
            :::||     :|.|      |..|:.|.:.||.|..|.| ..|..
  Rat   469 HNNRIVSIPKDVTH------LQALQELNVASNFLTDLPGCGAFSS-------------------- 507

  Fly   882 TFTHLYHLKILRLDHNAITSFAVWNFLPSYLN--ELRLASNPWTCSCEFIDKLRDYINRHEYVVD 944
                   |.:|.:|||:: |....:|..|..|  .:...:||:.|:||    ||:::..
  Rat   508 -------LSVLVIDHNSV-SHPSSDFFQSCQNIRSITAGNNPFRCTCE----LREFVKN------ 554

  Fly   945 KLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKM 1009
                     .|.:::::|    .|.|.|   .:|            :|.:...|      |..:.
  Rat   555 ---------IGQASREVV----EGWPDS---YRC------------DYPDSIKG------TPLQD 585

  Fly  1010 ILNQPPKLDYIPILVAI-----LTAFIFVMICISLVFIFRQEMRV---WCHSRFGVRLFYNAQKD 1066
            ....|...|.|.:.|.|     |.|.|...:|  |.|.....:|:   |..:|...|     ...
  Rat   586 FHMSPLSCDTILLTVTIGATLLLLAAIGASLC--LYFDLPWYLRMLWQWTQTRHRAR-----NIP 643

  Fly  1067 VDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPETIVQAIDSS 1131
            :::.:|...|.||||||..|..:|..||.|.||..:.|  :|||:|:|..|..:.|.|:..|:.|
  Rat   644 LEELQRNLQFHAFVSYSEHDSAWVKNELLPNLEKDDIR--VCLHERNFVPGKSIVENIIHFIEKS 706

  Fly  1132 RRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDP---DLRLYLKTNTY 1193
            .::|.|:|.:||:||||.:|...||.::..:....||:|:|..:.|..:..   .||..:...||
  Rat   707 YKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPIQQNNIPSRYHKLRALMAQRTY 771

  Fly  1194 LQW----GDK-LFWQKLR 1206
            |:|    |.: |||..||
  Rat   772 LEWPIEKGKRGLFWANLR 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	8/18 (44%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	99/408 (24%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380	9/20 (45%)
		LRR_RI	276..558	CDD:238064	71/294 (24%)
		leucine-rich repeat	284..307	CDD:275380	7/22 (32%)
		leucine-rich repeat	308..333	CDD:275380	6/24 (25%)
		leucine-rich repeat	334..357	CDD:275380	6/22 (27%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	382..405	CDD:275380	4/22 (18%)
		leucine-rich repeat	406..429	CDD:275380	4/22 (18%)
		leucine-rich repeat	430..452	CDD:275380	5/21 (24%)
		leucine-rich repeat	453..500	CDD:275380	8/48 (17%)
		leucine-rich repeat	501..521	CDD:275380	7/19 (37%)
		leucine-rich repeat	525..547	CDD:275380	6/27 (22%)
		leucine-rich repeat	548..573	CDD:275380	7/29 (24%)
		leucine-rich repeat	604..640	CDD:275380	7/35 (20%)
		leucine-rich repeat	641..688	CDD:275380	9/48 (19%)
		leucine-rich repeat	689..816	CDD:275380	22/135 (16%)
		LRR_8	815..875	CDD:290566	17/65 (26%)
		leucine-rich repeat	817..864	CDD:275380	17/52 (33%)
		LRR_8	864..921	CDD:290566	9/58 (16%)
		leucine-rich repeat	865..888	CDD:275380	0/22 (0%)
		leucine-rich repeat	889..910	CDD:275380	7/20 (35%)
		TIR	1076..1211	CDD:214587	54/139 (39%)
Tlr6	NP_997487.1	leucine-rich repeat	46..64	CDD:275380	8/17 (47%)
		leucine-rich repeat	65..88	CDD:275378	9/25 (36%)
		LRR_8	87..144	CDD:290566	17/61 (28%)
		leucine-rich repeat	89..112	CDD:275378	6/24 (25%)
		leucine-rich repeat	113..133	CDD:275378	6/22 (27%)
		leucine-rich repeat	134..158	CDD:275378	8/25 (32%)
		leucine-rich repeat	369..385	CDD:275380	4/15 (27%)
		LRR_RI	<380..>500	CDD:238064	33/171 (19%)
		LRR_8	388..451	CDD:290566	14/93 (15%)
		leucine-rich repeat	390..415	CDD:275380	1/24 (4%)
		leucine-rich repeat	416..440	CDD:275380	9/47 (19%)
		leucine-rich repeat	441..462	CDD:275380	7/42 (17%)
		LRR_8	461..516	CDD:290566	20/87 (23%)
		leucine-rich repeat	463..485	CDD:275380	9/27 (33%)
		leucine-rich repeat	486..508	CDD:275380	8/48 (17%)
		leucine-rich repeat	510..531	CDD:275380	7/21 (33%)
		LRRCT	540..594	CDD:214507	17/97 (18%)
		TIR	652..791	CDD:214587	54/140 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820