DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tollo and Lrrtm3

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001099857.1	Gene:	Lrrtm3 / 294380	RGDID:	1304866	Length:	582	Species:	Rattus norvegicus

Alignment Length:	380	Identity:	101/380 - (26%)
Similarity:	162/380 - (42%)	Gaps:	58/380 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 LFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSA 341
            ::.|:::||||   .:||:.   |..|                                 |.|..
  Rat    45 VYCESQKLQEI---PSSISA---GCLG---------------------------------LSLRY 70

  Fly   342 NKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNL 406
            |.:.:|:.:.|:.|..|..|.|:.|:|..:....|..:..|..||||.||||.....|.:.:.||
  Rat    71 NSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNL 135

  Fly   407 LVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVP-EALAHVQLLKTLDVGENMISQIENTS 470
            ..|.|.:|::..:.........:|..|||..|.|:.:| ......:.|:.||:|.|.|..:....
  Rat   136 RNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNV 200

  Fly   471 ITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQL 535
            ...:..|..|.:..|..:.:...:|.|:.|||.|.:..||:..|........|.||.:.|.||::
  Rat   201 FAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYMQWNKISVIGQTMSWTWSSLQRLDLSGNEI 265

  Fly   536 KSIAG--LFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLD--VRANRITQLGNYFEIESEL-SL 595
            ::.:|  :|..:|||..||:..|:|..       ||.:.||  :..|.|:..||.:|....: ||
  Rat   266 EAFSGPSVFQCVPNLQRLNLDSNKLTF-------IGQEILDSWISLNDISLAGNIWECSRNICSL 323

  Fly   596 STFDASYNLLTEIT-ASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLT-RVDLVR 648
            ..:..|:..|.|.| ..:.|..::.:    |.|..::.|:...|...| |.||.|
  Rat   324 VNWLKSFKGLRENTILCASPKELQGV----NVIDAVKNYSICGKSTTTERFDLAR 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	0/3 (0%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	101/380 (27%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380	1/5 (20%)
		LRR_RI	276..558	CDD:238064	75/283 (27%)
		leucine-rich repeat	284..307	CDD:275380	8/22 (36%)
		leucine-rich repeat	308..333	CDD:275380	0/24 (0%)
		leucine-rich repeat	334..357	CDD:275380	6/22 (27%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	382..405	CDD:275380	10/22 (45%)
		leucine-rich repeat	406..429	CDD:275380	4/22 (18%)
		leucine-rich repeat	430..452	CDD:275380	7/22 (32%)
		leucine-rich repeat	453..500	CDD:275380	11/46 (24%)
		leucine-rich repeat	501..521	CDD:275380	6/19 (32%)
		leucine-rich repeat	525..547	CDD:275380	7/23 (30%)
		leucine-rich repeat	548..573	CDD:275380	7/24 (29%)
		leucine-rich repeat	604..640	CDD:275380	8/36 (22%)
		leucine-rich repeat	641..688	CDD:275380	5/9 (56%)
		leucine-rich repeat	689..816	CDD:275380
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
Lrrtm3	NP_001099857.1	LRRNT	33..61	CDD:214470	7/18 (39%)
		LRR 1	61..83		7/57 (12%)
		leucine-rich repeat	66..86	CDD:275380	6/19 (32%)
		LRR_RI	<81..300	CDD:238064	66/225 (29%)
		LRR 2	84..107		7/22 (32%)
		LRR_8	86..145	CDD:290566	21/58 (36%)
		leucine-rich repeat	87..110	CDD:275380	6/22 (27%)
		LRR 3	109..131		10/21 (48%)
		leucine-rich repeat	111..134	CDD:275380	10/22 (45%)
		LRR 4	132..155		5/22 (23%)
		LRR_8	133..193	CDD:290566	17/59 (29%)
		leucine-rich repeat	135..158	CDD:275380	4/22 (18%)
		LRR 5	156..179		7/22 (32%)
		leucine-rich repeat	159..182	CDD:275380	7/22 (32%)
		LRR_8	181..241	CDD:290566	16/59 (27%)
		LRR 6	181..203		6/21 (29%)
		leucine-rich repeat	183..206	CDD:275380	6/22 (27%)
		LRR 7	205..227		4/21 (19%)
		leucine-rich repeat	207..230	CDD:275380	5/22 (23%)
		LRR 8	229..251		7/21 (33%)
		LRR_8	230..290	CDD:290566	21/59 (36%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR 9	252..276		8/23 (35%)
		leucine-rich repeat	255..279	CDD:275380	7/23 (30%)
		LRR 10	277..300		10/29 (34%)
		leucine-rich repeat	280..300	CDD:275380	8/26 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..411
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910