DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tollo and Tlr4

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_062051.2 Gene:Tlr4 / 29260 RGDID:3870 Length:835 Species:Rattus norvegicus


Alignment Length:918 Identity:237/918 - (25%)
Similarity:358/918 - (38%) Gaps:229/918 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   433 LHLNDNKLQAV-PEALAHVQLLKTLDVGENMISQIENTSITQLE-----SLYGLRMTENSLTHIR 491
            |||....:.|: ...|....|...::|..|:..|..:.:::::.     |...|.::.|.|..:|
  Rat     5 LHLAGTLIMALFLSCLRPGSLNPCIEVLPNITYQCMDQNLSKIPHDIPYSTKNLDLSFNPLKILR 69

  Fly   492 RGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIA-GLF---TELPNLVWLN 552
            ...|...|.||.|:||:.::::||..:....:||..:.|.||.:||.: |.|   |.|.|||.:.
  Rat    70 SYSFSNFSQLQWLDLSRCEIETIEDKAWHGLNQLSTLVLTGNPIKSFSPGSFSGLTNLENLVAVE 134

  Fly   553 ISGNRLEKFDYSHIPIGLQWLDVRANRI--TQLGNYFEIESEL-SLSTFDASYNLLTEITASSI- 613
            .....||.|....: |.|:.|:|..|.|  .:|..||   |.| :|...|.|||.:..|:...: 
  Rat   135 TKMTSLEGFHIGQL-ISLKKLNVAHNLIHSFKLPEYF---SNLTNLEHVDLSYNYIQTISVKDLQ 195

  Fly   614 -----PNSVEVLYLNDNQISKIQPYTF-------------FKKPNLTRVDLVRNRLTTLEPNALR 660
                 |.....|.|:.|.|..||...|             |...|:.::.|  ..:|.|..:.|.
  Rat   196 FLRENPQVNLSLDLSLNPIDSIQAQAFQGIRLHELTLRSNFNSSNVLKMCL--QNMTGLHVHRLI 258

  Fly   661 LSPIAEDREIPEFYIGHNAYECDCNLD----WLQKVNRESRTQPQLMDLDQIHCRLAYARGSS-- 719
            |.....:|.:..|  ..:..|..||:.    .|..:|..|.      |:..::| ||.....|  
  Rat   259 LGEFKNERNLESF--DRSVMEGLCNVSIDEFRLTYINHFSD------DIYNLNC-LANISAMSFT 314

  Fly   720 --HVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSW--TSNVVDCSRAS 780
              |:..|......|  |:.|.....||...|.    |:..|      ..:||  |:|..|.|.. 
  Rat   315 GVHIKHIADVPRHF--KWQSLSIIRCHLKPFP----KLSLP------FLKSWTLTTNREDISFG- 366

  Fly   781 YEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQ 845
             :..|||...:|   |..:..:||...|::..|...||.|.|:.:.: :|.:..|.||.|||.|.
  Rat   367 -QLALPSLRYLD---LSRNAMSFRGCCSYSDFGTNNLKYLDLSFNGV-ILMSANFMGLEELEYLD 426

  Fly   846 LQSNQLK------------------------------------ALN-----GNEFQGLDN----- 864
            .|.:.||                                    :||     ||.|:  ||     
  Rat   427 FQHSTLKKVTEFSVFLSLEKLLYLDISYTNTKIDFDGIFLGLISLNTLKMAGNSFK--DNTLSNV 489

  Fly   865 ------------------------------LQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAI 899
                                          ||.|.:.||.:..:|...:..||.|:.|....|.|
  Rat   490 FTNTTNLTFLDLSKCQLEQISRGVFDTLYRLQLLNMSHNNLLFLDPSHYKQLYSLRTLDCSFNRI 554

  Fly   900 -TSFAVWNFLPSYLNELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVI 963
             ||..:....|..|....|.:|...|.||:.:.|:...::..::|:..:|||             
  Rat   555 ETSKGILQHFPKSLAVFNLTNNSVACICEYQNFLQWVKDQKMFLVNVEQMKC------------- 606

  Fly   964 YPGSGEPASLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILT 1028
                ..|     :....:|.|...|:..|.             .|.|::    :..:.:||....
  Rat   607 ----ASP-----IDMKASLVLDFTNSTCYI-------------YKTIIS----VSVVSVLVVATV 645

  Fly  1029 AFIFVMICISLVFIFRQEMRVWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEE 1093
            ||:..                  |..|.:.|....:|   .:..|.::||||.|||::|.:|..|
  Rat   646 AFLIY------------------HFYFHLILIAGCKK---YSRGESIYDAFVIYSSQNEDWVRNE 689

  Fly  1094 LAPMLEMGEHRYKLCLHQRDFPVGGYLPETIVQ-AIDSSRRTIMVVSENFIKSEWCRFEFKSAHQ 1157
            |...||.|..|::||||.|||..|..:...|:| ....||:.|:|||.:||:|.||.||::.|..
  Rat   690 LVKNLEEGVPRFQLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQT 754

  Fly  1158 SVLRDRRRRLIVIVLGEVPQKELDPDLRLY--LKTNTYLQWGDK-----LFWQKLRFAL------ 1209
            ......|..:|.|||.:|.:..|...:.||  |..||||:|.|.     :||::|:.||      
  Rat   755 WQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDNALGRHIFWRRLKKALLDGKAL 819

  Fly  1210 -PDVSSSQ 1216
             ||.:|.:
  Rat   820 NPDETSEE 827

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380
LRR_8 152..222 CDD:290566
leucine-rich repeat 154..177 CDD:275380
leucine-rich repeat 178..201 CDD:275380
LRR 210..656 CDD:227223 70/254 (28%)
leucine-rich repeat 212..235 CDD:275380
leucine-rich repeat 236..259 CDD:275380
leucine-rich repeat 260..283 CDD:275380
LRR_RI 276..558 CDD:238064 37/134 (28%)
leucine-rich repeat 284..307 CDD:275380
leucine-rich repeat 308..333 CDD:275380
leucine-rich repeat 334..357 CDD:275380
leucine-rich repeat 358..381 CDD:275380
leucine-rich repeat 382..405 CDD:275380
leucine-rich repeat 406..429 CDD:275380
leucine-rich repeat 430..452 CDD:275380 5/19 (26%)
leucine-rich repeat 453..500 CDD:275380 9/51 (18%)
leucine-rich repeat 501..521 CDD:275380 7/19 (37%)
leucine-rich repeat 525..547 CDD:275380 10/25 (40%)
leucine-rich repeat 548..573 CDD:275380 7/24 (29%)
leucine-rich repeat 604..640 CDD:275380 10/54 (19%)
leucine-rich repeat 641..688 CDD:275380 10/50 (20%)
leucine-rich repeat 689..816 CDD:275380 33/132 (25%)
LRR_8 815..875 CDD:290566 27/135 (20%)
leucine-rich repeat 817..864 CDD:275380 20/87 (23%)
LRR_8 864..921 CDD:290566 18/92 (20%)
leucine-rich repeat 865..888 CDD:275380 7/22 (32%)
leucine-rich repeat 889..910 CDD:275380 6/21 (29%)
TIR 1076..1211 CDD:214587 60/149 (40%)
Tlr4NP_062051.2 PLN00113 23..>456 CDD:215061 120/465 (26%)
LRR 1 54..75 6/20 (30%)
leucine-rich repeat 58..78 CDD:275380 5/19 (26%)
LRR 2 78..99 7/20 (35%)
leucine-rich repeat 79..102 CDD:275380 7/22 (32%)
LRR 3 102..123 9/20 (45%)
leucine-rich repeat 103..126 CDD:275380 8/22 (36%)
LRR 4 126..147 7/20 (35%)
leucine-rich repeat 127..150 CDD:275380 7/23 (30%)
LRR 5 150..171 8/23 (35%)
leucine-rich repeat 151..175 CDD:275380 10/26 (38%)
LRR 6 175..198 6/22 (27%)
leucine-rich repeat 176..204 CDD:275380 7/27 (26%)
LRR 7 204..224 7/19 (37%)
leucine-rich repeat 205..226 CDD:275380 7/20 (35%)
LRR 8 226..247 3/22 (14%)
leucine-rich repeat 256..310 CDD:275380 14/62 (23%)
LRR 9 372..381 3/11 (27%)
leucine-rich repeat 373..398 CDD:275380 6/27 (22%)
LRR 10 398..420 7/22 (32%)
leucine-rich repeat 399..421 CDD:275380 8/22 (36%)
LRR 11 421..442 7/20 (35%)
leucine-rich repeat 422..446 CDD:275380 6/23 (26%)
LRR 12 446..467 0/20 (0%)
leucine-rich repeat 447..470 CDD:275380 0/22 (0%)
LRR 13 470..491 7/22 (32%)
leucine-rich repeat 471..495 CDD:275380 7/25 (28%)
LRR_8 494..554 CDD:404697 11/59 (19%)
LRR 14 495..516 0/20 (0%)
leucine-rich repeat 496..519 CDD:275380 0/22 (0%)
LRR 15 519..540 6/20 (30%)
leucine-rich repeat 520..543 CDD:275380 7/22 (32%)
LRR 16 543..564 6/20 (30%)
leucine-rich repeat 544..567 CDD:275380 7/22 (32%)
TIR 672..813 CDD:214587 58/140 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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