DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Tlr5

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001139300.1	Gene:	Tlr5 / 289337	RGDID:	631351	Length:	871	Species:	Rattus norvegicus

Alignment Length:	1213	Identity:	240/1213 - (19%)
Similarity:	400/1213 - (32%)	Gaps:	461/1213 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SELENTNFSVIQPQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGL 121
            |.:..|:|.:::....:.|..:     :.:.::..::||:|..||.|.:...::..|...:|:||
  Rat    71 STVVTTSFPLLEQLLLLELGTQ-----YARLTIGQEAFRNLPNLRILDLGQSQIEVLNPDAFQGL 130

  Fly   122 QELRNLTIRTHNGDWSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYN 186
            ..|..|.:    .|....:..:....|.....|.|||||.|.|..:            ||::|:.
  Rat   131 PHLFELRL----FDCGLSNAVLRDAYFRNLNSLARLDLSANEIHSL------------HLHSSFQ 179

  Fly   187 KIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGR-LTHLNMAKNSMSFLA 250
            ::..:|:..||   .:|...:|...||.|.                 || |:...:...|   |.
  Rat   180 ELSSLSDINFS---FNRIFTLCEDELQPLQ-----------------GRTLSFFGLKSTS---LF 221

  Fly   251 DRAF----------EGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGI---- 301
            .|.|          .| :.|..:|||.|..|:.....|:.|.|...|.....:.:::..|.
  Rat   222 SRVFVDWEACRNPLRG-IRLETLDLSENGWTAAILGNFSHTIQGSHISSLILTYHIMGSGFGFQN 285

  Fly   302 --------FGELA--ELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLA 356
                    |..||  .:|.|||:...:.|  :|...|..||.|..|:|:.|||:::..:.|..|.
  Rat   286 IKDPDQSTFASLARSSVLQLDLSHGYIFS--LNPRLFETLKDLKKLNLAFNKINKISDYAFHGLD 348

  Fly   357 SLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQ 421
            |||||.|..|.:.:|....|..|.::..|.|.||.|.:|:.||.:.||
  Rat   349 SLQILNLSYNLLGELYNSNFYGLPSIAYLDLQRNHIGIIQDRTFRLLK----------------- 396

  Fly   422 RSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENS 486
                   :||.|.|.||.|:                            :|..:.|:..:.:..|.
  Rat   397 -------KLQTLDLRDNALK----------------------------TIGFIPSVQMVLLGSNK 426

  Fly   487 LTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWL 551
            |||:....|    :...:.||:|.|::                               |.:|.:|
  Rat   427 LTHLPHVRF----TANFIELSENGLEN-------------------------------LSDLYFL 456

  Fly   552 NISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNS 616
                        ..|| |||:|.:..||::...|.          .:..|.||           |
  Rat   457 ------------LRIP-GLQFLILNQNRLSSCSNV----------DYAPSQNL-----------S 487

  Fly   617 VEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYE 681
            :|.|:|.:|.:
  Rat   488 LEQLFLAENML------------------------------------------------------ 498

  Fly   682 CDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCC 746
                                         :||:..|                        ||
  Rat   499 -----------------------------QLAWETG------------------------LC--- 507

  Fly   747 DFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAF 811
                                  |                                       ..|
  Rat   508 ----------------------W---------------------------------------DIF 511

  Fly   812 IGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIA 876
            .|..||::|:||::.:..|....|.||:.|.:|.|.:|:|..|:......  ||:.|.:..|.:.
  Rat   512 KGLSRLQILYLNNNYLNFLPPGIFNGLVALRMLSLSANRLTMLSPGSLPA--NLEILDISRNQLF 574

  Fly   877 TIDTLTFTHLYHLKILRLDHN------AITSFAVWNFLPSYLNELRLASNPWTCSCEFIDKLRDY 935
            :.|...|:   .|:.|.:.||      .:::|.||      ||:..:
  Rat   575 SPDPGLFS---SLRALDITHNEFICDCELSTFIVW------LNQTNV------------------ 612

  Fly   936 INRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYA-EQAGGE 999
                            .:.|:......:||.|...:||                :|.: :....|
  Rat   613 ----------------TLFGSPADVYCMYPNSLLGSSL----------------YNISTKDCDEE 645

  Fly  1000 NASNATSTKMILNQPPKLDYIPILVAILTAFIFV-MICISLV--FIFRQEMRVWCHSRFGVRLFY 1061
            .|..:.:..:.:.....|....::..|:|.|..: .:|...:  .:|:.:.|
  Rat   646 EAVRSLNFSLFILCTVTLTLFLVITLIVTKFRGICFLCFKTIQKLMFKGKFR------------- 697

  Fly  1062 NAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLE---MGEHRYKLCLHQRDFPVGGYLPET 1123
            |.:....:      :||:..:||||..:....|...|:   ..::|.:||..:|||..|......
  Rat   698 NPEPSAYR------YDAYFCFSSKDFEWAQNALLKHLDAQYSSQNRLRLCFEERDFIPGENHISN 756

  Fly  1124 IVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKEL--DPDLRL 1186
            |..|:..||:|:.:||.:|:|..||...|:.|....|.|.:|.|||:|:|.:||.:|  ...:|.
  Rat   757 IQAAVWGSRKTVCLVSRHFLKDGWCLEAFRYAQSRCLSDLKRVLIVVVVGSLPQYQLMRHETIRG 821

  Fly  1187 YLKTNTYLQWGDKLFWQKLRFALPDVSSSQRSNVAGQSCHVPI 1229
            :|:...||:|.:.|  |.:.:.|..:|........|:....||
  Rat   822 FLQKQQYLRWPEDL--QDVDWFLDKLSGCILKEEKGKKRSSPI 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	48/206 (23%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		leucine-rich repeat	124..144	CDD:275380	3/19 (16%)
		LRR_8	152..222	CDD:290566	19/69 (28%)
		leucine-rich repeat	154..177	CDD:275380	8/22 (36%)
		leucine-rich repeat	178..201	CDD:275380	6/22 (27%)
		LRR	210..656	CDD:227223	100/470 (21%)
		leucine-rich repeat	212..235	CDD:275380	3/22 (14%)
		leucine-rich repeat	236..259	CDD:275380	6/32 (19%)
		leucine-rich repeat	260..283	CDD:275380	8/22 (36%)
		LRR_RI	276..558	CDD:238064	66/295 (22%)
		leucine-rich repeat	284..307	CDD:275380	5/36 (14%)
		leucine-rich repeat	308..333	CDD:275380	8/24 (33%)
		leucine-rich repeat	334..357	CDD:275380	8/22 (36%)
		leucine-rich repeat	358..381	CDD:275380	9/22 (41%)
		leucine-rich repeat	382..405	CDD:275380	9/22 (41%)
		leucine-rich repeat	406..429	CDD:275380	0/22 (0%)
		leucine-rich repeat	430..452	CDD:275380	7/21 (33%)
		leucine-rich repeat	453..500	CDD:275380	7/46 (15%)
		leucine-rich repeat	501..521	CDD:275380	4/19 (21%)
		leucine-rich repeat	525..547	CDD:275380	1/21 (5%)
		leucine-rich repeat	548..573	CDD:275380	7/24 (29%)
		leucine-rich repeat	604..640	CDD:275380	6/35 (17%)
		leucine-rich repeat	641..688	CDD:275380	0/46 (0%)
		leucine-rich repeat	689..816	CDD:275380	8/126 (6%)
		LRR_8	815..875	CDD:290566	19/59 (32%)
		leucine-rich repeat	817..864	CDD:275380	14/46 (30%)
		LRR_8	864..921	CDD:290566	15/62 (24%)
		leucine-rich repeat	865..888	CDD:275380	5/22 (23%)
		leucine-rich repeat	889..910	CDD:275380	7/26 (27%)
		TIR	1076..1211	CDD:214587	47/139 (34%)
Tlr5	NP_001139300.1	LRR_8	<96..143	CDD:404697	13/50 (26%)
		PLN00113	<108..>384	CDD:215061	83/317 (26%)
		leucine-rich repeat	109..132	CDD:275380	7/22 (32%)
		leucine-rich repeat	133..158	CDD:275380	4/28 (14%)
		leucine-rich repeat	159..183	CDD:275380	11/35 (31%)
		leucine-rich repeat	184..217	CDD:275380	11/52 (21%)
		leucine-rich repeat	240..301	CDD:275380	14/60 (23%)
		leucine-rich repeat	302..325	CDD:275380	8/24 (33%)
		LRR	314..>578	CDD:227223	98/559 (18%)
		LRR_8	326..384	CDD:404697	22/57 (39%)
		leucine-rich repeat	326..349	CDD:275380	8/22 (36%)
		leucine-rich repeat	350..373	CDD:275380	9/22 (41%)
		leucine-rich repeat	374..397	CDD:275380	10/46 (22%)
		leucine-rich repeat	398..432	CDD:275380	13/61 (21%)
		leucine-rich repeat	433..461	CDD:275380	10/75 (13%)
		leucine-rich repeat	462..487	CDD:275380	9/45 (20%)
		leucine-rich repeat	488..516	CDD:275380	12/198 (6%)
		leucine-rich repeat	517..540	CDD:275380	8/22 (36%)
		leucine-rich repeat	541..559	CDD:275380	6/17 (35%)
		leucine-rich repeat	563..586	CDD:275380	6/25 (24%)
		PCC	567..>645	CDD:188093	19/136 (14%)
		TIR	706..856	CDD:396246	48/151 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820