DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Slitrk6

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001099527.1	Gene:	Slitrk6 / 290467	RGDID:	1306550	Length:	840	Species:	Rattus norvegicus

Alignment Length:	933	Identity:	200/933 - (21%)
Similarity:	335/933 - (35%)	Gaps:	264/933 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 SLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGEN-MISQIENTSITQLESL-------YG 479
            ||:.|..||       ....:|........|.|.:..:. ||...|...|..|..:       :.
  Rat    11 SLLACLSLQ-------SQSPMPPVRGSCDTLCTCEEKDGIMIINCEEKGINTLSQISVPPSRPFH 68

  Fly   480 LRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTE 544
            |.:..|.||.:....|..:::...::|..|.:..||.|:                       |..
  Rat    69 LSLLNNGLTTLHTNDFSGLTNALSIHLGFNNIADIETGA-----------------------FNG 110

  Fly   545 LPNLVWLNISGNRLE--KFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTE 607
            |..|..|:|:.|.||  |.|..|   ||:                      :|....|..|.:|.
  Rat   111 LGLLKQLHINHNSLEILKEDTFH---GLE----------------------NLEFLQADNNFITV 150

  Fly   608 ITASSIP--NSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREI 670
            |..|:..  |.::||.||||.|..:.|..|...| ||.:||..|:|.|| |....|..|.   .|
  Rat   151 IEQSAFSKLNRLKVLILNDNAIESLPPNIFRFVP-LTHLDLRGNQLQTL-PYVGFLEHIG---RI 210

  Fly   671 PEFYIGHNAYECDCNL----DWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDF 731
            .:..:..|.:.|:|.|    :||:.:      .||.:..|.|    .|:......|::.....:.
  Rat   211 LDLQLEDNKWACNCELLQLKNWLENM------PPQSIIGDVI----CYSPPLFKGSILSRLKKES 265

  Fly   732 LCK----YASH------CFALCHCCDFQACDCKME------------------------------ 756
            :|.    |..|      ..|:..    ...|.::.
  Rat   266 ICPTPPVYEEHEDPAGSLLAITS----STSDSRLSSKNTSILKQPTKAPGSVPYLTKPSTQLPVP 326

  Fly   757 -CPDRCSCYHDQSWTSNVVDCSRASYEQTL----PSHIPMDSTQLYLDGNNFRELQSHAFIGRKR 816
             ||..|:| ...|.:..::.|...:.|...    |.|.|   .:|.|.||....|.....:....
  Rat   327 YCPVPCNC-KVLSPSGLLIHCQERNIESVSDLQPPPHNP---RKLILAGNIIHTLMKADLMDYFT 387

  Fly   817 LKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTL 881
            |::|||.::|||||...:|..|..|:.|.|..|.|..|....|.||.:|:.|||::||:..|...
  Rat   388 LEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLYKGMFLGLSSLEYLYLEYNAVKEILPG 452

  Fly   882 TFTHLYHLKILRLDHNAI-----------------------TSFAVWNFLP--SYLNELRLASNP 921
            ||..:..||:|.|::|.:                       |...|.|.|.  ..|.::.|..||
  Rat   453 TFNPMPKLKVLYLNNNLLHVLPAHIFLGIPLTRVNLKTNQFTHLPVSNILDDLDLLIQIDLEDNP 517

  Fly   922 WTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGL 986
            |.|||:.:. |:.:|::    :.|..:..|::..:        ||..:...|..:. |:.|..||
  Rat   518 WDCSCDLVG-LQQWIHK----LGKGTVTDDILCAS--------PGHLDKKELKALN-SELLCPGL 568

  Fly   987 DNNFNYAEQAGGENASNATSTKMILNQPPKL-------------DYIP---ILVAILTAFIFVMI 1035
            .|           |.|..|.|..|:...|.:             |.:|   :::.:|..||.::.
  Rat   569 VN-----------NPSMPTQTSYIIVTSPTMAADAAGTLLSSLTDAVPLSVLILGLLIVFITIVF 622

  Fly  1036 CISLVFIFRQEMRVWCHSRFGVRLFYNAQKDVDKNEREKLFDA------FVSYSSK--------- 1085
            |.:.:.:|               :.:..::...|...|:|.|.      :..|..|
  Rat   623 CAAGIVVF---------------VLHRRRRYKKKKVEEQLRDTSPVHLQYSMYGHKTTHHTTERP 672

  Fly  1086 -DELFVNEELAPMLEMGEHRYKLC---------LHQRDFPVGG---YLPETIVQ-----AIDSSR 1132
             ..|:....::||:    |.|:..         :.:|....|.   :|..::::     .:..|.
  Rat   673 SSSLYEQHMVSPMV----HVYRSPSFGPKHLEEVEERSDKEGNDAKHLQRSLLERENHSPLTGSN 733

  Fly  1133 RTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQK---ELDPDLRL-YLKTNTY 1193
            ....||.::   :::..|:..|.....:.|:.|.|..:.:.|..:|   :|.||:.: |...:..
  Rat   734 MKYKVVDQS---TDFLPFQDASLLYRNILDKERELQQLGITEYLRKNIAQLQPDVEVNYPGAHEE 795

  Fly  1194 LQWGDKLFWQKLRFALPDVSSSQ 1216
            |:..:.|.:.:.|..|.:.:.::
  Rat   796 LKLMETLMYSRPRKVLVEQTKNE 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	61/244 (25%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380
		LRR_RI	276..558	CDD:238064	29/142 (20%)
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..333	CDD:275380
		leucine-rich repeat	334..357	CDD:275380
		leucine-rich repeat	358..381	CDD:275380
		leucine-rich repeat	382..405	CDD:275380
		leucine-rich repeat	406..429	CDD:275380	3/5 (60%)
		leucine-rich repeat	430..452	CDD:275380	3/21 (14%)
		leucine-rich repeat	453..500	CDD:275380	12/54 (22%)
		leucine-rich repeat	501..521	CDD:275380	5/19 (26%)
		leucine-rich repeat	525..547	CDD:275380	2/21 (10%)
		leucine-rich repeat	548..573	CDD:275380	11/26 (42%)
		leucine-rich repeat	604..640	CDD:275380	13/37 (35%)
		leucine-rich repeat	641..688	CDD:275380	16/50 (32%)
		leucine-rich repeat	689..816	CDD:275380	27/171 (16%)
		LRR_8	815..875	CDD:290566	25/59 (42%)
		leucine-rich repeat	817..864	CDD:275380	20/46 (43%)
		LRR_8	864..921	CDD:290566	20/81 (25%)
		leucine-rich repeat	865..888	CDD:275380	9/22 (41%)
		leucine-rich repeat	889..910	CDD:275380	9/45 (20%)
		TIR	1076..1211	CDD:214587	29/171 (17%)
Slitrk6	NP_001099527.1	leucine-rich repeat	68..89	CDD:275380	5/20 (25%)
		LRR_8	69..124	CDD:290566	16/77 (21%)
		leucine-rich repeat	94..113	CDD:275380	7/41 (17%)
		leucine-rich repeat	114..137	CDD:275380	11/47 (23%)
		LRR_8	137..195	CDD:290566	22/58 (38%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..177	CDD:275380	7/14 (50%)
		leucine-rich repeat	185..260	CDD:275380	24/88 (27%)
		leucine-rich repeat	210..222	CDD:275378	2/11 (18%)
		TPKR_C2	218..268	CDD:301599	12/59 (20%)
		leucine-rich repeat	261..411	CDD:275380	31/157 (20%)
		leucine-rich repeat	365..387	CDD:275380	5/21 (24%)
		LRR_8	387..444	CDD:290566	24/56 (43%)
		LRR_4	388..425	CDD:289563	16/36 (44%)
		LRR_4	410..449	CDD:289563	15/38 (39%)
		leucine-rich repeat	412..435	CDD:275380	9/22 (41%)
		LRR_8	434..493	CDD:290566	14/58 (24%)
		leucine-rich repeat	436..459	CDD:275380	9/22 (41%)
		leucine-rich repeat	460..481	CDD:275380	5/20 (25%)
		LRRCT	516..566	CDD:214507	15/63 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3875
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050